Title: Top Independent in O Brien, FL - Expedia.com [O Brien Travel Guide](https://expedia.com/O-Brien.dx3000431472)[Hotels in O Brien](https://expedia.com/O-Brien-Hotels.d3000431472.Travel-Guide-Hotels)[Vacation Rentals in O Brien](https://expedia.com/O-Brien-Vacation-Rentals.d3000431472.Travel-Guide-VacationRentals)[Flights to O Brien](https://expedia.com/Cheap-Flights-To-O-Brien.d3000431472.Travel-Guide-Flights)[Car Rentals in O Brien](https://expedia.com/Car-Rentals-In-O-Brien.d3000431472.Car-Rental-Guide)[O Brien Vacation Packages](https://expedia.com/O-Brien.d3000431472.Destination-Travel-Guides) ![kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Apr 1 - Apr 2](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-04-01&endDate=2026-04-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Apr 2 - Apr 3](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-04-02&endDate=2026-04-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FO-Brien-Hotels-Independent.0-0-d3000431472--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FO-Brien-Hotels-Independent.0-0-d3000431472--bIndependent.Travel-Guide-Filter-Hotels) ## Top O Brien Hotel Reviews ![Americas Best Value Inn Lake City](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/fddc9a15_y.jpg) ### Americas Best Value Inn Lake City 10/10 Excellent "The owner/manager does a great job with customer service on the afternoon/evening. The ladies in the morning - not so much. The facility is well taken care of." [](https://expedia.com/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) ![Holiday Inn Express & Suites Alachua - Gainesville Area by IHG](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf_y.jpg) ### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG 10/10 Excellent "Good" [](https://expedia.com/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information) ![Tru by Hilton Lake City](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/539e711a_y.jpg) ### Tru by Hilton Lake City 8/10 Good "Mattresses could be firmer." [](https://expedia.com/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information) ![Days Inn by Wyndham Lake City I-10](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/9948e87a_y.jpg) ### Days Inn by Wyndham Lake City I-10 10/10 Excellent "Parking was plentiful." [](https://expedia.com/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-10.h84936.Hotel-Information) ![Best Western Plus Lake City](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca_y.jpg) ### Best Western Plus Lake City 10/10 Excellent "Nice place. I recommend " [](https://expedia.com/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) ![Quality Inn Lake City](https://images.trvl-media.com/lodging/1000000/490000/484100/484004/dbe6bb59_y.jpg) ### Quality Inn Lake City 10/10 Excellent "Very friendly staff and quiet room" [](https://expedia.com/Lake-City-Hotels-Quality-Inn-Lake-City.h484004.Hotel-Information) ![Fairfield Inn & Suites Lake City](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/8c221c11_y.jpg) ### Fairfield Inn & Suites Lake City 10/10 Excellent "One of the best breakfasts we’ve had at a hotel. Everything was hot and very fresh and continuously stocked. " [](https://expedia.com/Lake-City-Hotels-Fairfield-Inn-Suites-Lake-City.h2076513.Hotel-Information) ![Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!](https://images.trvl-media.com/lodging/92000000/91440000/91435900/91435872/c7d330d9_y.jpg) ### Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! 10/10 Excellent "We had a BEAUTIFUL and relaxing stay at this river rental. Everything was so neat and organized with extras like kayaks, a canoes, games and what not. And it is just 0.5 miles from Royal Springs. The owners were quick to respond to any questions we had and we even got to meet them while they were another rental. Very nice couple. Would highly recommend it for family vacations or weekend get-away." [](https://expedia.com/O-Brien-Hotels-Royal-Springs-Riverfront-Retreat.h91435872.Hotel-Information) ![La Quinta Inn & Suite by Wyndham Lake City](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571_y.jpg) ### La Quinta Inn & Suite by Wyndham Lake City 10/10 Excellent "Never stayed at LaQuinta before but definitely will again as we take a lot of road trips! " [](https://expedia.com/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Troy Spring State Park ](https://www.expedia.com/Troy-Spring-State-Park-Hotels.0-l6285999-0.Travel-Guide-Filter-Hotels) - [Branford Hotels ](https://www.expedia.com/Branford-Hotels.d6188028.Travel-Guide-Hotels) - [Motels in Branford ](https://www.expedia.com/Branford-Motels.d6188028-aaMotels.Travel-Guide-Accommodation) - [Cabin Rentals in Branford ](https://www.expedia.com/Branford-Cabins.d6188028-aaCabins.Travel-Guide-Accommodation) - [Rv Parks in Branford ](https://www.expedia.com/Branford-RV-Parks.d6188028-aaRVParks.Travel-Guide-Accommodation) - [Apartments in Branford ](https://www.expedia.com/Branford-Apartments.d6188028-aaApartments.Travel-Guide-Accommodation) - [4 Star Hotels in Branford ](https://www.expedia.com/4Star-Branford-Hotels.s40-0-d6188028.Travel-Guide-Filter-Hotels) - 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[Visit Fort White ](https://www.expedia.com/Fort-White.dx6286968) - [Fort White Vacations ](https://www.expedia.com/Fort-White.d6286968.Destination-Travel-Guides) - [Bob's River Place ](https://www.expedia.com/Bobs-River-Place-Old-Town.d553248633992473977.Vacation-Attraction) - [First Federal Sportsplex ](https://www.expedia.com/First-Federal-Sportsplex-Live-Oak.d6185397.Vacation-Attraction) - [Car rentals near Branford ](https://www.expedia.com/Car-Rentals-In-Branford.d6188028.Car-Rental-Guide) - [Car rentals near Mcalpin ](https://www.expedia.com/Car-Rentals-In-Mcalpin.d3000345299.Car-Rental-Guide) - [Car rentals near Ichetucknee Springs State Park ](https://www.expedia.com/Car-Rentals-In-Ichetucknee-Springs-State-Park.d6285986.Car-Rental-Guide) - [Car rentals near Alton ](https://www.expedia.com/Car-Rentals-In-Alton.d553248635975876473.Car-Rental-Guide) - [Car rentals near Wes Skiles Peacock Springs State Park ](https://www.expedia.com/Car-Rentals-In-Wes-Skiles-Peacock-Springs-State-Park.d553248621532654050.Car-Rental-Guide) - 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