$384 Cheap Flights from Florence (FLO) to Myrtle Beach (MYR)

View $384 flight on Sat, Sep 20, 2025Opens in a new window

Popular airlines from Florence, SC (FLO-Florence Regional) to Myrtle Beach Intl. Airport (MYR)

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Cheap Flights from Florence to Myrtle Beach (FLO-MYR)

Prices were available within the past 7 days and start at $384 for one-way flights and $378 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Oct 7 - Wed, Oct 15
FLO
Florence
MYR
Myrtle Beach
$378 Roundtrip, found 4 days ago
$378
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Oct 7 from Florence to Myrtle Beach, returning Wed, Oct 15, priced at $378 found 4 days ago
American Airlines
Tue, Oct 7 - Wed, Oct 15
FLO
Florence
MYR
Myrtle Beach
$498 Roundtrip, found 4 days ago
$498
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Oct 7 from Florence to Myrtle Beach, returning Wed, Oct 15, priced at $498 found 4 days ago
American Airlines
Tue, Oct 7 - Wed, Oct 15
FLO
Florence
MYR
Myrtle Beach
$597 Roundtrip, found 4 days ago
$597
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Oct 7 from Florence to Myrtle Beach, returning Wed, Oct 15, priced at $597 found 4 days ago
American Airlines
Fri, Jan 9 - Sun, Jan 11
FLO
Florence
MYR
Myrtle Beach
$677 Roundtrip, found 14 hours ago
$677
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, Jan 9 from Florence to Myrtle Beach, returning Sun, Jan 11, priced at $677 found 14 hours ago
American Airlines
Fri, Jan 9 - Sun, Jan 11
FLO
Florence
MYR
Myrtle Beach
$696 Roundtrip, found 14 hours ago
$696
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, Jan 9 from Florence to Myrtle Beach, returning Sun, Jan 11, priced at $696 found 14 hours ago
American Airlines
Tue, Oct 7 - Wed, Oct 15
FLO
Florence
MYR
Myrtle Beach
$717 Roundtrip, found 4 days ago
$717
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Oct 7 from Florence to Myrtle Beach, returning Wed, Oct 15, priced at $717 found 4 days ago
American Airlines
Tue, Oct 7 - Wed, Oct 15
FLO
Florence
MYR
Myrtle Beach
$734 Roundtrip, found 4 days ago
$734
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Oct 7 from Florence to Myrtle Beach, returning Wed, Oct 15, priced at $734 found 4 days ago
American Airlines
Fri, Jan 9 - Sun, Jan 11
FLO
Florence
MYR
Myrtle Beach
$764 Roundtrip, found 14 hours ago
$764
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, Jan 9 from Florence to Myrtle Beach, returning Sun, Jan 11, priced at $764 found 14 hours ago
American Airlines
Tue, Oct 7 - Wed, Oct 15
FLO
Florence
MYR
Myrtle Beach
$769 Roundtrip, found 4 days ago
$769
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Oct 7 from Florence to Myrtle Beach, returning Wed, Oct 15, priced at $769 found 4 days ago
American Airlines
Fri, Jan 9 - Sun, Jan 11
FLO
Florence
MYR
Myrtle Beach
$797 Roundtrip, found 14 hours ago
$797
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, Jan 9 from Florence to Myrtle Beach, returning Sun, Jan 11, priced at $797 found 14 hours ago
Flights from Florence (FLO) to Myrtle Beach (MYR)
Origin airport
Florence Regional
Destination airport
Myrtle Beach Intl.
Roundtrip price
$377
Distance
58 mi

Florence to Myrtle Beach Flights

The cheapest times to fly from Florence to Myrtle Beach

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Myrtle Beach are during the month of October. You can find some of the cheapest flights from Florence to Myrtle Beach with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Florence to Myrtle Beach

Sunday is one of the best days to book for cheap flights from Florence to Myrtle Beach: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Florence to Myrtle Beach

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Myrtle Beach in 2025. You can also book with separate airlines for your outbound and return journeys, from $384 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Myrtle Beach flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Florence to Myrtle Beach airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR) cost?
Snag a cheap one-way flight from $384 or cheap return flight from $378 from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR)?
The cheapest month to fly from FLO to MYR is October, when demand is low. Off-peak season is typically when you'll find cheap fares for travel between these airports.
What is the cheapest airline that flies from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest FLO to MYR flight.
How many flights per day from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR)?
Nonstop flights from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from FLO to MYR?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can change based on a number of factors, such as the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR)?
To avoid possible delays on the Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR) route, travel before 3 PM. Departures after this hour are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR) last-minute?
Holding off until right before your break to book a flight from FLO to MYR often results in higher prices. While it's possible to find some last-minute discounts, there's no guarantee. Be flexible with your travel plans to maximize your chances of scoring a bargain.
Is it cheaper to book a FLO to MYR flight and hotel package?
You'll generally save money by securing a FLO to MYR flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one place. Once you've chosen your preferred flights and accommodations, consider adding extras including activities, car rentals and tours.
Can I cancel or change the date of my flight from Florence Regional Airport (FLO) to Myrtle Beach Intl. Airport (MYR)?
You can usually cancel or reschedule your FLO to MYR flight. However, if it's been more than 24 hours since booking, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.