Title: Seneca, SC Villas Rentals | Expedia.com [Seneca Travel Guide](https://expedia.com/Seneca.dx6548)[Hotels in Seneca](https://expedia.com/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.com/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.com/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Car Rentals in Seneca](https://expedia.com/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.com/Seneca.d6548.Destination-Travel-Guides) ![Lake Keowee South Carolina](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg) ### Bundle & Save Get more, spend less whenever you see Bundle & Save deals - ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg) ### OneKeyCash Earn OneKeyCash on all your eligible bookings - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg) ### Upfront pricing We are not like the others - we include taxes and fees ## Check prices for these dates In two weeks [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-04-03&endDate=2026-04-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [May 15 - May 17](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-05-15&endDate=2026-05-17&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [Jun 12 - Jun 14](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-06-12&endDate=2026-06-14&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jul 10 - Jul 12](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-07-10&endDate=2026-07-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Seneca villas ![Terrace/patio](https://images.trvl-media.com/lodging/126000000/125620000/125615300/125615210/cf42bcb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/126000000/125620000/125615300/125615210/2fea26bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/126000000/125620000/125615300/125615210/47cd874b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/126000000/125620000/125615300/125615210/04c7ff4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Villa in Westminster [](https://www.expedia.com/Westminster-Hotels-Hartwell-Nest-25-Mins-To-Clemson-Next-To-Lake.h125615210.Hotel-Information) $292 nightly $321 total Mar 23 - Mar 24 Total with taxes and fees [](https://www.expedia.com/Westminster-Hotels-Hartwell-Nest-25-Mins-To-Clemson-Next-To-Lake.h125615210.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-01&endDate=2026-04-02®ionId=6548&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find vacation rentals that suit your style Cabins [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-15&d1=2026-06-15&endDate=2026-06-18&d2=2026-06-18&lodging=CABIN) Cottages [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-15&d1=2026-06-15&endDate=2026-06-18&d2=2026-06-18&lodging=COTTAGE) Private vacation homes [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-15&d1=2026-06-15&endDate=2026-06-18&d2=2026-06-18&lodging=VACATION_HOME) Condos [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-15&d1=2026-06-15&endDate=2026-06-18&d2=2026-06-18&lodging=CONDO) Apartments [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-15&d1=2026-06-15&endDate=2026-06-18&d2=2026-06-18&lodging=APARTMENT) Aparthotels [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-15&d1=2026-06-15&endDate=2026-06-18&d2=2026-06-18&lodging=APART_HOTEL) Villas [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-15&d1=2026-06-15&endDate=2026-06-18&d2=2026-06-18&lodging=VILLA) Houseboats [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-15&d1=2026-06-15&endDate=2026-06-18&d2=2026-06-18&lodging=HOUSE_BOAT) Chalets [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-15&d1=2026-06-15&endDate=2026-06-18&d2=2026-06-18&lodging=CHALET) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Villas.d6548-aaVillas.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Villas.d6548-aaVillas.Travel-Guide-Accommodation) ## Top Seneca Hotel Reviews ![Fall fun at the cabin! Convenient to Lake Keowee and Clemson](https://images.trvl-media.com/lodging/19000000/18970000/18968900/18968828/6097ae54_y.jpg) ### Fall fun at the cabin! Convenient to Lake Keowee and Clemson 10/10 Excellent "It was great and convenient and perfect for what my family needed. Definitely stay again. Thank you so much." [](https://expedia.com/Anderson-Hotels-Fall-Fun-At-The-Cabin-Convenient-To-Lake-Keowee-And-Clemson.h18968828.Hotel-Information) ![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/83732283_y.jpg) ### Tru by Hilton Seneca Clemson 10/10 Excellent "Clean room, friendly staff. Great place to stay!" [](https://expedia.com/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![Fairfield Inn & Suites Seneca Clemson Univ Area ](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/w4000h2662x0y0-18bf21d5_y.jpg) ### Fairfield Inn & Suites Seneca Clemson Univ Area 10/10 Excellent "Clean room freindly staff and convenient location to stores" [](https://expedia.com/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3837h2558x3y3-4efd29d6_y.jpg) ### Best Western Plus Clemson Hotel & Conference Center 8/10 Good "Clean room/friendly staff/good breakfast" [](https://expedia.com/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!](https://images.trvl-media.com/lodging/34000000/33730000/33728200/33728167/7de7c272_y.jpg) ### 4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly! 10/10 Excellent "The home was beautiful, the amenities fantastic, and we especially enjoyed the kayaks! The kitchen was also stocked with all the basics we needed which saved us from additional grocery expense for items we would only be using for a couple of days. The owner was also a delight to work with. Wonderful experience!" [](https://expedia.com/Anderson-Hotels-Beautiful-43.h33728167.Hotel-Information) ![The Shepherd Hotel Downtown Clemson](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/bd45b45c_y.jpg) ### The Shepherd Hotel Downtown Clemson 10/10 Excellent "Excellent stay, I highly recommend! Accommodations, location, overall vibe, great food and drinks! " [](https://expedia.com/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) ![Lake House with Dock, Pool, and Pet Friendly. 8 Minutes from Clemson.](https://images.trvl-media.com/lodging/34000000/33940000/33932300/33932265/0adee99d_y.jpg) ### Lake House with Dock, Pool, and Pet Friendly. 8 Minutes from Clemson. 10/10 Excellent "Lots of Wonderful space, close to campus, great communication with property manager. Easy check-in and out. " [](https://expedia.com/Seneca-Hotels-Lake-House-With-Dock.h33932265.Hotel-Information) ![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/8f736b3a_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 2/10 Terrible "Rooms good for the night. No issues with rooms" [](https://expedia.com/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/d7c06df6_y.jpg) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "I bought things like plates, towels, " [](https://expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ## Find out more about Seneca ## Seneca Villas information | Number of reviews | | | ----------------- | -------- | | Accommodation | 9 Villas | | Lowest Price | $321 | | Highest Price | $321 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [Hotels near Keowee Plantation ](https://www.expedia.com/Keowee-Plantation-Seneca-Hotels.0-n553248635976477960-0.Travel-Guide-Filter-Hotels) - [Hotels near Oconee County Regional ](https://www.expedia.com/Oconee-County-Regional-Airport-Hotels.0-aCEU-0.Travel-Guide-Filter-Hotels) - 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