$136 Cheap Flights from Des Moines (DSM) to Knoxville (TYS)

View $136 flight on Tue, Jan 20, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to McGhee Tyson Airport (TYS)

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Cheap Flights from Des Moines to Knoxville (DSM-TYS)

Prices were available within the past 7 days and start at $136 for one-way flights and $271 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Dec 31 - Tue, Jan 6
DSM
Des Moines
TYS
Knoxville
$271 Roundtrip, found 13 hours ago
$271
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Wed, Dec 31 from Des Moines to Knoxville, returning Tue, Jan 6, priced at $271 found 13 hours ago
United
Wed, Aug 19 - Wed, Aug 26
DSM
Des Moines
TYS
Knoxville
$276 Roundtrip, found 1 day ago
$276
Roundtrip
found 1 day ago
Select United flight, departing Wed, Aug 19 from Des Moines to Knoxville, returning Wed, Aug 26, priced at $276 found 1 day ago
Southwest Airlines
Sat, Apr 25 - Sat, May 2
DSM
Des Moines
TYS
Knoxville
$281 Roundtrip, found 19 hours ago
$281
Roundtrip
found 19 hours ago
Select Southwest Airlines flight, departing Sat, Apr 25 from Des Moines to Knoxville, returning Sat, May 2, priced at $281 found 19 hours ago
Southwest Airlines
Wed, Apr 1 - Tue, Apr 7
DSM
Des Moines
TYS
Knoxville
$286 Roundtrip, found 2 days ago
$286
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Apr 1 from Des Moines to Knoxville, returning Tue, Apr 7, priced at $286 found 2 days ago
Southwest Airlines
Wed, Apr 1 - Tue, Apr 7
DSM
Des Moines
TYS
Knoxville
$292 Roundtrip, found 2 days ago
$292
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Apr 1 from Des Moines to Knoxville, returning Tue, Apr 7, priced at $292 found 2 days ago
United
Wed, Aug 19 - Wed, Aug 26
DSM
Des Moines
TYS
Knoxville
$292 Roundtrip, found 1 day ago
$292
Roundtrip
found 1 day ago
Select United flight, departing Wed, Aug 19 from Des Moines to Knoxville, returning Wed, Aug 26, priced at $292 found 1 day ago
United
Sat, Apr 4 - Sat, Apr 11
DSM
Des Moines
TYS
Knoxville
$293 Roundtrip, found 3 days ago
$293
Roundtrip
found 3 days ago
Select United flight, departing Sat, Apr 4 from Des Moines to Knoxville, returning Sat, Apr 11, priced at $293 found 3 days ago
United
Wed, Aug 19 - Wed, Aug 26
DSM
Des Moines
TYS
Knoxville
$299 Roundtrip, found 1 day ago
$299
Roundtrip
found 1 day ago
Select United flight, departing Wed, Aug 19 from Des Moines to Knoxville, returning Wed, Aug 26, priced at $299 found 1 day ago
Delta
Wed, Dec 17 - Thu, Dec 25
DSM
Des Moines
TYS
Knoxville
$300 Roundtrip, found 5 hours ago
$300
Roundtrip
found 5 hours ago
Select Delta flight, departing Wed, Dec 17 from Des Moines to Knoxville, returning Thu, Dec 25, priced at $300 found 5 hours ago
Frontier Airlines
Mon, Dec 29 - Thu, Jan 15
DSM
Des Moines
TYS
Knoxville
$302 Roundtrip, found 2 days ago
$302
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Mon, Dec 29 from Des Moines to Knoxville, returning Thu, Jan 15, priced at $302 found 2 days ago

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Find the cheapest month to fly from Des Moines (DSM) to Knoxville (TYS)

May is typically the cheapest month to fly

From $216 - $494 per traveler.

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $315
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $315
Flights from Des Moines (DSM) to Knoxville (TYS)
Origin airport
Des Moines Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$270
Distance
653 mi

Des Moines to Knoxville Flights

The cheapest times to fly from Des Moines to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Knoxville are during the month of December. You can find some of the cheapest flights from Des Moines to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Knoxville

Sunday is one of the best days to book for cheap flights from Des Moines to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $136 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS) cost?
Lock in a cheap one-way flight from $136 or cheap return flight from $271 from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS)?
December is the cheapest month to fly from DSM to TYS. Traveling during an off-peak travel window is often the key to finding better fares.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS)?
Expedia's filter tool lets you easily compare different airlines, departure times and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest DSM to TYS flight.
How many flights per day from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS)?
There are no daily nonstop flights from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS). But you can book flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from DSM to TYS?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can change depending on a number of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What airline has the least delays from DSM to TYS?
Consider booking with Delta Air Lines if you'd like to fly straight from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS) without any delays. This airline has the strongest track record for punctuality, with an on-time performance of 100%. Want to be notified if anything changes? You can check your flight status using the Expedia App.
What is the best time to fly from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS)?
Choose a flight from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS) that leaves before 3 PM to reduce the likelihood of delays. Departures after this hour are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS) last-minute?
Booking your plane ticket from DSM to TYS shortly before your trip is typically more expensive. But if you're flexible with your schedule, you could snag a cheap last-minute fare.
Is it cheaper to book a DSM to TYS flight and hotel package?
Compared with arranging flights and hotels separately, booking a DSM to TYS flight and hotel package with Expedia could lead to significant savings. What's more, managing everything in one place will take the hassle out of planning your trip. Simply secure your flights and choose from our wide range of hotels, then customize your trip with other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS)?
Generally, it's possible to cancel or reschedule your DSM to TYS flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.