Photo by Bill Dillard

Best Resorts in Southeast Missouri

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Check prices for these dates

Next weekend
Nov 20 - Nov 22
In two weeks
Nov 27 - Nov 29
In one month
Dec 11 - Dec 13
In two months
Jan 8 - Jan 10
No exact matches found, but these alternatives could be just right

Recommended hotels in Southeast Missouri

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

1. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very good, (1,002 reviews)
"Our room was spacious, clean and the bed was super comfortable!"
Canada
Kim
$54 nightly
The price is $62
Nov 18 - Nov 19
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO
A modern kitchen with a coffee machine, a refrigerator, and a microwave.

2. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
2.0 star property
Farmington
8.0 out of 10, Very good, (691 reviews)
"Clean nice staff are great"
United States
Marisa
$60 nightly
The price is $68
Nov 18 - Nov 19
Total with taxes and fees
Super 8 by Wyndham Farmington
A motel with a covered entrance, a flag, and a phone number.

3. Madison Inn Lodge

Madison Inn Lodge
2.5 star property
Fredericktown
7.6 out of 10, Good, (314 reviews)
"Nice and clean friendly staff"
United States
Bawan
$87 nightly
The price is $95
Nov 15 - Nov 16
Total with taxes and fees
Madison Inn Lodge
An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

4. Hampton Inn Farmington

Hampton Inn Farmington
2.5 star property
Farmington
8.8 out of 10, Excellent, (583 reviews)
"The staff were so friendly & housekeeping came in each day to take care of our room. The breakfast was one of the best we have had. We had a great stay. Thank you to the staff!"
United States
Charlie
$104 nightly
The price is $119
Dec 13 - Dec 14
Total with taxes and fees
Hampton Inn Farmington
A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

5. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
2.5 star property
Farmington
8.6 out of 10, Excellent, (445 reviews)
"We stayed one night and it was great! Breakfast was delicious."
United States
January
$111 nightly
The price is $127
Dec 13 - Dec 14
Total with taxes and fees
Holiday Inn Express & Suites Farmington by IHG
A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

6. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
9.4 out of 10, Exceptional, (29 reviews)
"Good location, updated hotel!"
United States
Shanna
$114 nightly
The price is $130
Nov 22 - Nov 23
Total with taxes and fees
Hampton Inn & Suites By Hilton Festus
A spacious lobby with a reception desk, seating area, and large windows.

7. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,001 reviews)
"Clean, great food, excellent staff."
United States
Dean
$94 nightly
The price is $106
Nov 19 - Nov 20
Total with taxes and fees
Drury Inn & Suites Poplar Bluff
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

8. Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (339 reviews)
"Clean room, wifi easy to connect to, parking right in front."
United States
Jonathan
$137 nightly
The price is $150
Nov 13 - Nov 14
Total with taxes and fees
Shepherd Mountain Inn
A hotel room with two beds, a desk, a chair, a TV, and a lamp.

9. Fort Davidson Hotel

Fort Davidson Hotel
2.5 star property
Ironton
9.2 out of 10, Wonderful, (190 reviews)
"Clean rooms , nice pool."
United States
richard
$125 nightly
The price is $137
Nov 13 - Nov 14
Total with taxes and fees
Fort Davidson Hotel
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

10. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
8.8 out of 10, Excellent, (703 reviews)
"Tucked away gem."
United States
christopher
$101 nightly
The price is $116
Nov 19 - Nov 20
Total with taxes and fees
Crown Pointe Lodge, BW Signature Collection
A Super 8 hotel with a covered entrance, a parking lot, and a building facade.

11. Super 8 by Wyndham Bonne Terre

Super 8 by Wyndham Bonne Terre
2.0 star property
Bonne Terre
7.0 out of 10, Good, (591 reviews)
"Very clean and friendly place to stay."
United States
Elizabeth
$61 nightly
The price is $67
Nov 15 - Nov 16
Total with taxes and fees
Super 8 by Wyndham Bonne Terre
A spacious cafe with wooden tables and chairs, large windows, and a bar area.

12. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (806 reviews)
"Always an enjoyable stay"
United States
Nathan
$75 nightly
The price is $85
Dec 13 - Dec 14
Total with taxes and fees
Holiday Inn Poplar Bluff by IHG
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

13. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (978 reviews)
"Everything was great- breakfast, cleanliness, price— will stay there again"
United States
ELAINE
$93 nightly
The price is $105
Nov 22 - Nov 23
Total with taxes and fees
Fairfield Inn & Suites by Marriott Poplar Bluff
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

14. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,020 reviews)
"Everything was great about the stay!"
United States
Denise
$89 nightly
The price is $100
Nov 29 - Nov 30
Total with taxes and fees
Hampton Inn Poplar Bluff
A hotel lobby with a reception desk, seating area, and a patterned carpet.

15. Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (645 reviews)
"Excellent stay , couldn't believe the property was 10 years old , it looks like it was just built , great place , highly recommend ."
United States
allan p.
$99 nightly
The price is $113
Dec 13 - Dec 14
Total with taxes and fees
Holiday Inn Express & Suites Perryville by IHG
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

16. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (896 reviews)
"Very clean and every one very nice and helpful"
United States
richard
$80 nightly
The price is $86
Nov 15 - Nov 16
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

17. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,000 reviews)
"The hotel was clean, comfortable and the breakfast was good."
United States
Leonardo
$80 nightly
The price is $85
Nov 22 - Nov 23
Total with taxes and fees
Drury Inn & Suites Jackson MO
A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

18. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (82 reviews)
"Got there late and staff was very helpful. Room was clean and comfortable"
United States
Wendy
$58 nightly
The price is $66
Nov 15 - Nov 16
Total with taxes and fees
Super 8 By Wyndham Marston
A living room with a blue wall, a fireplace, a sofa, and a chair.

19. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (118 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
United States
Jan
$117 nightly
The price is $127
Nov 15 - Nov 16
Total with taxes and fees
EC Reed's Mercantile and Hotel
A modern retail area with a display of local items and snacks.

20. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (201 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
$85 nightly
The price is $97
Nov 18 - Nov 19
Total with taxes and fees
Tru By Hilton Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard
Open Photo by Bill Dillard

Top reviews in Southeast Missouri

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson

10/10 Excellent

Very nice place to stay friendly staff! Rooms are cleaned well!
United States
Nicole
Reviewed October 11, 2021
Drury Inn & Suites Jackson MO

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