Title: The Best 5 Star Hotels in Mendon, MI from $158 | Expedia.com [Mendon Travel Guide](https://expedia.com/Mendon.dx132397)[Hotels in Mendon](https://expedia.com/Mendon-Hotels.d132397.Travel-Guide-Hotels)[Vacation Rentals in Mendon](https://expedia.com/Mendon-Vacation-Rentals.d132397.Travel-Guide-VacationRentals)[Flights to Mendon](https://expedia.com/Cheap-Flights-To-Mendon.d132397.Travel-Guide-Flights)[Car Rentals in Mendon](https://expedia.com/Car-Rentals-In-Mendon.d132397.Car-Rental-Guide)[Mendon Vacation Packages](https://expedia.com/Mendon.d132397.Destination-Travel-Guides) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mendon 5 Star Hotels Tonight [Mar 19 - Mar 20](https://www.expedia.com/Hotel-Search?regionId=132397&startDate=2026-03-19&endDate=2026-03-20&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 20 - Mar 21](https://www.expedia.com/Hotel-Search?regionId=132397&startDate=2026-03-20&endDate=2026-03-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=132397&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=132397&startDate=2026-03-27&endDate=2026-03-29&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mendon 5-star hotels ![Exterior](https://images.trvl-media.com/lodging/101000000/100540000/100532100/100532028/a55546f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Room | Terrace/patio](https://images.trvl-media.com/lodging/101000000/100540000/100532100/100532028/38c1119b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/101000000/100540000/100532100/100532028/b9358b69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/101000000/100540000/100532100/100532028/f32a5bae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Henderson Castle [](https://www.expedia.com/Kalamazoo-Hotels-Henderson-Castle.h100532028.Hotel-Information) West Main HIll 7.4/10 Good (22 reviews) "Amazing place with a great staff and delicious food. Pristine environment. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Francois [](https://www.expedia.com/Kalamazoo-Hotels-Henderson-Castle.h100532028.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mendon-Hotels.s50-0-d132397.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mendon-Hotels.s50-0-d132397.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mendon. ![The Kalamazoo House Downtown Hotel & Suites](https://images.trvl-media.com/lodging/13000000/12440000/12433700/12433616/7e82d27d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Kalamazoo House Downtown Hotel & Suites 447 W South St. Kalamazoo MI $179 nightly $198 total Apr 5 - Apr 6 Total with taxes and fees 9.8/10 Exceptional! (207 reviews) [](https://expedia.com/Kalamazoo-Hotels-Kalamazoo-House.h12433616.Hotel-Information) ![Upjohn House Inn](https://images.trvl-media.com/lodging/113000000/112310000/112309100/112309022/1f2594c5_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Upjohn House Inn 530 W South St Kalamazoo MI $142 nightly $158 total Mar 29 - Mar 30 Total with taxes and fees 7.2/10 Good! (23 reviews) [](https://expedia.com/Kalamazoo-Hotels-Upjohn-House-Inn.h112309022.Hotel-Information) Still don't see what you're looking for? [See all properties in Mendon.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F20%2F2026&endDate=3%2F21%2F2026®ionId=132397&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F20%2F2026&endDate=3%2F21%2F2026®ionId=132397&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F20%2F2026&endDate=3%2F21%2F2026®ionId=132397&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F20%2F2026&endDate=3%2F21%2F2026®ionId=132397&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F20%2F2026&endDate=3%2F21%2F2026®ionId=132397&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F20%2F2026&endDate=3%2F21%2F2026®ionId=132397&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Mendon Head to sights like Mendon Township Hall and Mendon Township Library as you discover Mendon. [See all hotels in Mendon](https://www.expedia.com/Hotel-Search?startDate=2026-04-02&endDate=2026-04-03&adults=2®ionId=132397) ![Fall colors in St. Joseph County, Pure Michigan. #Fall #Autumn #Michigan #PureMichigan #FallColor #FallColorTour #abandoned](https://images.trvl-media.com/place/132397/caa044ae-bd86-4332-b994-0703b4943004.jpg?impolicy=fcrop&w=655&h=655&p=1&q=high) Photo by Patrick Laughlin  ## Top Mendon Hotel Reviews ## Find out more about Mendon Pamper your every whim on your upcoming sabbatical. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Mendon so popular in the last year. There's no reason to delay a getaway to Mendon any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Our 5-star hotels in Mendon are the perfect places to relax in during your next getaway. You deserve an outstanding getaway. ### 5-Star Hotels in Mendon You'll have a fantastic time at one of these 5-star hotels. Highly-rated eateries, concierges, and pillow-fluffing are all at the ready. You're sure to find exactly the accommodation you need. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A full-body massage to help your cares fall away? A concierge to help you make reservations at that outstanding restaurant? Comfortable beds, lip-smacking main courses, and even space for your family pet in some cases...these hotels will leave you amazed. But you aren't going to spend your entire vacation in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Mendon are the perfect place to rest up after a busy day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs. ### Make Your Escape The results are in, and Mendon 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Don't put off your dream vacation any longer -- Expedia can help you land a great deal on accommodation. Decide on one of Expedia's Mendon 5-star hotels today and decompress in luxe surroundings at your convenience. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Mendon? > - Search for the lowest price per night from $158 ### What makes a hotel 5 stars in Mendon? ### Are there any 5-star all-inclusive resorts in Mendon? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Leonidas Hotels ](https://www.expedia.com/Leonidas-Hotels.d3000442264.Travel-Guide-Hotels) - [5 Star Hotels in Centreville ](https://www.expedia.com/5Star-Centreville-Hotels.s50-0-d3000441800.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Colon ](https://www.expedia.com/4Star-Colon-Hotels.s40-0-d3000441845.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Colon ](https://www.expedia.com/5Star-Colon-Hotels.s50-0-d3000441845.Travel-Guide-Filter-Hotels) - [Centreville Hotels ](https://www.expedia.com/Centreville-Hotels.d3000441800.Travel-Guide-Hotels) - 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