$659 Cheap Flights from Mayagüez (MAZ) to San Diego (SAN)

View $659 flight on Fri, Dec 26, 2025Opens in a new window

Popular airlines from Mayagüez (MAZ-Eugenio María de Hostos) to San Diego Intl. Airport (SAN)

Cheap Flights from Mayagüez to San Diego (MAZ-SAN)

Prices were available within the past 7 days and start at $659 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Flights from Mayagüez (MAZ) to San Diego (SAN)
Origin airport
Eugenio María de Hostos
Destination airport
San Diego Intl.
Distance
3245 mi

Mayagüez to San Diego Flights

The cheapest times to fly from Mayagüez to San Diego

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mayagüez to San Diego are during the month of . You can find some of the cheapest flights from Mayagüez to San Diego with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mayagüez to San Diego

Sunday is one of the best days to book for cheap flights from Mayagüez to San Diego: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mayagüez to San Diego

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mayagüez to San Diego in 2026. You can also book with separate airlines for your outbound and return journeys, from $659 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mayagüez to San Diego flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mayagüez to San Diego airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Eugenio Maria de Hostos Airport (MAZ) to San Diego Intl. Airport (SAN) cost?
Snag a cheap one-way flight from $659 or cheap return flight from Eugenio Maria de Hostos Airport (MAZ) to San Diego Intl. Airport (SAN) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Eugenio Maria de Hostos Airport (MAZ) to San Diego Intl. Airport (SAN)?
The cheapest month to fly from MAZ to SAN is , when there's less demand. Off-peak season is usually when you'll find lower airfares between these airports.
What is the cheapest airline that flies from Eugenio Maria de Hostos Airport (MAZ) to San Diego Intl. Airport (SAN)?
To find the cheapest airline that'll fly you from MAZ to SAN, use Expedia's filter tool. Customize your search based on your travel style, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from Eugenio Maria de Hostos Airport (MAZ) to San Diego Intl. Airport (SAN)?
You'll need to catch a flight with a layover when traveling from Eugenio Maria de Hostos Airport (MAZ) to San Diego Intl. Airport (SAN). Direct flights don't operate daily on this route. However, just filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from MAZ to SAN?
Usually you'll have the most choice when it comes to flights on a Friday. Tuesdays tend to be the quietest.* But this can vary based on the season, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Eugenio Maria de Hostos Airport (MAZ) to San Diego Intl. Airport (SAN)?
To reach San Diego Intl. Airport (SAN) on time, select a flight that leaves from Eugenio Maria de Hostos Airport (MAZ) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Eugenio Maria de Hostos Airport (MAZ) to San Diego Intl. Airport (SAN) last-minute?
Waiting until right before your break to book a ticket from MAZ to SAN generally means paying more. While you might find some last-minute deals, they're not always guaranteed. Keep your travel schedule open to boost your chances of snagging a bargain.
Is it cheaper to book a MAZ to SAN flight and hotel package?
Booking a MAZ to SAN flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip all in one place. Choose from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Eugenio Maria de Hostos Airport (MAZ) to San Diego Intl. Airport (SAN)?
If you reserved your MAZ to SAN flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you want more information.

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*Available to One Key members.