Photo by Bill Dillard

Best Resorts in Southeast Missouri

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Check prices for these dates

Next weekend
Nov 20 - Nov 22
In two weeks
Nov 27 - Nov 29
In one month
Dec 11 - Dec 13
In two months
Jan 8 - Jan 10
No exact matches found, but these alternatives could be just right

Recommended hotels in Southeast Missouri

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

1. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very good, (1,004 reviews)
"Our room was spacious, clean and the bed was super comfortable!"
Canada
Kim
$54 nightly
The price is $62
Nov 15 - Nov 16
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO
A spacious lobby with a reception desk, seating area, and large windows.

2. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,001 reviews)
"Clean, great food, excellent staff."
United States
Dean
$90 nightly
The price is $102
Nov 15 - Nov 16
Total with taxes and fees
Drury Inn & Suites Poplar Bluff
A modern kitchen with a coffee machine, a refrigerator, and a microwave.

3. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
2.0 star property
Farmington
8.0 out of 10, Very good, (690 reviews)
"Clean nice staff are great"
United States
Marisa
$60 nightly
The price is $68
Nov 15 - Nov 16
Total with taxes and fees
Super 8 by Wyndham Farmington
A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

4. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
9.4 out of 10, Exceptional, (26 reviews)
"This was a wonderful hotel and had a wonderful stay. Room was clean and staff was wonderful."
United States
Misty
$114 nightly
The price is $130
Nov 22 - Nov 23
Total with taxes and fees
Hampton Inn & Suites By Hilton Festus
A motel with a covered entrance, a flag, and a phone number.

5. Madison Inn Lodge

Madison Inn Lodge
2.5 star property
Fredericktown
7.6 out of 10, Good, (314 reviews)
"Nice and clean friendly staff"
United States
Bawan
$86 nightly
The price is $94
Nov 11 - Nov 12
Total with taxes and fees
Madison Inn Lodge
An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

6. Hampton Inn Farmington

Hampton Inn Farmington
2.5 star property
Farmington
8.8 out of 10, Excellent, (582 reviews)
"The staff were so friendly & housekeeping came in each day to take care of our room. The breakfast was one of the best we have had. We had a great stay. Thank you to the staff!"
United States
Charlie
$103 nightly
The price is $118
Nov 20 - Nov 21
Total with taxes and fees
Hampton Inn Farmington
A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

7. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
2.5 star property
Farmington
8.6 out of 10, Excellent, (445 reviews)
"We stayed one night and it was great! Breakfast was delicious."
United States
January
$114 nightly
The price is $130
Nov 22 - Nov 23
Total with taxes and fees
Holiday Inn Express & Suites Farmington by IHG
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

8. Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (338 reviews)
"Clean room, wifi easy to connect to, parking right in front."
United States
Jonathan
$137 nightly
The price is $150
Nov 11 - Nov 12
Total with taxes and fees
Shepherd Mountain Inn
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

9. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
8.8 out of 10, Excellent, (702 reviews)
"Tucked away gem."
United States
christopher
$101 nightly
The price is $116
Nov 19 - Nov 20
Total with taxes and fees
Crown Pointe Lodge, BW Signature Collection
A hotel room with two beds, a desk, a chair, a TV, and a lamp.

10. Fort Davidson Hotel

Fort Davidson Hotel
2.5 star property
Ironton
9.2 out of 10, Wonderful, (190 reviews)
"Clean rooms , nice pool."
United States
richard
$120 nightly
The price is $131
Nov 17 - Nov 18
Total with taxes and fees
Fort Davidson Hotel
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

11. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (977 reviews)
"Everything was great- breakfast, cleanliness, price— will stay there again"
United States
ELAINE
$97 nightly
The price is $109
Nov 22 - Nov 23
Total with taxes and fees
Fairfield Inn & Suites by Marriott Poplar Bluff
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

12. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,002 reviews)
"The hotel was clean, comfortable and the breakfast was good."
United States
Leonardo
$80 nightly
The price is $85
Nov 22 - Nov 23
Total with taxes and fees
Drury Inn & Suites Jackson MO
A living room with a sofa, coffee table, and a small table with a vase. There is a window with blinds and a door in the background.

13. Super 8 by Wyndham Bonne Terre

Super 8 by Wyndham Bonne Terre
2.0 star property
Bonne Terre
7.0 out of 10, Good, (591 reviews)
"Very clean and friendly place to stay."
United States
Elizabeth
$61 nightly
The price is $67
Nov 11 - Nov 12
Total with taxes and fees
Super 8 by Wyndham Bonne Terre
A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

14. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (82 reviews)
"Got there late and staff was very helpful. Room was clean and comfortable"
United States
Wendy
$58 nightly
The price is $66
Nov 12 - Nov 13
Total with taxes and fees
Super 8 By Wyndham Marston
A spacious cafe with wooden tables and chairs, large windows, and a bar area.

15. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (806 reviews)
"Always an enjoyable stay"
United States
Nathan
$79 nightly
The price is $89
Dec 11 - Dec 12
Total with taxes and fees
Holiday Inn Poplar Bluff by IHG
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

16. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,018 reviews)
"Everything was great about the stay!"
United States
Denise
$89 nightly
The price is $100
Dec 6 - Dec 7
Total with taxes and fees
Hampton Inn Poplar Bluff
A hotel lobby with a reception desk, seating area, and a patterned carpet.

17. Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (645 reviews)
"Excellent stay , couldn't believe the property was 10 years old , it looks like it was just built , great place , highly recommend ."
United States
allan p.
$101 nightly
The price is $116
Nov 15 - Nov 16
Total with taxes and fees
Holiday Inn Express & Suites Perryville by IHG
A cabin surrounded by a natural forest setting with a fire pit and outdoor seating.

18. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
10.0 out of 10, Exceptional, (119 reviews)
"Recomend this location"
United States
Jose
$128 nightly
The price is $145
Dec 9 - Dec 10
Total with taxes and fees
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

19. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (118 reviews)
"Friendly staff, great breakfast, nice amenities"
United States
Roslyn
$101 nightly
The price is $115
Nov 15 - Nov 16
Total with taxes and fees
Fairfield Inn & Suites by Marriott Sikeston
A hotel room with a large bed, two bedside tables, a nightstand, and a framed picture on the wall.

20. Quality Inn Farmington

Quality Inn Farmington
2.5 star property
Farmington
7.6 out of 10, Good, (938 reviews)
"Nice hotel."
United States
Tracy
$67 nightly
The price is $76
Nov 12 - Nov 13
Total with taxes and fees
Quality Inn Farmington
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard
Open Photo by Bill Dillard

Top reviews in Southeast Missouri

A cabin surrounded by a natural forest setting with a fire pit and outdoor seating.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village

10/10 Excellent

Limpio,muy fácil el check in cómodo y limpio.
United States
Dixon
Reviewed November 2, 2026
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

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