$126 Cheap Flights from Key West (EYW) to Myrtle Beach (MYR)

View $126 flight on Tue, Sep 23, 2025Opens in a new window

Popular airlines from Key West Intl. Airport (EYW) to Myrtle Beach Intl. Airport (MYR)

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Cheap Flights from Key West to Myrtle Beach (EYW-MYR)

Prices were available within the past 7 days and start at $126 for one-way flights and $249 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Sep 18 - Sun, Sep 21
EYW
Key West
MYR
Myrtle Beach
$249 Roundtrip, found 2 days ago
$249
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Sep 18 from Key West to Myrtle Beach, returning Sun, Sep 21, priced at $249 found 2 days ago
Delta
Tue, Sep 9 - Wed, Sep 10
EYW
Key West
MYR
Myrtle Beach
$251 Roundtrip, found 6 days ago
$251
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Sep 9 from Key West to Myrtle Beach, returning Wed, Sep 10, priced at $251 found 6 days ago
American Airlines
Fri, Sep 26 - Wed, Oct 1
EYW
Key West
MYR
Myrtle Beach
$254 Roundtrip, found 5 days ago
$254
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Sep 26 from Key West to Myrtle Beach, returning Wed, Oct 1, priced at $254 found 5 days ago
Delta
Sat, Sep 6 - Mon, Sep 15
EYW
Key West
MYR
Myrtle Beach
$279 Roundtrip, found 6 days ago
$279
Roundtrip
found 6 days ago
Select Delta flight, departing Sat, Sep 6 from Key West to Myrtle Beach, returning Mon, Sep 15, priced at $279 found 6 days ago
American Airlines
Fri, Sep 26 - Wed, Oct 1
EYW
Key West
MYR
Myrtle Beach
$284 Roundtrip, found 5 days ago
$284
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Sep 26 from Key West to Myrtle Beach, returning Wed, Oct 1, priced at $284 found 5 days ago
Delta
Fri, Sep 26 - Tue, Sep 30
EYW
Key West
MYR
Myrtle Beach
$304 Roundtrip, found 5 days ago
$304
Roundtrip
found 5 days ago
Select Delta flight, departing Fri, Sep 26 from Key West to Myrtle Beach, returning Tue, Sep 30, priced at $304 found 5 days ago
American Airlines
Tue, Oct 21 - Wed, Oct 22
EYW
Key West
MYR
Myrtle Beach
$305 Roundtrip, found 6 days ago
$305
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Oct 21 from Key West to Myrtle Beach, returning Wed, Oct 22, priced at $305 found 6 days ago
American Airlines
Thu, Sep 18 - Sun, Sep 21
EYW
Key West
MYR
Myrtle Beach
$319 Roundtrip, found 2 days ago
$319
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Sep 18 from Key West to Myrtle Beach, returning Sun, Sep 21, priced at $319 found 2 days ago
American Airlines
Fri, Sep 26 - Wed, Oct 1
EYW
Key West
MYR
Myrtle Beach
$324 Roundtrip, found 5 days ago
$324
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Sep 26 from Key West to Myrtle Beach, returning Wed, Oct 1, priced at $324 found 5 days ago
American Airlines
Sat, Oct 18 - Wed, Oct 22
EYW
Key West
MYR
Myrtle Beach
$329 Roundtrip, found 6 days ago
$329
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Oct 18 from Key West to Myrtle Beach, returning Wed, Oct 22, priced at $329 found 6 days ago
Flights from Key West (EYW) to Myrtle Beach (MYR)
Origin airport
Key West Intl.
Destination airport
Myrtle Beach Intl.
Airlines serving
American Airlines, Delta
Roundtrip price
$248
Distance
653 mi

Key West to Myrtle Beach Flights

The cheapest times to fly from Key West to Myrtle Beach

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Key West to Myrtle Beach are during the month of September. You can find some of the cheapest flights from Key West to Myrtle Beach with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Key West to Myrtle Beach

Sunday is one of the best days to book for cheap flights from Key West to Myrtle Beach: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Key West to Myrtle Beach

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Key West to Myrtle Beach in 2025. You can also book with separate airlines for your outbound and return journeys, from $126 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Key West to Myrtle Beach flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Key West to Myrtle Beach airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Key West Intl. Airport (EYW) to Myrtle Beach Intl. Airport (MYR) cost?
Grab a cheap one-way flight from $126 or cheap return flight from $249 from Key West Intl. Airport (EYW) to Myrtle Beach Intl. Airport (MYR) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Key West Intl. Airport (EYW) to Myrtle Beach Intl. Airport (MYR)?
September is the most affordable month to fly from EYW to MYR. Traveling during an off-peak travel window is often the key to finding a great deal.
What is the cheapest airline that flies from Key West Intl. Airport (EYW) to Myrtle Beach Intl. Airport (MYR)?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll fly you from EYW to MYR. Then, sort your results by "Price (lowest to highest)" to pick up a good deal.
How many flights per day from Key West Intl. Airport (EYW) to Myrtle Beach Intl. Airport (MYR)?
Nonstop flights from Key West Intl. Airport (EYW) to Myrtle Beach Intl. Airport (MYR) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from EYW to MYR?
Usually you'll find the most flight options available on a Friday. Tuesdays tend to be the quietest.* However, this can change based on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Key West Intl. Airport (EYW) to Myrtle Beach Intl. Airport (MYR)?
Select a flight from Key West Intl. Airport (EYW) to Myrtle Beach Intl. Airport (MYR) that takes off before 3 PM to reduce the risk of cancellations and delays. Departures after this time are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Key West Intl. Airport (EYW) to Myrtle Beach Intl. Airport (MYR) last-minute?
Booking your ticket from EYW to MYR right before your trip is typically more expensive. But if there's some wiggle room with your schedule, you could land a cheap last-minute fare.
Is it cheaper to book an EYW to MYR flight and hotel package?
Compared with arranging hotels and flights separately, booking an EYW to MYR flight and hotel package with Expedia could result in significant savings. Better still, having everything in one easy place will take the stress out of travel planning. Just secure your flights and select from our extensive range of stays, then customize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Key West Intl. Airport (EYW) to Myrtle Beach Intl. Airport (MYR)?
If you booked your EYW to MYR flight in the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more details.

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*Available to One Key members.