Title: Top Independent in O Brien, FL - Expedia.com [O Brien Travel Guide](https://expedia.com/O-Brien.dx3000431472)[Hotels in O Brien](https://expedia.com/O-Brien-Hotels.d3000431472.Travel-Guide-Hotels)[Vacation Rentals in O Brien](https://expedia.com/O-Brien-Vacation-Rentals.d3000431472.Travel-Guide-VacationRentals)[Flights to O Brien](https://expedia.com/Cheap-Flights-To-O-Brien.d3000431472.Travel-Guide-Flights)[Car Rentals in O Brien](https://expedia.com/Car-Rentals-In-O-Brien.d3000431472.Car-Rental-Guide)[O Brien Vacation Packages](https://expedia.com/O-Brien.d3000431472.Destination-Travel-Guides) ![kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 17 - Mar 18](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-03-17&endDate=2026-03-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 18 - Mar 19](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-03-18&endDate=2026-03-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FO-Brien-Hotels-Independent.0-0-d3000431472--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FO-Brien-Hotels-Independent.0-0-d3000431472--bIndependent.Travel-Guide-Filter-Hotels) ## Top O Brien Hotel Reviews ![La Quinta Inn & Suite by Wyndham Lake City](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571_y.jpg) ### La Quinta Inn & Suite by Wyndham Lake City 4/10 Poor "Room was clean and comfortable. Wi Fi was terrible. TV kept going off and reloading every few minutes. None of our devices would work right. Couldn’t download anything. Was always giving an error. When we went to lobby in morning everything worked fine. Obliviously it was a room with terrible connection problems." [](https://expedia.com/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information) ![Courtyard By Marriott Lake City](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/4156d709_y.jpg) ### Courtyard By Marriott Lake City 10/10 Excellent "Very nice hotel!" [](https://expedia.com/Lake-City-Hotels-Courtyard-By-Marriott-Lake-City.h99922616.Hotel-Information) ![Americas Best Value Inn Lake City](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/fddc9a15_y.jpg) ### Americas Best Value Inn Lake City 6/10 Okay "Old property, but well run. No issues." [](https://expedia.com/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) ![Best Western Plus Lake City](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca_y.jpg) ### Best Western Plus Lake City 10/10 Excellent "Great check in - nice facility- good breakfast " [](https://expedia.com/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) ![Days Inn by Wyndham Lake City I-75](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/eb9ba6b8_y.jpg) ### Days Inn by Wyndham Lake City I-75 10/10 Excellent "Quiet comfortable and courteous staff. We Had great time!" [](https://expedia.com/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-75.h17650.Hotel-Information) ![Comfort Suites Lake City](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/2b2698df_y.jpg) ### Comfort Suites Lake City 8/10 Good "Room was clean and bed was comfortable. We were disappointed in the breakfast a bit. We like sausage and bacon and they only had ham. We heard the scrambled eggs were real. The attendant was very nice. They had a waffle maker but they stay so busy it's hard to get to make one. " [](https://expedia.com/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information) ![Tru by Hilton Lake City](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/539e711a_y.jpg) ### Tru by Hilton Lake City 10/10 Excellent "Great" [](https://expedia.com/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information) ![Holiday Inn Express & Suites Live Oak by IHG](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/ddd17ce3_y.jpg) ### Holiday Inn Express & Suites Live Oak by IHG 8/10 Good "Friendly staff. Nice pool. Rooms smelled musty." [](https://expedia.com/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information) ![Baymont by Wyndham Lake City I-75](https://images.trvl-media.com/lodging/1000000/20000/15800/15747/84b0e094_y.jpg) ### Baymont by Wyndham Lake City I-75 8/10 Good "Internet was fast, hot tub was not hot though, but the hot water in the shower gets very hot! Very close to several restaurants and a package store should you require one. Good room rates, I will stay there again. " [](https://expedia.com/Lake-City-Hotels-Baymont-By-Wyndham-Lake-City.h15747.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Troy Spring State Park ](https://www.expedia.com/Troy-Spring-State-Park-Hotels.0-l6285999-0.Travel-Guide-Filter-Hotels) - [Branford Hotels ](https://www.expedia.com/Branford-Hotels.d6188028.Travel-Guide-Hotels) - [Motels in Branford ](https://www.expedia.com/Branford-Motels.d6188028-aaMotels.Travel-Guide-Accommodation) - [Cabin Rentals in Branford ](https://www.expedia.com/Branford-Cabins.d6188028-aaCabins.Travel-Guide-Accommodation) - [Rv Parks in Branford ](https://www.expedia.com/Branford-RV-Parks.d6188028-aaRVParks.Travel-Guide-Accommodation) - [Apartments in Branford ](https://www.expedia.com/Branford-Apartments.d6188028-aaApartments.Travel-Guide-Accommodation) - [4 Star Hotels in Branford ](https://www.expedia.com/4Star-Branford-Hotels.s40-0-d6188028.Travel-Guide-Filter-Hotels) - 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