$299 Cheap Flights from Florence (FLO) to Myrtle Beach (MYR)

View $299 flight on Thu, Nov 27, 2025Opens in a new window

Popular airlines from Florence, SC (FLO-Florence Regional) to Myrtle Beach Intl. Airport (MYR)

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Cheap Flights from Florence to Myrtle Beach (FLO-MYR)

Prices were available within the past 7 days and start at $299 for one-way flights and $1,000 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Nov 20 - Thu, Nov 27
FLO
Florence
MYR
Myrtle Beach
$1,000 Roundtrip, found 6 days ago
$1,000
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 20 from Florence to Myrtle Beach, returning Thu, Nov 27, priced at $1,000 found 6 days ago
American Airlines
Thu, Nov 20 - Thu, Nov 27
FLO
Florence
MYR
Myrtle Beach
$1,059 Roundtrip, found 6 days ago
$1,059
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 20 from Florence to Myrtle Beach, returning Thu, Nov 27, priced at $1,059 found 6 days ago
American Airlines
Thu, Nov 20 - Thu, Nov 27
FLO
Florence
MYR
Myrtle Beach
$1,097 Roundtrip, found 6 days ago
$1,097
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 20 from Florence to Myrtle Beach, returning Thu, Nov 27, priced at $1,097 found 6 days ago
American Airlines
Thu, Nov 20 - Thu, Nov 27
FLO
Florence
MYR
Myrtle Beach
$1,166 Roundtrip, found 6 days ago
$1,166
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 20 from Florence to Myrtle Beach, returning Thu, Nov 27, priced at $1,166 found 6 days ago
American Airlines
Thu, Nov 20 - Thu, Nov 27
FLO
Florence
MYR
Myrtle Beach
$1,189 Roundtrip, found 6 days ago
$1,189
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 20 from Florence to Myrtle Beach, returning Thu, Nov 27, priced at $1,189 found 6 days ago
American Airlines
Thu, Nov 20 - Thu, Nov 27
FLO
Florence
MYR
Myrtle Beach
$1,199 Roundtrip, found 6 days ago
$1,199
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 20 from Florence to Myrtle Beach, returning Thu, Nov 27, priced at $1,199 found 6 days ago
American Airlines
Thu, Nov 20 - Thu, Nov 27
FLO
Florence
MYR
Myrtle Beach
$1,240 Roundtrip, found 6 days ago
$1,240
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 20 from Florence to Myrtle Beach, returning Thu, Nov 27, priced at $1,240 found 6 days ago
American Airlines
Thu, Nov 20 - Thu, Nov 27
FLO
Florence
MYR
Myrtle Beach
$1,247 Roundtrip, found 6 days ago
$1,247
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 20 from Florence to Myrtle Beach, returning Thu, Nov 27, priced at $1,247 found 6 days ago
American Airlines
Thu, Nov 20 - Thu, Nov 27
FLO
Florence
MYR
Myrtle Beach
$1,254 Roundtrip, found 6 days ago
$1,254
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 20 from Florence to Myrtle Beach, returning Thu, Nov 27, priced at $1,254 found 6 days ago
American Airlines
Thu, Nov 20 - Thu, Nov 27
FLO
Florence
MYR
Myrtle Beach
$1,287 Roundtrip, found 6 days ago
$1,287
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 20 from Florence to Myrtle Beach, returning Thu, Nov 27, priced at $1,287 found 6 days ago

Frequently asked questions

How much does a flight from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR) cost?
Snag a cheap one-way flight from $299 or cheap return flight from $1,000 from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR)?
The cheapest month to fly from FLO to MYR is November, when demand is low. Off-peak season is typically when you'll find cheap fares for travel between these airports.
What is the cheapest airline that flies from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest FLO to MYR flight.
How many flights per day from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR)?
Nonstop flights from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from FLO to MYR?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can change based on a number of factors, such as the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR)?
To avoid possible delays on the Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR) route, travel before 3 PM. Departures after this hour are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR) last-minute?
Holding off until right before your break to book a flight from FLO to MYR often results in higher prices. While it's possible to find some last-minute discounts, there's no guarantee. Be flexible with your travel plans to maximize your chances of scoring a bargain.
Is it cheaper to book a FLO to MYR flight and hotel package?
You'll generally save money by securing a FLO to MYR flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one place. Once you've chosen your preferred flights and accommodations, consider adding extras including activities, car rentals and tours.
Can I cancel or change the date of my flight from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR)?
You can usually cancel or reschedule your FLO to MYR flight. However, if it's been more than 24 hours since booking, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Origin airport
Florence Regional
Destination airport
Myrtle Beach Intl.
Roundtrip price
$1,000
Distance
58 mi

Book with confidence

Florence to Myrtle Beach Flights

The cheapest times to fly from Florence to Myrtle Beach

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Myrtle Beach are during the month of November. You can find some of the cheapest flights from Florence to Myrtle Beach with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Florence to Myrtle Beach

Sunday is one of the best days to book for cheap flights from Florence to Myrtle Beach: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Florence to Myrtle Beach

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Myrtle Beach in 2025. You can also book with separate airlines for your outbound and return journeys, from $299 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Myrtle Beach flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Florence to Myrtle Beach airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Florence to Myrtle Beach Flights

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*Available to One Key members.