Santa Isabel Vacations from $487
Book a Hotel + Flight or Car together to unlock savings
Photo by Eddie Melendez
- Plan, book, travel with confidence
Better together
Save up to $1,045 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Your Santa Isabel Vacation
Book a Santa Isabel vacation package and get set for an awesome adventure. Well known for its lively atmosphere and welcoming locals, there's loads to love about this city. When the time comes to get out and see the sights, be sure to put Coamo Springs and Playa La Ochenta on the to-do list for your trip to Santa Isabel. Expedia has what you need to escape your routine. Tailor your vacation to Santa Isabel to suit your travel style, whatever that may look like.
The Latest Santa Isabel vacation packages
Price found within the past 48 hours. Click for updated prices.
Ola Boutique Hotel
Condado
Price was $1,088, price is now $487 per person
$487
per person
Oct 23 - Oct 26
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to San Juan (SJU)
9/10 Wonderful! (466 reviews)
Both Marco and Francisco were professional and helpful. We would definitely stay here again.
Reviewed on Aug 22, 2025
San Agustin Apartments
San Juan Antiguo
Save 100% on your flight
Price was $1,498, price is now $784 per person
$784
per person
Nov 4 - Nov 9
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to San Juan (SJU)
9.2/10 Wonderful! (370 reviews)
La propiedad en excelentes condiciones y ubicación perfecta
Reviewed on Aug 23, 2025
Urbana Hotel
San Juan Antiguo
Save 100% on your flight
Price was $1,256, price is now $662 per person
$662
per person
Nov 9 - Nov 16
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Juan (SJU)
8.6/10 Excellent! (328 reviews)
The front desk staff was amazing, they welcomed us with champagne
Reviewed on Aug 22, 2025
The Oliver Hotel
San Juan Antiguo
Save 100% on your flight
Price was $1,137, price is now $609 per person
$609
per person
Nov 4 - Nov 9
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to San Juan (SJU)
9/10 Wonderful! (32 reviews)
El hotel por dentro es muy bonito, el staff amable. Pero, como es nuevo necesitan estar mas al día con el mantenimiento (aires, inodoros, agua caliente, etc). También mejorar el manejo de los empleados de limpieza (debe hacer menos escándalo) y mejorar la comunicación con las personas de mantenimiento (horarios para hacerlo y si hay huéspedes en la habitación o no).
Reviewed on Aug 9, 2025
Hotel Puerto Valdes
San Juan Antiguo
Save 100% on your flight
Price was $1,155, price is now $672 per person
$672
per person
Nov 13 - Nov 17
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Juan (SJU)
9/10 Wonderful! (467 reviews)
This place smell so good and staff was so great. The room was very spacious. The bathroom need to update.
Reviewed on Aug 22, 2025
Don't see what you're looking for?
See all available trips from Columbus to Santa Isabel
View all tripsSanta Isabel Hotel Deals
Hotel Las Vegas
PR 153, Km 2.9, Santa Isabel
$70 nightly
The price is $76 total per night from Aug 24 to Aug 25
$76 total
Aug 24 - Aug 25
Total with taxes and fees
7.8/10 Good! (293 reviews)
"Easy access"
Reviewed on Jul 28, 2025
Hacienda del Sur
Carr 545 KM 1.5, Sector Gabia, Santa Isabel
$140 nightly
The price is $153 total per night from Aug 25 to Aug 26
$153 total
Aug 25 - Aug 26
Total with taxes and fees
9.4/10 Exceptional! (18 reviews)
Hidden gem
"I stayed here for the Bad Bunny residency because I rather stay closer to family, and I feel like I found a hidden gem in the south of PR. From the moment I walked in, everyone (especially Rosie) was so attentive. I stayed alone a few days before my friend arrived, but I didn't feel alone. The owner's ..."
Reviewed on Aug 11, 2025
Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep
Santa Isabel
$343 nightly
The price is $364 total per night from Aug 26 to Aug 27
$364 total
Aug 26 - Aug 27
Total with taxes and fees
8.8/10 Excellent! (41 reviews)
Relax and Unwind
"We needed a place as a base camp to visit family while also large enough to host everyone during our visit. The host accommodated a last minute request and the rental did not disappoint. This house is located right on the ocean with direct access to a small beach area with plenty of space for family ..."
Reviewed on Jul 24, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More vacations you might like
Frequently asked questions
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- All-inclusive Resorts in Puerto Rico
- Jauca I Hotels
- Villas in Rio Canas Abajo
- Rio Canas Abajo Hotels
- Hotels near Coamo Springs
- Salinas Hotels
- Motels in Salinas
- Hostels in Salinas
- Villas in Salinas
- Guest Houses in Salinas
- Apartments in Salinas
- Condo Rentals in Salinas
- Vacation Homes in Salinas
- 5 Star Hotels in Salinas
- Resorts in Salinas
- 4 Star Hotels in Salinas
- Hotels near Marina de Salinas
- Coamo Hotels
- Villas in Coamo
- Vacation Homes in Coamo
- Motels in Coamo
- Resorts in Coamo
- Apartments in Coamo
- B&B in Coamo
- Condo Rentals in Coamo
- Guest Houses in Coamo
- Juana Diaz Hotels
- Motels in Juana Diaz
- Vacation Homes in Juana Diaz
- Apartments in Juana Diaz
- Guest Houses in Juana Diaz
- 3 Star Hotels in Juana Diaz
- Resorts in Juana Diaz
- 5 Star Hotels in Juana Diaz
- Villas in Juana Diaz
- Condo Rentals in Juana Diaz
- Isla Caja de Muertos Hotels
- 3 Star Hotels in Isla Caja de Muertos
- Villas in Isla Caja de Muertos
- Flights to Puerto Rico Island
- Flights to Salinas
- Flights from Salinas
- Flights to Coamo
- Flights from Coamo
- Flights to Juana Diaz
- Flights from Juana Diaz
- Flights to Isla Caja de Muertos
- Flights from Mercedita
- Flights from Orlando (MCO) to Ponce (PSE)
- Flights from New York (JFK) to Ponce (PSE)
- Flights from San Juan (SJU) to Ponce (PSE)
- Flights from Philadelphia (PHL) to Ponce (PSE)
- Flights from Tampa (TPA) to Ponce (PSE)
- Flights from Chicago (ORD) to Ponce (PSE)
- Flights from Miami (MIA) to Ponce (PSE)
- Flights from Hartford (BDL) to Ponce (PSE)
- Flights from Boston (BOS) to Ponce (PSE)
- Flights from Fort Lauderdale (FLL) to Ponce (PSE)
- Flights to Mercedita
- Flights from Raleigh (RDU) to Ponce (PSE)
- Flights from Atlanta (ATL) to Ponce (PSE)
- Flights from Dallas (DFW) to Ponce (PSE)
- Flights from Houston (IAH) to Ponce (PSE)
- JetBlue Airways New York (JFK) to Ponce (PSE) flights
- JetBlue Airways Orlando (MCO) to Ponce (PSE) flights
- Flights from Baltimore (BWI) to Ponce (PSE)
- Flights from Jacksonville (JAX) to Ponce (PSE)
- Flights from Cleveland (CLE) to Ponce (PSE)
- Flights from Detroit (DTW) to Ponce (PSE)
- Puerto Rico Island Vacations
- Visit Rio Canas Abajo
- Coamo Springs
- Visit Urbanization Las Fuentes de Coamo
- Salinas Vacations
- Marina de Salinas
- Visit Salinas
- Puerto Rico National Guard Museum
- Coamo Vacations
- Juana Diaz Vacations
- Visit Coamo
- Isla Caja de Muertos Vacations
- Visit Juana Diaz
- Visit Isla Caja de Muertos
- Car rentals near Rio Canas Abajo
- Car rentals near Coamo Springs
- Car rentals near Salinas
- Enterprise Rental Cars in Salinas
- Car rentals near Puerto Rico National Guard Museum
- Car rentals near Coamo
- Car rentals near Juana Diaz
- Enterprise Rental Cars in Juana Diaz
- Alamo Rent A Car Rental Cars in Juana Diaz
- Car rental Ponce Airport (PSE)
- Thrifty Car Rental Rental Cars in Mercedita
- Hertz Rental Cars in Mercedita
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.