A historic building with a clock tower, columns, and a flag.

Find 4 Star Hotels in Chillicothe, OH from $128

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Chillicothe 4 Star Hotels

Tonight
Oct 17 - Oct 18
Tomorrow
Oct 18 - Oct 19
Next weekend
Oct 23 - Oct 25
In two weeks
Oct 30 - Nov 1

Our top choices for Chillicothe 4-star hotels

A large indoor swimming pool with clear pool rules and a view of the outdoors through large windows.
A spacious lobby with a reception desk, seating area, and large windows offering views of the outdoors.
A hotel room with a sofa, a bed, a desk, and a chair.
A swimming pool with a metal ladder and steps leading up to it.

1. Christopher Inn and Suites

Christopher Inn and Suites
Chillicothe
United States
Brittany
$155 nightly
$177 total
Oct 18 - Oct 19
Total with taxes and fees
Christopher Inn and Suites
A bar area with wooden bar stools, a counter with liquor bottles, and a television screen.
A conference room with round tables and chairs, a chandelier, and a patterned carpet.
A hotel lobby with a reception desk, a sofa, a coffee table with flowers, and framed artwork on the walls.
A hotel room with a large bathtub, a bed, a desk with a chair, a wardrobe, and a mirror.

2. Quality Inn Chillicothe

Quality Inn Chillicothe
Chillicothe
United States
DAVID
$111 nightly
$127 total
Nov 15 - Nov 16
Total with taxes and fees
Quality Inn Chillicothe
A hotel lobby with a stone pillar, a reception desk, and a staircase.
A parking lot with a white pickup truck and a black SUV.
A hotel room with a large bed, two bedside tables with lamps, a chair, and a wall-mounted coat rack.
A room with stone walls, two red chairs, a floor lamp, and a potted plant.

3. Executive Inn

Executive Inn
Chillicothe
United States
Starlie
$64 nightly
$74 total
Nov 17 - Nov 18
Total with taxes and fees
Executive Inn
A modern bathroom with a flat-screen TV, a built-in microwave, a large bathtub, and a tiled floor.
A building entrance with a brick facade, American flag, blue lights, a wheelchair parking sign, and outdoor seating.
A hotel room with a bed, two armchairs, a desk with a computer, a TV, a hot tub, and a wooden door.
A vending machine with a Pepsi logo and a snack vending machine beside it.

4. Best Western Adena Inn

Best Western Adena Inn
Chillicothe
United States
Michelle
$94 nightly
$108 total
Nov 1 - Nov 2
Total with taxes and fees
Best Western Adena Inn
A modern lobby with a sofa, armchairs, a coffee table, a TV, a fireplace, and a kitchen area.
A lobby with seating areas, a fireplace, and a television mounted on the wall.
A swimming pool with clear blue water, surrounded by lounge chairs and a small table.
A modern breakfast area with a central counter, various food stations, and a bakery section.

5. Holiday Inn Express Chillicothe East by IHG

Holiday Inn Express Chillicothe East by IHG
Chillicothe
United States
Linda
$159 nightly
$182 total
Oct 25 - Oct 26
Total with taxes and fees
Holiday Inn Express Chillicothe East by IHG
An outdoor patio area with tables and chairs, surrounded by greenery and decorative lighting.
An indoor swimming pool with clear water, surrounded by windows and chairs.
A kitchen with wooden cabinets, a white countertop, a built-in oven, a dishwasher, and a wine bottle with glasses on the counter.
A hotel room with a bed, a desk with a computer, a TV, and a bathroom mirror.

6. Hampton Inn & Suites Chillicothe

Hampton Inn & Suites Chillicothe
Chillicothe
United States
Mark
$204 nightly
$234 total
Oct 31 - Nov 1
Total with taxes and fees
Hampton Inn & Suites Chillicothe
An outdoor patio area with a fire pit, seating, and a stone wall.
A modern living room with a stone fireplace, comfortable seating, and large windows.
A multi-story Fairfield Inn & Suites hotel with a modern facade, a covered entrance, and a landscaped entrance area.
A hotel dining area with a wooden table, chairs, a fruit bowl, and a TV mounted on the wall.

7. Fairfield Inn and Suites by Marriott Chillicothe

Fairfield Inn and Suites by Marriott Chillicothe
Chillicothe
United States
Curtis
$188 nightly
$215 total
Nov 1 - Nov 2
Total with taxes and fees
Fairfield Inn and Suites by Marriott Chillicothe
Breakfast area
Lobby
Room
Front of property

8. Americas Best Value Inn Chillicothe

Americas Best Value Inn Chillicothe
Chillicothe
United States
Ssan
$72 nightly
$83 total
Nov 1 - Nov 2
Total with taxes and fees
Americas Best Value Inn Chillicothe
A two-story house with a dark gray exterior and white trim. There is a sign for 'The Willis-James Bed & Breakfast' on the right.
A modern bathroom with a large mirror, a vanity with a sink, a glass shower enclosure, and a window with curtains.
A hotel room with a large bed, two bedside lamps, a chair, a nightstand, and a window with curtains.
A white robe hanging on a rack.

9. Matrons Room at The Willis-James

Matrons Room at The Willis-James
Chillicothe
United States
Brent L.
$280 nightly
$310 total
Oct 19 - Oct 20
Total with taxes and fees
Matrons Room at The Willis-James
A two-story building with a dark gray facade, white trim, and black shutters.
A door with a sign that reads "LEGACY" in a black frame with gold trim.
A hotel room with a desk, laptop, lamp, and a view of buildings through the window.
A four-poster bed with a fireplace, a desk, and a chair in a hotel room.

10. Legacy Room at The Willis-James

Legacy Room at The Willis-James
Chillicothe
United States
Kathleen C.
Legacy Room at The Willis-James
A two-story house with a dark gray exterior and white trim. There is a sign for 'The Willis-James Bed & Breakfast' on the right.
A hotel room with a television, a sofa, a chair, a patterned rug, and a window with curtains.
A modern bathroom with a glass-enclosed shower, a bathtub, and a vanity with a sink.
A hotel room with a bed, two armchairs, a small table, a fireplace, and a view of the city.

11. Spencer Suite at The Willis-James

Spencer Suite at The Willis-James
Chillicothe
United States
Chip
Spencer Suite at The Willis-James
A two-story house with a dark gray exterior and white trim. There is a sign for 'The Willis-James Bed & Breakfast' on the right.
A clear glass bottle labeled 'THE WILIS-JAMES BED & BREAKFAST' with two ornate glass cups beside it.
A bedroom with a large bed, two bedside tables, a mirror, a fireplace, and a patterned rug.
A door with a sign that reads "HONEY CREEK".

12. Honey Creek Room at The Willis-James

Honey Creek Room at The Willis-James
Chillicothe
United States
Logan
$294 nightly
$324 total
Oct 18 - Oct 19
Total with taxes and fees
Honey Creek Room at The Willis-James
A hotel room with a bed, a desk, a chair, a TV, a ceiling fan, and a window with curtains.
A fireplace with a framed landscape painting above it, a vase with dried plants, and two candles on the mantel.
A bathroom with a white marble wall and a shelf containing three bottles of Beekman products.
A two-story building with a dark gray facade, white trim, and black shutters.

13. Confluence Room at The Willis-James

Confluence Room at The Willis-James
Chillicothe
United States
Ryanne
$313 nightly
$346 total
Oct 18 - Oct 19
Total with taxes and fees
Confluence Room at The Willis-James
A modern lounge area with seating arrangements, a coffee bar, and a television screen displaying a sports game.
A compact kitchen with a built-in microwave, coffee maker, and a small dining area with a table and chairs.
A modern bathroom with a built-in sink, mirror, and toilet.
A modern lounge area with sofas, chairs, and a coffee table.

14. TownePlace Suites by Marriott Chillicothe

TownePlace Suites by Marriott Chillicothe
Chillicothe
United States
Heather
$152 nightly
$174 total
Oct 25 - Oct 26
Total with taxes and fees
TownePlace Suites by Marriott Chillicothe
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Chillicothe.
Le Méridien Columbus, The Joseph

Le Méridien Columbus, The Joseph

620 North High Street Columbus OH
$173 nightly
$204 total
Nov 1 - Nov 2
Total with taxes and fees
9.2/10 Wonderful! (738 reviews)
Le Méridien Columbus, The Joseph
Jungle House Boutique Lofts – Downtown Columbus & Short North

Jungle House Boutique Lofts – Downtown Columbus & Short North

1235 Highland St Columbus OH
$114 nightly
$134 total
Nov 2 - Nov 3
Total with taxes and fees
9.8/10 Exceptional! (39 reviews)
Jungle House Boutique Lofts – Downtown Columbus & Short North
Jungle House Modern Lofts – Arena District & Short North

Jungle House Modern Lofts – Arena District & Short North

605 Dennison Avenue Columbus OH
$109 nightly
$128 total
Nov 17 - Nov 18
Total with taxes and fees
9.6/10 Exceptional! (38 reviews)
Jungle House Modern Lofts – Arena District & Short North
Still don't see what you're looking for?
See all properties in Chillicothe.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Chillicothe and related destinations

Immerse yourself in Ohio's rich history at the Hopewell Culture National Historical Park, where ancient earthworks tell tales of indigenous civilizations. After dark, catch an outdoor drama at Sugarloaf Mountain Amphitheatre or enjoy a show at the historic Majestic Theatre for a dose of local culture.

See all hotels in Chillicothe
A grassy field with rolling hills and a clear sky.

Top Chillicothe Hotel Reviews

The Plaza Hotel Columbus at Capitol Square

The Plaza Hotel Columbus at Capitol Square

8/10 Good
"It was a great place to stay if you’re going to do business or lost lands festival!"
Michelle 4-night trip
Posted 9 hours ago
The Plaza Hotel Columbus at Capitol Square

Find out more about Chillicothe

Chillicothe Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Chillicothe, Ohio are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Chillicothe 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Chillicothe. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Chillicothe, Ohio, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Chillicothe hotels offer everything your heart desires.

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Chillicothe?
With Expedia's handy search filters, scoring a superb deal on a 4-star hotel in Chillicothe just got easier. Start by keying in your chosen travel dates and length of your break. Then list the results by price and pick a hotel that best matches your budget and style.
  • Search for the lowest price from $128
What's the difference between 5-star and 4-star hotels in Chillicothe?
Offering a friendly traveler experience and upscale décor, 4-star hotels are a great option for your Chillicothe escape. These kinds of stays generally feature lots of useful amenities that make it a breeze to kick back and relax — think pillowtop mattresses, restaurants and pools. Or get a taste of the high life at a 5-star hotel designed to pamper with luxury perks and amenities. Full-service health clubs, complimentary toiletries and gourmet dining are typically included at these deluxe properties.
Does Chillicothe have any 4-star all-inclusive resorts?
Use our "All inclusive" filter to find your next dream getaway in Chillicothe where everything is taken care of, from your accommodations to your food, entertainment and activities. We can also help you find standard 4-star stays in and around this destination.

Explore a world of travel with Expedia