$315 Cheap Flights from La Crosse (LSE) to Myrtle Beach (MYR)

View $315 flight on Fri, Aug 8, 2025Opens in a new window

Popular airlines from La Crosse, WI (LSE-La Crosse Municipal) to Myrtle Beach Intl. Airport (MYR)

Cheap Flights from La Crosse to Myrtle Beach (LSE-MYR)

Prices were available within the past 7 days and start at $315 for one-way flights and $556 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Sep 2 - Sat, Sep 6
LSE
La Crosse
MYR
Myrtle Beach
$556 Roundtrip, found 5 days ago
$556
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Sep 2 from La Crosse to Myrtle Beach, returning Sat, Sep 6, priced at $556 found 5 days ago
American Airlines
Wed, Sep 3 - Sat, Sep 6
LSE
La Crosse
MYR
Myrtle Beach
$561 Roundtrip, found 5 days ago
$561
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 3 from La Crosse to Myrtle Beach, returning Sat, Sep 6, priced at $561 found 5 days ago
American Airlines
Tue, Aug 5 - Sat, Aug 9
LSE
La Crosse
MYR
Myrtle Beach
$566 Roundtrip, found 6 hours ago
$566
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Aug 5 from La Crosse to Myrtle Beach, returning Sat, Aug 9, priced at $566 found 6 hours ago
American Airlines
Sat, Aug 2 - Sat, Aug 9
LSE
La Crosse
MYR
Myrtle Beach
$571 Roundtrip, found 6 hours ago
$571
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Sat, Aug 2 from La Crosse to Myrtle Beach, returning Sat, Aug 9, priced at $571 found 6 hours ago
American Airlines
Tue, Sep 2 - Mon, Sep 8
LSE
La Crosse
MYR
Myrtle Beach
$576 Roundtrip, found 5 days ago
$576
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Sep 2 from La Crosse to Myrtle Beach, returning Mon, Sep 8, priced at $576 found 5 days ago
American Airlines
Thu, Jul 31 - Sat, Aug 9
LSE
La Crosse
MYR
Myrtle Beach
$580 Roundtrip, found 6 hours ago
$580
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Thu, Jul 31 from La Crosse to Myrtle Beach, returning Sat, Aug 9, priced at $580 found 6 hours ago
American Airlines
Tue, Aug 5 - Mon, Aug 11
LSE
La Crosse
MYR
Myrtle Beach
$586 Roundtrip, found 6 hours ago
$586
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Aug 5 from La Crosse to Myrtle Beach, returning Mon, Aug 11, priced at $586 found 6 hours ago
American Airlines
Mon, Aug 4 - Sat, Aug 9
LSE
La Crosse
MYR
Myrtle Beach
$591 Roundtrip, found 1 day ago
$591
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Aug 4 from La Crosse to Myrtle Beach, returning Sat, Aug 9, priced at $591 found 1 day ago
American Airlines
Mon, Sep 1 - Mon, Sep 8
LSE
La Crosse
MYR
Myrtle Beach
$596 Roundtrip, found 5 days ago
$596
Roundtrip
found 5 days ago
Select American Airlines flight, departing Mon, Sep 1 from La Crosse to Myrtle Beach, returning Mon, Sep 8, priced at $596 found 5 days ago
American Airlines
Thu, Jul 31 - Mon, Aug 11
LSE
La Crosse
MYR
Myrtle Beach
$600 Roundtrip, found 6 hours ago
$600
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Thu, Jul 31 from La Crosse to Myrtle Beach, returning Mon, Aug 11, priced at $600 found 6 hours ago

Alternative airports near Myrtle Beach

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Myrtle Beach Intl. Airport MYR. Cheapest and Closest option available. Average driving time to city center is 6 minutes. Flights from $630
MYR
Myrtle Beach Intl. Airport
CheapestClosest
Average driving time to city center6 min
Flights from $630
Flights from La Crosse (LSE) to Myrtle Beach (MYR)
Origin airport
La Crosse Municipal
Destination airport
Myrtle Beach Intl.
Airlines serving
American Airlines
Roundtrip price
$555
Distance
966 mi

La Crosse to Myrtle Beach Flights

The cheapest times to fly from La Crosse to Myrtle Beach

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from La Crosse to Myrtle Beach are during the month of September. You can find some of the cheapest flights from La Crosse to Myrtle Beach with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from La Crosse to Myrtle Beach

Sunday is one of the best days to book for cheap flights from La Crosse to Myrtle Beach: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from La Crosse to Myrtle Beach

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from La Crosse to Myrtle Beach in 2025. You can also book with separate airlines for your outbound and return journeys, from $315 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap La Crosse to Myrtle Beach flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your La Crosse to Myrtle Beach airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from La Crosse Municipal Airport (LSE) to Myrtle Beach Intl. Airport (MYR) cost?
Discover the latest flight deals from LSE to MYR by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from LSE to MYR?
The cheapest flights from LSE to MYR are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from LSE to MYR?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from LSE to MYR. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from La Crosse Municipal Airport (LSE) to Myrtle Beach Intl. Airport (MYR)?
Direct flights from La Crosse Municipal Airport (LSE) to Myrtle Beach Intl. Airport (MYR) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from LSE to MYR?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can change based on various factors, such as the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from La Crosse Municipal Airport (LSE) to Myrtle Beach Intl. Airport (MYR)?
Book a flight from La Crosse Municipal Airport (LSE) to Myrtle Beach Intl. Airport (MYR) that takes off before 3 PM to reduce the likelihood of delays and cancellations. Departures after this time are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from La Crosse Municipal Airport (LSE) to Myrtle Beach Intl. Airport (MYR) last-minute?
Last-minute fares from LSE to MYR are generally more expensive. To secure the best prices, start looking for flights as soon as possible. That said, if your travel plans are flexible, it's possible to score a cheap ticket right before your trip.
Is it cheaper to book a LSE to MYR flight and hotel package?
Compared with arranging flights and hotels separately, booking a LSE to MYR flight and hotel package with Expedia could lead to significant savings. Better still, having everything in one place will take the stress out of travel planning. Simply secure your flights and choose from our wide range of stays, then customize your trip with other add-ons like car rentals and activities.
Can I cancel or change the date of my flight from La Crosse Municipal Airport (LSE) to Myrtle Beach Intl. Airport (MYR)?
Typically, you're able to reschedule or cancel your LSE to MYR flight. However, there may be additional fees, especially if you booked more than 24 hours ago. Double-check your itinerary for the airline's rules and fees on flight changes, or if you'd like more details, head to our Customer Service portal.

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*Available to One Key members.