Top 10 Hotels in Middletown, MO (from $78) 2026 - Competitive Prices

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Our top choices for Middletown hotels

A hotel reception desk with a modern design, a sign indicating it's a Hilton Honors location, and a variety of snacks and beverages on shelves.

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

1. Hampton Inn By Hilton Warrenton I-70

Warrenton

$139 nightly

$159 total

Oct 28 - Oct 29

Total with taxes and fees

A hotel lobby with a wooden reception desk, hexagonal ceiling lights, a dining area, and a reception desk with a sign.

A reception area with a wooden reception desk, a clock, and a sign indicating amenities.

A sign for Stone Hill Winery with directions to the winery, tours, tasting, and a restaurant.

A picnic area with benches and a food station, overlooking a body of water and hills.

2. Knights Inn New Florence

New Florence

Tracy

$130 nightly

$148 total

Oct 25 - Oct 26

Total with taxes and fees

A hotel room with two beds, a desk with a computer, a TV, and a window with a view.

A modern kitchen area with wooden cabinets, a white countertop, and a coffee machine.

A breakfast buffet counter with a bakery section, a coffee station, and a sign indicating the availability of breakfast.

A Holiday Inn Express building with a covered entrance, a flag, and a clear sky.

3. Holiday Inn Express Warrenton by IHG

Warrenton

RORY

$115 nightly

$131 total

Nov 22 - Nov 23

Total with taxes and fees

A Bay Inn hotel with a sign, a parking lot, and a grassy area.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A kitchenette with a waffle maker, a waffle batter dispenser, a waffle syrup bottle, and a cold beverage dispenser.

A hotel lobby with a reception desk, a blue sofa, and orange armchairs.

4. Bay Inn & Suites Troy

Troy

Judy Ann

$68 nightly

$78 total

Nov 17 - Nov 18

Total with taxes and fees

A gazebo with a table and benches, surrounded by trees and a body of water.

A hotel room with a desk, a television, a chair, a small refrigerator, a lamp, and a plant.

A two-story building with a flat roof and a covered entrance. There are two cars parked in front, and a truck is visible on the left.

A hotel room with a bed, two sofas, a small table, a desk with a chair, a TV, and a potted plant.

5. River's Edge Motel

Louisiana

Joseph

$83 nightly

$94 total

Oct 23 - Oct 24

Total with taxes and fees

Three promotional posters on a wall, a wooden table with two vases of flowers, and a white wall with electrical outlets.

A neatly made bed with a dark headboard, a bedside lamp, and a blue wall.

A laundry facility with multiple washing machines and dryers, fire extinguisher, and safety posters on the wall.

Two vending machines, one with Coca-Cola branded drinks and the other with snacks.

6. Troy Inn and Suites

Troy

RONALD

$68 nightly

$78 total

Oct 23 - Oct 24

Total with taxes and fees

An indoor swimming pool with a wooden interior, clear blue water, and a few lounge chairs.

A hotel room with a large bed, a bedside table with a phone, a chair, a bathroom with a mirror and sink, and a patterned carpet.

A modern living room with a gray sectional sofa, yellow armchairs, and a glass coffee table.

A modern room with two yellow armchairs, a glass coffee table with a decorative elephant sculpture, a brick wall, and a view of a parking lot through large windows.

7. Baymont by Wyndham Warrenton

Warrenton

Albert

$84 nightly

$96 total

Nov 8 - Nov 9

Total with taxes and fees

A hotel room with two beds, a nightstand, and a lamp.

A parking lot with a building that has a clock tower and arched windows.

A hotel room with two beds, a nightstand, and a bathroom visible through an open door.

A bathroom with a bathtub, a shower, and a towel rack.

8. The Junction Inn

Perry

PAUL

$74 nightly

$79 total

Nov 1 - Nov 2

Total with taxes and fees

A restaurant with a bar area, wooden flooring, checkered tablecloths, and a brick wall.

A staircase with wooden steps and a wooden handrail, leading up a brick wall.

A downtown area with a mix of historic and modern buildings, a prominent Mercantile Bank, and a view of a lake.

A row of multi-story buildings with a variety of storefronts, including a coffee shop and a restaurant.

9. The Eagles Nest Inn

Louisiana

Kimberly

$112 nightly

$127 total

Nov 22 - Nov 23

Total with taxes and fees

A hotel room with a large bed, a desk, a chair, a nightstand with a lamp, an air conditioner, and a cityscape view.

A breakfast restaurant with a counter, seating, and a TV.

A vending machine with snacks and drinks.

10. Super 8 by Wyndham Warrenton

Warrenton

Anne

$73 nightly

$83 total

Nov 11 - Nov 12

Total with taxes and fees

A living room with a sofa set, a coffee table, and a TV.

A kitchen with a dishwasher, a dining table with chairs, and a pendant light.

A bedroom with a bed, a ceiling fan, a nightstand, a lamp, and a window with curtains.

A two-story house with a blue exterior, a front porch, and a small front yard.

11. Hickory Lake House

Wright City

$411 nightly

$439 total

Oct 24 - Oct 25

Total with taxes and fees

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Top Middletown Hotel Reviews

Baymont by Wyndham Warrenton

10/10 Excellent

"The pool was nice and allowed my kid to burn off some nighttime energy so thankful for that! but there is no hottub like I thought. I look in all the nooks and crannies in a hotel room when entering, upon arrival it was a bit dirty around frames. But there was no bugs. The breakfast had eggs (contains milk powder so not dairyfree) and biscuits n gravy along with some other items. Convient location and nice staff. I would stay there again."

NEW - Treehouse - Dogwood

10/10 Excellent

"The Treehouse was exactly as described, beautiful, clean, quiet and relaxing. The host went above and beyond to provide a special request to make our stay even more memorable. Communication with the host was excellent, she provided answers to any and all questions that I had. I look forward to staying here again soon, and would recommend to anyone to stay with them. Whether you're just looking to get a little peace and quiet, or looking for somewhere peaceful to stay while visiting Herman or even St. Charles, I would definitely give Whispering Pines a close look."

Bay Inn & Suites Troy

10/10 Excellent

"It was very clean and you could tell it was recently updated. Everyone was nice and helpful. It will be even better when the pool is up and running. Very nice overall."

Knights Inn New Florence

10/10 Excellent

"Hotel was very clean, and conveniently located near the interstate. Parking lot was well lit, felt safe during our stay."

Treehouse - Sunrise

10/10 Excellent

"We had an excellent stay. The hot tub and fireplace were fantastic; a great getaway. Already planning a 2nd visit."

The Junction Inn

8/10 Good

"good beds nice people good if your fishing Mark Twain"

Troy Inn and Suites

8/10 Good

"Rooms clean staff friendly"

Hampton Inn By Hilton Warrenton I-70

10/10 Excellent

"Breakfast was amazing. Room AC was excellent, large TV, hot water!!!! Everything was perfect and I’d definitely book again if needed"

River's Edge Motel

10/10 Excellent

"we enjoyed our stay at rivers edge. the view was amazing overlooking the Mississippi river. very quaint town and the murals are worth the drive by. room was very clean and the beds were very comfortable. would stay again"

More cheap stays in Middletown

Troy Inn and Suites

14 Frenchman Bluff Rd Troy MO

$68 nightly

$78 total

Oct 23 - Oct 24

Total with taxes and fees

5.4/10 (92 reviews)

Bay Inn & Suites Troy

107 King Dr Troy MO

$68 nightly

$78 total

Nov 17 - Nov 18

Total with taxes and fees

9.2/10 Wonderful! (54 reviews)

Super 8 by Wyndham Warrenton

1429 North Service Road East, I-70 Warrenton MO

$73 nightly

$83 total

Nov 11 - Nov 12

Total with taxes and fees

Baymont by Wyndham Warrenton

425 E Veterans Memorial Pkwy Warrenton MO

$84 nightly

$96 total

Nov 8 - Nov 9

Total with taxes and fees

7.8/10 Good! (1,002 reviews)

Holiday Inn Express Warrenton by IHG

1008 N Hwy 47 And Interstate 7 Warrenton MO

$115 nightly

$131 total

Nov 22 - Nov 23

Total with taxes and fees

Extended Stay Warrenton Inn

220 Arlington Way Warrenton MO

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Hotels in Middletown with star-rating

Frequently asked questions

What is the best area to stay in Middletown?

Middletown is a small town, and the best area to stay is generally near the central intersection of Main Street and Highway 161.This central area offers convenient access to the town's few local businesses, including a diner and a small grocery store. It's the most practical location for visitors looking to be at the heart of Middletown's limited offerings. Solo travelers will find this area suitable for easily accessing essential services.For those seeking a quiet stay with direct access to natural surroundings, accommodations just outside the town's central area, particularly towards the eastern edge, are ideal. This allows for quick access to the nearby Graham Cave State Park, which is popular for hiking and exploring.

When is the best time to go to Middletown?

The best time to visit Middletown, Missouri, is during the spring (April to May) and fall (September to October) for pleasant weather and outdoor activities.Spring offers mild temperatures and blooming wildflowers, making it ideal for exploring the natural beauty of the surrounding area. It's a great time for couples to enjoy scenic drives and quiet walks in the countryside.Fall brings comfortable temperatures and colorful foliage, superb for those who appreciate picturesque landscapes.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Middletown.

How much is the nightly rate at a Middletown hotel?

Prices for hotels in Middletown often vary, but you can find a great deal from $78 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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Find hotels in Middletown, MO from $78

Upfront pricing

Treat yourself

Be picky

Go beyond your typical stay in Middletown

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Middletown hotels

1. Hampton Inn By Hilton Warrenton I-70

2. Knights Inn New Florence

3. Holiday Inn Express Warrenton by IHG

4. Bay Inn & Suites Troy

5. River's Edge Motel

6. Troy Inn and Suites

7. Baymont by Wyndham Warrenton

8. The Junction Inn

9. The Eagles Nest Inn

10. Super 8 by Wyndham Warrenton

11. Hickory Lake House

Top Middletown Hotel Reviews

Baymont by Wyndham Warrenton

NEW - Treehouse - Dogwood

Bay Inn & Suites Troy

Knights Inn New Florence

Treehouse - Sunrise

The Junction Inn

Troy Inn and Suites

Hampton Inn By Hilton Warrenton I-70

River's Edge Motel

More cheap stays in Middletown

Troy Inn and Suites

Bay Inn & Suites Troy

Super 8 by Wyndham Warrenton

Baymont by Wyndham Warrenton

Holiday Inn Express Warrenton by IHG

Extended Stay Warrenton Inn

Hotels in Middletown with star-rating

Frequently asked questions

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