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Find Resorts & Hotels with Spas in Southeast Missouri, MO

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Top Southeast Missouri Resorts & Hotels with Spas

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1002)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
$95 nightly
The price is $107
Dec 22 - Dec 23
Total with taxes and fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Southeast Missouri

Top Southeast Missouri attractions for a relaxing vacation

Southeast Missouri offers a delightful blend of relaxation and adventure for travelers seeking spa hotels. Begin your journey at the stunning Lake of the Ozarks, where you can indulge in water-based activities like boating and fishing, then unwind at one of the lakeside spas offering rejuvenating treatments with panoramic views. For a taste of nature, visit the picturesque Johnson's Shut-Ins State Park, where you can hike through scenic trails and then return to your hotel for a soothing massage. Explore the vibrant town of Cape Girardeau, known for its rich history and charming Riverfront, where you can enjoy local cuisine and art galleries, complete with nearby hotels featuring luxurious spa amenities. Don’t miss the chance to visit the historic town of Ste. Genevieve, where you can immerse yourself in French historic culture and relax at nearby resorts that prioritize guest pampering. Staying in this region not only provides access to unique attractions but also ensures your comfort, with attentive service and exceptional quality at every turn.

Top Southeast Missouri Hotel Reviews

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