Title: The Best 2 Star Hotels in Santee, SC from $64 | Expedia.com [Santee Travel Guide](https://expedia.com/Santee.dx9953)[Hotels in Santee](https://expedia.com/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.com/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.com/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Car Rentals in Santee](https://expedia.com/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.com/Santee.d9953.Destination-Travel-Guides) ![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santee 2 Star Hotels Tonight [Mar 10 - Mar 11](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-03-10&endDate=2026-03-11&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 11 - Mar 12](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-03-11&endDate=2026-03-12&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santee 2-star hotels ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/cce2b53c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/11da224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/99021580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Santee [](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) Santee 9.2/10 Wonderful (755 reviews) "Large, clean room, friendly staff, nice breakfast. Would stay again. Also a nice Mexican restaurant nearby for dinner. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan $113 nightly $125 total Mar 16 - Mar 17 Total with taxes and fees [](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/d2da67e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/320acff9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/756b4cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee [](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) Santee 8.0/10 Very Good (1,448 reviews) "Room were very clean and staff was very helpful. I would stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charolette $76 nightly $84 total Mar 24 - Mar 25 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/99c8fb35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/f2adc30e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c5155ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c836e9b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Orangeburg [](https://www.expedia.com/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) Orangeburg 9.2/10 Wonderful (1,006 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas $114 nightly $127 total Mar 23 - Mar 24 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/27e78d69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/e0b4742d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/e5b64ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/3ffa2f0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SpringHill Suites by Marriott Orangeburg [](https://www.expedia.com/Orangeburg-Hotels-SpringHill-Suites-Orangeburg.h54931475.Hotel-Information) Orangeburg 8.8/10 Excellent (712 reviews) "3rd stay at this location would highly recommend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Athanassios $119 nightly $132 total Mar 11 - Mar 12 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-SpringHill-Suites-Orangeburg.h54931475.Hotel-Information) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/27faffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/e4316a7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/0ca73b4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/e6b95688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SureStay Hotel by Best Western Manning [](https://www.expedia.com/Sumter-Hotels-SureStay-Hotel-By-Best-Western-Manning.h569301.Hotel-Information) Manning 8.6/10 Excellent (1,006 reviews) "The room was very clean, the staff were very nice and the breakfast was ok. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samantha $89 nightly $99 total Mar 15 - Mar 16 Total with taxes and fees [](https://www.expedia.com/Sumter-Hotels-SureStay-Hotel-By-Best-Western-Manning.h569301.Hotel-Information) ![Breakfast area](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/bfdc100f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/5f1ffd39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/c4ff1065.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Smoking | Bathroom sink](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/13cfcb42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Orangeburg [](https://www.expedia.com/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information) Orangeburg 8.2/10 Very Good (1,007 reviews) "The evening clerk is a joy, so friendly and helpful! Room clean and comfortable. Nice stay for passing through. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debra $75 nightly $83 total Mar 11 - Mar 12 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/b15e751d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/581bc335.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/cfcbf535.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/3e8501ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Orangeburg North [](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Orangeburg-North.h20500.Hotel-Information) Orangeburg 6.0/10 (1,004 reviews) "The rooms were clean and staff was courteous. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yojuana $60 nightly $66 total Mar 17 - Mar 18 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Orangeburg-North.h20500.Hotel-Information) ![Room, 2 Queen Beds, Accessible, Non Smoking (Efficiency) | Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990272/2dd4e6c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990272/09406598.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990272/c5e580c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990272/2f324808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Orangeburg [](https://www.expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites.h1990272.Hotel-Information) Orangeburg 8.0/10 Very Good (584 reviews) "Nice room and great breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle $109 nightly $121 total Mar 30 - Mar 31 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites.h1990272.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3840h2556x0y4-5cb4ef80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3837h2482x3y0-b2c385e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3840h2557x0y3-a96a0495.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3837h2557x3y3-7acc8337.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark by Hilton Orangeburg [](https://www.expedia.com/Orangeburg-Hotels-Spark-By-Hilton-Orangeburg.h1877930.Hotel-Information) Orangeburg 7.8/10 Good (1,008 reviews) "Clean rooms, good location, nice and polite staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kenya $103 nightly $115 total Mar 15 - Mar 16 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Spark-By-Hilton-Orangeburg.h1877930.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Jetted Tub | Desk, laptop workspace, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ec6d0d77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/67da47be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ab86ecd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Santee Inn [](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) Santee 8.8/10 Excellent (1,008 reviews) "Courteous reception,clean rooms and great breakfast! Have been there many times in the last 15 years and I will return.!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Roger $106 nightly $118 total Mar 24 - Mar 25 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/fc94b516.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/2824d996.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/0b55a618.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Santee [](https://www.expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) Santee 8.0/10 Very Good (1,009 reviews) "Clean rooms, nice staff, decent breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dale $104 nightly $115 total Mar 17 - Mar 18 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/10000000/9860000/9854700/9854604/637dd914.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/10000000/9860000/9854700/9854604/ca4d16db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/10000000/9860000/9854700/9854604/e844503c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/10000000/9860000/9854700/9854604/3941a18e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Orangeburg [](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Suites-Orangeburg.h9854604.Hotel-Information) Orangeburg 9.4/10 Exceptional (789 reviews) "We travel regularly and this was the best breakfast of any of the places we had stayed. Facility was clean and service was friendly." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janet $131 nightly $145 total Mar 30 - Mar 31 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Suites-Orangeburg.h9854604.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/c1880a3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hair dryer, towels](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/bc8b5a93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/b034ff09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/3a41c72c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Peach Tree Inn [](https://www.expedia.com/St-George-Hotels-Peach-Tree-Inn.h2911319.Hotel-Information) St. George 7.4/10 Good (172 reviews) "The room was very clean , the price was very reasonable and the staff was very helpful. I'll definitely stay again. And recommend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Precious $68 nightly $73 total Mar 11 - Mar 12 Total with taxes and fees [](https://www.expedia.com/St-George-Hotels-Peach-Tree-Inn.h2911319.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/40000/34400/34400/c9ac8d21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/40000/34400/34400/7655013c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/40000/34400/34400/fd9a2ff0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34400/34400/ca4e9299.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham, Orangeburg [](https://www.expedia.com/Orangeburg-Hotels-Super-8-By-Wyndham.h34400.Hotel-Information) Orangeburg 6.8/10 (924 reviews) "Always a pleasure to stay, staff is very welcoming and the breakfast is a great plus!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debra $58 nightly $64 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Super-8-By-Wyndham.h34400.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/c2c672f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/60f2d52c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/8a3bfd5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/54902f8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Manning [](https://www.expedia.com/Sumter-Hotels-Hampton-Inn-Manning.h1418684.Hotel-Information) Manning 8.4/10 Very Good (1,004 reviews) "The room and lobby was very clean and nicely decorated. Staff was very friendly and helpful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carey $119 nightly $133 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Sumter-Hotels-Hampton-Inn-Manning.h1418684.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/300000/297200/297104/97d6098f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/300000/297200/297104/2616bf68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/300000/297200/297104/5e401dfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/300000/297200/297104/bc1bdbe2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn Orangeburg [](https://www.expedia.com/Orangeburg-Hotels-Sleep-Inn-Orangeburg.h297104.Hotel-Information) Orangeburg 7.8/10 Good (402 reviews) "Very clean, comfortable beds, friendly staff. would stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michele $79 nightly $88 total Mar 17 - Mar 18 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Sleep-Inn-Orangeburg.h297104.Hotel-Information) ![Room, 1 King Bed, Non Smoking | Premium bedding, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/e088653f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/2eadf4bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/a66aad1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/59cd1b4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham St George [](https://www.expedia.com/St-George-Hotels-Days-Inn-By-Wyndham-St-George.h18873.Hotel-Information) St. George 7.6/10 Good (1,004 reviews) "Clean, relaxing, friendly staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Smith $100 nightly $111 total Mar 11 - Mar 12 Total with taxes and fees [](https://www.expedia.com/St-George-Hotels-Days-Inn-By-Wyndham-St-George.h18873.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/cd0ca695.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/e77a8624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/50891687.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/4c792a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Santee I-95 [](https://www.expedia.com/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information) Santee 6.0/10 (480 reviews) "Clean room but needs an exhaust fan in the bathroom " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leesa $59 nightly $66 total Mar 17 - Mar 18 Total with taxes and fees [](https://www.expedia.com/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information) ![Suite, 1 King Bed, Accessible, Smoking | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/15200/15145/81259c64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15200/15145/706081d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/15200/15145/3f3e2740.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15200/15145/6a21d794.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Orangeburg [](https://www.expedia.com/Orangeburg-Hotels-Quality-Inn-Suites.h15145.Hotel-Information) Orangeburg 6.2/10 (643 reviews) "Clean and staff very pleasant" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Larry $63 nightly $70 total Mar 17 - Mar 18 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Quality-Inn-Suites.h15145.Hotel-Information) ![Deluxe Room, 1 King Bed, Non Smoking | Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/120000/119200/119159/62fd9b11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/120000/119200/119159/e00356a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/120000/119200/119159/a9426d53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/120000/119200/119159/ee6426a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Manning [](https://www.expedia.com/Sumter-Hotels-Baymont-By-Wyndham-Manning.h119159.Hotel-Information) Manning 6.8/10 (1,001 reviews) "Clean. Good value. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tom $78 nightly $87 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Sumter-Hotels-Baymont-By-Wyndham-Manning.h119159.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F2Star-Santee-Hotels.s20-0-d9953.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F2Star-Santee-Hotels.s20-0-d9953.Travel-Guide-Filter-Hotels) ## Explore similar 3-star hotels Many 3-star hotels have the same amenities as 2-star hotels. See all 3-star hotels in Santee. ![Fairfield Inn & Suites by Marriott Santee](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Fairfield Inn & Suites by Marriott Santee 9074 Old Number Six Hwy Santee SC $125 nightly $139 total Mar 17 - Mar 18 Total with taxes and fees 9.8/10 Exceptional! (1,012 reviews) [](https://expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Fairfield Inn by Marriott Orangeburg](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/ae964a26_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Fairfield Inn by Marriott Orangeburg 663 Citadel Road Orangeburg SC $93 nightly $103 total Mar 11 - Mar 12 Total with taxes and fees 8.4/10 Very Good! (736 reviews) [](https://expedia.com/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information) ![Holiday Inn Santee by IHG](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/278d9dc3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Santee by IHG 139 Bradford Blvd Santee SC $127 nightly $141 total Mar 15 - Mar 16 Total with taxes and fees 8.2/10 Very Good! (1,002 reviews) [](https://expedia.com/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information) Still don't see what you're looking for? [See all properties in Santee.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F11%2F2026&endDate=3%2F12%2F2026®ionId=9953&star=20) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F11%2F2026&endDate=3%2F12%2F2026®ionId=9953&star=20&star=20&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F11%2F2026&endDate=3%2F12%2F2026®ionId=9953&star=20&star=20&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F11%2F2026&endDate=3%2F12%2F2026®ionId=9953&star=20&star=20&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F11%2F2026&endDate=3%2F12%2F2026®ionId=9953&star=20&star=20&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F11%2F2026&endDate=3%2F12%2F2026®ionId=9953&star=20&star=20&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Santee Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campgrounds. [See all hotels in Santee](https://www.expedia.com/Hotel-Search?startDate=2026-03-24&endDate=2026-03-25&adults=2®ionId=9953) ![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=899&h=634&p=1&q=high) ## Top Santee Hotel Reviews ![Super 8 by Wyndham Santee](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2fd60881_y.jpg) ### Super 8 by Wyndham Santee 8/10 Good "The beds are super comfy. I liked how quiet it was in the room and the staff was very friendly " [](https://expedia.com/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information) ![Red Roof Inn Santee](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/8136c59d_y.jpg) ### Red Roof Inn Santee 2/10 Terrible "I haven’t be returned my $50 security yet " [](https://expedia.com/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) ![Ramada by Wyndham Santee I-95](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/d34bd120_y.jpg) ### Ramada by Wyndham Santee I-95 8/10 Good "Clean room and good staff" [](https://expedia.com/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) ![Travelodge by Wyndham Santee](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/28717b40_y.jpg) ### Travelodge by Wyndham Santee 8/10 Good "Good location for amenities and walking and driving distance " [](https://expedia.com/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ## Find out more about Santee When you've got to get away to a new or favorite destination without breaking the bank, Santee awaits with top 2 Star hotels and a change of scenery. Stay on your feet visiting top attractions that draw of visitors, or sip a cup of coffee nearby and relax. You're about to find out why both locals and travelers love this place. ### The Perfect 2 Star Hotel at the Perfect Price 2 Star hotels are in high demand in Santee. You'll find the best deals right here, so book early and save on a great getaway. Thanks to several convenient locations and comfortable amenities, you'll find 2 Star Hotel that suits your vacation style. Stay here and be one of the first guests to leave a review and share your thoughts. So, savor the comfort of a well-kept room and attentive hospitality. With our travel deals, the world is wide open to you one hotel at a time, and the globe-trotting starts in Santee. ### Reserve Your Two-Star Accommodation Today Plan your trip to Santee now with Expedia's easy online travel booking and start relaxing before you even leave the house. Recently, this region has seen a decline in tourism. 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