Find hotels in Santee, SC from US$ 65

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Our top choices for Santee hotels

1. Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (1,019 reviews)
"Good hotel for a quick stop. The room was clean, staff was friendly and I was very thankful for the breakfast before a long drive."
United States
Angela
$104 nightly
The price is $115
29 Nov - 30 Nov
Total with taxes and fees
Tru By Hilton Santee

2. Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,515 reviews)
"Good one night stay Staff was wonderful"
United States
Thomas
$80 nightly
The price is $89
16 Nov - 17 Nov
Total with taxes and fees
Baymont by Wyndham Santee

3. Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
3.0 star property
Santee
9.8 out of 10, Exceptional, (1,001 reviews)
"Convenient location close to the highway and restaurants. Large parking , excellent breakfast and comfortable room."
United States
Victor
$139 nightly
The price is $154
29 Nov - 30 Nov
Total with taxes and fees
Fairfield Inn & Suites by Marriott Santee

4. Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1,002 reviews)
"Nice place to stay"
United States
sandra
$129 nightly
The price is $144
22 Nov - 23 Nov
Total with taxes and fees
Hampton Inn Santee-I-95

5. Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1,002 reviews)
"Very nice breakfast area and breakfast food."
United States
Jack
$119 nightly
The price is $132
22 Nov - 23 Nov
Total with taxes and fees
Best Western Plus Santee Inn

6. Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
3.0 star property
Santee
8.2 out of 10, Very good, (1,000 reviews)
"Great staff and really clean room!"
United States
Traci
$130 nightly
The price is $144
18 Nov - 19 Nov
Total with taxes and fees
Holiday Inn Santee by IHG

7. Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,001 reviews)
"Great hotel"
United States
Alexis
$112 nightly
The price is $124
29 Nov - 30 Nov
Total with taxes and fees
Comfort Inn & Suites Santee

8. Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
Santee
7.2 out of 10, Good, (789 reviews)
"Extremely good value for money, room was clean, tidy and very well appointed. Will absolutely come here again."
United States
Robert
$65 nightly
The price is $72
16 Nov - 17 Nov
Total with taxes and fees
Travelodge by Wyndham Santee

9. Clark's Inn

Clark's Inn
3.0 star property
Santee
$184 nightly
The price is $205
16 Nov - 17 Nov
Total with taxes and fees
Clark's Inn

10. Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
2.5 star property
Santee
5.8 out of 10, (621 reviews)
"Clean room and nice staff"
United States
Louis
$54 nightly
The price is $65
8 Dec - 9 Dec
Total with taxes and fees
Quality Inn & Suites Santee I-95

11. Super 8 by Wyndham Santee/I-95

Super 8 by Wyndham Santee/I-95
2.0 star property
Santee
6.8 out of 10, (477 reviews)
"Ok hotel when money is tight. Only stayed one night but the room was clean and the beds were pretty comfy."
United States
Christalyn
$64 nightly
The price is $71
22 Nov - 23 Nov
Total with taxes and fees
Super 8 by Wyndham Santee/I-95

12. Red Roof Inn Santee

Red Roof Inn Santee
2.0 star property
Santee
6.6 out of 10, (669 reviews)
"Everything was adequate or good."
United States
Sharyn
$63 nightly
The price is $70
18 Nov - 19 Nov
Total with taxes and fees
Red Roof Inn Santee

13. Econo Lodge Santee

Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (317 reviews)
"Pretty nice and clean with a comfortable bed at a great rate."
United States
Arthur
$63 nightly
The price is $70
8 Dec - 9 Dec
Total with taxes and fees
Econo Lodge Santee

14. Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
2.0 star property
Santee
6.4 out of 10, (597 reviews)
"The price rate was great"
United States
Stevenson
$78 nightly
The price is $86
22 Nov - 23 Nov
Total with taxes and fees
Ramada by Wyndham Santee I-95

15. Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (103 reviews)
"Love it"
United States
Mark
$79 nightly
The price is $91
16 Nov - 17 Nov
Total with taxes and fees
Bells Marina & Resort

16. Ashburn Inn Manning I 95

Ashburn Inn Manning I 95
2.0 star property
Manning
$69 nightly
The price is $80
16 Nov - 17 Nov
Total with taxes and fees
Ashburn Inn Manning I 95

17. Fairfield Inn by Marriott Orangeburg

Fairfield Inn by Marriott Orangeburg
3.0 star property
Orangeburg
8.4 out of 10, Very good, (853 reviews)
"Staff is great. However , the facility needs a refresh."
United States
Timothy
$101 nightly
The price is $112
22 Nov - 23 Nov
Total with taxes and fees
Fairfield Inn by Marriott Orangeburg

18. Peach Tree Inn

Peach Tree Inn
2.5 star property
St. George
7.2 out of 10, Good, (271 reviews)
"Very nice staff and the room was clean. Definitely would syat again."
United States
Daniel
Peach Tree Inn

19. Tru by Hilton Orangeburg

Tru by Hilton Orangeburg
2.5 star property
Orangeburg
9.2 out of 10, Wonderful, (1,000 reviews)
"Awesome staff and extremely clean rooms."
United States
Allen
$110 nightly
The price is $122
29 Nov - 30 Nov
Total with taxes and fees
Tru by Hilton Orangeburg

20. Hampton Inn & Suites Orangeburg

Hampton Inn & Suites Orangeburg
2.5 star property
Orangeburg
9.4 out of 10, Exceptional, (864 reviews)
"Staffs are friendly, hotel is clean breakfast great .Stayed 3 nights."
United States
sonia
Hampton Inn & Suites Orangeburg
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santee attractions

Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campgrounds.

A tree with Spanish moss and autumn leaves in a body of water.

Top Santee Hotel Reviews

Frequently Asked Questions

Where can I learn more about changing or cancelling my trip to Santee?

For more information about updating your trip to Santee or cancelling it, click here.

What's the seasonal weather like in Santee?

The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches.

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