Car Rental Perryville, MO

These Perryville insights are based on real traveler data from Expedia, aggregated using AI to help you plan your trip. Updated: September 2, 2026.

Reasons to book a car rental in and around Perryville

Renting a car in and around Perryville offers the freedom and flexibility to explore various attractions at your own pace. This is especially beneficial for those traveling with family or large luggage, as a rental car makes it easier to manage your belongings while you journey through the area. You can visit the National Shrine of Our Lady of the Miraculous Medal right in Perryville or take a short drive to the Popeye Museum and Elzie C. Segar Memorial Park, both located 13 miles away. If you wish to explore further, the charming city of Chester is just 14 miles away and features additional sites like Mary's River Covered Bridge and Fort Kaskaskia. Additionally, the nearby city of Lithium, only 8 miles from Perryville, is home to the same attractions that make Perryville appealing. Whether you're seeking outdoor adventures, romantic scenery, or cultural experiences, having a rental car allows you to create a flexible travel itinerary tailored to your interests. With so many destinations within easy reach, a rental car simplifies your journey and enhances your exploration of this beautiful region.

Where to stay in and around Perryville

• Perryville: As the central hub for your trip, Perryville offers a range of accommodations while being close to various attractions. You can explore local culture at the nearby National Shrine of Our Lady of the Miraculous Medal and the historic sites like the Popeye Museum and Mary's River Covered Bridge, all within the village.
• Chester: Located 14 miles from Perryville, Chester is perfect for those seeking outdoor adventures and scenic views. Enjoy recreational activities in the national state park or visit the Fort Kaskaskia for a taste of history. Chester also offers dining options nearby, including wineries, making it an appealing stay for food enthusiasts.
• St Mary: Just 11 miles away from Perryville, St Mary is an excellent choice for a romantic and adventurous getaway. With attractions like the Elzie C. Segar Memorial Park and Mitchell Island, visitors can enjoy a blend of outdoor activities and serene landscapes. The golf courses and nearby wineries further enhance the charm of this picturesque city.
• Belgique: Nestled in the vicinity of Perryville, Belgique presents a quaint experience for travelers. Rich in cultural significance, you can visit the National Shrine of Our Lady of the Miraculous Medal and enjoy the artistic side of the Popeye Museum. Its close proximity to Perryville makes it an ideal stop for a peaceful retreat.

10 tips to save on your car rental in and around Perryville

1. Use filters to find the right car: Refine your search by selecting vehicle types and features. Whether you require an SUV for additional space, a convertible for summer fun, or an economy car to save money, utilize filters on Expedia to discover the perfect option for your journey.
2. Book in advance to help lower costs: Rental rates can vary based on demand, so it's advisable to reserve your vehicle well ahead of your trip. By booking early, you are more likely to secure lower prices and enjoy greater availability, particularly during peak seasons.
3. Consider a smaller car for savings: Compact cars are typically more affordable to rent and easier to maneuver in crowded areas. Mid-size vehicles strike a good balance between cost, comfort, and fuel efficiency.
4. Age guidelines: Drivers under 30 may encounter higher deposits or daily fees, and certain vehicle categories—such as SUVs or luxury models—might not be accessible. This can also apply to renters over 70 years old. Always verify the age requirements prior to making a reservation.
5. Check fuel policies: Some rental agreements may require a full-to-full fuel policy, which means you must return the car with a full tank to avoid extra charges. This option is usually the most favorable. Other policies may include full-to-empty or prepaid fueling options, which can also be acceptable, but ensure you return the vehicle empty in those cases.
6. Save on city and airport pickups: Picking up your rental car at airports often incurs a surcharge, although the convenience may justify the extra cost.
7. Know your payment options: Most car rental companies only accept credit cards as a form of payment.
8. Understand your insurance coverage: Car rental insurance can help protect you from unexpected expenses and provides peace of mind during your trip. Adding car rental insurance is a straightforward process when booking with Expedia.
9. Consider unlimited mileage: If you plan to take long road trips, seek rentals that offer unlimited mileage to avoid additional charges.
10. Bring your driver's license and ID: A valid driver's license is necessary to rent a car.

Finding the cheapest car rentals in Perryville

Using our Search Wizard

If the deals that are available on our page do not suit your needs, then enter Perryville into the search wizard at the top of the page. We will compare all the best deals available for your car rental in Perryville and provide you with a list of the cheapest options, with no added fees.

Renting a car in Perryville

Pay at pickup is available, so you don’t have to worry about spending your money until you arrive at your vehicle in Perryville. We partner with reliable partners that guarantee an enjoyable experience for solo travelers, couples, and families. Package your car with a flight or hotel to unlock even more savings from Expedia.

Expected prices in Perryville

Prices are subject to seasonal change depending on when you decide to arrange your car rental but right now you can book .

Flexibility & Cancellation

Most car suppliers offer penalty-free cancellations, so you don’t have to worry about losing money if your plans change. To cancel your booking log into your account through the Trips portal. Click manage booking and cancel this car. If you needed to alter your booking, then you can create a new one once you have canceled.

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Car classes available from Expedia in 2026

The classes of vehicles available will change depending on your chosen location.

• Compact car rentals    
• Convertible car rentals    
• Economy car rentals    
• Fullsize car rentals    
• Luxury car rentals
• Midsize car rentals    
• Mini car rentals    
• Minivan rentals    
• Pickup car rentals    
• Premium car rentals
• Sportscar rentals    
• Standard car rentals    
• SUV rentals    
• Van rentals