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A historic building with a clock tower, surrounded by palm trees and statues.

Find 5 Star Hotels in Mayagüez from $95

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    Check prices for these dates, December 13 – 14, 2026

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    Top Mayagüez Hotel Reviews

    Villa Cofresi Hotel

    A wooden deck with a bar area and outdoor seating overlooking the ocean.

    Hacienda Tres Casitas

    A cozy wooden cabin interior with a hammock, a small table, and a potted plant.

    Palmeras Beach Apartments

    A wooden deck with a hot tub, a hammock, and a view of a town and hills.

    Casa Campo Bed and Breakfast

    Exterior

    Blue House Joyuda

    A dining area with a wooden table, white chairs, and a ceiling fan.

    Holiday Inn Mayaguez and Tropical Casino by IHG

    A pool area with a water fountain, lounge chairs, and umbrellas.

    Hotel Colonial

    A double wooden door with intricate ironwork.

    Parguera Plaza Hotel - Adults Only

    A clear, shallow water body surrounded by dense mangrove trees under a bright blue sky.

    Royal Isabela

    A modern interior with a four-poster bed, a round coffee table, and a bookshelf.

    Red Flamboyan Guesthouse

    A balcony with a white table and red chair, overlooking a tropical landscape with palm trees and the ocean.

    Tryp by Wyndham Mayaguez

    An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.

    I Love Combate Rooms & Suites

    A bedroom with a bed, a chair, a nightstand, a ceiling fan, and a window with curtains.

    El Oasis Hotel

    A living room with a dark sofa, a coffee table, a TV mounted on the wall, and a wooden ceiling.

    Coconut Palms Rincon

    A balcony with a view of the ocean, white railings, and a seating area with a table and chairs.

    Hotel Mayaguez Plaza, BW Signature Collection

    A hotel entrance with a sign reading "Hotel Maya Plaza" and an "EXIT" sign above the door.

    Hacienda Doña Minga

    A tented accommodation with a bed, bedside tables, a lamp, a refrigerator, and a plant.

    Find out more about Mayagüez

    There's nothing wrong with enjoying the finer things in life. Add an extra layer of luxury on your next trip to Mayagüez by treating yourself to the best of the best when it comes to accommodation. It's an ideal pairing. There's no reason to delay a getaway to Mayagüez any longer. You'll join the multitudes of vacationers who have made Mayagüez so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Don't wait any longer. Reserve one of our 5-star hotels in Mayagüez and indulge in the finer things in life for a while.

    Get a Great Deal on 5-Star Hotels in Mayagüez

    You'll have a wonderful time at one of these 5-star hotels. High-end restaurants, excellent customer care, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. How do you want to relax? 24-hour room service, so you can order that Turkish coffee in the wee hours of the morning? A body scrub that will leave you feeling like a million bucks? Butler services? No matter what you want on a perfect getaway, you're bound to find it here. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs.

    But you aren't going to spend your entire vacation in your room, of course. Don't worry. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Mayagüez are waiting for you to relax after an exciting day.

    Your Getaway Starts Today

    The results are in, and Mayagüez 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. It's time to plan your next great escape -- Expedia can help you land a great deal on accommodation. Decide on one of our Mayagüez 5-star hotels today and dive into in complete comfort tomorrow.

    Frequently Asked Questions

    How much does it cost to stay in a 5-star hotel in Mayagüez?

    The amount you pay for a 5-star hotel in Mayagüez depends on factors such as when you plan to go and the length of your getaway. An insider tip for scoring the best deal? Use our pricing filters to compare the available accommodations for your selected dates.

    What makes a hotel 5 stars in Mayagüez?

    In Mayagüez, a hotel must provide a certain amount of top-notch amenities to earn 5 stars. These may include on-site gyms, gourmet restaurants, saunas and spas, luxury toiletries, premium bedding and more. What also sets 5-star hotels apart is their guest-focused service. You can look forward to things like concierge services, in-room massages and nightly turn-down services. Some may also offer additional touches such as welcome gifts.

    Are there any 5-star all-inclusive resorts in Mayagüez?

    Our handy filters are the easiest way to find exactly what you want. Select "All inclusive" and "5-star" to show the most luxurious hotels in Mayagüez where your meals, accommodations, entertainment and activities are included in the upfront price. At these getaways, your vacation is pure indulgence from the moment you check in.

    Are there any 5-star vacation rentals in Mayagüez?

    You won't find any 5-star vacation rentals in Mayagüez on our site, but there are some other top-rated options worth checking out. Search through our vacation rentals in Mayagüez to find the perfect place for your stay.

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