$102 Cheap Flights from Knoxville (TYS) to Myrtle Beach (MYR)

View $102 flight on Sat, Dec 13, 2025Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Myrtle Beach Intl. Airport (MYR)

Cheap Flights from Knoxville to Myrtle Beach (TYS-MYR)

Prices were available within the past 7 days and start at $102 for one-way flights and $203 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Dec 9 - Wed, Dec 17
TYS
Knoxville
MYR
Myrtle Beach
$203 Roundtrip, found 5 days ago
$203
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Dec 9 from Knoxville to Myrtle Beach, returning Wed, Dec 17, priced at $203 found 5 days ago
American Airlines
Wed, Jan 14 - Wed, Jan 21
TYS
Knoxville
MYR
Myrtle Beach
$204 Roundtrip, found 6 days ago
$204
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Jan 14 from Knoxville to Myrtle Beach, returning Wed, Jan 21, priced at $204 found 6 days ago
Delta
Tue, Jan 13 - Tue, Jan 27
TYS
Knoxville
MYR
Myrtle Beach
$216 Roundtrip, found 4 days ago
$216
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Jan 13 from Knoxville to Myrtle Beach, returning Tue, Jan 27, priced at $216 found 4 days ago
American Airlines
Wed, Jan 14 - Wed, Jan 21
TYS
Knoxville
MYR
Myrtle Beach
$235 Roundtrip, found 6 days ago
$235
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Jan 14 from Knoxville to Myrtle Beach, returning Wed, Jan 21, priced at $235 found 6 days ago
Delta
Sun, Dec 14 - Wed, Dec 17
TYS
Knoxville
MYR
Myrtle Beach
$242 Roundtrip, found 5 days ago
$242
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Dec 14 from Knoxville to Myrtle Beach, returning Wed, Dec 17, priced at $242 found 5 days ago
Delta
Sun, Dec 14 - Mon, Dec 15
TYS
Knoxville
MYR
Myrtle Beach
$255 Roundtrip, found 5 days ago
$255
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Dec 14 from Knoxville to Myrtle Beach, returning Mon, Dec 15, priced at $255 found 5 days ago
Delta
Mon, Dec 1 - Tue, Dec 9
TYS
Knoxville
MYR
Myrtle Beach
$260 Roundtrip, found 4 days ago
$260
Roundtrip
found 4 days ago
Select Delta flight, departing Mon, Dec 1 from Knoxville to Myrtle Beach, returning Tue, Dec 9, priced at $260 found 4 days ago
American Airlines
Tue, Jan 13 - Sat, Jan 24
TYS
Knoxville
MYR
Myrtle Beach
$263 Roundtrip, found 4 days ago
$263
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Jan 13 from Knoxville to Myrtle Beach, returning Sat, Jan 24, priced at $263 found 4 days ago
Southwest Airlines
Wed, Jul 1 - Sat, Jul 11
TYS
Knoxville
MYR
Myrtle Beach
$332 Roundtrip, found 2 days ago
$332
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Jul 1 from Knoxville to Myrtle Beach, returning Sat, Jul 11, priced at $332 found 2 days ago
United
Mon, Nov 10 - Mon, Nov 17
TYS
Knoxville
MYR
Myrtle Beach
$842 Roundtrip, found 9 hours ago
$842
Roundtrip
found 9 hours ago
Select United flight, departing Mon, Nov 10 from Knoxville to Myrtle Beach, returning Mon, Nov 17, priced at $842 found 9 hours ago

Find the cheapest month to fly from Knoxville (TYS) to Myrtle Beach (MYR)

May is typically the cheapest month to fly

From $198 - $448 per traveler.

Alternative airports near Myrtle Beach

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Myrtle Beach Intl. Airport MYR. Cheapest and Closest option available. Average driving time to city center is 6 minutes. Flights from $377
MYR
Myrtle Beach Intl. Airport
CheapestClosest
Average driving time to city center6 min
Flights from $377

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Myrtle Beach Intl. Airport (MYR) cost?
Grab a cheap one-way flight from $102 or cheap return flight from $203 from McGhee Tyson Airport (TYS) to Myrtle Beach Intl. Airport (MYR) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to Myrtle Beach Intl. Airport (MYR)?
Traveling in December is a good way to save, as it's the cheapest month for flights between TYS and MYR. You'll usually find the lowest prices during the off-season.
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to Myrtle Beach Intl. Airport (MYR)?
Use the filter tool on Expedia to compare different airlines and find the most affordable carrier that'll fly you from TYS to MYR. Then, sort your results by "Price (lowest to highest)" to pick up the best deal available.
How many flights per day from McGhee Tyson Airport (TYS) to Myrtle Beach Intl. Airport (MYR)?
There aren't any daily direct flights departing from McGhee Tyson Airport (TYS) to Myrtle Beach Intl. Airport (MYR). But you can book flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from TYS to MYR?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to Myrtle Beach Intl. Airport (MYR)?
To touch down at Myrtle Beach Intl. Airport (MYR) on schedule, choose a flight that leaves McGhee Tyson Airport (TYS) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Myrtle Beach Intl. Airport (MYR) last-minute?
Booking your flight from TYS to MYR right before your getaway is usually more expensive. However, if there's some wiggle room with your schedule, you could grab a cheap last-minute fare.
Is it cheaper to book a TYS to MYR flight and hotel package?
Compared with arranging hotels and flights separately, booking a TYS to MYR flight and hotel package with Expedia could result in significant savings. What's more, managing everything in one place will take the hassle out of travel planning. Just secure your flights and choose from our wide range of hotels, then tailor your trip with extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Myrtle Beach Intl. Airport (MYR)?
If you booked your TYS to MYR flight within the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of fare you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
McGhee Tyson
Destination airport
Myrtle Beach Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$202
Distance
322 mi

Book with confidence

Knoxville to Myrtle Beach Flights

The cheapest times to fly from Knoxville to Myrtle Beach

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Myrtle Beach are during the month of December. You can find some of the cheapest flights from Knoxville to Myrtle Beach with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Myrtle Beach

Sunday is one of the best days to book for cheap flights from Knoxville to Myrtle Beach: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Myrtle Beach

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Myrtle Beach in 2025. You can also book with separate airlines for your outbound and return journeys, from $102 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Myrtle Beach flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Myrtle Beach airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Knoxville to Myrtle Beach Flights

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*Available to One Key members.