Title: The Best 2 Star Hotels in Santee, SC from $64 | Expedia.com

[Santee Travel Guide](https://expedia.com/Santee.dx9953)[Hotels in Santee](https://expedia.com/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.com/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.com/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Car Rentals in Santee](https://expedia.com/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.com/Santee.d9953.Destination-Travel-Guides)

![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Santee 2 Star Hotels

Tonight

[Mar 13 - Mar 14](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-03-13&endDate=2026-03-14&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 14 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-03-14&endDate=2026-03-15&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Santee 2-star hotels

![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/d2da67e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/756b4cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/320acff9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont by Wyndham Santee

[](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information)

Santee

8.0/10

Very Good

(1,425 reviews)

"Room were very clean and staff was very helpful. I would stay there again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Charolette

$80 nightly

$89 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business center](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/11da224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/cce2b53c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/40f69ad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tru By Hilton Santee

[](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information)

Santee

9.2/10

Wonderful

(757 reviews)

"Great place to stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Deborah

$114 nightly

$127 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information)

![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/27faffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/9246a04a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/e6b95688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/e4316a7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### SureStay Hotel by Best Western Manning

[](https://www.expedia.com/Sumter-Hotels-SureStay-Hotel-By-Best-Western-Manning.h569301.Hotel-Information)

Manning

8.6/10

Excellent

(1,002 reviews)

"The room was very clean, the staff were very nice and the breakfast was ok. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Samantha

$95 nightly

$105 total

Mar 17 - Mar 18

Total with taxes and fees

[](https://www.expedia.com/Sumter-Hotels-SureStay-Hotel-By-Best-Western-Manning.h569301.Hotel-Information)

![Free breakfast](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/d82e6496.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5472b058.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/fcd98400.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Santee-I-95

[](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information)

Santee

9.6/10

Exceptional

(1,001 reviews)

"Clean, great staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Joseph

$135 nightly

$150 total

Mar 25 - Mar 26

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information)

![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/40000/34400/34400/c9ac8d21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/40000/34400/34400/fd9a2ff0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 1 King Bed, Non Smoking | Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/40000/34400/34400/b4a7d12b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34400/34400/ca4e9299.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham, Orangeburg

[](https://www.expedia.com/Orangeburg-Hotels-Super-8-By-Wyndham.h34400.Hotel-Information)

Orangeburg

6.8/10

(925 reviews)

"Easy check in and out, good location"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Theresa

$58 nightly

$64 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Super-8-By-Wyndham.h34400.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/99c8fb35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c836e9b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/f2adc30e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c5155ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tru by Hilton Orangeburg

[](https://www.expedia.com/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information)

Orangeburg

9.2/10

Wonderful

(1,000 reviews)

"Excellent stopover for us!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Georgina

$114 nightly

$127 total

Mar 30 - Mar 31

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Queen Beds, Non Smoking, Jetted Tub | Desk, laptop workspace, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ec6d0d77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ab86ecd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/67da47be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Santee Inn

[](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information)

Santee

8.8/10

Excellent

(1,004 reviews)

"Clean room, polite staff , "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

samantha

$112 nightly

$124 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/27e78d69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/e0b4742d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/8229e487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/3ffa2f0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### SpringHill Suites by Marriott Orangeburg

[](https://www.expedia.com/Orangeburg-Hotels-SpringHill-Suites-Orangeburg.h54931475.Hotel-Information)

Orangeburg

8.8/10

Excellent

(713 reviews)

"3rd stay at this location would highly recommend "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Athanassios

$129 nightly

$143 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-SpringHill-Suites-Orangeburg.h54931475.Hotel-Information)

![Room, 2 Queen Beds, Accessible, Non Smoking (Efficiency) | Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990272/2dd4e6c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990272/09406598.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990272/2f324808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990272/c5e580c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn & Suites Orangeburg

[](https://www.expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites.h1990272.Hotel-Information)

Orangeburg

8.0/10

Very Good

(584 reviews)

"Great location "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cynthia

$107 nightly

$119 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites.h1990272.Hotel-Information)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3840h2556x0y4-5cb4ef80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3837h2557x3y3-7acc8337.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3837h2482x3y0-b2c385e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3837h2558x3y4-5a11a251.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Spark by Hilton Orangeburg

[](https://www.expedia.com/Orangeburg-Hotels-Spark-By-Hilton-Orangeburg.h1877930.Hotel-Information)

Orangeburg

7.8/10

Good

(1,002 reviews)

"Newly Renovated, clean carpet, comfortable bed and pillows."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Vivian

$103 nightly

$115 total

Mar 16 - Mar 17

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Spark-By-Hilton-Orangeburg.h1877930.Hotel-Information)

![Breakfast area](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/bfdc100f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/c4ff1065.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/d4b79aee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Double Beds, Smoking | Bathroom sink](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/13cfcb42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Travelodge by Wyndham Orangeburg

[](https://www.expedia.com/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information)

Orangeburg

8.2/10

Very Good

(1,002 reviews)

"Conveniently located just off I26, this motel is very clean and beds are comfortable and rooms are quiet. Rooms could use some updating but can’t complain for the price. Lots of restaurants around to choose from and motel supplies coffee and cereal for breakfast in front dining area. "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Yvonne

$71 nightly

$79 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information)

![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/c1880a3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/3a41c72c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/tub, hair dryer, towels](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/bc8b5a93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/efa2345e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Peach Tree Inn

[](https://www.expedia.com/St-George-Hotels-Peach-Tree-Inn.h2911319.Hotel-Information)

St. George

7.4/10

Good

(173 reviews)

"Clean carpetted floor.."

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Conrad

$68 nightly

$73 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/St-George-Hotels-Peach-Tree-Inn.h2911319.Hotel-Information)

![Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/fc94b516.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/0b55a618.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Queen Bed with Sofa bed, Non Smoking (Non Smoking/Interior Hall) | Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/91286f8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/2824d996.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn & Suites Santee

[](https://www.expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information)

Santee

8.0/10

Very Good

(1,001 reviews)

"Hotel was a little dated but clean."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Deborah

$105 nightly

$117 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information)

![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/b15e751d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/3e8501ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/3ea4aa47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/581bc335.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont by Wyndham Orangeburg North

[](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Orangeburg-North.h20500.Hotel-Information)

Orangeburg

6.0/10

(1,001 reviews)

"The rooms were clean and staff was courteous. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Yojuana

$58 nightly

$64 total

Apr 5 - Apr 6

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Orangeburg-North.h20500.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/10000000/9860000/9854700/9854604/637dd914.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/10000000/9860000/9854700/9854604/e844503c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/10000000/9860000/9854700/9854604/44be5cac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/10000000/9860000/9854700/9854604/ca4d16db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn & Suites Orangeburg

[](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Suites-Orangeburg.h9854604.Hotel-Information)

Orangeburg

9.4/10

Exceptional

(790 reviews)

"We travel regularly and this was the best breakfast of any of the places we had stayed. Facility was clean and service was friendly."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Janet

$131 nightly

$145 total

Mar 30 - Mar 31

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Suites-Orangeburg.h9854604.Hotel-Information)

![Free daily full breakfast](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/cd0ca695.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/1295e8cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/4c792a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/e77a8624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn & Suites Santee I-95

[](https://www.expedia.com/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information)

Santee

6.0/10

(482 reviews)

"Rooms are updated and clean. Very good value for the price of the room. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mark

$59 nightly

$66 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information)

![Suite, 1 King Bed, Accessible, Smoking | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/15200/15145/81259c64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15200/15145/706081d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/15200/15145/3f3e2740.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/15200/15145/d44bb419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn & Suites Orangeburg

[](https://www.expedia.com/Orangeburg-Hotels-Quality-Inn-Suites.h15145.Hotel-Information)

Orangeburg

6.2/10

(643 reviews)

"Clean and staff very pleasant"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Larry

$63 nightly

$70 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Quality-Inn-Suites.h15145.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/600000/597800/597750/c19ebd52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/600000/597800/597750/acfce64d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed with Sofa bed | In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/600000/597800/597750/37c1c14e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/600000/597800/597750/c4341f52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Orangeburg by IHG

[](https://www.expedia.com/Orangeburg-Hotels-Holiday-Inn-Express-Hotel-Suites-Orangeburg.h597750.Hotel-Information)

Orangeburg

8.6/10

Excellent

(815 reviews)

"Needed a place for the night and this was just what we wanted"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Steve

$122 nightly

$135 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Holiday-Inn-Express-Hotel-Suites-Orangeburg.h597750.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/c2c672f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/8a3bfd5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/54902f8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/fb6254c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Manning

[](https://www.expedia.com/Sumter-Hotels-Hampton-Inn-Manning.h1418684.Hotel-Information)

Manning

8.4/10

Very Good

(1,003 reviews)

"The gym was closed for.the 6 days we stayed "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Carol

$119 nightly

$132 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Sumter-Hotels-Hampton-Inn-Manning.h1418684.Hotel-Information)

![In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/28717b40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business center](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/eeb5fa18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/5b7ee831.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Travelodge by Wyndham Santee

[](https://www.expedia.com/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information)

Santee

7.2/10

Good

(704 reviews)

"Good location for amenities and walking and driving distance "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gezeall

$63 nightly

$70 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information)

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## Explore similar 3-star hotels

Many 3-star hotels have the same amenities as 2-star hotels. See all 3-star hotels in Santee.

![Fairfield Inn & Suites by Marriott Santee](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Fairfield Inn & Suites by Marriott Santee

9074 Old Number Six Hwy Santee SC

$125 nightly

$139 total

Mar 22 - Mar 23

Total with taxes and fees

9.8/10 Exceptional! (1,004 reviews)

[](https://expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information)

![Fairfield Inn by Marriott Orangeburg](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/ae964a26_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Fairfield Inn by Marriott Orangeburg

663 Citadel Road Orangeburg SC

$88 nightly

$98 total

Apr 13 - Apr 14

Total with taxes and fees

8.4/10 Very Good! (737 reviews)

[](https://expedia.com/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information)

![Holiday Inn Santee by IHG](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/278d9dc3_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Holiday Inn Santee by IHG

139 Bradford Blvd Santee SC

$127 nightly

$141 total

Mar 29 - Mar 30

Total with taxes and fees

8.2/10 Very Good! (1,000 reviews)

[](https://expedia.com/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information)

Still don't see what you're looking for?

[See all properties in Santee.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F14%2F2026&endDate=3%2F15%2F2026&regionId=9953&star=20)

You can also use these popular filters to refine your search.

[Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F14%2F2026&endDate=3%2F15%2F2026&regionId=9953&star=20&star=20&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F14%2F2026&endDate=3%2F15%2F2026&regionId=9953&star=20&star=20&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F14%2F2026&endDate=3%2F15%2F2026&regionId=9953&star=20&star=20&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F14%2F2026&endDate=3%2F15%2F2026&regionId=9953&star=20&star=20&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F14%2F2026&endDate=3%2F15%2F2026&regionId=9953&star=20&star=20&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campgrounds.

[See all hotels in Santee](https://www.expedia.com/Hotel-Search?startDate=2026-03-27&endDate=2026-03-28&adults=2&regionId=9953)

![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=899&h=634&p=1&q=high)

## Top Santee Hotel Reviews

![Super 8 by Wyndham Santee](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2fd60881_y.jpg)

### Super 8 by Wyndham Santee

10/10 Excellent

"I originally booked one night, but because the entire staff made me feel relaxed, I decided to stay an additional night. The lady at the check-in desk said they try to get good reviews from guests. I needed to do a Microsoft Teams interview, so I needed a really good internet connection. The pool is open from 9 am to 10 pm. The staff is very kind and friendly."

[](https://expedia.com/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information)

![Red Roof Inn Santee](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/8136c59d_y.jpg)

### Red Roof Inn Santee

2/10 Terrible

"I haven’t be returned my $50 security yet "

[](https://expedia.com/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information)

![Ramada by Wyndham Santee I-95](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/d34bd120_y.jpg)

### Ramada by Wyndham Santee I-95

8/10 Good

"Clean room and good staff"

[](https://expedia.com/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information)

![Travelodge by Wyndham Santee](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/28717b40_y.jpg)

### Travelodge by Wyndham Santee

8/10 Good

"Good location for amenities and walking and driving distance "

[](https://expedia.com/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information)

## Find out more about Santee

When you've got to get away to a new or favorite destination without breaking the bank, Santee awaits with top 2 Star hotels and a change of scenery. Stay on your feet visiting top attractions that draw of visitors, or sip a cup of coffee nearby and relax. You're about to find out why both locals and travelers love this place. 

### The Perfect 2 Star Hotel at the Perfect Price

2 Star hotels are in high demand in Santee. You'll find the best deals right here, so book early and save on a great getaway. Thanks to several convenient locations and comfortable amenities, you'll find 2 Star Hotel that suits your vacation style. Stay here and be one of the first guests to leave a review and share your thoughts. So, savor the comfort of a well-kept room and attentive hospitality. With our travel deals, the world is wide open to you one hotel at a time, and the globe-trotting starts in Santee.

### Reserve Your Two-Star Accommodation Today

Plan your trip to Santee now with Expedia's easy online travel booking and start relaxing before you even leave the house. Recently, this region has seen a decline in tourism. Take advantage of the 2 Star Hotel availability and easy-going atmosphere.

## Explore a world of travel with Expedia

- Lodging
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- [Visit Vance ](https://www.expedia.com/Vance.dx3000456153)
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