Title: Seneca, SC Villas Rentals | Expedia.com [Seneca Travel Guide](https://expedia.com/Seneca.dx6548)[Hotels in Seneca](https://expedia.com/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.com/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.com/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Car Rentals in Seneca](https://expedia.com/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.com/Seneca.d6548.Destination-Travel-Guides) ![Lake Keowee South Carolina](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg) ### Bundle & Save Get more, spend less whenever you see Bundle & Save deals - ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg) ### OneKeyCash Earn OneKeyCash on all your eligible bookings - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg) ### Upfront pricing We are not like the others - we include taxes and fees ## Check prices for these dates In two weeks [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-03-13&endDate=2026-03-15&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Apr 24 - Apr 26](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-04-24&endDate=2026-04-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [May 22 - May 24](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jun 19 - Jun 21](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-06-19&endDate=2026-06-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Seneca villas ![Exterior](https://images.trvl-media.com/lodging/92000000/91910000/91908600/91908503/5efbc53f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/92000000/91910000/91908600/91908503/96d7fead.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/92000000/91910000/91908600/91908503/5c2269e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91910000/91908600/91908503/f2c1860f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Villa in Pickens [](https://www.expedia.com/Pickens-Hotels-Grand-Southern-Elegance-Near-Downtown-Pickens.h91908503.Hotel-Information) $1,691 nightly $1,877 total Mar 3 - Mar 4 Total with taxes and fees [](https://www.expedia.com/Pickens-Hotels-Grand-Southern-Elegance-Near-Downtown-Pickens.h91908503.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-10&endDate=2026-03-11®ionId=6548&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this yearโ€™s big trip and save. [Book now](https://expedia.com/deals?rfrr=AA_SPRING_PROMO_6548) ## Find vacation rentals that suit your style Cabins [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-25&d1=2026-05-25&endDate=2026-05-28&d2=2026-05-28&lodging=CABIN) Private vacation homes [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-25&d1=2026-05-25&endDate=2026-05-28&d2=2026-05-28&lodging=VACATION_HOME) Cottages [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-25&d1=2026-05-25&endDate=2026-05-28&d2=2026-05-28&lodging=COTTAGE) Condos [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-25&d1=2026-05-25&endDate=2026-05-28&d2=2026-05-28&lodging=CONDO) Apartments [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-25&d1=2026-05-25&endDate=2026-05-28&d2=2026-05-28&lodging=APARTMENT) Aparthotels [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-25&d1=2026-05-25&endDate=2026-05-28&d2=2026-05-28&lodging=APART_HOTEL) Villas [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-25&d1=2026-05-25&endDate=2026-05-28&d2=2026-05-28&lodging=VILLA) Houseboats [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-25&d1=2026-05-25&endDate=2026-05-28&d2=2026-05-28&lodging=HOUSE_BOAT) Chalets [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-25&d1=2026-05-25&endDate=2026-05-28&d2=2026-05-28&lodging=CHALET) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Villas.d6548-aaVillas.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Villas.d6548-aaVillas.Travel-Guide-Accommodation) ## Top Seneca Hotel Reviews ![Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/8c11b789_y.jpg) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "it smelled good and it was clean " [](https://expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8_y.jpg) ### Tru by Hilton Seneca Clemson 10/10 Excellent "Always clean and friendly! " [](https://expedia.com/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff_y.jpg) ### Lakeside Lodge Clemson 10/10 Excellent "Wonderful! Clean and comfortable room. Great staff!" [](https://expedia.com/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Perfect Lake Hartwell Getaway - Gorgeous Lake Views!](https://images.trvl-media.com/lodging/38000000/37750000/37749500/37749425/391b1689_y.jpg) ### Perfect Lake Hartwell Getaway - Gorgeous Lake Views! 10/10 Excellent "Host was very responsive. House was clean. Would stay here again. " [](https://expedia.com/Anderson-Hotels-Perfect-Lake-Hartwell-Getaway-Gorgeous-Lake-Views.h37749425.Hotel-Information) ![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 10/10 Excellent "yes" [](https://expedia.com/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Quality Inn Seneca Clemson Area US-123](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg) ### Quality Inn Seneca Clemson Area US-123 10/10 Excellent "Everting was good" [](https://expedia.com/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Days Inn by Wyndham Seneca / Clemson Area](https://images.trvl-media.com/lodging/1000000/20000/14900/14854/9f69229a_y.jpg) ### Days Inn by Wyndham Seneca / Clemson Area 10/10 Excellent "Room was very clean and the staff are great. " [](https://expedia.com/Anderson-Hotels-Days-Inn-By-Wyndham-Seneca-Clemson-Area.h14854.Hotel-Information) ![5๐ŸŒŸ Modern Lakefront Luxury Oasis ๐Ÿ‡บ๐Ÿ‡ธ 270ยฐ Lake Views w/Dock & Hot Tub!](https://images.trvl-media.com/lodging/62000000/61020000/61010400/61010330/fa789e5c_y.jpg) ### 5๐ŸŒŸ Modern Lakefront Luxury Oasis ๐Ÿ‡บ๐Ÿ‡ธ 270ยฐ Lake Views w/Dock & Hot Tub! 10/10 Excellent "Nick, the host, was helpful and prompt to respond. The home was beautiful and was perfect for our corporate event. " [](https://expedia.com/Seneca-Hotels-Modern-Lakefront-Luxury-Oasis-270-Lake-Views-WDock.h61010330.Hotel-Information) ![Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock](https://images.trvl-media.com/lodging/28000000/27120000/27118400/27118346/67cc829e_y.jpg) ### Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock 10/10 Excellent "We will definitely be booking this property again. We usually have family gathering inJanuary and I think this will be our new location. It accommodated those lodging with us and who came to visit while we were there. The flow of the house and outdoors was so convenient especially for our large gathering when we roasted oysters. " [](https://expedia.com/Seneca-Hotels-Quiet-Cove.h27118346.Hotel-Information) ## Find out more about Seneca ## Seneca Villas information | Number of reviews | | | ----------------- | -------- | | Accommodation | 9 Villas | | Lowest Price | $1,877 | | Highest Price | $1,877 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [Hotels near Keowee Plantation ](https://www.expedia.com/Keowee-Plantation-Seneca-Hotels.0-n553248635976477960-0.Travel-Guide-Filter-Hotels) - [Hotels near Oconee County Regional ](https://www.expedia.com/Oconee-County-Regional-Airport-Hotels.0-aCEU-0.Travel-Guide-Filter-Hotels) - [Gay friendly Hotels in Keowee ](https://www.expedia.com/Keowee-Hotels-LGBT-Welcoming-Hotel.0-0-d553248635975848347-tLGBTWelcomingHotel.Travel-Guide-Filter-Hotels) - [Clemson Hotels ](https://www.expedia.com/Clemson-Hotels.d6594.Travel-Guide-Hotels) - [Hotels near Clemson University ](https://www.expedia.com/Clemson-University-Hotels.0-l6127431-0.Travel-Guide-Filter-Hotels) - 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