Central West End Vacations from $526
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $1,045 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Central West End Vacation
Whatever your style of travel, you can see and do more with a tailor-made Central West End vacation package. Spend your break enjoying this neighborhood's shopping and its other charms. When it's time to head out and explore, you'll find lots of big-name attractions nearby including St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis. Visit one, two or more during your trip to Central West End. Stop daydreaming and start doing. When it's time to lock in your vacation to Central West End, Expedia will help get you there.
The Latest Central West End Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Hilton Pennywell St. Louis at the Arch
Downtown St. Louis
Price was $686, price is now $526 per person
$526
per person
Jun 8 - Jun 12
found 22 hours ago
Roundtrip non-stop flight included
Los Angeles (LAX) to St. Louis (STL)
8.8/10 Excellent! (1,029 reviews)
Good, safe distance to the dome and restaurants. The hotel is equipped with everything you need. Bar is really nice!
Reviewed on Apr 5, 2026
The Wildwood Hotel
Price was $882, price is now $606 per person
$606
per person
Jun 22 - Jun 26
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
9.2/10 Wonderful! (1,627 reviews)
The breakfaat was average, thou fresh. There was enough street parking nearby, safe.
Reviewed on Mar 30, 2026
The Knight Center at Washington University
Price was $862, price is now $681 per person
$681
per person
Jun 22 - Jun 26
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
9.4/10 Exceptional! (505 reviews)
Great, simple breakfast options. Clean fitness room. Terrific location steps from main campus and a short walk to town and restaurants.
Reviewed on Mar 26, 2026
Where to stay in Central West End
Find the best Central West End areas and neighborhoods for the activities you enjoy most. Learn more about Central West End
Downtown St. Louis
3 out of top 10 points of interest in this area
4/5(4,044 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Central West End Hotel Deals
Hotel Indigo St Louis - Central West End by IHG
4630 Lindell St. Louis MO
Fully refundable
$140 nightly
The price is $176 total per night from Apr 12 to Apr 13
$176 total
Apr 12 - Apr 13
Total with taxes and fees
8.4/10 Very Good! (1,008 reviews)
We enjoyed our stay so much…Being a pet friendly hotel meant everything to a person like me because we love our pets like our children. The hotel staff, atmosphere and the fact that location was a plus. I will visit again in the near future. I really wish there was a pool but anywho the overall experience ...
Reviewed on Apr 4, 2026
The Royal Sonesta Chase Park Plaza St. Louis
212 N Kingshighway St. Louis MO
Fully refundableReserve now, pay when you stay
$172 nightly
The price is $232 total per night from Apr 12 to Apr 13
$232 total
Apr 12 - Apr 13
Total with taxes and fees
9/10 Wonderful! (1,004 reviews)
Nice fitness center.
Reviewed on Apr 4, 2026
DoubleTree by Hilton St. Louis Forest Park
4550 Forest Park Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $154 total per night from Apr 19 to Apr 20
$154 total
Apr 19 - Apr 20
Total with taxes and fees
8.2/10 Very Good! (1,002 reviews)
great
Reviewed on Apr 1, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Central West End
Barnes Jewish Hospital
Though Barnes Jewish Hospital might be what brings you to town, perhaps you'll have a chance to explore more of St. Louis while you are here.
Cathedral Basilica of St. Louis
Marvel at the vast collection of mosaic art that beautifies the interior of this colossal cathedral built in the Romanesque Revival style.
World Chess Hall of Fame
Play a game of chess on a giant outdoor board, inspect chess-related artifacts and view artworks inspired by the two-player board game at this fascinating center.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
Lemp Haunted Neighborhood Walking Tour
$30
per adult
84% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
$174
per adult
100% of travellers recommend
Explore a world of travel with Expedia
- St. Louis Hotels
- Hotels near Cathedral Basilica of St. Louis
- Hotels near World Chess Hall of Fame
- Hotels near Barnes Jewish Hospital
- Hotels near St. Louis Children's Hospital
- Hotels near Central West End Station
- Hotels near Forest Park
- Cheap Hotels in St. Louis
- Hotels near Cabanne House
- Hotels near St. Louis Science Center
- Hotels near Pagoda Circle
- Hotels near Contemporary Art Museum St. Louis
- Hotels near The Muny Theater
- Hotels near Fox Theater
- Hotels near Jewel Box
- Hotels near St. Louis University
- Hotels near DeBaliviere Place
- Hotels near St. Louis Zoo
- Hotels near Pulitzer Foundation for the Arts
- Hotels near Sheldon Concert Hall
- Hotels near Dennis and Judith Jones Visitor and Education Center
- Hotels near Grandel Theater
- Hotels near Grand Center
- Luxury Hotels in Grand Center
- Family Hotels in Grand Center
- Boutique Hotels in Grand Center
- La Quinta Inn & Suites Hotels in Grand Center
- Historic Hotels in Grand Center
- Hotels near St. Louis Symphony Orchestra
- Hotels near Powell Symphony Hall
- Hotels near Powell Hall
- Hotels near Downtown St. Louis
- Hotels near Missouri History Museum
- Hotels near Forest Park Station
- Hotels near St. Alphonsus Liguori Catholic Church
- Hotels near Chaifetz Arena
- Hotels near St. Teresa of Avila Catholic Church
- Hotels near The Hill
- Gay friendly Hotels in The Hill
- Hotels near St. Louis Art Museum
- Hotels near Busch Stadium
- Hotels near Missouri Botanical Gardens and Arboretum
- Hotels near Delmar Station
- Hotels near Shaw
- Hotels near Clayton-Tamm
- Hotels near The Gate
- Hotels near Compton Hill Reservoir Park
- Hotels with Free Airport Shuttle in St. Louis
- Hotels near Skinker Station
- Hotels near Compton Heights
- 5 Star Hotels in Compton Heights
- Hotels with Restaurants in Compton Heights
- Cathedral Basilica of St. Louis
- World Chess Hall of Fame
- St. Louis Zoo
- Barnes Jewish Hospital
- The Muny Theater
- Jewel Box
- Cabanne House
- St. Louis Art Museum
- Pagoda Circle
- Contemporary Art Museum St. Louis
- Fox Theater
- Bruno David Gallery
- Pulitzer Foundation for the Arts
- Sheldon Concert Hall
- Missouri History Museum
- Grandel Theater
- St. Louis University
- St. Louis Symphony Orchestra
- Powell Hall
- St. Alphonsus Liguori Catholic Church
- Missouri Botanical Gardens and Arboretum
- Chaifetz Arena
- Visit Grand Center
- St. Louis Vacations
- Turtle Playground
- Scott Joplin House State Historic Site
- Washington Avenue Historic District
- Tower Grove Park
- Fairgrounds Park
- Anheuser-Busch Brewery
- Tivoli Theatre
- St. Louis Walk of Fame
- Messiah Lutheran Church
- St. Louis Union Station Mini Golf
- Visit Compton Heights
- Car rentals near St. Louis
- Car rentals near Cathedral Basilica of St. Louis
- Car rentals near World Chess Hall of Fame
- Car rentals near Barnes Jewish Hospital
- Car rentals near Forest Park
- Car rentals near Ellen Clark Sculpture Park
- Car rentals near St. Louis University
- Mini Car Rentals near St. Louis University
- Car rentals near St. Louis Zoo
- Minivan Car Rentals near St. Louis Zoo
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.