Title: The Best 5 Star Hotels in Pickens, SC from $221 | Expedia.com [Pickens Travel Guide](https://expedia.com/Pickens.dx8570)[Hotels in Pickens](https://expedia.com/Pickens-Hotels.d8570.Travel-Guide-Hotels)[Vacation Rentals in Pickens](https://expedia.com/Pickens-Vacation-Rentals.d8570.Travel-Guide-VacationRentals)[Flights to Pickens](https://expedia.com/Cheap-Flights-To-Pickens.d8570.Travel-Guide-Flights)[Things to do in Pickens](https://expedia.com/Things-To-Do-In-Pickens.d8570.Travel-Guide-Activities)[Car Rentals in Pickens](https://expedia.com/Car-Rentals-In-Pickens.d8570.Car-Rental-Guide)[Pickens Vacation Packages](https://expedia.com/Pickens.d8570.Destination-Travel-Guides) ![Table Rock State Park South Carolina Blue Ridge Mountains Landscape sunrise morning scenic photography](https://images.trvl-media.com/place/553248621532656715/f701e42d-1399-4e17-8ef8-402a7a79a6b1.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248621532656715/f701e42d-1399-4e17-8ef8-402a7a79a6b1.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Pickens 5 Star Hotels Tonight [Feb 5 - Feb 6](https://www.expedia.com/Hotel-Search?regionId=8570&startDate=2026-02-05&endDate=2026-02-06&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 6 - Feb 7](https://www.expedia.com/Hotel-Search?regionId=8570&startDate=2026-02-06&endDate=2026-02-07&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 6 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=8570&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=8570&startDate=2026-02-13&endDate=2026-02-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Pickens-Hotels.s50-0-d8570.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Pickens-Hotels.s50-0-d8570.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Pickens. ![Grand Bohemian Lodge Greenville, Autograph Collection](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6a375dd3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Grand Bohemian Lodge Greenville, Autograph Collection 44 EAST CAMPERDOWN WAY Greenville SC $236 nightly $259 total Feb 8 - Feb 9 Total with taxes and fees 9.4/10 Exceptional! (442 reviews) [](https://expedia.com/Greenville-Hotels-Grand-Bohemian-Lodge-Greenville.h71762652.Hotel-Information) ![The Westin Poinsett Greenville](https://images.trvl-media.com/lodging/1000000/580000/576000/575983/3e47bf88_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Westin Poinsett Greenville 120 South Main St Greenville SC $209 nightly $230 total Feb 8 - Feb 9 Total with taxes and fees 9.2/10 Wonderful! (1,000 reviews) [](https://expedia.com/Greenville-Hotels-The-Westin-Poinsett-Greenville.h575983.Hotel-Information) ![The Shepherd Hotel Downtown Clemson](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/8f34da45_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Shepherd Hotel Downtown Clemson 110 Sloan St Clemson SC $199 nightly $221 total Feb 8 - Feb 9 Total with taxes and fees 9.8/10 Exceptional! (757 reviews) [](https://expedia.com/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) Still don't see what you're looking for? [See all properties in Pickens.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026®ionId=8570&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026®ionId=8570&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026®ionId=8570&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026®ionId=8570&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026®ionId=8570&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026®ionId=8570&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Pickens Nestled in the foothills of the Blue Ridge Mountains, this charming town offers a slice of small-town Americana. Hike the trails at Table Rock State Park, then explore the Hagood Mill Historic Site to experience local heritage and traditional bluegrass music. [See all hotels in Pickens](https://www.expedia.com/Hotel-Search?startDate=2026-02-19&endDate=2026-02-20&adults=2®ionId=8570) ![Table Rock State Park South Carolina Blue Ridge Mountains Landscape sunrise morning scenic photography](https://images.trvl-media.com/place/553248621532656715/f701e42d-1399-4e17-8ef8-402a7a79a6b1.jpg?impolicy=fcrop&w=900&h=593&p=1&q=high) ## Top Pickens Hotel Reviews ## Find out more about Pickens You enjoy the finer things in life, both at home and on vacation. Add even more luxury on your next trip to Pickens by treating yourself to the best of the best when it comes to lodging. It's an ideal fusion. There's no reason to delay a getaway to Pickens any longer. You'll join the multitudes of vacationers who have made Pickens so fashionable recently. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Don't wait any longer. Book one of Expedia's luxurious 5-star hotels in Pickens and get ready to be pampered like never before. ### Get a Great Deal on 5-Star Hotels in Pickens You'll have a fantastic time at one of these 5-star hotels. Michelin-starred restaurants, excellent customer care, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What creature comforts do you want in your lodging? 24-hour room service, so you can order that filet mignon in the wee hours of the morning? A body scrub that will leave you feeling outstanding? Butler services? Whatever it is your heart desires, you're bound to find it here. But you aren't going to spend your entire vacation in your room, of course. Don't worry. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Pickens are waiting for you to rest up after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs. ### Make Your Escape The results are in, and Pickens 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. It's time to indulge yourself. Choose one of our Pickens 5-star hotels today and soothe yourself in complete comfort tomorrow. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Pickens? > - Search for the lowest price per night from $221 ### What makes a hotel 5 stars in Pickens? ### Are there any 5-star all-inclusive resorts in Pickens? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Hotels near Hagood Mill Historic Site ](https://www.expedia.com/Hagood-Mill-Historic-Site-Hotels.0-l553248621532656711-0.Travel-Guide-Filter-Hotels) - [Hotels near Pickens County ](https://www.expedia.com/Pickens-County-Airport-Hotels.0-aLQK-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Liberty ](https://www.expedia.com/5Star-Liberty-Hotels.s50-0-d125755.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Easley ](https://www.expedia.com/5Star-Easley-Hotels.s50-0-d7021.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Easley ](https://www.expedia.com/4Star-Easley-Hotels.s40-0-d7021.Travel-Guide-Filter-Hotels) - 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