The illuminated Gateway Arch at night with a city skyline in the background.

Clayton Vacations from $348

Book a Hotel + Flight or Car together to unlock savings

Your Clayton Vacation

Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.

The Latest Clayton Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.
    Dec 29 - Dec 31

    The Wildwood Hotel + Flight

    Wildwood
    2 nights
    3.5 star property
    9.2/10 - Wonderful (1,682 reviews)
    Roundtrip • Atlanta (ATL) - St. Louis (STL)
    ATL - STL • Nonstop STL - ATL • Nonstop
    $498
    $348
    per traveler
    found 1 day ago
    The Wildwood Hotel
  • An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.
    Jan 29 - Feb 1

    Ameristar Casino Resort and Spa + Flight

    St. Charles
    3 nights
    4.5 star property
    8.8/10 - Excellent (1,090 reviews)
    Roundtrip • Houston (HOU) - St. Louis (STL)
    HOU - STL • Nonstop STL - IAH • 1 stop
    $720
    $599
    per traveler
    found 1 day ago
    Ameristar Casino Resort and Spa
  • A modern dining area with round tables, orange chairs, and a decorative wall with pottery.
    Jan 29 - Feb 1

    Marriott St. Louis Airport + Flight

    Edmundson
    3 nights
    4.0 star property
    8.0/10 - Very good (1,000 reviews)
    Roundtrip • Houston (HOU) - St. Louis (STL)
    HOU - STL • Nonstop STL - IAH • 1 stop
    $568
    $487
    per traveler
    found 1 day ago
    Marriott St. Louis Airport
  • A rooftop restaurant with round tables, chairs, and a view of the city.
    Dec 29 - Dec 31

    Moonrise Hotel + Flight

    Delmar Loop
    2 nights
    4.0 star property
    9.0/10 - Wonderful (2,053 reviews)
    Roundtrip • Atlanta (ATL) - St. Louis (STL)
    ATL - STL • Nonstop STL - ATL • Nonstop
    $455
    $393
    per traveler
    found 1 day ago
    Moonrise Hotel
  • A room with two leather chairs, a wooden side table with a menu and a phone, and a large cityscape mural on the wall.
    Jan 14 - Jan 18

    Americas Best Value Inn St. Louis Downtown + Flight

    Near North Riverfront
    4 nights
    2.0 star property
    5.6/10 - (873 reviews)
    "This was by far the sketchiest place I've ever stayed in. But you pay for what you get and it was the cheapest nearest to the archway. Staff were friendly."
    Reviewed November 14, 2026
    Roundtrip • Philadelphia (PHL) - St. Louis (STL)
    PHL - STL • Nonstop STL - PHL • 1 stop
    $1,246
    $1,076
    per traveler
    found 19 hours ago
    Americas Best Value Inn St. Louis Downtown

Where to stay in Clayton

Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Learn more about Clayton
The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

A historic building with a green dome and adjacent modern high-rise buildings.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

A large airplane suspended in a net structure in an urban setting with modern buildings in the background.

Downtown West

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Discover the most popular places to visit in Clayton

Chapel of St. Timothy And St. Titus, Concordia Seminary

Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's great live music or attend a sporting event.
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What to do near Clayton

Lemp Haunted Neighborhood Walking Tour

Lemp Haunted Neighborhood Walking Tour

$25
per adult
84% of travelers recommend
Lemp Haunted Neighborhood Walking Tour
See all activities near Clayton

Clayton Hotel Deals

A hotel room with two beds, a desk, a chair, and a television.

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
Clayton
8.8 out of 10, Excellent, (3,526 reviews)
$105 nightly
The price is $122
Dec 6 - Dec 7
Total with taxes and fees
Clayton Plaza Hotel & Extended Stay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Clayton
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.