$335 Cheap Flights from Des Moines (DSM) to Quito (UIO)

View $335 flight on Tue, Dec 9, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Mariscal Sucre Intl. Airport (UIO)

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • one key icon

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Des Moines to Quito (DSM-UIO)

Prices were available within the past 7 days and start at $335 for one-way flights and $638 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Dec 2 - Thu, Mar 12
DSM
Des Moines
UIO
Quito
$638 Roundtrip, found 18 hours ago
$638
Roundtrip
found 18 hours ago
Select Delta flight, departing Tue, Dec 2 from Des Moines to Quito, returning Thu, Mar 12, priced at $638 found 18 hours ago
United
Wed, Dec 10 - Wed, Dec 24
DSM
Des Moines
UIO
Quito
$638 Roundtrip, found 3 days ago
$638
Roundtrip
found 3 days ago
Select United flight, departing Wed, Dec 10 from Des Moines to Quito, returning Wed, Dec 24, priced at $638 found 3 days ago
American Airlines
Wed, Dec 10 - Mon, Dec 29
DSM
Des Moines
UIO
Quito
$643 Roundtrip, found 1 day ago
$643
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Dec 10 from Des Moines to Quito, returning Mon, Dec 29, priced at $643 found 1 day ago
Delta
Sun, Dec 7 - Thu, Mar 12
DSM
Des Moines
UIO
Quito
$648 Roundtrip, found 18 hours ago
$648
Roundtrip
found 18 hours ago
Select Delta flight, departing Sun, Dec 7 from Des Moines to Quito, returning Thu, Mar 12, priced at $648 found 18 hours ago
Delta
Tue, Dec 9 - Sun, Dec 28
DSM
Des Moines
UIO
Quito
$648 Roundtrip, found 2 hours ago
$648
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Dec 9 from Des Moines to Quito, returning Sun, Dec 28, priced at $648 found 2 hours ago
Delta
Wed, Dec 10 - Thu, Jan 15
DSM
Des Moines
UIO
Quito
$652 Roundtrip, found 16 hours ago
$652
Roundtrip
found 16 hours ago
Select Delta flight, departing Wed, Dec 10 from Des Moines to Quito, returning Thu, Jan 15, priced at $652 found 16 hours ago
Delta
Sun, Nov 23 - Sun, Dec 7
DSM
Des Moines
UIO
Quito
$658 Roundtrip, found 3 days ago
$658
Roundtrip
found 3 days ago
Select Delta flight, departing Sun, Nov 23 from Des Moines to Quito, returning Sun, Dec 7, priced at $658 found 3 days ago
LATAM Airlines Group
Mon, Nov 17 - Mon, Nov 24
DSM
Des Moines
UIO
Quito
$658 Roundtrip, just found
$658
Roundtrip
just found
Select LATAM Airlines Group flight, departing Mon, Nov 17 from Des Moines to Quito, returning Mon, Nov 24, priced at $658 just found
American Airlines
Wed, Dec 10 - Mon, Dec 29
DSM
Des Moines
UIO
Quito
$661 Roundtrip, found 1 day ago
$661
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Dec 10 from Des Moines to Quito, returning Mon, Dec 29, priced at $661 found 1 day ago
avianca
Mon, Oct 6 - Fri, Oct 17
DSM
Des Moines
UIO
Quito
$780 Roundtrip, found 5 hours ago
$780
Roundtrip
found 5 hours ago
Select avianca flight, departing Mon, Oct 6 from Des Moines to Quito, returning Fri, Oct 17, priced at $780 found 5 hours ago

Alternative airports near Quito

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Mariscal Sucre Intl. UIO. Cheapest and Closest option available. Average driving time to city center is 33 minutes. Flights from $828
UIO
Mariscal Sucre Intl.
CheapestClosest
Average driving time to city center33 min
Flights from $828

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Mariscal Sucre Intl. Airport (UIO) cost?
Grab a cheap one-way flight from $335 or cheap return flight from $638 from Des Moines Intl. Airport (DSM) to Mariscal Sucre Intl. Airport (UIO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Mariscal Sucre Intl. Airport (UIO)?
The cheapest month to fly from DSM to UIO is December, when demand is low. Off-peak season is often when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Mariscal Sucre Intl. Airport (UIO)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest DSM to UIO flight.
How many flights per day from Des Moines Intl. Airport (DSM) to Mariscal Sucre Intl. Airport (UIO)?
There are no daily nonstop flights from Des Moines Intl. Airport (DSM) to Mariscal Sucre Intl. Airport (UIO). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be cruising above the clouds in no time.
What day of the week has the most flights from DSM to UIO?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can change depending on a range of factors, including the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Mariscal Sucre Intl. Airport (UIO)?
Opt for a flight from Des Moines Intl. Airport (DSM) to Mariscal Sucre Intl. Airport (UIO) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Departures after this hour are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Mariscal Sucre Intl. Airport (UIO) last-minute?
Booking your plane ticket from DSM to UIO just before your getaway is usually more expensive. But if there's some wiggle room with your departure times and dates, you could bag a cheap last-minute fare.
Is it cheaper to book a DSM to UIO flight and hotel package?
Compared with arranging hotels and flights separately, booking a DSM to UIO flight and hotel package with Expedia could result in significant savings. Better still, having it all in one place takes the hassle out of planning your trip. Just pick your flights and select from our extensive range of stays, then tailor your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Mariscal Sucre Intl. Airport (UIO)?
Typically, you can reschedule or cancel your DSM to UIO flight. However, there may be additional charges, especially if you booked over 24 hours ago. Check your itinerary for the airline's fees and rules on flight changes, or if you'd like further information, head to our Customer Service portal.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
Mariscal Sucre Intl.
Airlines serving
American Airlines, Delta, LATAM Airlines Group, United
Roundtrip price
$638
Distance
3032 mi

Book with confidence

Book with confidence

Des Moines to Quito Flights

The cheapest times to fly from Des Moines to Quito

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Quito are during the month of December. You can find some of the cheapest flights from Des Moines to Quito with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Quito

Sunday is one of the best days to book for cheap flights from Des Moines to Quito: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Quito

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Quito in 2025. You can also book with separate airlines for your outbound and return journeys, from $335 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Quito flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Quito airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Quito Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.