Title: Central San Diego Vacation Rentals from $113: Search Short-Term Rentals | Expedia.com [Central San Diego Travel Guide](https://expedia.com/Central-San-Diego.dx6056570)[Hotels in Central San Diego](https://expedia.com/Central-San-Diego-Hotels.d6056570.Travel-Guide-Hotels)[Flights to Central San Diego](https://expedia.com/Cheap-Flights-To-Central-San-Diego.d6056570.Travel-Guide-Flights)[Things to do in Central San Diego](https://expedia.com/Things-To-Do-In-Central-San-Diego.d6056570.Travel-Guide-Activities)[Car Rentals in Central San Diego](https://expedia.com/Car-Rentals-In-Central-San-Diego.d6056570.Car-Rental-Guide)[Central San Diego Vacation Packages](https://expedia.com/Central-San-Diego.d6056570.Destination-Travel-Guides) ![San Diego, California cityscape at the Gaslamp Quarter.; Shutterstock ID 446681584](https://images.trvl-media.com/place/6056570/11e424d0-560b-422b-97ab-cce270c46858.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6056570/11e424d0-560b-422b-97ab-cce270c46858.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg) ### Bundle & Save Get more, spend less whenever you see Bundle & Save deals - ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg) ### OneKeyCash Earn OneKeyCash on all your eligible bookings - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg) ### Upfront pricing We are not like the others - we include taxes and fees ## Check prices for these dates In two weeks [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6056570&startDate=2026-03-20&endDate=2026-03-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [May 1 - May 3](https://www.expedia.com/Hotel-Search?regionId=6056570&startDate=2026-05-01&endDate=2026-05-03&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=6056570&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jun 26 - Jun 28](https://www.expedia.com/Hotel-Search?regionId=6056570&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Central San Diego vacation rentals ![Deluxe 2 King Bedrooms, Multiple Beds, Sleeps 11ppl | Terrace/patio](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/6ef835b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/1b9a69bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/333bf268.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/aa1995cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aparthotel in Middletown [](https://www.expedia.com/San-Diego-Hotels-City24-Hotel-Little-Italy-Mission-Hill.h104140458.Hotel-Information) 9.6/10 Exceptional (125 reviews) "Very clean, quiet, walking distance to great food" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amanda $186 nightly $210 total Mar 10 - Mar 11 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-City24-Hotel-Little-Italy-Mission-Hill.h104140458.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/105000000/104290000/104283900/104283827/f051791c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Room, 1 Queen Bed (East - Freeway Facing) | Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/105000000/104290000/104283900/104283827/61427440.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/105000000/104290000/104283900/104283827/06030fb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/105000000/104290000/104283900/104283827/e8d02919.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aparthotel in Hillcrest [](https://www.expedia.com/San-Diego-Hotels-Uptown-Inn.h104283827.Hotel-Information) 8.4/10 Very Good (309 reviews) "The room was very small but very clean. Great place to stay for the short amount of time we needed it. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debra $100 nightly $113 total Mar 9 - Mar 10 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Uptown-Inn.h104283827.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106660000/106656300/106656297/30e3d4c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/107000000/106660000/106656300/106656297/41801063.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106660000/106656300/106656297/e2add57c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/107000000/106660000/106656300/106656297/4c69726c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Mid-City [](https://www.expedia.com/San-Diego-Hotels-Beautiful-Normal-Heights-Living.h106656297.Hotel-Information) 10/10 Exceptional (77 reviews) "Great location, nice cozy place, had everything we needed. Would definitely stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sheila S. $286 nightly $318 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Beautiful-Normal-Heights-Living.h106656297.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/37000000/36370000/36363200/36363200/4738f1b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/37000000/36370000/36363200/36363200/ccf5ebbc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/37000000/36370000/36363200/36363200/acb43342.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/37000000/36370000/36363200/36363200/95df4213.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cottage in University City [](https://www.expedia.com/San-Diego-Hotels-Ive-Traveled-The-World.h36363200.Hotel-Information) 10/10 Exceptional (33 reviews) "Great property, very well maintained & the hosts were wonderful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ryan B. $511 nightly $569 total Mar 5 - Mar 6 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Ive-Traveled-The-World.h36363200.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/19000000/19000000/18992900/18992847/209c4e9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/19000000/19000000/18992900/18992847/7e95c61c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player, books, video library](https://images.trvl-media.com/lodging/19000000/19000000/18992900/18992847/51d1386a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/19000000/19000000/18992900/18992847/35623cec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cottage in Old Town San Diego [](https://www.expedia.com/San-Diego-Hotels-Adorable-1-Bd-Cottage.h18992847.Hotel-Information) 10/10 Exceptional (271 reviews) "Convenient and comfortable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anya B. $170 nightly $189 total Mar 24 - Mar 25 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Adorable-1-Bd-Cottage.h18992847.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/90000000/89800000/89796700/89796695/d6cca75f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89800000/89796700/89796695/9bca105e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/90000000/89800000/89796700/89796695/b2536455.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/90000000/89800000/89796700/89796695/411fa398.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Bankers Hill [](https://www.expedia.com/San-Diego-Hotels-Cozy-2Bed-1BA-Bankers-Hill-Residence-With-Parking.h89796695.Hotel-Information) 9.4/10 Exceptional (45 reviews) "This place was well stocked and very inviting. We also enjoyed the design and layout of the property because it allowed for those who wanted to continue the night to do so downstairs while the other who wished to go to bed could find their resting place upstairs. Not to mention the back area that clean and great for keeping the night alive. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paris W. $392 nightly $436 total Mar 5 - Mar 6 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Cozy-2Bed-1BA-Bankers-Hill-Residence-With-Parking.h89796695.Hotel-Information) ![TV, fireplace](https://images.trvl-media.com/lodging/121000000/120120000/120111400/120111384/201d0451.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Game room](https://images.trvl-media.com/lodging/121000000/120120000/120111400/120111384/ee906404.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/121000000/120120000/120111400/120111384/2df5b9b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/121000000/120120000/120111400/120111384/770a1ba2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Linda Vista [](https://www.expedia.com/San-Diego-Hotels-Modern-3-Bed-Hub-Resort-Ping-Pong-Pool-Table-Game-Room.h120111384.Hotel-Information) 9.8/10 Exceptional (7 reviews) "Everything was so well decorated and well thought of. We had a very comfortable stay here. Will definitely come back" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nazreen c. $702 nightly $780 total Mar 9 - Mar 10 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Modern-3-Bed-Hub-Resort-Ping-Pong-Pool-Table-Game-Room.h120111384.Hotel-Information) ![TV, fireplace, video games, offices](https://images.trvl-media.com/lodging/124000000/123220000/123218700/123218623/c838fc17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/124000000/123220000/123218700/123218623/1bdc1511.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/124000000/123220000/123218700/123218623/eae07215.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/124000000/123220000/123218700/123218623/f34eec82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Bankers Hill [](https://www.expedia.com/San-Diego-Hotels-Bridgeview-Retreat-Walk-To-Balboa-Park.h123218623.Hotel-Information) 10/10 Exceptional (1 review) "Exelente " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Rosalio $479 nightly $479 total Mar 5 - Mar 6 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Bridgeview-Retreat-Walk-To-Balboa-Park.h123218623.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/92000000/91270000/91261900/91261851/72eaef15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books, video library](https://images.trvl-media.com/lodging/92000000/91270000/91261900/91261851/076082a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/92000000/91270000/91261900/91261851/f540ebc4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/92000000/91270000/91261900/91261851/f9b6d84c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in North Park [](https://www.expedia.com/San-Diego-Hotels-ArtisticFastWi-FiParkingPets.h91261851.Hotel-Information) 9.8/10 Exceptional (18 reviews) "My family of four had a wonderful week-long stay here! The apartment was clean, had everything we needed, and we appreciated the secured parking garage. The provided high chair and pack-n-play also worked very well for us. We loved being so close to San Diego's many attractions; it was easy to drive anywhere from this relatively central location. Our host was responsive, helpful, and made sure we had a great stay. We would not hesitate to book this again in the future!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Benjamin C. $405 nightly $451 total Mar 5 - Mar 6 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-ArtisticFastWi-FiParkingPets.h91261851.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/19000000/18990000/18980300/18980206/3472170f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books, video library](https://images.trvl-media.com/lodging/19000000/18990000/18980300/18980206/1c95892f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/19000000/18990000/18980300/18980206/0f89ed12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/19000000/18990000/18980300/18980206/8c061621.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Old Town San Diego [](https://www.expedia.com/San-Diego-Hotels-2-Bd-W-Yard-In-Heart-Of-Old-Town-WE-LOVE-PETS-Check-Our-Insta-Oldtownvacay.h18980206.Hotel-Information) 10/10 Exceptional (197 reviews) "Perfect location for enjoying the city of San Diego. We walked every night in old San Diego. Ten minutes from the beach, ten minutes from the zoo. Here is the big question, would i stay here again? Oh heck yea!!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ted H. $221 nightly $246 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-2-Bd-W-Yard-In-Heart-Of-Old-Town-WE-LOVE-PETS-Check-Our-Insta-Oldtownvacay.h18980206.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/68000000/67270000/67266000/67265928/06c0457a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/68000000/67270000/67266000/67265928/e21f7ec4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/68000000/67270000/67266000/67265928/a358876f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/68000000/67270000/67266000/67265928/001c0c4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Mission Hills [](https://www.expedia.com/San-Diego-Hotels-2-Bed.h67265928.Hotel-Information) 6.6/10 (11 reviews) "Me and my girlfriend stayed here for a weekend to kind of just enjoy not having to be home for a weekend and staying here was very nice; the view from the living room and balcony was amazing, was close to all the hotspots in SD and just felt like a second home. I was a bit of a chaotic guest leading up to the check-in and that is because of my work but the host Daniel was very helpful and patient with my mistakes and I appreciate what he did for us." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nico E. $367 nightly $408 total Mar 5 - Mar 6 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-2-Bed.h67265928.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/107000000/106620000/106611000/106611000/61d7f537.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, travel crib, free WiFi](https://images.trvl-media.com/lodging/107000000/106620000/106611000/106611000/7b6f4608.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/107000000/106620000/106611000/106611000/0b860b57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/107000000/106620000/106611000/106611000/ed445105.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Golden Hill [](https://www.expedia.com/San-Diego-Hotels-Cali-DreamingHot-TubSaunaeBikes.h106611000.Hotel-Information) 10/10 Exceptional (13 reviews) "Tiny but clean as a whistle and easy access to Balboa Park and Coronado Island." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dee Dee S. $1,324 nightly $1,350 total Mar 15 - Mar 16 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Cali-DreamingHot-TubSaunaeBikes.h106611000.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/120000000/119760000/119752200/119752122/589649fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/120000000/119760000/119752200/119752122/c9c3025c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/120000000/119760000/119752200/119752122/e26781bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/120000000/119760000/119752200/119752122/325e8bfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Mid-City [](https://www.expedia.com/San-Diego-Hotels-Gorgeous-3-Bedroom-4-Bed-Home-In-San-Diego.h119752122.Hotel-Information) $497 nightly $553 total Mar 24 - Mar 25 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Gorgeous-3-Bedroom-4-Bed-Home-In-San-Diego.h119752122.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/20000000/19630000/19625400/19625342/932d6159.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/20000000/19630000/19625400/19625342/37b9e9e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player, books, music library](https://images.trvl-media.com/lodging/20000000/19630000/19625400/19625342/2786c71b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/20000000/19630000/19625400/19625342/53e94ed7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in North Park [](https://www.expedia.com/San-Diego-Hotels-Charming-Craftsman-Cottage-With-Serene-Backyard-And-Hot-Tub.h19625342.Hotel-Information) 10/10 Exceptional (104 reviews) "My family and I loved our stay here. Check-in and communication with Tasha was a breeze. We thoroughly enjoyed the enclosed yard, jacuzzi, and close proximity to numerous restaurants and cafes." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jason & Cass $433 nightly $481 total Mar 10 - Mar 11 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Charming-Craftsman-Cottage-With-Serene-Backyard-And-Hot-Tub.h19625342.Hotel-Information) ![Beach nearby](https://images.trvl-media.com/lodging/51000000/50500000/50491100/50491007/15dc68d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/51000000/50500000/50491100/50491007/efd0e13c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/51000000/50500000/50491100/50491007/5faad2b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/51000000/50500000/50491100/50491007/3474fb42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Mission Valley [](https://www.expedia.com/San-Diego-Hotels-Secluded.h50491007.Hotel-Information) 9.2/10 Wonderful (57 reviews) " 100% satisfied. Would stay again if in the area." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eugene $300 nightly $333 total Mar 11 - Mar 12 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Secluded.h50491007.Hotel-Information) ![Smart TV, books](https://images.trvl-media.com/lodging/79000000/78690000/78689600/78689516/2c22d911.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/79000000/78690000/78689600/78689516/w1123h1079x1y0-650d44f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/79000000/78690000/78689600/78689516/004eb8b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/79000000/78690000/78689600/78689516/896c2b02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Condo in Hillcrest [](https://www.expedia.com/San-Diego-Hotels-Luxury-Modern-Resort-Apt-Pool-Spa-In-The-Heart-Of-Sunny-San-Diego-Friendly.h78689516.Hotel-Information) 10/10 Exceptional (2 reviews) "The condo is very well decorated and clean. The neighborhood is vibrant and full of walkable bars/restaurants. Natasha was very responsive to my questions. Would recommend her and her home to my friends and family." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hiren P. $810 nightly $900 total Mar 10 - Mar 11 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Luxury-Modern-Resort-Apt-Pool-Spa-In-The-Heart-Of-Sunny-San-Diego-Friendly.h78689516.Hotel-Information) ![TV](https://images.trvl-media.com/lodging/111000000/110610000/110602900/110602802/60116cc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/111000000/110610000/110602900/110602802/ff9e215f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/111000000/110610000/110602900/110602802/4534bc34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, travel crib, WiFi, bed sheets](https://images.trvl-media.com/lodging/111000000/110610000/110602900/110602802/86253c8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Mid-City [](https://www.expedia.com/San-Diego-Hotels-Charming-2-Bedroom-San-Diego-Home-Close-To-DowntownBalboa-ParkSeaWorldBeaches.h110602802.Hotel-Information) 8.0/10 Very Good (2 reviews) "Wir hatten eine tolle Zeit in San Diego und in der Wohnung. Die Kommunikation mit Rebecca hat super geklappt. Sie hat uns die nötigen Infos für den Check In zur rightigen Zeit gegeben und war während des Aufenthaltes sehr hilfsbereit. Die Wohnung ist für 4 Personen ausreichend groß und perfekt ausgestattet, inkl Waschmaschine und Trockner. Vor allem die Küche haben wir ausgiebig genutzt und haben sehr viel selbst gekocht. Es fehlten lediglich eine Schere und ein Gemüsemesser. Rebecca hat uns... ![Germany](https://a.travel-assets.com/egds/marks/flags/de.svg) Hanna S. $531 nightly $531 total Mar 5 - Mar 6 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Charming-2-Bedroom-San-Diego-Home-Close-To-DowntownBalboa-ParkSeaWorldBeaches.h110602802.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/100000000/99360000/99357200/99357141/fb85101c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/100000000/99360000/99357200/99357141/689d1bf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/100000000/99360000/99357200/99357141/82987ba1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/100000000/99360000/99357200/99357141/58a64a03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Linda Vista [](https://www.expedia.com/San-Diego-Hotels-MINUTES-TO-BEACH-FUN10-Min-To-Airport.h99357141.Hotel-Information) 9.8/10 Exceptional (27 reviews) "Nice house. Good location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew K. [](https://www.expedia.com/San-Diego-Hotels-MINUTES-TO-BEACH-FUN10-Min-To-Airport.h99357141.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/126000000/125600000/125599500/125599474/c4c02083.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/126000000/125600000/125599500/125599474/b6ae205c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/126000000/125600000/125599500/125599474/dc2af394.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels](https://images.trvl-media.com/lodging/126000000/125600000/125599500/125599474/da8475a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Birdland [](https://www.expedia.com/San-Diego-Hotels-Centralized-San-Diego-Retreat.h125599474.Hotel-Information) $337 nightly $357 total Mar 19 - Mar 20 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Centralized-San-Diego-Retreat.h125599474.Hotel-Information) ![Beach towels](https://images.trvl-media.com/lodging/94000000/93250000/93245900/93245882/a981e220.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/94000000/93250000/93245900/93245882/e3ba4b42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/94000000/93250000/93245900/93245882/df13d4b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/94000000/93250000/93245900/93245882/230494dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Bay Ho [](https://www.expedia.com/San-Diego-Hotels-Adorable-1-Bedroom-House-8-Minutes-From-La-Jolla.h93245882.Hotel-Information) 10/10 Exceptional (47 reviews) "The home is beautiful, everything was fantastic! The hosts were very helpful and accommodating. The location was convenient and quiet. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paulina B. $204 nightly $228 total Mar 5 - Mar 6 Total with taxes and fees [](https://www.expedia.com/San-Diego-Hotels-Adorable-1-Bedroom-House-8-Minutes-From-La-Jolla.h93245882.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-18&endDate=2026-03-19®ionId=6056570&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=VR_SPRING_PROMO_6056570) ## Find vacation rentals that suit your style Aparthotels [](https://www.expedia.com/Hotel-Search?destination=Central+San+Diego%2C+California%2C+United+States+of+America®ionId=6056570&latLong=32.824702%2C-117.136273&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=APART_HOTEL) Apartments [](https://www.expedia.com/Hotel-Search?destination=Central+San+Diego%2C+California%2C+United+States+of+America®ionId=6056570&latLong=32.824702%2C-117.136273&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=APARTMENT) Villas [](https://www.expedia.com/Hotel-Search?destination=Central+San+Diego%2C+California%2C+United+States+of+America®ionId=6056570&latLong=32.824702%2C-117.136273&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=VILLA) Condos [](https://www.expedia.com/Hotel-Search?destination=Central+San+Diego%2C+California%2C+United+States+of+America®ionId=6056570&latLong=32.824702%2C-117.136273&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=CONDO) Private vacation homes [](https://www.expedia.com/Hotel-Search?destination=Central+San+Diego%2C+California%2C+United+States+of+America®ionId=6056570&latLong=32.824702%2C-117.136273&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=VACATION_HOME) Houseboats [](https://www.expedia.com/Hotel-Search?destination=Central+San+Diego%2C+California%2C+United+States+of+America®ionId=6056570&latLong=32.824702%2C-117.136273&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=HOUSE_BOAT) Cottages [](https://www.expedia.com/Hotel-Search?destination=Central+San+Diego%2C+California%2C+United+States+of+America®ionId=6056570&latLong=32.824702%2C-117.136273&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=COTTAGE) Cabins [](https://www.expedia.com/Hotel-Search?destination=Central+San+Diego%2C+California%2C+United+States+of+America®ionId=6056570&latLong=32.824702%2C-117.136273&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=CABIN) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FCentral-San-Diego-Vacation-Rentals.d6056570.Travel-Guide-VacationRentals)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FCentral-San-Diego-Vacation-Rentals.d6056570.Travel-Guide-VacationRentals) ## Top Central San Diego Hotel Reviews ![Best Western Inn & Suites San Diego – Zoo/SeaWorld Area ](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/297b9804_y.jpg) ### Best Western Inn & Suites San Diego – Zoo/SeaWorld Area 8/10 Good "Needed to clean around pool " [](https://expedia.com/San-Diego-Hotels-Comfort-Inn-Suites-San-Diego-Zoo-SeaWorld-Area.h40745.Hotel-Information) ![Courtyard by Marriott Old Town](https://images.trvl-media.com/lodging/1000000/20000/11200/11116/122af7ca_y.jpg) ### Courtyard by Marriott Old Town 10/10 Excellent "Loved the location and hotel" [](https://expedia.com/San-Diego-Hotels-Courtyard-By-Marriott-Old-Town.h11116.Hotel-Information) ![DoubleTree by Hilton San Diego - Hotel Circle](https://images.trvl-media.com/lodging/1000000/30000/25600/25536/983f923b_y.jpg) ### DoubleTree by Hilton San Diego - Hotel Circle 10/10 Excellent "Wonderful stay at Double Tree Hotel! Staff were great! Very polite and helpful. The rooms were comfortable and spacious. " [](https://expedia.com/San-Diego-Hotels-DoubleTree-By-Hilton-San-Diego-Hotel-Circle.h25536.Hotel-Information) ![Handlery Hotel](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 8/10 Good "Very convenient and a good value, but pretty old and tired in general. Well kept & great staff. " [](https://expedia.com/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Hilton Garden Inn San Diego Old Town/SeaWorld Area](https://images.trvl-media.com/lodging/1000000/920000/919100/919096/ed62594a_y.jpg) ### Hilton Garden Inn San Diego Old Town/SeaWorld Area 10/10 Excellent "Front desk personnel were very helpful! Rooms were clean" [](https://expedia.com/San-Diego-Hotels-Hilton-Garden-Inn-San-Diego-Old-TownSeaWorld-Area.h919096.Hotel-Information) ![Hampton Inn San Diego/Mission Valley](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/036e1947_y.jpg) ### Hampton Inn San Diego/Mission Valley 10/10 Excellent "Good breakfast and clean rooms. Helpful staff." [](https://expedia.com/San-Diego-Hotels-Hampton-Inn-San-Diego-Mission-Valley.h4415.Hotel-Information) ![Crowne Plaza San Diego - Mission Valley by IHG](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/48aa6044_y.jpg) ### Crowne Plaza San Diego - Mission Valley by IHG 2/10 Terrible "The staff were rude and disrespectful. Would not recommend." [](https://expedia.com/San-Diego-Hotels-Crowne-Plaza-San-Diego-Mission-Valley.h571545.Hotel-Information) ![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg) ### Best Western Seven Seas 8/10 Good "Second stay, would stay again. Rooms are older but serve their purpose. " [](https://expedia.com/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) ![Kings Inn San Diego](https://images.trvl-media.com/lodging/1000000/20000/17000/16910/bf074aa5_y.jpg) ### Kings Inn San Diego 8/10 Good "Clean room, restaurants on property were good. Rooms need more outlets if you’re traveling with a family. Overall I would stay again. Good value. " [](https://expedia.com/San-Diego-Hotels-Kings-Inn-San-Diego-Seaworld-Zoo.h16910.Hotel-Information) ## Find out more about Central San Diego **Everything you need to know about Central San Diego vacation rentals** Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Central San Diego vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on. There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Central San Diego vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. **Central San Diego vacation rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Central San Diego. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Central San Diego in high season. Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $113 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals! **How to find incredible deals on Central San Diego rentals** At Expedia, we put the best Central San Diego vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Central San Diego rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Central San Diego vacation. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Central San Diego. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. ## Explore a world of travel with Expedia - Trending destinations on Expedia.com - All accommodation types in Central San Diego ### Trending destinations on Expedia.com - [Destin Vacation Rentals ](https://www.expedia.com/Destin-Vacation-Rentals.d6906.Travel-Guide-VacationRentals) - [Panama City Vacation Rentals ](https://www.expedia.com/Panama-City-Beach-Vacation-Rentals.d8021.Travel-Guide-VacationRentals) - [Hilton Head Vacation Rentals ](https://www.expedia.com/Hilton-Head-Island-Vacation-Rentals.d601684.Travel-Guide-VacationRentals) - [Gulf Shores Vacation Rentals ](https://www.expedia.com/Gulf-Shores-Vacation-Rentals.d603078.Travel-Guide-VacationRentals) - [Key West Vacation Rentals ](https://www.expedia.com/Key-West-Vacation-Rentals.d1187.Travel-Guide-VacationRentals) - [Gatlinburg Vacation Rentals ](https://www.expedia.com/Gatlinburg-Vacation-Rentals.d7474.Travel-Guide-VacationRentals) - 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