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Santa Isabel Vacation Rentals

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Our top choices for Santa Isabel vacation rentals

Casa Palma Serena - Garden Retreat • Tropical Stay

Casa Palma Serena - Garden Retreat • Tropical Stay
2.0 star property
Santa Isabel
$257 nightly
The price is $273
Jan 9 - Jan 10, 2026
Total with taxes and fees
Casa Palma Serena - Garden Retreat • Tropical Stay

Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep

Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep
Santa Isabel
8.8 out of 10, Excellent, (44)
"It was amazing to be in the center of the culture. Friendly neighbors! Food amazing! Beach’s all around I would definitely stay there again!!!"
United States
Claudine N.
$342 nightly
The price is $363
Jan 4 - Jan 5, 2026
Total with taxes and fees
Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep

Coming and enjoy panoramic views to mountains and sea in Santa Isabel

Coming and enjoy panoramic views to mountains and sea in Santa Isabel
Santa Isabel
$320 nightly
The price is $340
Dec 30 - Dec 31
Total with taxes and fees
Coming and enjoy panoramic views to mountains and sea in Santa Isabel

Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL

Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL
Santa Isabel
10.0 out of 10, Exceptional, (1)
"Our stay at Mimi’s VRBO was unforgettable, and we’re already planning our return! After searching for the ideal family rental, we chose Mimi’s listing and it was a game-changer. Her warmth and quick responses made everything seamless. When our flight was delayed, Mimi arranged a car to get us to the property and coordinated a rental car delivery the next morning.The house is a gem in a safe, friendly neighborhood, steps from Walmart and close to dining options. Packed with kid-friendly amenities...
United States
Henry S.
$554 nightly
The price is $588
Dec 27 - Dec 28
Total with taxes and fees
Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL

La Gozadera Park

La Gozadera Park
1.0 star property
Salinas
$150 nightly
The price is $164
Dec 27 - Dec 28
Total with taxes and fees
La Gozadera Park

The Place at the Sea

The Place at the Sea
2.0 star property
Ponce
9.2 out of 10, Wonderful, (218)
"Extra clean, perfect place, A+"
Mexico
Pedro
$61 nightly
The price is $67
Jan 13 - Jan 14, 2026
Total with taxes and fees
The Place at the Sea

Playa Apartments

Playa Apartments
2.5 star property
Salinas
7.6 out of 10, Good, (36)
"Definitely clean, safe, user friendly place"
United States
JULIO
$145 nightly
The price is $154
Jan 1 - Jan 2, 2026
Total with taxes and fees
Playa Apartments

Aibonito Hotel 201

Aibonito Hotel 201
2.5 star property
Aibonito
7.4 out of 10, Good, (27)
"Friendly staff and room were clean everything was close by "
United States
Kristi
$125 nightly
The price is $134
Dec 27 - Dec 28
Total with taxes and fees
Aibonito Hotel 201

Nostra Casa Vagón

Nostra Casa Vagón
2.0 star property
Coamo
10.0 out of 10, Exceptional, (1)
"Everything was very clean and organized I got confused with the address and the owner communicated with me and directed me to the exact address when I go to Puerto Rico again I will contact them again to stay at the same place "
United States
Carlos Reyes
$126 nightly
The price is $132
Jan 9 - Jan 10, 2026
Total with taxes and fees
Nostra Casa Vagón

Oasis Salinas

Oasis Salinas
Salinas
7.8 out of 10, Good, (13)
"Excellent place to stay near everything in town "
United States
Mayra
$130 nightly
The price is $138
Dec 27 - Dec 28
Total with taxes and fees
Oasis Salinas

Grandpa's lake house lake private access mountain view museum 1950's experience

Grandpa's lake house lake private access mountain view museum 1950's experience
Cidra
9.4 out of 10, Exceptional, (6)
"We had a great peaceful visit!"
United States
Kelly N.
$105 nightly
The price is $111
Dec 28 - Dec 29
Total with taxes and fees
Grandpa's lake house lake private access mountain view museum 1950's experience

Enjoyable 2nd story, 3-bedroom house with AC in Coamo, PR

Enjoyable 2nd story, 3-bedroom house with AC in Coamo, PR
2.0 star property
Coamo
$126 nightly
The price is $133
Dec 31 - Jan 1, 2026
Total with taxes and fees
Enjoyable 2nd story, 3-bedroom house with AC in Coamo, PR

HW Tiny Home Cidra

HW Tiny Home Cidra
Cidra
10.0 out of 10, Exceptional, (2)
"Beautiful area, great AC, clean hot tub, lovely acces to lake with paddleboat!"
United States
Elizabeth C.
$177 nightly
The price is $188
Dec 30 - Dec 31
Total with taxes and fees
HW Tiny Home Cidra

Points Apartments

Points Apartments
Guayama
9.4 out of 10, Exceptional, (3)
"The host was great. The location was very good too. It fit our needs well. "
United States
Annie B.
$199 nightly
The price is $211
Jan 9 - Jan 10, 2026
Total with taxes and fees
Points Apartments

Trinitarias Guest's House's pool/bar/karaoke/wifi

Trinitarias Guest's House's pool/bar/karaoke/wifi
Salinas
10.0 out of 10, Exceptional, (2)
"Felt like home beautiful super clean quiet I will definitely be back to this home in our vacations Host is amazing Thank You for sharing this beautiful house with my family "
United States
julio
$159 nightly
The price is $169
Jan 7 - Jan 8, 2026
Total with taxes and fees
Trinitarias Guest's House's pool/bar/karaoke/wifi

Cozy studio with private Pool and Bar modern amentities perfect for relaxation.

Cozy studio with private Pool and Bar modern amentities perfect for relaxation.
Cidra
9.6 out of 10, Exceptional, (4)
"We have a wonderful time! The pool and bar were perfect!"
United States
Anna D.
$238 nightly
The price is $252
Jan 5 - Jan 6, 2026
Total with taxes and fees
Cozy studio with private Pool and Bar modern amentities perfect for relaxation.

LA CASITA DEL LAGO

LA CASITA DEL LAGO
Cidra
10.0 out of 10, Exceptional, (2)
"The location was amazing "
United States
Maria
$179 nightly
The price is $190
Jan 8 - Jan 9, 2026
Total with taxes and fees
LA CASITA DEL LAGO

A cozy place to stay walking distance from the beach and Restaurants.

A cozy place to stay walking distance from the beach and Restaurants.
Salinas
9.4 out of 10, Exceptional, (23)
"The description of the house is accurate and the cleanliness of the rental was perfect. The neighborhood was amazing with restaurants and access to the water within walking distance. "
United States
Melanie D.
$150 nightly
The price is $159
Dec 29 - Dec 30
Total with taxes and fees
A cozy place to stay walking distance from the beach and Restaurants.

3-bedroom house in Coamo with AC on bedroom 1

3-bedroom house in Coamo with AC on bedroom 1
Coamo
6.4 out of 10, (5)
"The house was nice ,comfortable and community was quiet and safe. we will be back..."
United States
Kenny R.
$111 nightly
The price is $117
Jan 8 - Jan 9, 2026
Total with taxes and fees
3-bedroom house in Coamo with AC on bedroom 1

Cozy cabin with hot water jacuzzi and AC in the mountains of Guayama.

Cozy cabin with hot water jacuzzi and AC in the mountains of Guayama.
Guayama
10.0 out of 10, Exceptional, (2)
"Property was so beautiful didn’t have any complains. Everything you need in one spot you’d never want to leave."
United States
Jonathan
$184 nightly
The price is $195
Jan 5 - Jan 6, 2026
Total with taxes and fees
Cozy cabin with hot water jacuzzi and AC in the mountains of Guayama.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Isabel Hotel Reviews

Find out more about Santa Isabel

Everything you need to know about Santa Isabel vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Isabel vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Isabel vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santa Isabel vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Isabel. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Isabel in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $67 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santa Isabel rentals

At Expedia, we put the best Santa Isabel vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Isabel rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Isabel vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Isabel. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Are there vacation rentals in Santa Isabel?

Yes, there are vacation rentals close to the most popular attractions in Santa Isabel, or you can choose a secluded option if you're looking for relaxation. Santa Isabel is known for its shopping and restaurants. Make sure you have time to check out the beaches while you're in the area.

What's the top vacation rental that Santa Isabel has to offer?

Private Oceanfront Caribbean Escape – Infinity Pool + Tranquil Garden Sanctuary: This highly rated vacation home rental in Santa Isabel is located by the ocean and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind. Other favorite homes for rent in Santa Isabel are Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL and Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep.

How many vacation rentals will I find in Santa Isabel?

Expedia has 7 vacation rentals for your stay in Santa Isabel.

What can I see and do in Santa Isabel?

Explore the area and family-friendly sights such as Museo de la Musica Puertorriquena, or get out into nature at a spot like Playa La Ochenta. Carribbean Cinemas Santa Isabel and Coamo Springs are a couple of places you'll find in the larger area.

What are vacation rentals like in Santa Isabel?

Vacation rentals are privately owned properties you can reserve for a couple days or more in Santa Isabel. Vacation rentals offer extras like WiFi and washers and dryers so you'll be comfy for your stay. If you're concerned about cleanliness, vacation rentals can provide a sense of safety away from shared hotel elevators and busy lobbies while still allowing you the experience of travel. You'll also find more space in a vacation rental than in a standard hotel, which makes a vacation rental a popular option for a family trip.