Downtown Des Moines Vacations from $471

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • payments icon

    Better together

    Save up to $1,045 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Your Downtown Des Moines Vacation

Experience all the fabulous things this neighborhood has to offer with a customized Downtown Des Moines vacation package. However you imagine spending your time here, you'll find countless opportunities for fun, relaxation and adventure. Some nearby attractions to see during your trip to Downtown Des Moines include Iowa State Capitol Building, Greater Des Moines Botanical Garden and Des Moines Art Center. Expedia will help put your plans into action. Book your perfect Downtown Des Moines vacation today.

The Latest Downtown Des Moines Vacation Packages

Price found within the past 48 hours. Click for updated prices.
My Place Hotel - Ankeny/ Des Moines, IA
Des Moines Alluring 2BD 2BA Downtown Apartment
Des Moines Classy 2BD 2BA Downtown Apartment
Microtel Inn & Suites by Wyndham Urbandale/Des Moines
Surety Hotel, Autograph Collection

Where to stay in Downtown Des Moines

Find the best Downtown Des Moines areas and neighborhoods for the activities you enjoy most. Learn more about Downtown Des Moines

Downtown Des Moines Hotel Deals

Hotel Fort Des Moines, Curio Collection by Hilton

Hotel Fort Des Moines, Curio Collection by Hilton

4.5 out of 5
1000 Walnut St, Des Moines, IA
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $156 total per night from Aug 31 to Sep 1
$156 total
Aug 31 - Sep 1
Total with taxes and fees
9.4/10 Exceptional! (1,023 reviews)
"Excellent"

Reviewed on Aug 21, 2025

Hotel Fort Des Moines, Curio Collection by Hilton
Holiday Inn Downtown - Mercy Area by IHG

Holiday Inn Downtown - Mercy Area by IHG

3 out of 5
1050 6th Ave, Des Moines, IA
Fully refundable
$113 nightly
The price is $126 total per night from Aug 31 to Sep 1
$126 total
Aug 31 - Sep 1
Total with taxes and fees
7.8/10 Good! (1,005 reviews)
"Great"

Reviewed on Aug 19, 2025

Holiday Inn Downtown - Mercy Area by IHG
Des Lux Hotel

Des Lux Hotel

3.5 out of 5
800 Locust St, Des Moines, IA
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $189 total per night from Aug 24 to Aug 25
$189 total
Aug 24 - Aug 25
Total with taxes and fees
9.6/10 Exceptional! (1,007 reviews)
"Simply the BEST hotel in Des Moines! The staff is INCREDIBLE and we’re SO hospitable to us despite a slight booking error which was quickly and graciously corrected!"

Reviewed on Aug 19, 2025

Des Lux Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Downtown Des Moines

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.