Central Iowa Vacation Packages 2025 from $354

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Your Central Iowa Vacation

Embrace new adventures with a Central Iowa vacation package. Culture and festivals will make the highlight reel of your getaway. Kick off your trip to Central Iowa with some time exploring Des Moines visiting popular attractions like Iowa State Fairgrounds and Adventureland. Ames is another top city that draws crowds from near and far. Jack Trice Stadium and Hilton Coliseum are two of the top places to see here. Whether you're planning to travel on a shoestring or in the lap of luxury, Expedia are here to help you tailor-make your next Central Iowa vacation.

The Latest Central Iowa vacation packages

Price found within the past 48 hours. Click for updated prices.

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester

per person

Sep 2 - Sep 5

found 5 hours ago

Roundtrip flight included

New York (JFK) to Rochester (RST)

8.8/10 Excellent! (787 reviews)

This is a pleasant place to stay if you’re being seen at the Mayo Clinic. It’s a 5 minute walk to the subway level, via the skyway. There are numerous restaurants nearby. The restaurant in the hotel, Crave, is convenient and very good. Disappointed that the hotel did not provide bottled water in the room and no microwave .

Reviewed on Jul 17, 2025

Aspen Select

per person

Sep 2 - Sep 5

found 5 hours ago

Roundtrip flight included

New York (JFK) to Rochester (RST)

8.6/10 Excellent! (1,000 reviews)

The hotel was quiet and the room was clean with all standard amenities. The bed was comfortable and the rooms were affordable. The only drawback is very limited space to pull into the hotel drop off and almost no parking available.

Reviewed on Jul 18, 2025

AmericInn by Wyndham Winona

per person

Sep 24 - Sep 29

found 6 hours ago

Roundtrip non-stop flight included

New York (NYC) to Rochester (RST)

9/10 Wonderful! (808 reviews)

The hotel was super clean and inviting! Our only critique would be to mayne have some benches outside the lobby for people to be able to sit outside and have their coffee, etc.

Reviewed on Jul 15, 2025

Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

per person

Sep 2 - Sep 5

found 6 hours ago

Roundtrip flight included

New York (JFK) to Rochester (RST)

9.2/10 Wonderful! (960 reviews)

The room was clean and spacious, beds were comfortable and it had a little kitchenette. The parking garage was full, and we had to park on the street where we could see broken bottles and intoxicated people walking around. It wasn’t the safest area to leave a vehicle.

Reviewed on Jul 12, 2025

Aspen Suites

per person

Sep 2 - Sep 5

found 6 hours ago

Roundtrip flight included

New York (JFK) to Rochester (RST)

9/10 Wonderful! (606 reviews)

Staff very friendly and helpful. Room is very spacious and clean.

Reviewed on Jul 14, 2025

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Where to stay in Central Iowa

Find the best Central Iowa areas and neighborhoods for the activities you enjoy most. Learn more about Central Iowa

State Historical Society of Iowa Museum which includes landscape views, a skyscraper and a city

Downtown Des Moines

3 out of top 10 points of interest in this area

4.5/5(711 area reviews)

Downtown Des Moines boasts corporate campuses, fine dining, and unique retail destinations. Explore the Pappajohn Sculpture Park, and enjoy easy access to DART transit and skywalk connections.