Top 10 Hotels in Lithium, MO (from $73) 2026 - Competitive Prices

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Our top choices for Lithium hotels

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

1. Super 8 by Wyndham Perryville

Perryville

Matthew

$68 nightly

$78 total

Nov 8 - Nov 9

Total with taxes and fees

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A kitchen counter with a coffee machine, a kettle, and storage boxes.

A Holiday Inn Express & Suites building with a covered entrance and multiple windows.

A gym with treadmills, elliptical machines, and weight equipment.

2. Holiday Inn Express & Suites Perryville by IHG

Perryville

Lisa

$101 nightly

$116 total

Nov 1 - Nov 2

Total with taxes and fees

A hotel room with a bed, a desk with a chair, a small table, a sofa, a bathtub, and a window with curtains.

A modern bathroom with a large bathtub, a wooden floor, and a dark wall with a colorful abstract painting.

A breakfast area with a counter, seating, and kitchen appliances.

A gym with treadmills, a weight machine, and exercise balls.

3. Baymont by Wyndham Chester IL

Chester

Keng

$80 nightly

$89 total

Nov 8 - Nov 9

Total with taxes and fees

A hotel room with a large bed, a bathroom with a bathtub, and a mirror reflecting the room.

A hotel hallway with a patterned carpet, blue walls, and a sign indicating an office.

A reception area with a blue couch, a wooden table with a vase of flowers, and a reception desk with a digital screen.

A kitchen with wooden cabinets, a dining area with a table and chairs, and various kitchen appliances.

4. Days Inn by Wyndham Perryville

Perryville

karen

$68 nightly

$77 total

Oct 15 - Oct 16

Total with taxes and fees

A lobby with a TV, framed pictures, a plant, and patterned chairs.

A hotel reception desk with a sign that reads "Quality by Choice Hotels."

A breakfast bar with a toaster, coffee maker, and fruit juice dispenser.

A hotel room with a large bathtub, a bed with two pillows, a nightstand, and a wall-mounted lamp.

5. Quality Inn Perryville I-55

Perryville

Evelynmaryeka

$64 nightly

$73 total

Nov 3 - Nov 4

Total with taxes and fees

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

6. The Atrium - A Boutique Hotel

Perryville

Brian

$98 nightly

$112 total

Oct 15 - Oct 16

Total with taxes and fees

A rustic cabin-style lodging with a covered porch, picnic tables, and a fire pit.

A cabin interior with a kitchenette, a ceiling fan, a television, a sofa, and a window with blinds.

A playground with a wooden playhouse, a slide, and two animal-shaped swings.

A lakeside RV resort with wooden cabins, a picnic area, and a reflection in the water.

7. Perryville RV Resort

Perryville

Kevin

$74 nightly

$84 total

Oct 15 - Oct 16

Total with taxes and fees

A row of single-story houses with attached garages, a paved driveway, and a clear sky.

A modern living room with a flat-screen TV, a desk with a computer, two armchairs, a coffee table, and large windows with a view.

A hotel room with two beds, a desk, a chair, and a window with curtains.

A hotel dining area with tables and chairs, a kitchen area, and a flat-screen TV mounted on the wall.

8. Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

Samantha

$85 nightly

$99 total

Nov 1 - Nov 2

Total with taxes and fees

A building with a stone facade, a yellow door, a green chair, and a potted plant.

A room with a wooden table, two patterned chairs, a framed artwork on the wall, and a window with brown curtains.

A compact kitchen with black cabinets, a black refrigerator, a microwave, and a sink.

9. Triangle Inn Motel

Ste Genevieve

Kimmy

$68 nightly

$79 total

Oct 18 - Oct 19

Total with taxes and fees

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

10. Urban Lofts

Perryville

Grace

$295 nightly

$338 total

Oct 15 - Oct 16

Total with taxes and fees

A modern kitchen with stainless steel appliances, a large window, and a green cabinet.

A two-story building with a balcony, a front door with a wreath, and a sign indicating a restaurant.

A kitchen with a large black sink, a window with a view of trees, and a microwave on the counter.

A wooden interior with a dining area, staircase, and a television mounted on the wall.

11. The Mediterranean House 1858

Perryville

$632 nightly

$724 total

Oct 15 - Oct 16

Total with taxes and fees

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Hotels recommended for families in Lithium

Holiday Inn Express & Suites Perryville by IHG

Perryville

$101 nightly

$116 total

Nov 1 - Nov 2

Total with taxes and fees

Super 8 by Wyndham Perryville

Perryville

$68 nightly

$78 total

Nov 8 - Nov 9

Total with taxes and fees

Baymont by Wyndham Chester IL

Chester

$80 nightly

$89 total

Nov 8 - Nov 9

Total with taxes and fees

Days Inn by Wyndham Perryville

Perryville

$68 nightly

$77 total

Oct 15 - Oct 16

Total with taxes and fees

Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

$85 nightly

$99 total

Nov 1 - Nov 2

Total with taxes and fees

Urban Lofts

Perryville

$295 nightly

$338 total

Oct 15 - Oct 16

Total with taxes and fees

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Top Lithium Hotel Reviews

Triangle Inn Motel

10/10 Excellent

"The nicest budget motel we have ever stayed in!"

⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4

10/10 Excellent

"We loved our visit to Ste Genevieve. The house was in the perfect spot being close to food and shopping! Folks here are exceptionally kind & helpful. We loved the historical slant to every thing… one comes away with a great sense of what colonial living was like. Everyone we met was eager to make sure our time was well spent. The house is a treasure and very comfortable. The hosts are responsive and helpful with any issues that arise. We would love to return in order to finish our sightseeing"

Quality Inn Perryville I-55

8/10 Good

"Utilitarian hotel room. Clean, neat, well maintained. Refrigerators have freezer compartments. Outlets on lamp bases but no USB charging ports."

Cozy Haven Our Little Gem Sleeps 4

10/10 Excellent

"The cozy cottage had just about everything you could need for a weekend stay. It was the perfect base for all the things we wanted to do - sightseeing, hiking, visiting wineries and relaxing. We would definitely stay here again when in St. Genevieve."

Microtel Inn & Suites by Wyndham Sainte Genevieve

10/10 Excellent

"Every one were friendly and helpful"

Beautiful Modern Loft In Wine Country!

10/10 Excellent

"My Wife and I had a wonderful stay at GooseHill loft. Great view of nice property with lake. Very clean and tidy. Great location near Charlesville. My wife loved the playful kittens."