$271 Cheap Flights from Tyler (TYR) to St. Louis (STL)

View $271 flight on Thu, Nov 27, 2025Opens in a new window

Popular airlines from Tyler, TX (TYR-Pounds Regional) to St. Louis Lambert Intl. Airport (STL)

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Cheap Flights from Tyler to St. Louis (TYR-STL)

Prices were available within the past 7 days and start at $271 for one-way flights and $378 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Oct 16 - Thu, Oct 23
TYR
Tyler
STL
St. Louis
$378 Roundtrip, found 19 hours ago
$378
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Thu, Oct 16 from Tyler to St. Louis, returning Thu, Oct 23, priced at $378 found 19 hours ago
American Airlines
Thu, Oct 30 - Sat, Nov 15
TYR
Tyler
STL
St. Louis
$398 Roundtrip, found 2 days ago
$398
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Oct 30 from Tyler to St. Louis, returning Sat, Nov 15, priced at $398 found 2 days ago
American Airlines
Wed, Oct 29 - Sat, Nov 15
TYR
Tyler
STL
St. Louis
$404 Roundtrip, found 2 days ago
$404
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Oct 29 from Tyler to St. Louis, returning Sat, Nov 15, priced at $404 found 2 days ago
American Airlines
Sun, Nov 23 - Fri, Nov 28
TYR
Tyler
STL
St. Louis
$419 Roundtrip, found 3 days ago
$419
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sun, Nov 23 from Tyler to St. Louis, returning Fri, Nov 28, priced at $419 found 3 days ago
American Airlines
Fri, Oct 17 - Sat, Nov 1
TYR
Tyler
STL
St. Louis
$428 Roundtrip, found 2 days ago
$428
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Oct 17 from Tyler to St. Louis, returning Sat, Nov 1, priced at $428 found 2 days ago
American Airlines
Thu, Oct 16 - Thu, Oct 23
TYR
Tyler
STL
St. Louis
$439 Roundtrip, found 19 hours ago
$439
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Thu, Oct 16 from Tyler to St. Louis, returning Thu, Oct 23, priced at $439 found 19 hours ago
American Airlines
Fri, Nov 14 - Wed, Dec 3
TYR
Tyler
STL
St. Louis
$447 Roundtrip, found 2 days ago
$447
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Nov 14 from Tyler to St. Louis, returning Wed, Dec 3, priced at $447 found 2 days ago
American Airlines
Mon, Oct 20 - Sat, Oct 25
TYR
Tyler
STL
St. Louis
$448 Roundtrip, found 7 hours ago
$448
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Mon, Oct 20 from Tyler to St. Louis, returning Sat, Oct 25, priced at $448 found 7 hours ago
American Airlines
Tue, Nov 25 - Sun, Nov 30
TYR
Tyler
STL
St. Louis
$458 Roundtrip, found 3 days ago
$458
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Nov 25 from Tyler to St. Louis, returning Sun, Nov 30, priced at $458 found 3 days ago
American Airlines
Thu, Nov 20 - Mon, Dec 1
TYR
Tyler
STL
St. Louis
$466 Roundtrip, found 3 days ago
$466
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Nov 20 from Tyler to St. Louis, returning Mon, Dec 1, priced at $466 found 3 days ago

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $428
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $428

Frequently asked questions

How much does a flight from Pounds Regional Airport (TYR) to Lambert-St. Louis Intl. Airport (STL) cost?
Get a cheap one-way flight from $271 or cheap return flight from $378 from Pounds Regional Airport (TYR) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Pounds Regional Airport (TYR) to Lambert-St. Louis Intl. Airport (STL)?
Traveling in October can help you save, as it's the cheapest month for flights between TYR and STL. You'll typically find the lowest fares during the off-season.
What is the cheapest airline that flies from Pounds Regional Airport (TYR) to Lambert-St. Louis Intl. Airport (STL)?
To find the cheapest airline flying from TYR to STL, use Expedia's filter tool. Customize your search based on your travel needs, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Pounds Regional Airport (TYR) to Lambert-St. Louis Intl. Airport (STL)?
Nonstop flights from Pounds Regional Airport (TYR) to Lambert-St. Louis Intl. Airport (STL) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from TYR to STL?
Typically you'll find the most flight options available on a Friday. Tuesdays tend to be the quietest.* However, this can change depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Pounds Regional Airport (TYR) to Lambert-St. Louis Intl. Airport (STL)?
To avoid potential delays on the Pounds Regional Airport (TYR) to Lambert-St. Louis Intl. Airport (STL) route, travel before 3 PM. Departures after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Pounds Regional Airport (TYR) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Last-minute bookings from TYR to STL are usually more expensive. To secure the lowest rates, start searching for flights as early as possible. That being said, if your travel plans are flexible, it's possible to find a cheap fare just before your departure.
Is it cheaper to book a TYR to STL flight and hotel package?
Compared with arranging hotels and flights separately, booking a TYR to STL flight and hotel package with Expedia could lead to significant savings. Better still, having everything in one easy place takes the hassle out of travel planning. Just pick your flights and select from our wide range of stays, then personalize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Pounds Regional Airport (TYR) to Lambert-St. Louis Intl. Airport (STL)?
If you booked your TYR to STL flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Travel information

Origin airport
Pounds Regional
Destination airport
Lambert-St. Louis Intl.
Roundtrip price
$378
Distance
524 mi

Book with confidence

Book with confidence

Tyler to St. Louis Flights

The cheapest times to fly from Tyler to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Tyler to St. Louis are during the month of October. You can find some of the cheapest flights from Tyler to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Tyler to St. Louis

Sunday is one of the best days to book for cheap flights from Tyler to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Tyler to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Tyler to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $271 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Tyler to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Tyler to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Tyler to St. Louis Flights

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*Available to One Key members.