Santa Isabel Vacation Rentals

Check prices for these dates

In two weeks
Nov 20 - Nov 22
In two months
Jan 1 - Jan 3
In three months
Jan 29 - Jan 31
In four months
Feb 26 - Feb 28

Our top choices for Santa Isabel vacation rentals

A pool with clear blue water, surrounded by rocks and palm trees, with a view of the ocean.

1. Romantic 1BR Puerto Rico Villa w Pool|Aqua Bella 2

Romantic 1BR Puerto Rico Villa w Pool|Aqua Bella 2
Santa Isabel
10.0 out of 10, Exceptional, (3 reviews)
"We enjoyed our stay immensely. The bed was very comfortable. We loved the outdoor spaces. The parking was a little hard to figure out at first. We loved sitting by the water’s edge with morning coffee and evening glass of wine. "
United States
Penny O.
$511 nightly
The price is $545
Nov 9 - Nov 10
Total with taxes and fees
Romantic 1BR Puerto Rico Villa w Pool|Aqua Bella 2
A modern house with a pool, wooden deck, and outdoor seating area.

2. Coming and enjoy panoramic views to mountains and sea in Santa Isabel

Coming and enjoy panoramic views to mountains and sea in Santa Isabel
Santa Isabel
10.0 out of 10, Exceptional, (1 review)
"This is a unique property with beautiful views. The hosts were incredibly helpful and responsive!"
United States
Annie H.
$290 nightly
The price is $310
Nov 9 - Nov 10
Total with taxes and fees
Coming and enjoy panoramic views to mountains and sea in Santa Isabel
A view through a window with a view of the sea and a small island.

3. Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep

Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep
Santa Isabel
8.8 out of 10, Excellent, (50 reviews)
"Host was very responsive to our texts"
United States
Arnie S.
$325 nightly
The price is $346
Nov 30 - Dec 1
Total with taxes and fees
Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep
A rooftop terrace with a red pool, string lights, and a hanging chair.

4. Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL

Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL
Santa Isabel
10.0 out of 10, Exceptional, (5 reviews)
"Great host communication, central location, lovely home. "
United States
Scott P.
$409 nightly
The price is $437
Nov 9 - Nov 10
Total with taxes and fees
Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL
An outdoor seating area with black wicker furniture, a hammock, and a mural of a surfboard on a blue wall.

5. The Place at the Sea

The Place at the Sea
3.0 star property
Ponce
9.4 out of 10, Exceptional, (497 reviews)
"Everything was amazing"
United States
Dalier
$55 nightly
The price is $60
Nov 12 - Nov 13
Total with taxes and fees
The Place at the Sea
A compact RV kitchen with wooden cabinets, a built-in TV, a small dining area, and a sink.

6. La Gozadera Park

La Gozadera Park
1.0 star property
Salinas
10.0 out of 10, Exceptional, (9 reviews)
"It was easy to find and the host was very friendly, humble and professional"
United States
Ondina
$99 nightly
The price is $108
Nov 17 - Nov 18
Total with taxes and fees
La Gozadera Park
A cozy living room with a wooden ceiling, a sofa with cushions, a small table with decorative items, and a potted plant.

7. A cozy place to stay walking distance from the beach and Restaurants.

A cozy place to stay walking distance from the beach and Restaurants.
Salinas
9.4 out of 10, Exceptional, (27 reviews)
"Complete kitchen, fairly quiet area, near great restaurants "
United States
John W.
$117 nightly
The price is $125
Nov 9 - Nov 10
Total with taxes and fees
A cozy place to stay walking distance from the beach and Restaurants.
An outdoor patio area with wicker furniture and a stone floor, surrounded by lush greenery and trees.

8. Oasis Salinas

Oasis Salinas
Salinas
8.0 out of 10, Very good, (15 reviews)
"Excelente"
United States
Lizbeth
$114 nightly
The price is $122
Nov 9 - Nov 10
Total with taxes and fees
Oasis Salinas
Interior

9. Enjoyable 2nd story, 3-bedroom house with AC in Coamo, PR

Enjoyable 2nd story, 3-bedroom house with AC in Coamo, PR
Coamo
7.0 out of 10, Good, (2 reviews)
"Spotless cozy , ice cold air"
United States
Alberto
$129 nightly
The price is $137
Nov 9 - Nov 10
Total with taxes and fees
Enjoyable 2nd story, 3-bedroom house with AC in Coamo, PR
A wooden deck with a welcome mat and potted plants.

10. Nostra Casa Vagón

Nostra Casa Vagón
Coamo
10.0 out of 10, Exceptional, (1 review)
"Everything was very clean and organized I got confused with the address and the owner communicated with me and directed me to the exact address when I go to Puerto Rico again I will contact them again to stay at the same place "
United States
Carlos Reyes
$129 nightly
The price is $137
Nov 9 - Nov 10
Total with taxes and fees
Nostra Casa Vagón
A living room with a round table, a sofa, a television, and ceiling fans.

11. House Salinas (WIFI) - The best part of your getaway

House Salinas (WIFI) - The best part of your getaway
Salinas
9.8 out of 10, Exceptional, (24 reviews)
"Nice cozy home near downtiwn, Salinas PR"
United States
Kenneth C.
$207 nightly
The price is $221
Nov 9 - Nov 10
Total with taxes and fees
House Salinas (WIFI) - The best part of your getaway
A kitchen with a window, a shelf with a cactus, a mug, and a sign that says "Blessed".

12. Trinitaria Guesthouse with Pool/Bar/Karaoke/Wi-Fi

Trinitaria Guesthouse with Pool/Bar/Karaoke/Wi-Fi
Salinas
9.0 out of 10, Wonderful, (4 reviews)
"Felt like home beautiful super clean quiet I will definitely be back to this home in our vacations Host is amazing Thank You for sharing this beautiful house with my family "
United States
julio
$165 nightly
The price is $176
Nov 10 - Nov 11
Total with taxes and fees
Trinitaria Guesthouse with Pool/Bar/Karaoke/Wi-Fi
A compact kitchen with a dining area, a sofa, and a TV.

13. Compact Haven with Private Entrance and FREE Parking and Laundry

Compact Haven with Private Entrance and FREE Parking and Laundry
Ponce
9.2 out of 10, Wonderful, (17 reviews)
"Apartment was very good, location was close to everything. Off street parking great."
United States
Anonymous traveler
$158 nightly
The price is $169
Nov 11 - Nov 12
Total with taxes and fees
Compact Haven with Private Entrance and FREE Parking and Laundry
A bedroom with a bed, a glass table, and a plant.

14. Cozy 1-bedroom apartment with AC in vibrant Ponce

Cozy 1-bedroom apartment with AC in vibrant Ponce
Ponce
$178 nightly
The price is $190
Nov 9 - Nov 10
Total with taxes and fees
Cozy 1-bedroom apartment with AC in vibrant Ponce
A hot tub with a safety sign, surrounded by lush greenery and a mountainous backdrop.

15. Botanical Hot tub- cabin with AC in Mountains of Orocovis

Botanical Hot tub- cabin with AC in Mountains of Orocovis
Orocovis
10.0 out of 10, Exceptional, (1 review)
"Good place to stay"
United States
Michael
$176 nightly
The price is $188
Nov 9 - Nov 10
Total with taxes and fees
Botanical Hot tub- cabin with AC in Mountains of Orocovis
A living room with a brown sofa, a coffee table, a patterned rug, a TV, and a balcony with a view of blue buildings and greenery.

16. Gladiolas 2201

Gladiolas 2201
3.0 star property
Ponce Centro
8.4 out of 10, Very good, (30 reviews)
"It’s a good place to spend a weekend. "
United States
Ruben
$127 nightly
The price is $136
Nov 9 - Nov 10
Total with taxes and fees
Gladiolas 2201
A modern living room with a central table, two hanging pendant lights, a ceiling fan, and a sofa with cushions.

17. Stylish & Comfy Retreat: 10 Mins to Beach, Parking

Stylish & Comfy Retreat: 10 Mins to Beach, Parking
Las Ochenta
$284 nightly
The price is $304
Nov 15 - Nov 16
Total with taxes and fees
Stylish & Comfy Retreat: 10 Mins to Beach, Parking
An outdoor patio with a wooden pergola, string lights, a grill, a cushioned chair, and a table with candles.

18. Private Patio Retreat with Zen Vibe and Laundry

Private Patio Retreat with Zen Vibe and Laundry
Ponce
9.4 out of 10, Exceptional, (16 reviews)
"Was great quiet, clean and very safe, we felt confortable and the neighbors were very friendly "
United States
Magda R.
$148 nightly
The price is $158
Nov 17 - Nov 18
Total with taxes and fees
Private Patio Retreat with Zen Vibe and Laundry
A bedroom with a bed, a desk, a round mirror, and a small plant.

19. 130-Year Historic Ponce Home - Jacuzzi Suite

130-Year Historic Ponce Home - Jacuzzi Suite
Ponce
$129 nightly
The price is $137
Nov 9 - Nov 10
Total with taxes and fees
130-Year Historic Ponce Home - Jacuzzi Suite
A view from a balcony with white walls, overlooking a cityscape with various buildings, including a tall structure and several smaller ones.

20. Apartment Double Bed- Sleeps 2 - Free WIFI

Apartment Double Bed- Sleeps 2 - Free WIFI
Ponce Centro
6.0 out of 10, (5 reviews)
"I stayed for 10 days, it was great. Location, amenities, locals and the Host was great. Amazing services! Keep up the great work. Would recommend ."
United States
ErnestV
$115 nightly
The price is $119
Nov 9 - Nov 10
Total with taxes and fees
Apartment Double Bed- Sleeps 2 - Free WIFI
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Isabel Hotel Reviews

A swimming pool with a thatched umbrella, two lounge chairs, and a view of the landscape.
Hacienda del Sur

Hacienda del Sur

Hacienda del Sur
Santa Isabel

10/10 Excellent

Todo perfecto 💯
United States
Karina
Reviewed October 25, 2026
Hacienda del Sur

Find out more about Santa Isabel

Everything you need to know about Santa Isabel vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Isabel vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Isabel vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santa Isabel vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Isabel. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Isabel in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $60 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santa Isabel rentals

At Expedia, we put the best Santa Isabel vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Isabel rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Isabel vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Isabel. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently Asked Questions

Are there vacation rentals in Santa Isabel?

Yes, there are vacation rentals close to the most popular attractions in Santa Isabel, or you can choose a secluded option if you're looking for relaxation. Santa Isabel is known for its shopping and restaurants. Make sure you have time to check out the beaches while you're in the area.

What's the top vacation rental that Santa Isabel has to offer?

Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep: This highly rated vacation home rental in Santa Isabel is located on the beach and has a balcony, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. Other favorite homes for rent in Santa Isabel are 3BR Puerto Rico Villa w Pool | Aqua Bella 1 and Modern Cozy Home in Puerto Rican Paradise.

How many vacation rentals will I find in Santa Isabel?

Expedia has 7 vacation rentals for your stay in Santa Isabel.

What can I see and do in Santa Isabel?

Explore the area and family-friendly sights such as Museo de la Musica Puertorriquena, or get out into nature at a spot like Coamo Springs. Carribbean Cinemas Santa Isabel and Marina de Salinas are a couple of places you'll find in the larger area.

What are vacation rentals like in Santa Isabel?

Vacation rentals are privately owned properties you can reserve for a couple days or more in Santa Isabel. Vacation rentals offer extras like WiFi and washers and dryers so you'll be comfy for your stay. If you're concerned about cleanliness, vacation rentals can provide a sense of safety away from shared hotel elevators and busy lobbies while still allowing you the experience of travel. You'll also find more space in a vacation rental than in a standard hotel, which makes a vacation rental a popular option for a family trip.

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