Title: Top Independent in O Brien, FL - Expedia.com [O Brien Travel Guide](https://expedia.com/O-Brien.dx3000431472)[Hotels in O Brien](https://expedia.com/O-Brien-Hotels.d3000431472.Travel-Guide-Hotels)[Vacation Rentals in O Brien](https://expedia.com/O-Brien-Vacation-Rentals.d3000431472.Travel-Guide-VacationRentals)[Flights to O Brien](https://expedia.com/Cheap-Flights-To-O-Brien.d3000431472.Travel-Guide-Flights)[Car Rentals in O Brien](https://expedia.com/Car-Rentals-In-O-Brien.d3000431472.Car-Rental-Guide)[O Brien Vacation Packages](https://expedia.com/O-Brien.d3000431472.Destination-Travel-Guides) ![kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 23 - Mar 24](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-03-23&endDate=2026-03-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 24 - Mar 25](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-03-24&endDate=2026-03-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FO-Brien-Hotels-Independent.0-0-d3000431472--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FO-Brien-Hotels-Independent.0-0-d3000431472--bIndependent.Travel-Guide-Filter-Hotels) ## Top O Brien Hotel Reviews ![Best Western Plus Lake City](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca_y.jpg) ### Best Western Plus Lake City 8/10 Good "Nice hotel but starting to show wear and tare" [](https://expedia.com/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) ![Americas Best Value Inn Lake City](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/fddc9a15_y.jpg) ### Americas Best Value Inn Lake City 10/10 Excellent "." [](https://expedia.com/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) ![Tru by Hilton Lake City](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/539e711a_y.jpg) ### Tru by Hilton Lake City 10/10 Excellent "Great experience all the amenities needed" [](https://expedia.com/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information) ![Baymont by Wyndham Lake City I-75](https://images.trvl-media.com/lodging/1000000/20000/15800/15747/84b0e094_y.jpg) ### Baymont by Wyndham Lake City I-75 2/10 Terrible "Horrible property. Room was not as nice as the pictures on hotels Com website. Bathroom was nasty. Door looked like it had been kicked in a few times. We didn't even stay we ended up at La Quinta hotel down the street." [](https://expedia.com/Lake-City-Hotels-Baymont-By-Wyndham-Lake-City.h15747.Hotel-Information) ![Holiday Inn Express & Suites Alachua - Gainesville Area by IHG](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf_y.jpg) ### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG 10/10 Excellent "The hotels common areas were super clean. We did have an issue with the cleanliness of my room upon check in but the front desk staff was very efficient in handling the matter. Breakfast was decent. Overall good experience! Staff was super friendly!" [](https://expedia.com/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information) ![BlueGem Motel](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/dffd0064_y.jpg) ### BlueGem Motel 10/10 Excellent "good parking at door made it very easy access to our car." [](https://expedia.com/High-Springs-Hotels-BlueGem-Motel.h87671816.Hotel-Information) ![Comfort Suites Lake City](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/2b2698df_y.jpg) ### Comfort Suites Lake City 10/10 Excellent "Did not use the gym but it was clean." [](https://expedia.com/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information) ![Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/5b1d647e_y.jpg) ### Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "Fue una experiencia muy agradable. " [](https://expedia.com/Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) ![La Quinta Inn & Suite by Wyndham Lake City](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571_y.jpg) ### La Quinta Inn & Suite by Wyndham Lake City 6/10 Okay "We really hate the fan noice in the bathroom. It never stops!! Toilet seat was falling off. You would think the maids would notice. No hand soap left just an empty wrapper. We probably wouldn’t stay there again. " [](https://expedia.com/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Troy Spring State Park ](https://www.expedia.com/Troy-Spring-State-Park-Hotels.0-l6285999-0.Travel-Guide-Filter-Hotels) - [Branford Hotels ](https://www.expedia.com/Branford-Hotels.d6188028.Travel-Guide-Hotels) - [Motels in Branford ](https://www.expedia.com/Branford-Motels.d6188028-aaMotels.Travel-Guide-Accommodation) - [Cabin Rentals in Branford ](https://www.expedia.com/Branford-Cabins.d6188028-aaCabins.Travel-Guide-Accommodation) - [Rv Parks in Branford ](https://www.expedia.com/Branford-RV-Parks.d6188028-aaRVParks.Travel-Guide-Accommodation) - [Apartments in Branford ](https://www.expedia.com/Branford-Apartments.d6188028-aaApartments.Travel-Guide-Accommodation) - [4 Star Hotels in Branford ](https://www.expedia.com/4Star-Branford-Hotels.s40-0-d6188028.Travel-Guide-Filter-Hotels) - [Vacation Homes in Branford ](https://www.expedia.com/Branford-Private-Vacation-Homes.d6188028-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [5 Star Hotels in Branford ](https://www.expedia.com/5Star-Branford-Hotels.s50-0-d6188028.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Branford ](https://www.expedia.com/3Star-Branford-Hotels.s30-0-d6188028.Travel-Guide-Filter-Hotels) - [Cottages in Branford ](https://www.expedia.com/Branford-Cottages.d6188028-aaCottages.Travel-Guide-Accommodation) - [Mcalpin Hotels ](https://www.expedia.com/Mcalpin-Hotels.d3000345299.Travel-Guide-Hotels) - [Cabin Rentals in Mcalpin ](https://www.expedia.com/Mcalpin-Cabins.d3000345299-aaCabins.Travel-Guide-Accommodation) - [Rv Parks in Mcalpin ](https://www.expedia.com/Mcalpin-RV-Parks.d3000345299-aaRVParks.Travel-Guide-Accommodation) - [Motels in Mcalpin ](https://www.expedia.com/Mcalpin-Motels.d3000345299-aaMotels.Travel-Guide-Accommodation) - [Cottages in Mcalpin ](https://www.expedia.com/Mcalpin-Cottages.d3000345299-aaCottages.Travel-Guide-Accommodation) - [5 Star Hotels in Mcalpin ](https://www.expedia.com/5Star-Mcalpin-Hotels.s50-0-d3000345299.Travel-Guide-Filter-Hotels) - [Apartments in Mcalpin ](https://www.expedia.com/Mcalpin-Apartments.d3000345299-aaApartments.Travel-Guide-Accommodation) - [Hotels near Ichetucknee River ](https://www.expedia.com/Ichetucknee-River-Hotels.0-l684521467895291904-0.Travel-Guide-Filter-Hotels) - [Hotels near Ichetucknee Springs State Park ](https://www.expedia.com/Ichetucknee-Springs-State-Park-Hotels.0-l6285986-0.Travel-Guide-Filter-Hotels) - [Alton Hotels ](https://www.expedia.com/Alton-Hotels.d553248635975876473.Travel-Guide-Hotels) - [Hotels near Wes Skiles Peacock Springs State Park ](https://www.expedia.com/Wes-Skiles-Peacock-Springs-State-Park-Hotels.0-l553248621532654050-0.Travel-Guide-Filter-Hotels) - [Mayo Hotels ](https://www.expedia.com/Mayo-Hotels.d6286979.Travel-Guide-Hotels) - [Cabin Rentals in Mayo ](https://www.expedia.com/Mayo-Cabins.d6286979-aaCabins.Travel-Guide-Accommodation) - [Cottages in Mayo ](https://www.expedia.com/Mayo-Cottages.d6286979-aaCottages.Travel-Guide-Accommodation) - [Motels in Mayo ](https://www.expedia.com/Mayo-Motels.d6286979-aaMotels.Travel-Guide-Accommodation) - [Apartments in Mayo ](https://www.expedia.com/Mayo-Apartments.d6286979-aaApartments.Travel-Guide-Accommodation) - [Vacation Homes in Mayo ](https://www.expedia.com/Mayo-Private-Vacation-Homes.d6286979-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Wellborn Hotels ](https://www.expedia.com/Wellborn-Hotels.d172275.Travel-Guide-Hotels) - [Cabin Rentals in Wellborn ](https://www.expedia.com/Wellborn-Cabins.d172275-aaCabins.Travel-Guide-Accommodation) - [Motels in Wellborn ](https://www.expedia.com/Wellborn-Motels.d172275-aaMotels.Travel-Guide-Accommodation) - [4 Star Hotels in Wellborn ](https://www.expedia.com/4Star-Wellborn-Hotels.s40-0-d172275.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Wellborn ](https://www.expedia.com/5Star-Wellborn-Hotels.s50-0-d172275.Travel-Guide-Filter-Hotels) - [Rv Parks in Wellborn ](https://www.expedia.com/Wellborn-RV-Parks.d172275-aaRVParks.Travel-Guide-Accommodation) - [La Quinta Inn & Suites Hotels in Fort White ](https://www.expedia.com/Fort-White-Hotels-La-Quinta-Inn-Suites.0-0-d6286968--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Fort White ](https://www.expedia.com/Fort-White-Hotels-Marriott-Hotels-Resorts.0-0-d6286968--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Fort White Hotels ](https://www.expedia.com/Fort-White-Hotels.d6286968.Travel-Guide-Hotels) - [Cabin Rentals in Fort White ](https://www.expedia.com/Fort-White-Cabins.d6286968-aaCabins.Travel-Guide-Accommodation) - [Hotels with a View in Fort White ](https://www.expedia.com/Fort-White-Hotels-Hotels-With-View.0-0-d6286968-tHotelswithView.Travel-Guide-Filter-Hotels) - [Condo Rentals in Fort White ](https://www.expedia.com/Fort-White-Condos.d6286968-aaCondos.Travel-Guide-Accommodation) - [Vacation Homes in Fort White ](https://www.expedia.com/Fort-White-Private-Vacation-Homes.d6286968-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [5 Star Hotels in Fort White ](https://www.expedia.com/5Star-Fort-White-Hotels.s50-0-d6286968.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Fort White ](https://www.expedia.com/Fort-White-Hotels-Romantic-Hotel.0-0-d6286968-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Hotels with Restaurants in Fort White ](https://www.expedia.com/Fort-White-Hotels-Hotels-With-Restaurants.0-0-d6286968-tHotelswithRestaurants.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Fort White ](https://www.expedia.com/Fort-White-Hotels-Pet-Friendly-Hotel.0-0-d6286968-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Historic Hotels in Fort White ](https://www.expedia.com/Fort-White-Hotels-Historic-Hotel.0-0-d6286968-tHistoricHotel.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Fort White ](https://www.expedia.com/3Star-Fort-White-Hotels.s30-0-d6286968.Travel-Guide-Filter-Hotels) - [Motels in Fort White ](https://www.expedia.com/Fort-White-Motels.d6286968-aaMotels.Travel-Guide-Accommodation) - [Hotels near Bob's River Place ](https://www.expedia.com/Bobs-River-Place-Hotels.0-l553248633992473977-0.Travel-Guide-Filter-Hotels) - [Hotels near Baker Park ](https://www.expedia.com/Baker-Park-Hotels.0-l6185391-0.Travel-Guide-Filter-Hotels) - [Hotels near First Federal Sportsplex ](https://www.expedia.com/First-Federal-Sportsplex-Hotels.0-l6185397-0.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Live Oak ](https://www.expedia.com/Live-Oak-Hotels-Hilton-Hotels.0-0-d10072--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Live Oak ](https://www.expedia.com/Live-Oak-Hotels-Best-Western.0-0-d10072--bBestWestern.Travel-Guide-Filter-Hotels) - [Red Roof Inn Hotels in Live Oak ](https://www.expedia.com/Live-Oak-Hotels-Red-Roof-Inn.0-0-d10072--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in Live Oak ](https://www.expedia.com/Live-Oak-Hotels-Wyndham-Hotels.0-0-d10072--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [Oyo Rooms Hotels in Live Oak ](https://www.expedia.com/Live-Oak-Hotels-OYO-Rooms.0-0-d10072--bOYORooms.Travel-Guide-Filter-Hotels) - [Independent Hotels in Live Oak ](https://www.expedia.com/Live-Oak-Hotels-Independent.0-0-d10072--bIndependent.Travel-Guide-Filter-Hotels) - [Live Oak Hotels ](https://www.expedia.com/Live-Oak-Hotels.d10072.Travel-Guide-Hotels) - [Pet-Friendly Hotels in Live Oak ](https://www.expedia.com/Live-Oak-Hotels-Pet-Friendly-Hotel.0-0-d10072-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Cabin Rentals in Live Oak ](https://www.expedia.com/Live-Oak-Cabins.d10072-aaCabins.Travel-Guide-Accommodation) - [Flights to Branford ](https://www.expedia.com/Cheap-Flights-To-Branford.d6188028.Travel-Guide-Flights) - [Flights from Branford ](https://www.expedia.com/lp/flights/6188028/flights-from-branford) - [Flights from Mcalpin ](https://www.expedia.com/lp/flights/3000345299/flights-from-mcalpin) - [Flights to Mayo ](https://www.expedia.com/Cheap-Flights-To-Mayo.d6286979.Travel-Guide-Flights) - [Flights from Mayo ](https://www.expedia.com/lp/flights/6286979/flights-from-mayo) - [Flights to Lafayette County ](https://www.expedia.com/Destinations-In-Lafayette-County.d553248635976430567.Flight-Destinations) - [Flights to Wellborn ](https://www.expedia.com/Cheap-Flights-To-Wellborn.d172275.Travel-Guide-Flights) - [Flights to Fort White ](https://www.expedia.com/Cheap-Flights-To-Fort-White.d6286968.Travel-Guide-Flights) - [Flights to Live Oak ](https://www.expedia.com/Cheap-Flights-To-Live-Oak.d10072.Travel-Guide-Flights) - [Flights from Live Oak ](https://www.expedia.com/lp/flights/10072/flights-from-live-oak) - [Visit Branford ](https://www.expedia.com/Branford.dx6188028) - [Visit Mcalpin ](https://www.expedia.com/Mcalpin.dx3000345299) - [Ichetucknee Springs State Park ](https://www.expedia.com/Ichetucknee-Springs-State-Park-Florida.d6285986.Vacation-Attraction) - [Wes Skiles Peacock Springs State Park ](https://www.expedia.com/Wes-Skiles-Peacock-Springs-State-Park-Live-Oak.d553248621532654050.Vacation-Attraction) - [Visit Mayo ](https://www.expedia.com/Mayo.dx6286979) - [Mayo Vacations ](https://www.expedia.com/Mayo.d6286979.Destination-Travel-Guides) - [Visit Wellborn ](https://www.expedia.com/Wellborn.dx172275) - [Wellborn Vacations ](https://www.expedia.com/Wellborn.d172275.Destination-Travel-Guides) - [Visit Fort White ](https://www.expedia.com/Fort-White.dx6286968) - [Fort White Vacations ](https://www.expedia.com/Fort-White.d6286968.Destination-Travel-Guides) - [Bob's River Place ](https://www.expedia.com/Bobs-River-Place-Old-Town.d553248633992473977.Vacation-Attraction) - [First Federal Sportsplex ](https://www.expedia.com/First-Federal-Sportsplex-Live-Oak.d6185397.Vacation-Attraction) - [Car rentals near Branford ](https://www.expedia.com/Car-Rentals-In-Branford.d6188028.Car-Rental-Guide) - [Car rentals near Mcalpin ](https://www.expedia.com/Car-Rentals-In-Mcalpin.d3000345299.Car-Rental-Guide) - [Car rentals near Ichetucknee Springs State Park ](https://www.expedia.com/Car-Rentals-In-Ichetucknee-Springs-State-Park.d6285986.Car-Rental-Guide) - [Car rentals near Alton ](https://www.expedia.com/Car-Rentals-In-Alton.d553248635975876473.Car-Rental-Guide) - [Car rentals near Wes Skiles Peacock Springs State Park ](https://www.expedia.com/Car-Rentals-In-Wes-Skiles-Peacock-Springs-State-Park.d553248621532654050.Car-Rental-Guide) - [Car rentals near Mayo ](https://www.expedia.com/Car-Rentals-In-Mayo.d6286979.Car-Rental-Guide) - [Car rentals near Wellborn ](https://www.expedia.com/Car-Rentals-In-Wellborn.d172275.Car-Rental-Guide) - [Car rentals near Fort White ](https://www.expedia.com/Car-Rentals-In-Fort-White.d6286968.Car-Rental-Guide) - [Car rentals near Bob's River Place ](https://www.expedia.com/Car-Rentals-In-Bobs-River-Place.d553248633992473977.Car-Rental-Guide) - [Car rentals near Live Oak ](https://www.expedia.com/Car-Rentals-In-Live-Oak.d10072.Car-Rental-Guide) - [Enterprise Rental Cars in Live Oak ](https://www.expedia.com/Enterprise-Car-Rentals-In-Live-Oak.d10072-c15.Car-Rental-Guide-Suppliers) - [Branford Vacation Rentals ](https://www.expedia.com/Branford-Vacation-Rentals.d6188028.Travel-Guide-VacationRentals) - [Mcalpin Vacation Rentals ](https://www.expedia.com/Mcalpin-Vacation-Rentals.d3000345299.Travel-Guide-VacationRentals) - [Mayo Vacation Rentals ](https://www.expedia.com/Mayo-Vacation-Rentals.d6286979.Travel-Guide-VacationRentals) - [Fort White Vacation Rentals ](https://www.expedia.com/Fort-White-Vacation-Rentals.d6286968.Travel-Guide-VacationRentals) - [Live Oak Vacation Rentals ](https://www.expedia.com/Live-Oak-Vacation-Rentals.d10072.Travel-Guide-VacationRentals) - [Things to do in Fort White ](https://www.expedia.com/Things-To-Do-In-Fort-White.d6286968.Travel-Guide-Activities)