Central West End Vacations from $478
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Your Central West End Vacation
Whatever your style of travel, you can see and do more with a tailor-made Central West End vacation package. Spend your break enjoying this neighborhood's shopping and its other charms. When it's time to head out and explore, you'll find lots of big-name attractions nearby including St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis. Visit one, two or more during your trip to Central West End. Stop daydreaming and start doing. When it's time to lock in your vacation to Central West End, Expedia will help get you there.
The Latest Central West End Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Price was $606, price is now $478 per person
$478
per person
May 8 - May 10
found 1 day ago
Roundtrip flight included
Charlotte (CLT) to St. Louis (STL)
8.8/10 Excellent! (1,022 reviews)
We enjoyed the unique concept of the art gallery. I do wish room service were an option. We were so exhausted once we arrived, and had hoped to stay in for dinner. The frosted glass door on the bathroom also created complications, as an earlier riser couldn't begin getting ready in the morning without turning on lights for those still sleeping.
Reviewed on Mar 2, 2026
The Wildwood Hotel
Save 100% on your flight
Price was $837, price is now $498 per person
$498
per person
Apr 16 - Apr 19
found 23 hours ago
Roundtrip flight included
Charlotte (CLT) to St. Louis (STL)
9.2/10 Wonderful! (1,600 reviews)
Great place to stay! We arrived later at night around 11pm and the front desk gal working at that time was wonderful. Nice, quiet, clean and in a very nice area.
Reviewed on Feb 27, 2026
Ameristar Casino Resort and Spa
Price was $629, price is now $506 per person
$506
per person
May 8 - May 10
found 1 day ago
Roundtrip flight included
Charlotte (CLT) to St. Louis (STL)
8.4/10 Very Good! (1,006 reviews)
Unfortunately stay was just alittle disappointing then the stay before this one. Casino not giving free coffee to room as time before and had no vending machines whatsoever. Only had one lonely ice machine. Could not get chips or soda. Guessing it’s the time we live in. Just so sad
Reviewed on Feb 24, 2026
Where to stay in Central West End
Find the best Central West End areas and neighborhoods for the activities you enjoy most. Learn more about Central West End
Downtown St. Louis
4 out of top 10 points of interest in this area
4/5(4,004 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Central West End Hotel Deals
The Royal Sonesta Chase Park Plaza St. Louis
212 N Kingshighway St. Louis MO
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $205 total per night from Mar 8 to Mar 9
$205 total
Mar 8 - Mar 9
Total with taxes and fees
9/10 Wonderful! (1,000 reviews)
Although the building appears older, it is very well maintained and overall extremely clean. The interior design of the hotel is also impressive. Our room was condominium-style with a separate bedroom, which made the stay very comfortable. It included a small kitchen with basic cooking equipment ...
Reviewed on Feb 23, 2026
Hotel Indigo St Louis - Central West End by IHG
4630 Lindell St. Louis MO
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $151 total per night from Mar 8 to Mar 9
$151 total
Mar 8 - Mar 9
Total with taxes and fees
8.2/10 Very Good! (1,008 reviews)
Great location
Reviewed on Mar 2, 2026
The West End
4215 Lindell Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $138 total per night from Mar 4 to Mar 5
$138 total
Mar 4 - Mar 5
Total with taxes and fees
8.6/10 Excellent! (440 reviews)
Very welcoming staff, hotel was clean
Reviewed on Mar 2, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Central West End
Barnes Jewish Hospital
Though Barnes Jewish Hospital might be what brings you to town, perhaps you'll have a chance to explore more of St. Louis while you are here.
Cathedral Basilica of St. Louis
Marvel at the vast collection of mosaic art that beautifies the interior of this colossal cathedral built in the Romanesque Revival style.
World Chess Hall of Fame
Play a game of chess on a giant outdoor board, inspect chess-related artifacts and view artworks inspired by the two-player board game at this fascinating center.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
Lemp Haunted Neighborhood Walking Tour
$30
per adult
84% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
$174
per adult
100% of travellers recommend
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- Cathedral Basilica of St. Louis
- World Chess Hall of Fame
- St. Louis Zoo
- Barnes Jewish Hospital
- The Muny Theater
- Jewel Box
- Cabanne House
- St. Louis Art Museum
- Pagoda Circle
- Contemporary Art Museum St. Louis
- Fox Theater
- Bruno David Gallery
- Pulitzer Foundation for the Arts
- Sheldon Concert Hall
- Missouri History Museum
- Grandel Theater
- St. Louis University
- St. Louis Symphony Orchestra
- Powell Hall
- St. Alphonsus Liguori Catholic Church
- Missouri Botanical Gardens and Arboretum
- Chaifetz Arena
- Visit Grand Center
- St. Louis Vacations
- Turtle Playground
- Scott Joplin House State Historic Site
- Washington Avenue Historic District
- Tower Grove Park
- Fairgrounds Park
- Anheuser-Busch Brewery
- Tivoli Theatre
- St. Louis Walk of Fame
- Messiah Lutheran Church
- St. Louis Union Station Mini Golf
- Visit Compton Heights
- Car rentals near St. Louis
- Car rentals near Cathedral Basilica of St. Louis
- Car rentals near World Chess Hall of Fame
- Car rentals near Barnes Jewish Hospital
- Car rentals near Forest Park
- Car rentals near Ellen Clark Sculpture Park
- Car rentals near St. Louis University
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.