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$194 Cheap Flights from Fort Myers (RSW) to St. Louis (STL)

View $194 flight on Mon, Oct 26, 2026Opens in a new window

Popular airlines from Southwest Florida Intl. Airport (RSW) to St. Louis Lambert Intl. Airport (STL)

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Cheap Flights from Fort Myers to St. Louis (RSW-STL)

Prices were available within the past 7 days and start at $194 for one-way flights and $340 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Wed, Oct 21 - Mon, Oct 26
RSW
Fort Myers
STL
St. Louis
$340 Roundtrip, found 2 days ago
$340
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Oct 21 from Fort Myers to St. Louis, returning Mon, Oct 26, priced at $340 found 2 days ago
Southwest Airlines
Wed, Dec 9 - Sat, Dec 12
RSW
Fort Myers
STL
St. Louis
$343 Roundtrip, found 2 days ago
$343
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Dec 9 from Fort Myers to St. Louis, returning Sat, Dec 12, priced at $343 found 2 days ago
Southwest Airlines
Wed, Nov 11 - Mon, Nov 16
RSW
Fort Myers
STL
St. Louis
$344 Roundtrip, found 4 days ago
$344
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Wed, Nov 11 from Fort Myers to St. Louis, returning Mon, Nov 16, priced at $344 found 4 days ago
Southwest Airlines
Thu, Nov 5 - Sat, Nov 7
RSW
Fort Myers
STL
St. Louis
$345 Roundtrip, found 3 days ago
$345
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Thu, Nov 5 from Fort Myers to St. Louis, returning Sat, Nov 7, priced at $345 found 3 days ago
Southwest Airlines
Wed, Oct 21 - Mon, Oct 26
RSW
Fort Myers
STL
St. Louis
$347 Roundtrip, found 2 days ago
$347
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Oct 21 from Fort Myers to St. Louis, returning Mon, Oct 26, priced at $347 found 2 days ago
Southwest Airlines
Wed, Nov 11 - Sat, Nov 14
RSW
Fort Myers
STL
St. Louis
$350 Roundtrip, found 4 days ago
$350
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Wed, Nov 11 from Fort Myers to St. Louis, returning Sat, Nov 14, priced at $350 found 4 days ago
United
Wed, Oct 21 - Mon, Oct 26
RSW
Fort Myers
STL
St. Louis
$357 Roundtrip, found 2 days ago
$357
Roundtrip
found 2 days ago
Select United flight, departing Wed, Oct 21 from Fort Myers to St. Louis, returning Mon, Oct 26, priced at $357 found 2 days ago
Delta
Fri, Oct 23 - Sat, Oct 24
RSW
Fort Myers
STL
St. Louis
$375 Roundtrip, found 2 days ago
$375
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Oct 23 from Fort Myers to St. Louis, returning Sat, Oct 24, priced at $375 found 2 days ago
American Airlines
Fri, Oct 23 - Fri, Oct 30
RSW
Fort Myers
STL
St. Louis
$433 Roundtrip, just found
$433
Roundtrip
just found
Select American Airlines flight, departing Fri, Oct 23 from Fort Myers to St. Louis, returning Fri, Oct 30, priced at $433 just found
Alaska Airlines
Sat, Dec 5 - Sat, Jan 9
RSW
Fort Myers
STL
St. Louis
$753 Roundtrip, found 1 day ago
$753
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Sat, Dec 5 from Fort Myers to St. Louis, returning Sat, Jan 9, priced at $753 found 1 day ago

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $432
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $432

What you need to know for your flight from Southwest Florida Intl. to Lambert-St. Louis Intl.

Fort Myers (RSW) to St. Louis (STL) at a glance

Travel between Fort Myers (RSW) and St. Louis (STL) with a range of airlines offering convenient options on this domestic short-haul route. Assess your choices from both full-service and budget airlines to discover flights that align with your budget and travel schedule as you prepare to explore the iconic attractions and neighborhoods of St. Louis. Get essential information on flights from Southwest Florida International Airport (RSW) to Lambert-St. Louis International Airport (STL).

  • Fastest flight duration: around 2h 45m non-stop
  • Route distance: roughly 1,000 miles (1,610 km)
  • Flights per week: around 14 flights with multiple daily departures on average
  • Typical fares (one-way): economy tickets often range from $80–$440, depending on seasonality and how far ahead you book

Flights from Southwest Florida International Airport (RSW) to Lambert-St. Louis International Airport (STL)

According to recent traveler bookings, here are the top airlines favored for flights from Fort Myers to St. Louis, featuring both non-stop and one-stop options. Common layover spots include Hartsfield-Jackson Atlanta International Airport (ATL), Charlotte-Douglas International Airport (CLT), and O'Hare International Airport (ORD), each with an average layover of about 1 hour and 15 minutes. This variety allows you to mix and match factors like price, total travel time, and cabin class to discover the ideal itinerary for your journey.

  • Southwest Airlines: This budget-friendly airline provides both non-stop and one-stop options, with one-way prices generally falling between $80 and $455. It represents about 47% of the departures on this route, typically taking around 2 hours and 45 minutes for a non-stop flight.
  • Delta: A full-service airline offering one-stop journeys, Delta's one-way fare usually ranges from $100 to $430. It accounts for roughly 24% of departures on this route, featuring an in-flight duration of 4 hours, with the total travel time averaging about 5 hours and 15 minutes, including layovers.
  • American Airlines: This full-service carrier also provides one-stop services, with one-way fares typically between $90 and $430. American Airlines covers approximately 22% of the departures on this route, with a 4-hour flight time and an overall journey length of about 5 hours and 15 minutes, factoring in layovers.
  • United: Another full-service option, United offers one-stop flights with one-way fares usually ranging from $110 to $380. It makes up around 7% of the departures on this route, featuring a flying time of 4 hours and a total travel duration of approximately 5 hours and 15 minutes, including layovers.

Travelers flying from Fort Myers to St. Louis can opt to upgrade their experience, as American Airlines provides first class service on this route.

Best time to fly from Fort Myers (RSW) to St. Louis (STL)

The most popular months for travelers flying from Fort Myers to St. Louis are January, March, and July, when peak temperatures in St. Louis reach up to 78.6°F in July. If you prefer quieter travel, consider September, the least busy time to visit with temperatures around 70.9°F and typically the lowest average one-way fare (around $156). Flight availability peaks in July and December, with approximately 17 flights per week, making it easier to find convenient departure times. May has the fewest flights, with approximately 11 flights per week.

  • Cheapest time to fly: September usually offers good deals with average one-way fare around $156, roughly 28% cheaper than the yearly average.
  • Another budget-friendly time to fly: August typically offers an average one-way fare of around $170.
  • Most flight options: July and December have the highest number of flights from Fort Myers to St. Louis, with approximately 17 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January31.6°F (-0.2°C)Moderately High14$264
February34.9°F (1.6°C)Average12$284
March46.4°F (8.0°C)Moderately High16$287
April56.1°F (13.4°C)Average14$245
May66.6°F (19.2°C)Moderately Low11$234
June76.1°F (24.5°C)Average15$228
July78.6°F (25.9°C)Moderately High17$179
August77.0°F (25.0°C)Average14$170
September70.9°F (21.6°C)Moderately Low14$156
October58.6°F (14.8°C)Average16$189
November46.2°F (7.9°C)Moderately Low15$187
December37.8°F (3.2°C)Average17$207

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative routes from Fort Myers (RSW) to St. Louis (STL)

  • Fort Myers to St. Louis (FMY-STL): Page Field Airport (FMY) is located approximately 8 miles from Southwest Florida International Airport (RSW), offering convenient access for travelers.
  • Fort Myers to St. Louis (RSW-SUS): Spirit of St. Louis Airport (SUS) lies around 16 miles from Lambert-St. Louis International Airport (STL), providing a quick connection for passengers.
  • Fort Myers to Springfield (RSW-SPI): Abraham Lincoln Capital Airport (SPI) is situated roughly 85 miles from Lambert-St. Louis International Airport (STL), making it a viable option for those heading to Springfield.

How to find the best prices for flights from Fort Myers (RSW) to St. Louis (STL)

Getting some of the best deals on flights from Fort Myers to St. Louis is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually available when booking at least two months in advance, though most travelers tend to book between two to eight weeks ahead. Morning departures, from 5 a.m. to 12 p.m., offer lower prices and are also the most popular flight times, while flying on Thursday provides both affordability and popularity as a travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Lambert-St. Louis International Airport from Southwest Florida International Airport

St. Louis welcomes travelers from Fort Myers with a range of transport options based on price, convenience, and proximity. Here's how to reach St. Louis efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in St. Louis, with private rides that can be arranged in advance.
  • Car rental: Renting a car from Lambert-St. Louis International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Lambert-St. Louis International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
  • Public transportation: From Lambert-St. Louis International Airport, Lambert Main Terminal Station, a metro station, is located about 0.1 miles away on foot, providing convenient access to public transportation.

Frequently asked questions

How much does a flight from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) cost?
You can find cheap one-way flights from $194 and cheap return flights from $340 Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) with Expedia. One-way flights typically cost between $157 and $670, and return flights often range between $301 and $987. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The cheapest month to fly from RSW to STL is October when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Enter RSW to STL and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
To find a cheap flight from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The best airline to fly with from Fort Myers, FL (RSW) to St. Louis, MO (STL) will differ from traveler to traveler. If you like to fly early, WN offers early morning flights. If price is the most important factor, WN typically offers the lowest fares. WN also offers the most daily flights from Fort Myers to St. Louis, which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
There are approximately 3 nonstop flights per day from Southwest Florida Intl. (RSW) to Lambert-St. Louis Intl. (STL). For more options, look at flights that include layovers.
What is the earliest flight from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The earliest flight from Southwest Florida Intl. Airport (RSW) to Lambert-St. Louis Intl. Airport (STL) typically leaves at 5:00 AM. Operated by Southwest Airlines, this early departure allows you to arrive in St. Louis with plenty of time to explore the city. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The most popular departure times for flights from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) are in the early morning, from 6am to 9am. About 28% of passengers prefer this time window. Many major carriers, including American Airlines, Southwest Airlines, and Delta, offer flights during this window. This timing works well because it allows you to arrive in St. Louis with plenty of time to enjoy your day.
How long does it take to fly from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Flying nonstop from RSW to STL takes around 2 hours 50 minutes, with the route covering approximately 980 miles. Flights with a layover typically take 3 hours 10 minutes longer than direct options. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Select the "Business class" and "First class" filters when looking for RSW to STL flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight with Expedia?
It's easy to earn miles on a Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for St. Louis from Southwest Florida Intl. (RSW)?
If you're planning to travel to St. Louis from Southwest Florida Intl. (RSW), you can fly into Lambert-St. Louis Intl. (STL) Some flights may connect through major hubs like Liberty Intl. (EWR), Hopkins Intl. (CLE), Baltimore Washington Intl. Thurgood Marshall (BWI) before reaching St. Louis. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) at the last minute?
Typically, booking a last minute flight from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight and hotel package?
Securing a Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) St Louis Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
If you booked your Fort Myers, FL (RSW-Southwest Florida Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Southwest Florida Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$340
Distance
980 mi
Average flight time
1 hour 32 mins

Book with confidence

Fort Myers to St. Louis Flights

The cheapest times to fly from Fort Myers to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Fort Myers to St. Louis are during the month of October. You can find some of the cheapest flights from Fort Myers to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Fort Myers to St. Louis

Sunday is one of the best days to book for cheap flights from Fort Myers to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Fort Myers to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Fort Myers to St. Louis in 2026. You can also book with separate airlines for your outbound and return journeys, from $194 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Fort Myers to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Fort Myers to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Fort Myers to St. Louis Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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