---
title: "The Best 5 Star Hotels in Tuscumbia, AL from $69 | Expedia"
description: "Save on luxurious 5★ hotels in Tuscumbia: Browse our selection of popular hotels & resorts in the region, providing top-notch amenities. Book an outstanding vacation with Expedia."
canonical: "https://www.expedia.com/5Star-Tuscumbia-Hotels.s50-0-d6203.Travel-Guide-Filter-Hotels"
language: en-US
market: US
currency: USD
prices_as_of: 2026-11-13T02:22:54Z
---

Plan your trip

- [Tuscumbia Travel Guide](https://www.expedia.com/Tuscumbia.dx6203)
- [Hotels in Tuscumbia](https://www.expedia.com/Tuscumbia-Hotels.d6203.Travel-Guide-Hotels)
- [Flights to Tuscumbia](https://www.expedia.com/Cheap-Flights-To-Tuscumbia.d6203.Travel-Guide-Flights)
- [Things to do in Tuscumbia](https://www.expedia.com/Things-To-Do-In-Tuscumbia.d6203.Travel-Guide-Activities)
- [Car Rentals in Tuscumbia](https://www.expedia.com/Car-Rentals-In-Tuscumbia.d6203.Car-Rental-Guide)
- [Tuscumbia Vacation Packages](https://www.expedia.com/Tuscumbia.d6203.Destination-Travel-Guides)
- [Vacation Rentals in Tuscumbia](https://www.expedia.com/Tuscumbia-Vacation-Rentals.d6203.Travel-Guide-VacationRentals)

# Find 5 Star Hotels in Tuscumbia, AL from $69
![A bridge over a river with a sunset in the background.](https://images.trvl-media.com/place/8239/39a638c5-40e4-4168-986c-6a79983a5e15.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

[Check prices for these dates, December 13 – 14, 2026](https://www.expedia.com/Hotel-Search?regionId=6203&startDate=2026-12-13&endDate=2026-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&star=50)

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## Top Tuscumbia Hotel Reviews

### [GunRunner Boutique Hotel](https://www.expedia.com/Florence-Hotels-GunRunner-Boutique-Hotel.h29351966.Hotel-Information)

![A spacious lounge with a fireplace, leather sofas, and a bar area.](https://images.trvl-media.com/lodging/30000000/29360000/29352000/29351966/54b7ba3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

- Location: Florence
- Review: Really cool boutique hotel that evokes the musical history and culture around Florence. Bed was extremely comfortable and hotel was surrounded by amazing restaurants and there’s a coffee shop downstairs! What else could you ask for?!? Only wish there was an elevator. Will def stay here again!!!, by Timothy, May 1, 2019, rated 10/10 Excellent

### [Renaissance Shoals Resort & Spa](https://www.expedia.com/Florence-Hotels-Marriott-Shoals-Hotel-And-Spa.h1192023.Hotel-Information)

![A hotel with a large pool area, a water tower, and a dome structure.](https://images.trvl-media.com/lodging/2000000/1200000/1192100/1192023/73b55f8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: East Florence
- Review: Wonderful stay., by Jeffrey, July 21, 2024, rated 10/10 Excellent

### [Residence Inn Florence Marriott](https://www.expedia.com/Florence-Hotels-Residence-Inn-Florence-Marriott.h3557696.Hotel-Information)

![A hotel lobby with a seating area, a reception desk, and a check-in counter.](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557696/8518663c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: East Florence
- Review: Loved my stay here will be staying again, by Faranshino, July 21, 2024, rated 10/10 Excellent

### [Hampton Inn & Suites Florence-Downtown](https://www.expedia.com/Florence-Hotels-Hampton-Inn-Suites-Florence-Downtown.h1818371.Hotel-Information)

![A spacious lobby with a blue sofa, a wooden table, and chairs. There is a TV on a stand and a painting on the wall.](https://images.trvl-media.com/lodging/2000000/1820000/1818400/1818371/9d66b3ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Florence
- Review: Everything about this hotel and my stay was excellent. From the time I walked in, I was greeted with smiling faces and assistance. The atmosphere was positive with all of the amenities I needed. My king size bed was very clean and comfortable and the room was huge, bathroom large with a wall between the sink and the bathroom and clean with a large full length mirror as a closet door I would like in my own home. I would recommend this hotel as one of the best in Florence, AL and I have stayed..., by El, July 19, 2015, rated 10/10 Excellent

### [Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites](https://www.expedia.com/Florence-Hotels-Best-Western-Plus-Tuscumbia-Muscle-Shoals-Hotel-And-Suites.h17793356.Hotel-Information)

![A spacious lobby with a reception desk, seating area, and a balcony.](https://images.trvl-media.com/lodging/18000000/17800000/17793400/17793356/ab7fab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Tuscumbia
- Review: Very friendly staff, by jeff, January 19, 2025, rated 10/10 Excellent

### [The Stricklin Hotel](https://www.expedia.com/Florence-Hotels-The-Stricklin-Hotel.h28803264.Hotel-Information)

![A restaurant interior with a bar area, seating, and a counter with a coffee machine.](https://images.trvl-media.com/lodging/29000000/28810000/28803300/28803264/a6f0c75f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Florence
- Review: The location is wonderful with several food and entertainment options within walking distance. The room was comfortable and clean., by Ryan, August 29, 2018, rated 10/10 Excellent

### [Holiday Inn Express Hotel & Suites FLORENCE NORTHEAST by IHG](https://www.expedia.com/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-FLORENCE-NORTHEAST.h2976409.Hotel-Information)

![A modern kitchen with wooden cabinets, a countertop with various appliances, and a view of the outdoors.](https://images.trvl-media.com/lodging/3000000/2980000/2976500/2976409/1fbbd61b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Florence
- Review: Kind friendly service, by Anonymous traveler, May 30, 2021, rated 10/10 Excellent

### [Spark by Hilton Tuscumbia Muscle Shoals](https://www.expedia.com/Florence-Hotels-The-ColdWater-Inn.h1549240.Hotel-Information)

![A spacious interior with a central staircase, a chandelier, and a view to the outdoors.](https://images.trvl-media.com/lodging/2000000/1550000/1549300/1549240/e21f6842.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Tuscumbia
- Review: Property is beautifully maintained & convenient to all the area attractions. Will definitely stay again next time we visit this area., by Susan, July 8, 2023, rated 10/10 Excellent

### [Hampton Inn Florence Midtown near University of North Alabama](https://www.expedia.com/Florence-Hotels-Hampton-Inn-Florence-Midtown.h120232.Hotel-Information)

![A snack bar with shelves of snacks and a refrigerator with beverages.](https://images.trvl-media.com/lodging/1000000/130000/120300/120232/5bb7a1a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Florence
- Review: Great choice for a family place to stay., by Michele, October 1, 2023, rated 10/10 Excellent

### [Days Inn by Wyndham Muscle Shoals Florence](https://www.expedia.com/Florence-Hotels-Days-Inn-By-Wyndham-Muscle-Shoals-Florence.h12032.Hotel-Information)

![A hotel room with a bed, a desk, a chair, a mirror, a painting, and a nightstand with a lamp.](https://images.trvl-media.com/lodging/1000000/20000/12100/12032/0700fc64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Muscle Shoals
- Review: My stay was great. Room was clean and was a typical two bed room. Everything was practically new. One issue: their was a lack of receptacles to plug into. At the sink area their was no plugin, had to go to lamp area at desk to plug coffee pot into the lamp., by Dunn, October 21, 2023, rated 10/10 Excellent

### [Comfort Suites Florence Shoals Area](https://www.expedia.com/Florence-Hotels-Comfort-Suites-Florence-Shoals-Area.h3160009.Hotel-Information)

![An indoor swimming pool with tiled steps and a sunlit room with chairs and a window.](https://images.trvl-media.com/lodging/4000000/3170000/3160100/3160009/66e294b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Florence
- Review: Hotel is several years old but looks brand new. Only issue was a noisy refrigerator which i unplugged. Staff was extremely friendly. Will stay there there again when i use North Alabama Med Center which is an easy 10 min away. By the way, neither the hotel nor Expedia mention the proximity to NAMC on the website. Had to figure that out on my own., by Anonymous traveler, March 7, 2019, rated 10/10 Excellent

### [Heritage PLACE HOTEL IUKA](https://www.expedia.com/Iuka-Hotels-Heritage-PLACE-HOTEL-IUKA.h96266398.Hotel-Information)

![A reception area with a wooden counter, a seating area with a chair and a sofa, and a trash bin.](https://images.trvl-media.com/lodging/97000000/96270000/96266400/96266398/08aedfd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Iuka
- Review: I like a place that smells clean when you walk in and is actually clean. I felt safe here. If im passing through again, i would be happy to stay here., by Naomi, June 7, 2025, rated 10/10 Excellent

### [Best Western Plus Russellville Hotel & Suites](https://www.expedia.com/Florence-Hotels-Best-Western-Plus-Russellville-Hotel-Suites.h477533.Hotel-Information)

![A spacious living area with a staircase, a flat-screen TV, and a seating area with a coffee table.](https://images.trvl-media.com/lodging/1000000/480000/477600/477533/c076cf09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Russellville
- Review: facalty was very friendly, beds were comfy, breakfast was good. would stay there again in a heartbeat., by Edward, October 24, 2016, rated 10/10 Excellent

### [Comfort Inn & Suites Tuscumbia - Muscle Shoals](https://www.expedia.com/Florence-Hotels-Comfort-Inn-Suites-Tuscumbia-Muscle-Shoals.h1990270.Hotel-Information)

![A modern bathroom with a freestanding bathtub, a blue chair, and a wooden bench.](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990270/8384096c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Tuscumbia
- Review: Very clean. Safe parking. Front desk lady was super nice. Breakfast from 6:30-9:00 am on a Saturday could be extended later. That was ok because we went to Waffle House next door. I would definitely stay here again., by Shelle, November 1, 2026, rated 10/10 Excellent

### [Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals](https://www.expedia.com/Florence-Hotels-Microtel-Inn-Suites-By-Wyndham-TuscumbiaMuscle-Shoals.h3173212.Hotel-Information)

![A hotel room with a bed, a desk with chairs, a small kitchenette, and a TV.](https://images.trvl-media.com/lodging/4000000/3180000/3173300/3173212/1d744d5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Tuscumbia
- Review: Good wifi and the bed was comfortable. Quiet inside but some road noise outside. Good Breakfast. The staff was courteous and helpful. I will be back there., by Bruce, April 7, 2022, rated 10/10 Excellent

### [Clarion Inn Sheffield Muscle Shoals](https://www.expedia.com/Florence-Hotels-Clarion-Inn-Sheffield-Muscle-Shoals.h8599.Hotel-Information)

![A spacious lobby with seating areas, a reception desk, and large windows.](https://images.trvl-media.com/lodging/1000000/10000/8600/8599/e70761df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Sheffield
- Review: Tim at the Front Desk was very helpful and very informative. He went above and beyond not only for us but for all whom he checked in. He has excellent customer service skills😊, by Hope, March 4, 2019, rated 10/10 Excellent

### [Econo Lodge Russellville](https://www.expedia.com/Florence-Hotels-Green-Woods-Inn.h898706.Hotel-Information)

![A reception area with a stone wall, a reception desk, and a door leading outside.](https://images.trvl-media.com/lodging/1000000/900000/898800/898706/c80bc2a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Russellville
- Review: Staff was unusually helpful. Due to an injury, I was on crutches. Before I could even ask, the clerk immediately stated she would put me on the ground floor. An employee escorted me back to my vehicle and even offered to meet me at my room to help unload luggage. The room was pleasant and clean. I was given a handicapped room (again without my asking) ... the bathroom was unexpectedly large, more handicapped bars than normal and even a seat in the shower. The next day I was allowed a late..., by Toni, May 21, 2012, rated 10/10 Excellent

## Find out more about Tuscumbia

You enjoy the finer things in life, both at home and on vacation. Pamper your every desire on your upcoming leisure time. There's no reason to delay a getaway to Tuscumbia any longer. You'll join the multitudes of vacationers who have made Tuscumbia so fashionable recently. Additionally, the hotels in this area receive high marks for guest services, so you know you'll want for nothing during your getaway. You deserve the great vacation you're dreaming about. Our 5-star hotels in Tuscumbia are the perfect places to relax in when you really need to escape.

### Book the Best Tuscumbia 5-Star Hotels

Don't be afraid to live the high life while you're on vacation, along with the best conditions. Exceptional customer care, granite-tiled bathrooms, and deeply relaxing spa offerings are all on offer. You're sure to find exactly the accommodation you need. Not only that, the hotels in this area receive fantastic marks for guest services, so you know you'll want for nothing during your getaway. How do you want to relax? A body scrub that will leave you feeling outstanding? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A rejuvenating facial treatment to help your cares fall away? Don't want to take our word for it? Plenty of visitors recommend this location.

Yearning for experiences outside your hotel room? You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Tuscumbia are waiting for you to rest up after an exciting day.

### Make Your Escape

The results are in, and Tuscumbia 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Don't put off your dream vacation any longer -- Expedia can help you land a great deal on accommodation. Decide on one of Expedia's Tuscumbia 5-star hotels today and relax in the lap of luxury tomorrow.

## Frequently Asked Questions

### How much does it cost to stay in a 5-star hotel in Tuscumbia?

There are a variety of pricing options for a 5-star hotel in Tuscumbia on Expedia. The amount you pay will depend on your vacation dates, length of your trip and other factors. Compare available accommodations for your preferred dates and use our pricing and other filters to lock in the perfect upscale stay.

- Search for the lowest price per night from $69

### What makes a hotel 5 stars in Tuscumbia?

In Tuscumbia, a hotel needs to provide a specific amount of upscale features to earn a 5-star rating. These may include on-site gyms, gourmet restaurants, saunas and spas, luxury bathroom products, premium bedding and more. What also sets 5-star hotels apart is their guest-centric standard of service. You'll enjoy things like concierge services, in-room massages and nightly turn-down services. Some may even offer thoughtful touches such as a welcome gift.

### Are there any 5-star all-inclusive resorts in Tuscumbia?

Find a luxurious getaway that includes your lodging, meals, bar and entertainment in Tuscumbia with our filter tool. Search for properties rated 5 stars and click on the "All inclusive" filter. Make sure you check what's included in the price. That way, you can take full advantage of all the premium perks when you arrive.

### Are there any 5-star vacation rentals in Tuscumbia?

You won't find any 5-star vacation rentals in Tuscumbia on our site, but there are a few other highly rated options worth checking out. Search through our [vacation rentals in Tuscumbia](https://www.expedia.com/Tuscumbia-Vacation-Rentals.d6203.Travel-Guide-VacationRentals) to discover the ideal place for your stay.

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- [3 Star Hotels in Arley](https://www.expedia.com/3Star-Arley-Hotels.s30-0-d6343787.Travel-Guide-Filter-Hotels)
- [5 Star Hotels in Moulton](https://www.expedia.com/5Star-Moulton-Hotels.s50-0-d8634.Travel-Guide-Filter-Hotels)
- [Romantic Hotels in Tuscumbia](https://www.expedia.com/Tuscumbia-Hotels-Romantic-Hotel.0-0-d6203-tRomanticHotel.Travel-Guide-Filter-Hotels)
- [Marriott Hotels & Resorts in Tuscumbia](https://www.expedia.com/Tuscumbia-Hotels-Marriott-Hotels-Resorts.0-0-d6203--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels)
- [2 Star Hotels in Detroit](https://www.expedia.com/2Star-Detroit-Hotels.s20-0-d553248635975847874.Travel-Guide-Filter-Hotels)
- [4 Star Hotels in Valhermoso Springs](https://www.expedia.com/4Star-Valhermoso-Springs-Hotels.s40-0-d3000342830.Travel-Guide-Filter-Hotels)
- [Pet-Friendly Hotels in Tuscumbia](https://www.expedia.com/Tuscumbia-Hotels-Pet-Friendly-Hotel.0-0-d6203-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [4 Star Hotels in Moulton](https://www.expedia.com/4Star-Moulton-Hotels.s40-0-d8634.Travel-Guide-Filter-Hotels)
- [Cheap Hotels in Muscle Shoals](https://www.expedia.com/Muscle-Shoals-Hotels-Cheap-Hotels.0-0-d2423-tCheapHotels.Travel-Guide-Filter-Hotels)
- [5 Star Hotels in Muscle Shoals](https://www.expedia.com/5Star-Muscle-Shoals-Hotels.s50-0-d2423.Travel-Guide-Filter-Hotels)
- [Cabin Rentals in Colbert County](https://www.expedia.com/Colbert-County-Cabins.d553248635976431268-aaCabins.Travel-Guide-Accommodation)
- [Fishing Resorts & in Tuscumbia](https://www.expedia.com/Tuscumbia-Hotels-Fishing-Hotels.0-0-d6203-tFishingHotels.Travel-Guide-Filter-Hotels)
- [Flights from Colbert County](https://www.expedia.com/lp/flights/553248635976431268/flights-from-colbert-county)
- [Flights from Huntsville Intl.](https://www.expedia.com/lp/airports/hsv/flights-from-huntsville-intl-airport)
- [Flights from Northwest Alabama Regional](https://www.expedia.com/lp/airports/msl/flights-from-northwest-alabama-regional-airport)
- [Flights from Charlotte (CLT) to Muscle Shoals (MSL)](https://www.expedia.com/lp/flights/clt/msl/charlotte-to-muscle-shoals)
- [Flights from Muscle Shoals](https://www.expedia.com/lp/flights/2423/flights-from-muscle-shoals)
- [Flights to Colbert County](https://www.expedia.com/Destinations-In-Colbert-County.d553248635976431268.Flight-Destinations)
- [Flights to Tuscumbia](https://www.expedia.com/Cheap-Flights-To-Tuscumbia.d6203.Travel-Guide-Flights)
- [Flights to Sheffield](https://www.expedia.com/Cheap-Flights-To-Sheffield.d6188.Travel-Guide-Flights)
- [Flights from Tuscumbia](https://www.expedia.com/lp/flights/6203/flights-from-tuscumbia)
- [Flights to Muscle Shoals](https://www.expedia.com/Cheap-Flights-To-Muscle-Shoals.d2423.Travel-Guide-Flights)
- [Flights to Florence](https://www.expedia.com/Cheap-Flights-To-Florence.d6057726.Travel-Guide-Flights)
- [Ivy Green](https://www.expedia.com/Ivy-Green-Tuscumbia.d6124298.Vacation-Attraction)
- [Visit Tuscumbia](https://www.expedia.com/Tuscumbia.dx6203)
- [Visit Florence](https://www.expedia.com/Florence.dx6057726)
- [Alabama Music Hall of Fame](https://www.expedia.com/Alabama-Music-Hall-Of-Fame-Tuscumbia.d553248621532655161.Vacation-Attraction)
- [Fame Recording Studios](https://www.expedia.com/Fame-Recording-Studios-Muscle-Shoals.d553248633956248260.Vacation-Attraction)
- [Visit Sheffield](https://www.expedia.com/Sheffield.dx6188)
- [Spring Creek Golf Course](https://www.expedia.com/Spring-Creek-Golf-Course-Tuscumbia.d553248621561790042.Vacation-Attraction)
- [Spring Park](https://www.expedia.com/Spring-Park-Tuscumbia.d553248621561790043.Vacation-Attraction)
- [Visit Muscle Shoals](https://www.expedia.com/Muscle-Shoals.dx2423)
- [Tuscumbia Vacations](https://www.expedia.com/Tuscumbia.d6203.Destination-Travel-Guides)
- [Car rental Tuscumbia](https://www.expedia.com/Car-Rentals-In-Tuscumbia.d6203.Car-Rental-Guide)
- [Enterprise Rental Cars in Tuscumbia](https://www.expedia.com/Enterprise-Car-Rentals-In-Tuscumbia.d6203-c15.Car-Rental-Guide-Suppliers)
- [Hertz Rental Cars in Muscle Shoals](https://www.expedia.com/Hertz-Car-Rentals-In-Muscle-Shoals.d2423-c40.Car-Rental-Guide-Suppliers)
- [Car rental Muscle Shoals](https://www.expedia.com/Car-Rentals-In-Muscle-Shoals.d2423.Car-Rental-Guide)
- [Enterprise Rental Cars in Muscle Shoals](https://www.expedia.com/Enterprise-Car-Rentals-In-Muscle-Shoals.d2423-c15.Car-Rental-Guide-Suppliers)
- [Car rentals in Budget 1460 North Federal Highway](https://www.expedia.com/Budget-at-1460-North-Federal-Highway-Fort-Lauderdale-Florida-USA.v6188.Car-Rental-Guide-Location)
- [Car rental Sheffield](https://www.expedia.com/Car-Rentals-In-Sheffield.d6188.Car-Rental-Guide)
- [Rental cars Northwest Alabama Regional airport](https://www.expedia.com/Car-Rentals-In-Northwest-Alabama-Regional.d6030298.Car-Rental-Guide)
- [Car rental Florence](https://www.expedia.com/Car-Rentals-In-Florence.d6057726.Car-Rental-Guide)
- [Avis Rental Cars in Tuscumbia](https://www.expedia.com/Avis-Car-Rentals-In-Tuscumbia.d6203-c41.Car-Rental-Guide-Suppliers)
- [Muscle Shoals Vacation Rentals](https://www.expedia.com/Muscle-Shoals-Vacation-Rentals.d2423.Travel-Guide-VacationRentals)
- [Sheffield Vacation Rentals](https://www.expedia.com/Sheffield-Vacation-Rentals.d6188.Travel-Guide-VacationRentals)
- [Tuscumbia Vacation Rentals](https://www.expedia.com/Tuscumbia-Vacation-Rentals.d6203.Travel-Guide-VacationRentals)

## Other language versions

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  ar: https://www.expedia.sa/5Star-Tuscumbia-Hotels.s50-0-d6203.Travel-Guide-Filter-Hotels
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  en-US: https://www.expedia.com/5Star-Tuscumbia-Hotels.s50-0-d6203.Travel-Guide-Filter-Hotels
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