Title: The Best 5 Star Hotels in Mayagüez from $176 | Expedia.com [Mayagüez Travel Guide](https://expedia.com/Mayaguez.dx2215)[Hotels in Mayagüez](https://expedia.com/Mayaguez-Hotels.d2215.Travel-Guide-Hotels)[Vacation Rentals in Mayagüez](https://expedia.com/Mayaguez-Vacation-Rentals.d2215.Travel-Guide-VacationRentals)[Flights to Mayagüez](https://expedia.com/Cheap-Flights-To-Mayaguez.d2215.Travel-Guide-Flights)[Things to do in Mayagüez](https://expedia.com/Things-To-Do-In-Mayaguez.d2215.Travel-Guide-Activities)[Car Rentals in Mayagüez](https://expedia.com/Car-Rentals-In-Mayaguez.d2215.Car-Rental-Guide)[Mayagüez Vacation Packages](https://expedia.com/Mayaguez.d2215.Destination-Travel-Guides) ![Christopher Columbus Statue showing a statue or sculpture and a fountain](https://images.trvl-media.com/place/553248621532872895/1e4308eb-a0ff-4373-a28d-418bbb76380e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248621532872895/1e4308eb-a0ff-4373-a28d-418bbb76380e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mayagüez 5 Star Hotels Tonight [Mar 11 - Mar 12](https://www.expedia.com/Hotel-Search?regionId=2215&startDate=2026-03-11&endDate=2026-03-12&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 12 - Mar 13](https://www.expedia.com/Hotel-Search?regionId=2215&startDate=2026-03-12&endDate=2026-03-13&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=2215&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=2215&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mayaguez-Hotels.s50-0-d2215.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mayaguez-Hotels.s50-0-d2215.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mayagüez. ![Parguera Plaza Hotel - Adults Only](https://images.trvl-media.com/lodging/12000000/11930000/11928100/11928077/da6c7968_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Parguera Plaza Hotel - Adults Only Street 304 Km 3.2 Lajas $162 nightly $176 total Mar 22 - Mar 23 Total with taxes and fees 9.6/10 Exceptional! (734 reviews) [](https://expedia.com/Lajas-Hotels-Parguera-Plaza-Hotel.h11928077.Hotel-Information) ![Royal Isabela ](https://images.trvl-media.com/lodging/6000000/5560000/5558100/5558043/f7ff1c34_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Royal Isabela 396 Ave Noel Estrada Isabela $683 nightly $744 total Apr 9 - Apr 10 Total with taxes and fees [](https://expedia.com/Isabela-Hotels-Royal-Isabela.h5558043.Hotel-Information) ![Aguada Beach Condos](https://images.trvl-media.com/lodging/94000000/93260000/93252500/93252477/07ccb9a1_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Aguada Beach Condos 530 PR-441 Aguada Aguada [Get rates](https://expedia.com/Hotel-Search?startDate=3%2F26%2F2026&endDate=3%2F27%2F2026&selected=93252477&PinnedHotelID=93252477&HadPinnedHotel=true®ionId=2215) 9.6/10 Exceptional! (45 reviews) [](https://expedia.com/Aguada-Hotels-Aguada-Beach-Condos.h93252477.Hotel-Information) Still don't see what you're looking for? [See all properties in Mayagüez.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F13%2F2026&endDate=3%2F14%2F2026®ionId=2215&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F13%2F2026&endDate=3%2F14%2F2026®ionId=2215&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F13%2F2026&endDate=3%2F14%2F2026®ionId=2215&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F13%2F2026&endDate=3%2F14%2F2026®ionId=2215&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F13%2F2026&endDate=3%2F14%2F2026®ionId=2215&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F13%2F2026&endDate=3%2F14%2F2026®ionId=2215&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Mayagüez Stroll through Plaza Colon, where Christopher Columbus' statue stands sentinel over the city's historic heart. Explore the lush grounds of the Tropical Agriculture Research Station or venture to nearby Mona Island for pristine beaches and hiking trails. [See all hotels in Mayagüez](https://www.expedia.com/Hotel-Search?startDate=2026-03-26&endDate=2026-03-27&adults=2®ionId=2215) ![Christopher Columbus Statue showing a statue or sculpture and a fountain](https://images.trvl-media.com/place/553248621532872895/1e4308eb-a0ff-4373-a28d-418bbb76380e.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Mayagüez Hotel Reviews ## Find out more about Mayagüez There's nothing wrong with enjoying the finer things in life. Add an extra layer of luxury on your next trip to Mayagüez by treating yourself to the best of the best when it comes to accommodation. It's an ideal pairing. There's no reason to delay a getaway to Mayagüez any longer. You'll join the multitudes of vacationers who have made Mayagüez so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Don't wait any longer. Reserve one of our 5-star hotels in Mayagüez and indulge in the finer things in life for a while. ### Get a Great Deal on 5-Star Hotels in Mayagüez You'll have a wonderful time at one of these 5-star hotels. High-end restaurants, excellent customer care, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. How do you want to relax? 24-hour room service, so you can order that Turkish coffee in the wee hours of the morning? A body scrub that will leave you feeling like a million bucks? Butler services? No matter what you want on a perfect getaway, you're bound to find it here. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs. But you aren't going to spend your entire vacation in your room, of course. Don't worry. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Mayagüez are waiting for you to relax after an exciting day. ### Your Getaway Starts Today The results are in, and Mayagüez 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. It's time to plan your next great escape -- Expedia can help you land a great deal on accommodation. Decide on one of our Mayagüez 5-star hotels today and dive into in complete comfort tomorrow. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Mayagüez? > - Search for the lowest price per night from $176 ### What makes a hotel 5 stars in Mayagüez? ### Are there any 5-star all-inclusive resorts in Mayagüez? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Hotels near Plaza Colon ](https://www.expedia.com/Plaza-Colon-Hotels.0-l6081861-0.Travel-Guide-Filter-Hotels) - [Hotels near Christopher Columbus Statue ](https://www.expedia.com/Christopher-Columbus-Statue-Hotels.0-l553248621532872895-0.Travel-Guide-Filter-Hotels) - [Hotels near Catedral de Nuestra Senora de la Candelaria ](https://www.expedia.com/Catedral-De-Nuestra-Senora-De-La-Candelaria-Hotels.0-l553248621533157904-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Santurce ](https://www.expedia.com/3Star-Santurce-Hotels.s30-0-d500172.Travel-Guide-Filter-Hotels) - 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[Flights from Seattle (SEA) to Mayagüez (MAZ) ](https://www.expedia.com/lp/flights/sea/maz/seattle-to-mayaguez) - [Flights from El Paso (ELP) to Mayagüez (MAZ) ](https://www.expedia.com/lp/flights/elp/maz/el-paso-to-mayaguez) - [Flights from Austin (AUS) to Mayagüez (MAZ) ](https://www.expedia.com/lp/flights/aus/maz/austin-to-mayaguez) - [Jetblue Airways Hartford (BDL) to Mayagüez (MAZ) flights ](https://www.expedia.com/lp/flight-routes/jetblue-airways-from-bradley-intl-to-eugenio-maria-de-hostos/b6/bdl/maz) - [Flights from Milwaukee (MKE) to Mayagüez (MAZ) ](https://www.expedia.com/lp/flights/mke/maz/milwaukee-to-mayaguez) - [Christopher Columbus Statue ](https://www.expedia.com/Christopher-Columbus-Statue-Carcel.d553248621532872895.Vacation-Attraction) - [Plaza Colon ](https://www.expedia.com/Plaza-Colon-Carcel.d6081861.Vacation-Attraction) - [Catedral de Nuestra Senora de la Candelaria ](https://www.expedia.com/Catedral-De-Nuestra-Senora-De-La-Candelaria-Carcel.d553248621533157904.Vacation-Attraction) - [Yaguez Theater ](https://www.expedia.com/Yaguez-Theater-Carcel.d553248635754740873.Vacation-Attraction) - [Art Deco Post Office ](https://www.expedia.com/Art-Deco-Post-Office-Mayaguez.d553248621532872893.Vacation-Attraction) - [Tropical Agriculture Research Station ](https://www.expedia.com/Tropical-Agriculture-Research-Station-Mayaguez.d553248621532872899.Vacation-Attraction) - [Santurce Vacations ](https://www.expedia.com/Santurce.d500172.Destination-Travel-Guides) - [Visit Santurce ](https://www.expedia.com/Santurce.dx500172) - [Parque Del Litoral ](https://www.expedia.com/Parque-Del-Litoral-Mayaguez.d553248622639701658.Vacation-Attraction) - [University of Puerto Rico Mayagüez Campus ](https://www.expedia.com/University-Of-Puerto-Rico-Mayaguez-Campus-Mayaguez.d553248621587527615.Vacation-Attraction) - [Visit Miradero ](https://www.expedia.com/Miradero.dx553248635976173721) - [Car rentals near Plaza Colon ](https://www.expedia.com/Car-Rentals-In-Plaza-Colon.d6081861.Car-Rental-Guide) - 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