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Our top choices for Cairo hotels

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (282 reviews)
"Amenities, microwave, refrigerator,iron and iron board,Shower soap options "
United States
Maurice
$68 nightly
The price is $75
Mar 27 - Mar 28
Total with taxes and fees
Quality Inn Cairo I-57

La Center Motel

La Center Motel
2.0 star property
La Center
7.6 out of 10, Good, (18 reviews)
"Quiet and convenient."
United States
Alma
$65 nightly
The price is $70
Mar 22 - Mar 23
Total with taxes and fees
La Center Motel

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (409 reviews)
"The staff was very friendly and accommodating "
United States
Arturo
$70 nightly
The price is $78
Mar 22 - Mar 23
Total with taxes and fees
The Riverstone Hotel Charleston-Sikeston

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (625 reviews)
"Affordable for a quick one night stay. Restaurant and gas station next to hotel."
United States
Annette
$62 nightly
The price is $69
Mar 22 - Mar 23
Total with taxes and fees
Super 8 by Wyndham Charleston/Sikeston East MO

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105 reviews)
"The hotel needs a renovation. For the price I didn’t expect much, but it feels neglected."
United States
Britani
$64 nightly
The price is $71
Mar 22 - Mar 23
Total with taxes and fees
Eagle Inn Charleston

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
$271 nightly
The price is $290
Mar 22 - Mar 23
Total with taxes and fees
Quiet Country Stay: Modern Home Near Paducah
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Cairo attractions

Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

Cairo Ohio River Bridge traversing over the Ohio River at sunset

Top Cairo Hotel Reviews

More cheap stays in Cairo

Hotels in Cairo with star-rating

Find out more about Cairo

Top reasons to visit Cairo

  • Outdoor Adventure: Cairo, Illinois, is an outdoor enthusiast's paradise with state parks, nature preserves, and recreational areas perfect for hiking and exploring.
  • Historic Attractions: Visit historic forts and local landmarks that highlight Cairo's rich history and cultural heritage.
  • Charming Downtown: Stroll through vibrant downtown Cairo, filled with local shops and eateries offering unique shopping and dining experiences.
  • Family-Friendly Atmosphere: South Cairo is known for its welcoming vibe, making it ideal for family outings and activities.
  • Diverse Accommodations: Enjoy a range of lodging options, from cozy motels to unique agritourism stays, catering to all types of travelers.

Find great hotels in and around Cairo

Discover a variety of hotel accommodations in Cairo, Illinois, perfect for every type of traveler. Whether you're looking for a cozy motel, a unique agritourism property, or pet-friendly options, you'll find a welcoming place to stay. Ideal for family vacations, business trips, or simply exploring the area, Cairo's hotels offer essential amenities to enhance your experience. Enjoy the charm of this quaint town while having comfortable lodging at your fingertips.

  • Super 8 by Wyndham Charleston/Sikeston East MO: This budget-friendly motel offers a warm and welcoming atmosphere, perfect for families and pet owners. Located 10 miles from Cairo, it provides a variety of amenities tailored for a comfortable stay. Families traveling with children will appreciate the complimentary cribs available upon reservation, ensuring a restful experience for the little ones. Super 8 also welcomes pets, offering flexibility for travelers who want to bring their furry friends along. The motel features essential services and a friendly staff committed to making your stay enjoyable.
  • The Riverstone Hotel: Situated 12 miles from Cairo, The Riverstone Hotel is an ideal choice for business travelers seeking a comfortable and convenient stay. This budget-friendly hotel is pet-friendly, accommodating your four-legged companions with specific policies in place. Guests can enjoy a relaxed atmosphere while benefiting from amenities designed for work and leisure. The hotel's location makes it easy to access local business districts, while the welcoming environment ensures a pleasant retreat after a busy day. Whether traveling for work or pleasure, The Riverstone Hotel provides a reliable base for your visit.
  • Quality Inn Cairo I-57: Located conveniently in Cairo, the Quality Inn offers a family-friendly environment with various amenities to enhance your stay. This budget-friendly hotel caters to families by providing free cribs and a first aid kit for added safety. Pets are also welcome here, with policies designed to accommodate your furry companions. Guests appreciate the friendly service and comfortable accommodations, making it an excellent choice for those looking to explore the area while enjoying the comforts of home. With its convenient location and thoughtful amenities, Quality Inn Cairo I-57 is perfect for family vacations.

Where to stay near Cairo

Discover the charm of Cairo, Illinois, where outdoor adventures and rich history meet. Explore the vibrant downtown Cairo, filled with local shops and eateries, or take a leisurely stroll through the scenic parks. Don’t miss the chance to visit South Cairo, known for its family-friendly atmosphere. Whether you're seeking adventure or a taste of local culture, Cairo offers a unique experience that will leave you wanting more.

  • Wickliffe: Located a mere 6 miles from Cairo, Wickliffe offers a charming escape for those seeking outdoor adventures and scenic beauty. With peak travel seasons in March to April and August, visitors flock here for romantic experiences and recreational activities. Enjoy golfing at local courses or explore the nearby national state park, where lush forests and picturesque lakes provide the perfect backdrop for a day of exploration. Wickliffe is the ideal destination for nature lovers and couples looking to unwind amidst stunning landscapes.
  • Mound City: Also situated just 6 miles from Cairo, Mound City is known for its adventurous spirit and outdoor recreation. With the highest visitor traffic occurring in March, July, and October, this city attracts travelers looking for romantic getaways and exciting activities. Mound City features a variety of recreational parks and golf options, making it perfect for families and couples. Surrounding landmarks, including serene forests and urban parks, enhance the area's natural charm, ensuring a delightful experience for all who visit.
  • Wyatt: A short 7 miles from Cairo, Wyatt is a family-friendly city known for its vibrant outdoor scene and city-themed experiences. Peak visitation occurs during the summer months of June to August, attracting families seeking fun and relaxation. Enjoy a round of golf, take your furry friend to the dog park, or relax in one of the local urban parks. Wyatt's event conference venue also makes it a great spot for gatherings and celebrations, ensuring visitors have access to both leisure and entertainment options.

Things to do in Cairo

Cairo, Illinois, offers a perfect blend of outdoor adventure and scenic beauty, making it an ideal spot for a weekend getaway. Visitors can explore local attractions, enjoy recreational areas, and unwind at campgrounds. While in town, don’t miss out on shopping malls and various local tours that highlight the area's charm and history.

Shopping

Cairo offers local shops like Cairo Gifts & Décor for unique souvenirs. If you're up for a drive, check out the Cape Girardeau Mall, about 15 miles away, featuring a variety of retail stores, restaurants, and entertainment options for a more extensive shopping experience.

Recreation

At the Cairo Wellness Center, indulge in rejuvenating spa treatments and calming yoga sessions. Enjoy the peaceful atmosphere and personalized wellness programs designed to enhance relaxation. For outdoor activities, visit the nearby Fort Defiance Park, where you can hike scenic trails and appreciate the confluence of the Mississippi and Ohio Rivers.

Adventure

Cairo's Riverfront Park offers scenic views of the confluence of rivers, perfect for picnicking and leisurely walks. For outdoor thrill-seekers, explore the nearby Cache River State Natural Area, where you can hike through stunning wetlands and observe diverse wildlife in a tranquil setting.

Nightlife

Cairo, Illinois, offers a laid-back nightlife atmosphere with local bars like The Cairo Lounge, perfect for enjoying live music and friendly conversation. For a more relaxed vibe, visit the Riverfront Cafe, where you can unwind with a drink while taking in views of the Mississippi River.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Cairo

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Cairo are November to January, where the prices are slightly lower. This is in comparison to April to May and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Cairo is Tuesday. The most expensive day to stay in Cairo is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia's search wizard to tailor your results according to your preferences, such as your budget, desired location, and preferred type of accommodation. For instance, selecting the Eco-certified option will showcase sustainable and environmentally-friendly hotels that are currently available. To find the best prices and deals, simply sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel stay in Cairo with your flights and activities when you book an Expedia package.

Find the best attractions in and around Cairo

Cairo, Illinois, is an outdoor enthusiast's paradise, offering a blend of adventure and scenic beauty. Visitors can explore local attractions such as historic forts, state parks, and nature preserves. Whether you're seeking cultural experiences or thrilling adventures, Cairo provides a variety of options to satisfy every traveler's curiosity and love for nature.

  • Columbus-Belmont State Park: Located 17 miles from Cairo, this park offers breathtaking scenery and outdoor adventures. Enjoy hiking, picnicking, and exploring the historical significance of the site, which played a role in the Civil War.
  • Ballard Wildlife Management Area: Just 5 miles away, this serene preserve is perfect for budget-friendly exploration. Discover historical landmarks while enjoying birdwatching and nature walks in a tranquil setting.
  • Fort Defiance State Park: Situated within Cairo, this historic fort provides a glimpse into the area's rich culture. Explore the grounds where the Mississippi and Ohio Rivers converge, and learn about its strategic importance in American history.

Best time to go to Cairo

The best time to visit Cairo is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January35.2°F (1.8°C)Light RainMostly SunnyModerately LowSlightly Low
February38.5°F (3.6°C)Light RainMostly SunnyModerately LowAverage
March48.7°F (9.3°C)Light RainMostly SunnyModerately HighAverage
April57.7°F (14.3°C)Light RainMostly SunnyModerately HighSlightly High
May67.5°F (19.7°C)Light RainMostly SunnyAverageSlightly High
June76.5°F (24.7°C)Light RainMostly SunnyAverageAverage
July79.0°F (26.1°C)Light RainMostly SunnyAverageAverage
August77.2°F (25.1°C)Light RainMostly SunnyModerately HighSlightly High
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October60.1°F (15.6°C)Light RainMostly SunnyAverageAverage
November47.8°F (8.8°C)Light RainMostly SunnyModerately LowSlightly Low
December40.6°F (4.8°C)Light RainMostly SunnyAverageSlightly Low

The nearest major airports for your trip to Cairo

When visiting Cairo, Illinois, you have several airport options. Cape Girardeau Municipal Airport (CGI) is 26 miles away, with nearby hotels like the Drury Plaza Hotel and Courtyard by Marriott, both approximately 6 miles from the airport. Williamson County Regional Airport (MWA) is 52 miles away, offering convenient accommodation at Drury Inn & Suites Marion, just 2 miles from the airport. For travelers flying into Barkley Regional Airport (PAH) in Paducah, Kentucky, located 23 miles from Cairo, you can find comfortable stays at The Respite Bed and Breakfast, 9 miles away, or Harrah's Metropolis Hotel, 6 miles from the airport.

Frequently asked questions

What are the best hotels in Cairo that travelers recommend?
For travelers seeking a recommended hotel in Cairo, Illinois, the Quality Inn Cairo I-57 is a frequently praised option.

This hotel offers a range of convenient amenities, including air conditioning, a complimentary full breakfast, and free self-parking, including accessible parking and space for vans, RVs, buses, and trucks. Guests consistently comment on the nice, clean rooms, the quite good breakfast, and the helpful staff. While in Cairo, you will be within a reasonable distance of the Mississippi River and the Ohio River.
What are the best family hotels in Cairo?
For families visiting Cairo, a highly-rated option is the Quality Inn Cairo I-57.

This hotel offers several amenities designed to make family stays comfortable, including complimentary cribs upon request, free full breakfast, and free WiFi access. Guests often note the nice, clean rooms and the quite good breakfast options. The staff is also frequently praised for being nice and helpful. Find more child-friendly accommodations in Cairo
What hotels in Cairo offer free breakfast?
For hotels in Cairo that offer free breakfast, consider the Quality Inn Cairo I-57.

This hotel provides a complimentary full breakfast daily, which guests describe as quite good. It also offers free WiFi and free self-parking for added convenience. The rooms are noted by guests as being nice and clean, and the staff is frequently mentioned as being welcoming. Find more hotels with free breakfast in Cairo
What are the top pet-friendly hotels in Cairo?
For pet-friendly accommodations in Cairo, the Quality Inn Cairo I-57 is a highly recommended option.

This hotel welcomes pets, specifically dogs, making it a convenient choice for travelers with furry companions. Guests often mention the nice and clean rooms, the quite good breakfast, and the helpful staff. It also offers a complimentary full breakfast, a welcome amenity for starting your day. See more pet-friendly hotels in Cairo
What are the best budget hotels in Cairo?
For a budget-friendly option in Cairo, consider the Quality Inn Cairo I-57.

This hotel offers convenient amenities such as complimentary WiFi, free toiletries, and free self-parking. Guests particularly appreciate the free full breakfast, which often receives praise for being quite good. The rooms are frequently described as nice and clean, and the staff are often noted for being helpful.
What are the best hotels in Cairo near Mississippi River?
For hotels in Cairo near the Mississippi River, the Quality Inn Cairo I-57 is a great option.

The Quality Inn Cairo I-57 offers a range of complimentary amenities including free breakfast, free WiFi, and free self-parking. Guests consistently praise the nice, clean rooms and the quite good breakfast. The staff are also noted for being nice and helpful. For families, the hotel provides a free crib.
When is the best time to go to Cairo?
When planning a visit to Cairo, Illinois, the best times to go are during the spring and fall months.

These seasons offer pleasant weather conditions, with comfortable temperatures that are ideal for exploring the town's historic sites and natural surroundings. Spring, from April to May, brings blooming foliage and mild days, while fall, from September to October, provides crisp air and colorful landscapes.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Cairo.
How can I save on a Cairo hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Cairo hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Cairo hotel?
Prices for hotels in Cairo often vary, but you can find a great deal from $69 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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