Central West End Vacations from $464
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Your Central West End Vacation
Whatever your style of travel, you can see and do more with a tailor-made Central West End vacation package. Spend your break enjoying this neighborhood's shopping and its other charms. When it's time to head out and explore, you'll find lots of big-name attractions nearby including St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis. Visit one, two or more during your trip to Central West End. Stop daydreaming and start doing. When it's time to lock in your vacation to Central West End, Expedia will help get you there.
The Latest Central West End Vacation Packages
Price found within the past 48 hours. Click for updated prices.
The Cheshire
Price was $726, price is now $581 per person
$581
per person
Apr 30 - May 3
found 1 day ago
Roundtrip flight included
Washington (DCA) to St. Louis (STL)
8.6/10 Excellent! (1,009 reviews)
Always a pleasure staying at this hotel. Favorite one in the area. Has the most character.
Reviewed on Mar 26, 2026
Hilton St. Louis Airport
Woodson Terrace
Price was $631, price is now $523 per person
$523
per person
Apr 30 - May 3
found 1 day ago
Roundtrip non-stop flight included
Los Angeles (LAX) to St. Louis (STL)
7.6/10 Good! (1,007 reviews)
The rooms are not clean they seem to be rushed. Hair on the ceiling, clogged sink, dust in. Vanity bathroom, hair on the TV, humidity in. The bathroom wall paper seems to have a bit of mold growing.
Convenience for location, staff is friendly, but the rooms are not cleaned properly.
Reviewed on Mar 18, 2026
21C Museum Hotel St Louis
Downtown West
Price was $722, price is now $608 per person
$608
per person
Apr 30 - May 3
found 1 day ago
Roundtrip flight included
Washington (DCA) to St. Louis (STL)
9/10 Wonderful! (1,647 reviews)
Great hotel with a friendly staff. The on-site restaurant is a great spot fir a cocktail after a day of exploring.
Reviewed on Mar 28, 2026
River City Casino & Hotel
Price was $686, price is now $582 per person
$582
per person
Apr 30 - May 3
found 1 day ago
Roundtrip flight included
Washington (DCA) to St. Louis (STL)
9/10 Wonderful! (1,498 reviews)
Room was clean. The bed was fine, except for the huge pillows that I could not use which made my sleep pretty bad. The staff put the liquids in the wrong containers that attached to the wall in the shower so I had to rewash hair and body with the right cleaner. All small minor things. Casino was clean. The restaurants were pricey for what it was.
Reviewed on Mar 27, 2026
Where to stay in Central West End
Find the best Central West End areas and neighborhoods for the activities you enjoy most. Learn more about Central West End
Downtown St. Louis
3 out of top 10 points of interest in this area
4/5(4,044 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Central West End Hotel Deals
Hotel Indigo St Louis - Central West End by IHG
4630 Lindell St. Louis MO
Fully refundable
$144 nightly
The price is $170 total per night from Apr 5 to Apr 6
$170 total
Apr 5 - Apr 6
Total with taxes and fees
8.4/10 Very Good! (1,006 reviews)
I have always booked and paid for the day before I show up just in case I roll into the area before the 3 pm check in. This was no different from other times I’ve booked hotels. Except the manager told me that’s not how hotels work and for lack of better words, called me stupid for being a “no show” ...
Reviewed on Mar 28, 2026
The Royal Sonesta Chase Park Plaza St. Louis
212 N Kingshighway St. Louis MO
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $217 total per night from Apr 5 to Apr 6
$217 total
Apr 5 - Apr 6
Total with taxes and fees
9/10 Wonderful! (1,005 reviews)
Clean and beautiful room
Reviewed on Mar 28, 2026
DoubleTree by Hilton St. Louis Forest Park
4550 Forest Park Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $146 total per night from Apr 5 to Apr 6
$146 total
Apr 5 - Apr 6
Total with taxes and fees
8.2/10 Very Good! (1,005 reviews)
It was an awful room for over three hundred bucks a night. I was in the second level, looking directly into the parking lot.
Reviewed on Mar 27, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Central West End
Barnes Jewish Hospital
Though Barnes Jewish Hospital might be what brings you to town, perhaps you'll have a chance to explore more of St. Louis while you are here.
Cathedral Basilica of St. Louis
Marvel at the vast collection of mosaic art that beautifies the interior of this colossal cathedral built in the Romanesque Revival style.
World Chess Hall of Fame
Play a game of chess on a giant outdoor board, inspect chess-related artifacts and view artworks inspired by the two-player board game at this fascinating center.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
Lemp Haunted Neighborhood Walking Tour
$30
per adult
84% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
$174
per adult
100% of travellers recommend
Explore a world of travel with Expedia
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- Cathedral Basilica of St. Louis
- World Chess Hall of Fame
- St. Louis Zoo
- Barnes Jewish Hospital
- The Muny Theater
- Jewel Box
- Cabanne House
- St. Louis Art Museum
- Pagoda Circle
- Contemporary Art Museum St. Louis
- Fox Theater
- Bruno David Gallery
- Pulitzer Foundation for the Arts
- Sheldon Concert Hall
- Missouri History Museum
- Grandel Theater
- St. Louis University
- St. Louis Symphony Orchestra
- Powell Hall
- St. Alphonsus Liguori Catholic Church
- Missouri Botanical Gardens and Arboretum
- Chaifetz Arena
- Visit Grand Center
- St. Louis Vacations
- Turtle Playground
- Scott Joplin House State Historic Site
- Washington Avenue Historic District
- Tower Grove Park
- Fairgrounds Park
- Anheuser-Busch Brewery
- Tivoli Theatre
- St. Louis Walk of Fame
- Messiah Lutheran Church
- St. Louis Union Station Mini Golf
- Visit Compton Heights
- Car rentals near St. Louis
- Car rentals near Cathedral Basilica of St. Louis
- Car rentals near World Chess Hall of Fame
- Car rentals near Barnes Jewish Hospital
- Car rentals near Forest Park
- Car rentals near Ellen Clark Sculpture Park
- Car rentals near St. Louis University
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- Car rentals near St. Louis Zoo
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.