A person paddleboarding on a calm sea with wind turbines in the background.

Santa Isabel Vacation Rentals

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Check prices for these dates

In two weeks
Oct 9 - Oct 11
In two months
Nov 20 - Nov 22
In three months
Dec 18 - Dec 20
In four months
Jan 15 - Jan 17

Our top choices for Santa Isabel vacation rentals

A beach with clear turquoise water, a sandy shore, and a rocky hill in the background.

1. Romantic 1BR Puerto Rico Villa w Pool|Aqua Bella 2

Romantic 1BR Puerto Rico Villa w Pool|Aqua Bella 2
Santa Isabel
10.0 out of 10, Exceptional, (3 reviews)
"We enjoyed our stay immensely. The bed was very comfortable. We loved the outdoor spaces. The parking was a little hard to figure out at first. We loved sitting by the water’s edge with morning coffee and evening glass of wine. "
United States
Penny O.
$553 nightly
The price is $587
Sep 27 - Sep 28
Total with taxes and fees
Romantic 1BR Puerto Rico Villa w Pool|Aqua Bella 2
A modern dining area with a glass table, white chairs, and a chandelier.

2. Casa Palma Serena - Garden Retreat • Tropical Stay

Casa Palma Serena - Garden Retreat • Tropical Stay
Santa Isabel
10.0 out of 10, Exceptional, (2 reviews)
$299 nightly
The price is $318
Oct 12 - Oct 13
Total with taxes and fees
Casa Palma Serena - Garden Retreat • Tropical Stay
A view through a window with a view of the sea and a small island.

3. Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep

Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep
Santa Isabel
8.8 out of 10, Excellent, (50 reviews)
"Host was very responsive to our texts"
United States
Arnie S.
$338 nightly
The price is $359
Sep 27 - Sep 28
Total with taxes and fees
Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep
A modern house with a pool, wooden deck, and outdoor seating area.

4. Coming and enjoy panoramic views to mountains and sea in Santa Isabel

Coming and enjoy panoramic views to mountains and sea in Santa Isabel
Santa Isabel
10.0 out of 10, Exceptional, (1 review)
"This is a unique property with beautiful views. The hosts were incredibly helpful and responsive!"
United States
Annie H.
$316 nightly
The price is $336
Sep 29 - Sep 30
Total with taxes and fees
Coming and enjoy panoramic views to mountains and sea in Santa Isabel
A rooftop terrace with a red pool, string lights, and a hanging chair.

5. Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL

Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL
Santa Isabel
10.0 out of 10, Exceptional, (5 reviews)
"Great host communication, central location, lovely home. "
United States
Scott P.
$507 nightly
The price is $539
Sep 28 - Sep 29
Total with taxes and fees
Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL
An outdoor seating area with wicker furniture, a table with a bottle, and a view of the sea.

6. The Place at the Sea

The Place at the Sea
3.0 star property
Ponce
9.4 out of 10, Exceptional, (446 reviews)
"The staff is very helpful and polite, the place is super nice and well decorated, the cabin was 20/10, its perfect for a couple. The place was so quiet at night that you could hear the ocean. I have already recommended this place to so many people and its been 2 hours and some mins that I checked out. Already did future reservertions, thanks alot to the owner/staff for this awesome experience!"
United States
Noel
$69 nightly
The price is $75
Sep 28 - Sep 29
Total with taxes and fees
The Place at the Sea
A compact RV kitchen with wooden cabinets, a built-in TV, a small dining area, and a sink.

7. La Gozadera Park

La Gozadera Park
1.0 star property
Salinas
10.0 out of 10, Exceptional, (3 reviews)
"Limpieza, ubicación, condiciones de la propiedad, comunidad con el host, todo excelente."
United States
Janice
$105 nightly
The price is $115
Sep 25 - Sep 26
Total with taxes and fees
La Gozadera Park
A cozy living room with a wooden ceiling, a sofa, a wicker chair, and a flag on the door.

8. A cozy place to stay walking distance from the beach and Restaurants.

A cozy place to stay walking distance from the beach and Restaurants.
Salinas
9.4 out of 10, Exceptional, (27 reviews)
"Complete kitchen, fairly quiet area, near great restaurants "
United States
John W.
$133 nightly
The price is $141
Oct 12 - Oct 13
Total with taxes and fees
A cozy place to stay walking distance from the beach and Restaurants.
An outdoor patio area with wicker furniture and a stone floor, surrounded by lush greenery and trees.

9. Oasis Salinas

Oasis Salinas
Salinas
8.0 out of 10, Very good, (14 reviews)
"Excellent place to stay near everything in town "
United States
Mayra
$130 nightly
The price is $138
Sep 25 - Sep 26
Total with taxes and fees
Oasis Salinas
A modern living room with a sofa, coffee table, and a dining area with a glass table and chairs.

10. Casa Luna Pool House NO POOL

Casa Luna Pool House NO POOL
Coamo
$150 nightly
The price is $159
Sep 28 - Sep 29
Total with taxes and fees
Casa Luna Pool House NO POOL
A person standing on a balcony with a view of a mountainous landscape.

11. Botanical Hot tub- cabin with AC in Mountains of Orocovis

Botanical Hot tub- cabin with AC in Mountains of Orocovis
Orocovis
$173 nightly
The price is $184
Oct 10 - Oct 11
Total with taxes and fees
Botanical Hot tub- cabin with AC in Mountains of Orocovis

12. Enjoyable 2nd story, 3-bedroom house with AC in Coamo, PR

Enjoyable 2nd story, 3-bedroom house with AC in Coamo, PR
Coamo
7.0 out of 10, Good, (2 reviews)
"Spotless cozy , ice cold air"
United States
Alberto
$140 nightly
The price is $148
Sep 25 - Sep 26
Total with taxes and fees
Enjoyable 2nd story, 3-bedroom house with AC in Coamo, PR
A bedroom with a bed, a desk, and a chair. There is a chandelier on the ceiling.

13. Aibonito Hotel 201

Aibonito Hotel 201
2.5 star property
Aibonito
6.8 out of 10, (39 reviews)
"Friendly staff and room were clean everything was close by "
United States
Kristi
Aibonito Hotel 201
A wooden deck with a welcome mat and potted plants.

14. Nostra Casa Vagón

Nostra Casa Vagón
Coamo
10.0 out of 10, Exceptional, (1 review)
"Everything was very clean and organized I got confused with the address and the owner communicated with me and directed me to the exact address when I go to Puerto Rico again I will contact them again to stay at the same place "
United States
Carlos Reyes
$140 nightly
The price is $148
Sep 25 - Sep 26
Total with taxes and fees
Nostra Casa Vagón
A modern two-story house with a garage, surrounded by palm trees and a clear sky.

15. Anime Escape with Private Jacuzzi & Themed Rooms

Anime Escape with Private Jacuzzi & Themed Rooms
San Ildefonso
8.8 out of 10, Excellent, (3 reviews)
"We had a blast! "
United States
Keyla F.
Anime Escape with Private Jacuzzi & Themed Rooms
A beach with boats docked in calm waters, a clear sky, and a sandy shore.

16. House Salinas (WIFI) - The best part of your getaway

House Salinas (WIFI) - The best part of your getaway
Salinas
9.8 out of 10, Exceptional, (24 reviews)
"Nice cozy home near downtiwn, Salinas PR"
United States
Kenneth C.
$223 nightly
The price is $237
Oct 4 - Oct 5
Total with taxes and fees
House Salinas (WIFI) - The best part of your getaway
A wooden dresser with a potted plant on top, a mirror above it, and a decorative piece on the dresser.

17. Trinitarias Guest's House's pool/bar/karaoke/wifi

Trinitarias Guest's House's pool/bar/karaoke/wifi
Salinas
9.0 out of 10, Wonderful, (4 reviews)
"Felt like home beautiful super clean quiet I will definitely be back to this home in our vacations Host is amazing Thank You for sharing this beautiful house with my family "
United States
julio
$166 nightly
The price is $176
Sep 25 - Sep 26
Total with taxes and fees
Trinitarias Guest's House's pool/bar/karaoke/wifi
A stone staircase leading to a white building with a statue in the center, surrounded by lush greenery and metal gates.

18. Casita Azul Boutique Stay in Heart of Barranquitas - Walk Downtown, AC + Balcony

Casita Azul Boutique Stay in Heart of Barranquitas - Walk Downtown, AC + Balcony
Barranquitas
10.0 out of 10, Exceptional, (4 reviews)
"great stay super clean and comfy"
United States
frankie q.
$175 nightly
The price is $186
Oct 5 - Oct 6
Total with taxes and fees
Casita Azul Boutique Stay in Heart of Barranquitas - Walk Downtown, AC + Balcony
A modern bedroom with a bed, bedside table, and a TV mounted on the wall.

19. Aibonito Hotel 205

Aibonito Hotel 205
3.0 star property
Aibonito
7.6 out of 10, Good, (29 reviews)
"It's a great location and convenient to another locations. Staff was was friendly and helpful. I ended up booking additional room for family."
United States
Christine
Aibonito Hotel 205
An aerial view of a small island with clear turquoise waters, a sandy beach, and a few structures.

20. Charming Retreat with Patio Access and Laundry

Charming Retreat with Patio Access and Laundry
Ponce
8.8 out of 10, Excellent, (24 reviews)
"Clean place, good communication with host, pleasant stay. Comfy beds, nice A/C. Nice neighborhood. Only issue, was the bathroom which had a musty odor all the time. "
United States
Jorge A T.
$157 nightly
The price is $166
Sep 25 - Sep 26
Total with taxes and fees
Charming Retreat with Patio Access and Laundry
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Isabel Hotel Reviews

Ponce Plaza Hotel & Casino

Ponce Plaza Hotel & Casino

10/10 Excellent
"El hotel tiene una ubicación excelente"
David Antonio 3-night trip
Posted 8 hours ago
Ponce Plaza Hotel & Casino

Find out more about Santa Isabel

Everything you need to know about Santa Isabel vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Isabel vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Isabel vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santa Isabel vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Isabel. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Isabel in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $75 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santa Isabel rentals

At Expedia, we put the best Santa Isabel vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Isabel rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Isabel vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Isabel. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Are there vacation rentals in Santa Isabel?

Yes, there are vacation rentals close to the most popular attractions in Santa Isabel, or you can choose a secluded option if you're looking for relaxation. Santa Isabel is known for its shopping and restaurants. Make sure you have time to check out the beaches while you're in the area.

What's the top vacation rental that Santa Isabel has to offer?

3BR Puerto Rico Villa w Pool | Aqua Bella 1: This highly rated vacation home rental in Santa Isabel is located by the ocean and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind. Other favorite homes for rent in Santa Isabel are Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep and Modern Cozy Home in Puerto Rican Paradise.

How many vacation rentals will I find in Santa Isabel?

Expedia has 7 vacation rentals for your stay in Santa Isabel.

What can I see and do in Santa Isabel?

Explore the area and family-friendly sights such as Museo de la Musica Puertorriquena, or get out into nature at a spot like Coamo Springs. Carribbean Cinemas Santa Isabel and Marina de Salinas are a couple of places you'll find in the larger area.

What are vacation rentals like in Santa Isabel?

Vacation rentals are privately owned properties you can reserve for a couple days or more in Santa Isabel. Vacation rentals offer extras like WiFi and washers and dryers so you'll be comfy for your stay. If you're concerned about cleanliness, vacation rentals can provide a sense of safety away from shared hotel elevators and busy lobbies while still allowing you the experience of travel. You'll also find more space in a vacation rental than in a standard hotel, which makes a vacation rental a popular option for a family trip.