Santa Isabel Vacations from $398
Book a Hotel + Flight or Car together to unlock savings
Photo by Eddie Melendez
Your Santa Isabel Vacation
Book a Santa Isabel vacation package and get set for an awesome adventure. Well known for its lively atmosphere and welcoming locals, there's loads to love about this city. When the time comes to get out and see the sights, be sure to put Coamo Springs and Playa La Ochenta on the to-do list for your trip to Santa Isabel. Expedia has what you need to escape your routine. Tailor your vacation to Santa Isabel to suit your travel style, whatever that may look like.
The Latest Santa Isabel vacation packages
Price found within the past 48 hours. Click for updated prices.
Urbana Hotel
San Juan Antiguo
Save 100% on your flight
per person
Sep 17 - Sep 21
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Juan (SJU)
8.6/10 Excellent! (297 reviews)
The staff was wonderful. There was a place across the street to have delicious empanadillas and a bakery down the road for breakfast. The room was small but clean and just what we needed for one night to explore Viejo San Juan. There is a club right next door so if noise bothers you keep that in mind but it didn’t bother us.
Reviewed on Jul 12, 2025
Ola Boutique Hotel
Condado
per person
Sep 15 - Sep 20
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to San Juan (SJU)
9/10 Wonderful! (429 reviews)
I just checked out today 7/12/25 and my stay was awesome! Close to everything shops,supermarkets,beaches etc.. the breakfast is really good. My room was very cleaned and the staff very helpful. Go check it out!
Reviewed on Jul 12, 2025
El Conquistador Resort
Cabezas
Save 100% on your flight
per person
Sep 17 - Sep 21
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Juan (SJU)
9/10 Wonderful! (3,033 reviews)
The resort was amazing!!! Definitely will come back for another stay. The WiFi connection definitely needs improvement, beside that I would recommend this place to anyone !!!
Reviewed on Jul 13, 2025
San Agustin Apartments
San Juan Antiguo
Save 100% on your flight
per person
Sep 17 - Sep 21
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to San Juan (SJU)
9.2/10 Wonderful! (347 reviews)
We needed to clean the stove too, repair the coffee pot and unclog the side sink that was clogged with sand.
Reviewed on Jul 8, 2025
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View all tripsSanta Isabel Hotel Deals
Hotel Las Vegas
PR 153, Km 2.9, Santa Isabel
$79 nightly
The price is $86 total per night from Jul 14 to Jul 15
$86 total
Jul 14 - Jul 15
Total includes taxes and fees
7.8/10 Good! (283 reviews)
"Perfect for the intended use. Clean and peaceful. Not hot water but it was warm enough to allow a good shower. Recommended for short stays like 1 or 2 night."
Reviewed on Jun 29, 2025
Hacienda del Sur
Carr 545 KM 1.5, Sector Gabia, Santa Isabel
$148 nightly
The price is $162 total per night from Aug 6 to Aug 7
$162 total
Aug 6 - Aug 7
Total includes taxes and fees
9.2/10 Wonderful! (12 reviews)
"I loved everything about the property and the staff was really friendly and always making sure we had what we needed"
Reviewed on Jul 1, 2025
Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL
Santa Isabel
Unforgettable Family Vacation at Mimi’s Stunning VRBO!
"Our stay at Mimi’s VRBO was unforgettable, and we’re already planning our return! After searching for the ideal family rental, we chose Mimi’s listing and it was a game-changer. Her warmth and quick responses made everything seamless. When our flight was delayed, Mimi arranged a car to get us to ..."
Reviewed on Jun 2, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Santa Isabel Vacation Packages
Santa Isabel Essential Information
Language | Spanish |
|---|---|
Currency | U.S dollars |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Mercedita Airport (PSE) |
Population | 7,300 |
Max Temp Winter | 80ºF |
Max Temp Summer | 85ºF |
Top Sights | Coamo Springs, Playa La Ochenta and Marina de Salinas |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.