---
title: "Top 10 Hotels in Santee, SC (from $65) 2026 - Competitive Prices | Expedia"
description: "Find 184 of the best hotels in Santee, SC in 2026. Compare room rates, hotel reviews and availability. Most hotels are fully refundable."
canonical: "https://www.expedia.com/Santee-Hotels.d9953.Travel-Guide-Hotels"
language: en-US
market: US
currency: USD
prices_as_of: 2026-11-13T02:28:10Z
---

Plan your trip

- [Santee Travel Guide](https://www.expedia.com/Santee.dx9953)
- [Flights to Santee](https://www.expedia.com/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)
- [Car Rentals in Santee](https://www.expedia.com/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)
- [Santee Vacation Packages](https://www.expedia.com/Santee.d9953.Destination-Travel-Guides)
- [Vacation Rentals in Santee](https://www.expedia.com/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)

# Find hotels in Santee, SC from $65
![A tree with Spanish moss and autumn leaves in a body of water.](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

## Go beyond your typical stay in Santee

[Pet friendly](https://www.expedia.com/Hotel-Search?destination=Santee,%20South%20Carolina,%20United%20States%20of%20America&regionId=9953&latLong=33.487602,-80.476242&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&amenities=PETS)

[Hot tub](https://www.expedia.com/Hotel-Search?destination=Santee,%20South%20Carolina,%20United%20States%20of%20America&regionId=9953&latLong=33.487602,-80.476242&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&amenities=HOT%5FTUB)

[Pool](https://www.expedia.com/Hotel-Search?destination=Santee,%20South%20Carolina,%20United%20States%20of%20America&regionId=9953&latLong=33.487602,-80.476242&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&amenities=POOL)

[Family friendly](https://www.expedia.com/Hotel-Search?destination=Santee,%20South%20Carolina,%20United%20States%20of%20America&regionId=9953&latLong=33.487602,-80.476242&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&travelerType=family%5Ffriendly)

[Cottage](https://www.expedia.com/Hotel-Search?destination=Santee,%20South%20Carolina,%20United%20States%20of%20America&regionId=9953&latLong=33.487602,-80.476242&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&lodging=COTTAGE)

[Waterpark](https://www.expedia.com/Hotel-Search?destination=Santee,%20South%20Carolina,%20United%20States%20of%20America&regionId=9953&latLong=33.487602,-80.476242&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&amenities=WATER%5FPARK)

[Apart­ment](https://www.expedia.com/Hotel-Search?destination=Santee,%20South%20Carolina,%20United%20States%20of%20America&regionId=9953&latLong=33.487602,-80.476242&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&lodging=APARTMENT)

[Condo](https://www.expedia.com/Hotel-Search?destination=Santee,%20South%20Carolina,%20United%20States%20of%20America&regionId=9953&latLong=33.487602,-80.476242&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&lodging=CONDO)

[Apart hotel](https://www.expedia.com/Hotel-Search?destination=Santee,%20South%20Carolina,%20United%20States%20of%20America&regionId=9953&latLong=33.487602,-80.476242&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&lodging=APART%5FHOTEL)

[Campsite](https://www.expedia.com/Hotel-Search?destination=Santee,%20South%20Carolina,%20United%20States%20of%20America&regionId=9953&latLong=33.487602,-80.476242&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&lodging=CARAVAN%5FPARK)

## Check prices for these dates

[Check prices for these dates, December 13 – 14, 2026](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-12-13&endDate=2026-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

[View in a map](https://www.expedia.com/Hotel-Search?regionId=9953&stayLength=1&daysInFuture=30&pwaOverlay=map)

## Our top choices for Santee hotels

### [1\. Tru By Hilton Santee](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information)

![A breakfast area with a self-service counter, refrigerated display, and a digital menu board.](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

- Location: Santee
- Guest rating: 9.2/10 (Wonderful, 1017 reviews)
- Price: $105 nightly, $116 total, Nov 29 - Nov 30, Total with taxes and fees
- Review: The property was clean and very comfortable., by Marie, 5 days ago

### [2\. Baymont by Wyndham Santee](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information)

![A hotel room with a bed, bedside table, lamp, and a mirror.](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/d2da67e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santee
- Guest rating: 8/10 (Very good, 1513 reviews)
- Price: $80 nightly, $89 total, Nov 15 - Nov 16, Total with taxes and fees
- Review: Evening check in staff was awesome. Room was clean., by Linda, 1 day ago

### [3\. Fairfield Inn & Suites by Marriott Santee](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information)

![A patio area with wicker furniture, a stone fire pit, and outdoor seating.](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santee
- Guest rating: 9.8/10 (Exceptional, 1001 reviews)
- Price: $130 nightly, $144 total, Nov 19 - Nov 20, Total with taxes and fees
- Review: Breakfast was very good. Definitely would stay again., by Heather, 6 days ago

### [4\. Hampton Inn Santee-I-95](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information)

![A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/d82e6496.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santee
- Guest rating: 9.6/10 (Exceptional, 1001 reviews)
- Price: $124 nightly, $138 total, Dec 13 - Dec 14, Total with taxes and fees
- Review: EVERYTHING about The Hampton Inn in Santee, SC is just perfect!, by Lenny, 17 days ago

### [5\. Comfort Inn & Suites Santee](https://www.expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information)

![A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/fc94b516.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santee
- Guest rating: 8/10 (Very good, 1000 reviews)
- Price: $108 nightly, $120 total, Nov 15 - Nov 16, Total with taxes and fees
- Review: Friendly staff and clean building with a great breakfast to start off a day of traveling or fun vacations., by Jeffrey, 15 days ago

### [6\. Best Western Plus Santee Inn](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information)

![A hotel entrance with a sign reading "Best Western PLISS."](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santee
- Guest rating: 8.8/10 (Excellent, 1000 reviews)
- Price: $119 nightly, $132 total, Nov 22 - Nov 23, Total with taxes and fees
- Review: Very accommodating hotel. Local restaurant right next to hotel was very convenient., by John, 16 days ago

### [7\. Holiday Inn Santee by IHG](https://www.expedia.com/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information)

![A water park with a pool, slides, and umbrellas.](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/9e3b16c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santee
- Guest rating: 8.2/10 (Very good, 1000 reviews)
- Price: $121 nightly, $134 total, Dec 13 - Dec 14, Total with taxes and fees
- Review: Great staff and really clean room!, by Traci, 25 days ago

### [8\. Ramada by Wyndham Santee I-95](https://www.expedia.com/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information)

![A hotel room with two beds, a desk, a chair, and a view of the hallway.](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/e4e30ce2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santee
- Guest rating: 6.4/10 (597 reviews)
- Review: This hotel was very clean. Our room was clean. The night clerk was personable., by Kathy, July 21st, 2026

### [9\. Quality Inn & Suites Santee I-95](https://www.expedia.com/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information)

![A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/cd0ca695.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santee
- Guest rating: 5.8/10 (618 reviews)
- Price: $59 nightly, $65 total, Dec 3 - Dec 4, Total with taxes and fees
- Review: It was very clean might need a few updates to the bathroom tho., by Clara, July 9th, 2026

### [10\. Travelodge by Wyndham Santee](https://www.expedia.com/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information)

![A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/28717b40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santee
- Guest rating: 7.2/10 (Good, 789 reviews)
- Price: $65 nightly, $72 total, Dec 2 - Dec 3, Total with taxes and fees
- Review: Extremely good value for money, room was clean, tidy and very well appointed., by Robert, October 6th, 2026

### [11\. Bells Marina & Resort](https://www.expedia.com/Eutawville-Hotels-Bells-Marina-Resort.h91244689.Hotel-Information)

![A tent with a view of a lake and boats, a wooden chair, and a potted plant.](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/caef79e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Eutawville
- Guest rating: 8.6/10 (Excellent, 103 reviews)
- Price: $75 nightly, $84 total, Nov 15 - Nov 16, Total with taxes and fees
- Review: Enjoyed our time there. On a beautiful cove of the lake., by Annette, September 30th, 2026

### [12\. Spark by Hilton Orangeburg](https://www.expedia.com/Orangeburg-Hotels-Spark-By-Hilton-Orangeburg.h1877930.Hotel-Information)

![A modern indoor pool area with a table and chairs, large windows, and a poolside lounge with sun loungers.](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3840h2556x0y4-5cb4ef80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Orangeburg
- Guest rating: 8/10 (Very good, 1004 reviews)
- Price: $89 nightly, $99 total, Nov 29 - Nov 30, Total with taxes and fees
- Review: Parking was convenient. The staff friendly. Shower had good water pressure., by Robert, 6 days ago

### [13\. Super 8 by Wyndham Santee/I-95](https://www.expedia.com/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information)

![A dining area with multiple tables and chairs, a ceiling fan, and large windows.](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2fd60881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santee
- Guest rating: 6.8/10 (477 reviews)
- Price: $64 nightly, $71 total, Nov 19 - Nov 20, Total with taxes and fees
- Review: The beds were pretty comfy. The room was clean., by Christalyn, May 18th, 2026

### [14\. Red Roof Inn Santee](https://www.expedia.com/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information)

![A cabin with a porch, surrounded by trees and a body of water.](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/bfe335ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santee
- Guest rating: 6.6/10 (668 reviews)
- Price: $63 nightly, $70 total, Nov 16 - Nov 17, Total with taxes and fees
- Review: Clean rooms and staff was great., by Tiffany, August 1st, 2026

### [15\. Tru by Hilton Orangeburg](https://www.expedia.com/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information)

![A modern interior with a dining area, seating, and a kitchen.](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/0ddcfc33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Orangeburg
- Guest rating: 9.2/10 (Wonderful, 1000 reviews)
- Price: $110 nightly, $122 total, Nov 29 - Nov 30, Total with taxes and fees
- Review: The hotel Nicky remodeled. Breakfast was very good., by Teresa, 5 days ago

### [16\. Econo Lodge Santee](https://www.expedia.com/Orangeburg-Hotels-Econo-Lodge.h905358.Hotel-Information)

![A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/6c8567ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santee
- Guest rating: 6.4/10 (317 reviews)
- Price: $63 nightly, $70 total, Dec 7 - Dec 8, Total with taxes and fees
- Review: Very clean room, fast staff, a lot of food spots nearby!, by Santiana

### [17\. Travelodge by Wyndham Orangeburg](https://www.expedia.com/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information)

![A breakfast bar with pastries, fruits, and a vase with flowers.](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/bfdc100f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Orangeburg
- Guest rating: 8.2/10 (Very good, 1000 reviews)
- Price: $67 nightly, $74 total, Nov 15 - Nov 16, Total with taxes and fees
- Review: Room was clean, bed was comfy, staff pleasant and friendly. Parking safe and large spots., by AMELIA, 11 days ago

### [18\. Fairfield Inn by Marriott Orangeburg](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information)

![A stone fireplace with a television mounted above it, a small statue on the mantel, and a wooden cabinet to the left.](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/ae964a26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Orangeburg
- Guest rating: 8.4/10 (Very good, 852 reviews)
- Price: $101 nightly, $112 total, Nov 23 - Nov 24, Total with taxes and fees
- Review: Staff is great. However , the facility needs a refresh., by Timothy, 16 days ago

### [19\. SureStay Hotel by Best Western Manning](https://www.expedia.com/Sumter-Hotels-SureStay-Hotel-By-Best-Western-Manning.h569301.Hotel-Information)

![A hotel room with two beds, a desk, a chair, and a mirror.](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/27faffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Manning
- Guest rating: 8.6/10 (Excellent, 1000 reviews)
- Price: $82 nightly, $91 total, Nov 29 - Nov 30, Total with taxes and fees
- Review: The room was very clean. Decided to add one night with the hotel., by JOSEPH, 4 days ago

### [20\. Hyatt Place Sumter / Downtown](https://www.expedia.com/Sumter-Hotels-Hyatt-Place-Sumter-Downtown.h22514748.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514748/6b1e007a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Sumter
- Guest rating: 9.2/10 (Wonderful, 988 reviews)
- Price: $143 nightly, $160 total, Nov 23 - Nov 24, Total with taxes and fees
- Review: Paris were great. What a great place. All of the staff was super helpful., by Kimberly, 24 days ago

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://www.expedia.com/Hotel-Search?startDate=2026-11-27&endDate=2026-11-28&regionId=9953&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Where to stay near Santee

Santee, South Carolina, offers a delightful mix of outdoor adventures and scenic beauty. Enjoy stunning waterfront views from beautiful lake condos, explore top locations nearby, and shop at local super stores. With its friendly atmosphere, Santee is perfect for romance, family vacations, and relaxation.

- [Vance](#)
- [Summerton](#)
- [Elloree](#)
- [Eutawville](#)
- [Providence](#)

![A river with a dam and a bridge, surrounded by greenery and fields.](https://images.trvl-media.com/place/3000456153/853d0648-5ca3-4a52-8d03-1e972c294c7d.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[View properties in map for Vance](https://www.expedia.com/Hotel-Search?pwaOverlay=map&regionId=3000456153)

### Vance

For outdoor enthusiasts and families looking for a memorable trip, Vance offers a perfect blend of adventure and relaxation. Nestled about 5 miles by car from Santee, this charming city features attractions like Santee State Park, where you can explore nature trails and enjoy stunning lake views. Golf lovers will appreciate the nearby golf course, while romantic spots like Pine Island provide a serene escape. Vance is a smart choice for travelers seeking a budget-friendly getaway with plenty of scenic beauty.

[See properties](https://www.expedia.com/Hotel-Search?regionId=3000456153)

![A calm lake with three trees with autumn foliage.](https://images.trvl-media.com/place/163488/b1951fd9-99a5-4db4-b561-cc653e87c4e2.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by Charles Arcudi

[View properties in map for Summerton](https://www.expedia.com/Hotel-Search?pwaOverlay=map&regionId=163488)

### Summerton

Experience the charm of Summerton, a perfect escape for families and budget-conscious travelers who want to immerse themselves in nature. This inviting city offers easy access to stunning spots like Santee State Park, Lake Marion, and Goat Island, ideal for outdoor adventures and scenic views. Located about 11 miles by car from Santee, Summerton makes for a convenient base to explore the area. Book your stay here for a memorable getaway that combines relaxation and recreation.

[See properties](https://www.expedia.com/Hotel-Search?regionId=163488)

[View properties in map for Elloree](https://www.expedia.com/Hotel-Search?pwaOverlay=map&regionId=3000455923)

### Elloree

If you are a nature-loving family traveler, look no further than Elloree, which features beautiful outdoor scenery and engaging activities. Here, you can explore the stunning landscapes of Santee State Park, delve into local history at the Elloree Heritage Museum and Cultural Center, or enjoy a peaceful day at the Orangeburg County Library Mentor Branch. Located about 6 miles by car from Santee, Elloree is a smart choice for a memorable getaway.

[See properties](https://www.expedia.com/Hotel-Search?regionId=3000455923)

![A calm lake with several trees standing in the water.](https://images.trvl-media.com/place/10546/8cdd9cf0-9105-4e04-9424-e8f3081b5d7f.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[View properties in map for Eutawville](https://www.expedia.com/Hotel-Search?pwaOverlay=map&regionId=3000455924)

### Eutawville

Ideally situated for families and nature enthusiasts, Eutawville offers a charming escape just about 10 miles by car from Santee. Visitors can enjoy the scenic beauty of Lake Marion, explore the trails at Santee State Park, and relax on the shores of Pine Island. With outdoor activities and serene landscapes, Eutawville ensures a refreshing getaway throughout the year. Choosing Eutawville for your stay promises a delightful blend of adventure and relaxation for every traveler.

[See properties](https://www.expedia.com/Hotel-Search?regionId=3000455924)

[View properties in map for Providence](https://www.expedia.com/Hotel-Search?pwaOverlay=map&regionId=553248635975849205)

### Providence

Travelers seeking a family-friendly getaway will find Providence to be the ideal base for their vacation, featuring a picturesque village atmosphere with easy access to outdoor activities and scenic spots. With attractions like Santee State Park, the local marina, and the Elloree Heritage Museum and Cultural Center, visitors can immerse themselves in nature and culture. Located about 12 miles by car from Santee, Providence offers a convenient retreat for anyone looking to unwind and explore the beauty of South Carolina.

[See properties](https://www.expedia.com/Hotel-Search?regionId=553248635975849205)

## Stay near popular Santee attractions

Discover the charm of Santee, SC, where outdoor adventures await at Santee State Park. Immerse yourself in stunning scenery, romantic lakeside strolls, and the beauty of nearby islands. Whether you're seeking relaxation or adventure, Santee offers the perfect getaway for every traveler.

### Lake Marion
![A long bridge over a calm body of water with a clear sky.](https://images.trvl-media.com/place/6140630/534c7087-37b1-44f4-a788-fb66ba417ff9.jpg?impolicy=fcrop&w=960&h=640&p=1&q=medium)

Rating: 8.2/10 (225 reviews)

Considered a premier spot for romance and outdoor enthusiasts, Lake Marion offers stunning scenery and relaxing beach vibes. Located about 16 miles from Santee, this picturesque destination provides a perfect getaway for nature lovers. Staying near Lake Marion allows easy access to its tranquil waters and beautiful surroundings.

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6140630)

### Pine Island
![A beach with a tree casting a shadow, a sandy shore, and a body of water in the background.](https://images.trvl-media.com/place/911206190552551424/bf4a7588-c635-4b56-8d75-7f7514d2bbd6.jpg?impolicy=fcrop&w=960&h=640&p=1&q=medium)

A must-see for outdoor lovers, Pine Island offers a serene escape with its beautiful beach vibes and natural landscapes. Located about 12 miles by car from Santee, this island provides easy access for visitors looking to relax or explore the great outdoors, making it an ideal spot for your vacation.

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=911206190552551424)

### Santee State Park

Rating: 8.0/10 (219 reviews)

Set the stage for your outdoor adventure at Santee State Park, a haven for nature lovers and recreational seekers. With stunning scenery and a range of activities, this park invites you to explore its beautiful landscapes. Conveniently located within Santee, it makes for an ideal base to enjoy everything the area has to offer.

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6140632)

### Santee Indian Mound and Fort Watson Site

Ideal for history buffs, Santee Indian Mound and Fort Watson Site offers a glimpse into the region's rich Native American heritage. Located about 6 miles by car from Santee, this cultural site invites exploration of its historical significance, making it a convenient stop during your visit.

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=908645736573743104)

### Taw Caw Creek

Rating: 6.6/10 (4 reviews)

Ideal for travelers interested in outdoor adventures, Taw Caw Creek offers stunning scenery and a romantic atmosphere perfect for relaxation. Located about 15 miles by car from Santee, this beautiful lake provides a serene escape, making it a convenient spot to unwind during your visit.

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248635976195616)

### Santee Town Hall

Discover the appeal of Santee Town Hall, a hub for visitors interested in local governance and community vibes. This town hall, located in the heart of Santee, offers a glimpse into the town's business and civic life. Staying nearby provides easy access to local attractions and amenities.

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=911209496341475328)

### Elloree Heritage Museum and Cultural Center

A fascinating mix of history and culture awaits visitors at the Elloree Heritage Museum and Cultural Center. Located about 6 miles by car from Santee, this museum offers a unique glimpse into local heritage and traditions, making it a convenient stop for those exploring the area.

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=911208868024246272)

### Orangeburg County Library Mentor Branch

Perfectly suited for families and culture seekers, the Orangeburg County Library Mentor Branch offers a welcoming environment with enriching resources and community events. Located about 6 miles by car from Santee, this library is a great stop for a leisurely visit, making it easy to incorporate into your travel plans.

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=911209797387653120)

## Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campgrounds.

[See all hotels in Santee](https://www.expedia.com/Hotel-Search?startDate=2026-11-27&endDate=2026-11-28&adults=2&regionId=9953)

![A tree with Spanish moss and autumn leaves in a body of water.](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=899&h=634&p=1&q=high)

## Top Santee Hotel Reviews

### [Fairfield Inn & Suites by Marriott Santee](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information)

![A patio area with wicker furniture, a stone fire pit, and outdoor seating.](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: 9074 Old Number Six Hwy, Santee, SC, 29142, US
- Location: Santee
- Star rating: 3/5
- Guest rating: 9.8/10 (1001 reviews)
- Review: Choose this hotel for a pet-friendly stop-over on our drive to Florida and had a great experience. This staff was super-friendly and this nearly-brand-new property was immaculate. They have us a great 1st floor room with easy access to the walking and parking area. We took advantage of the patio to have dinner (take-out from a local restaurant) and breakfast with our dog. The breakfast was excellent, including hot omelets, eggs, and sausage, and the 6 am start (on a Sunday) allowed us to get..., by Douglas, September 18, 2023, rated 10/10 Excellent

### [Hampton Inn Santee-I-95](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information)

![A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/d82e6496.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: 9060 Old Number Six Hwy, Santee, SC, 29142, US
- Location: Santee
- Star rating: 2.5/5
- Guest rating: 9.6/10 (1001 reviews)
- Review: Great stop-over on trips up I-95\. Friendly staff, lots of mowed, open spaces for dog walking. Highly recommend, by Michael, June 6, 2024, rated 10/10 Excellent

### [Tru By Hilton Santee](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information)

![A breakfast area with a self-service counter, refrigerated display, and a digital menu board.](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: 263 Britain St. and 273 Britain St., Santee, SC, 29142, US
- Location: Santee
- Star rating: 2.5/5
- Guest rating: 9.2/10 (1017 reviews)
- Review: Great common area with couches and games for the kids so we weren't stuck in the room. Very clean and comfortable. Very friendly employees!, by Rebecca, July 8, 2024, rated 10/10 Excellent

### [Hampton Inn & Suites Orangeburg](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Suites-Orangeburg.h9854604.Hotel-Information)

![A Hampton Inn & Suites hotel with a modern design, featuring a parking lot and a well-lit entrance.](https://images.trvl-media.com/lodging/10000000/9860000/9854700/9854604/637dd914.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Orangeburg
- Review: Great hotel! Right off the interstate, quiet, clean, great staff. Would definitely recommend., by Kevin, November 28, 2016, rated 10/10 Excellent

### [Best Western Plus Santee Inn](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information)

![A hotel entrance with a sign reading "Best Western PLISS."](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: I 95 Exit 98, Santee, SC, 29142, US
- Location: Santee
- Star rating: 2.5/5
- Guest rating: 8.8/10 (1000 reviews)
- Review: Great property, clean rooms, nice staff, and we were able to accommodate me and a motorcycle trailer. As far as the room, it was immaculate as far as peacefulness to sleep it was great in the bed and pillows. I wish I could’ve taken them home with me., by Richard, December 9, 2023, rated 10/10 Excellent

### [Bells Marina & Resort](https://www.expedia.com/Eutawville-Hotels-Bells-Marina-Resort.h91244689.Hotel-Information)

![A tent with a view of a lake and boats, a wooden chair, and a potted plant.](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/caef79e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: 12907 Old Number Six Hwy, Eutawville, SC, 29048, US
- Location: Eutawville
- Star rating: 2.5/5
- Guest rating: 8.6/10 (103 reviews)
- Review: Enjoyable stay with very clean comfortable accommodations. Owner and workers were helpful and friendly. Will recommend to others., by Jack, July 31, 2023, rated 10/10 Excellent

### [SureStay Hotel by Best Western Manning](https://www.expedia.com/Sumter-Hotels-SureStay-Hotel-By-Best-Western-Manning.h569301.Hotel-Information)

![A hotel room with two beds, a desk, a chair, and a mirror.](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/27faffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: 2816 Paxville Highway, Manning, SC, 29102, US
- Location: Manning
- Star rating: 2.5/5
- Guest rating: 8.6/10 (1000 reviews)
- Review: Coming off I-95 the property is on the left with a narrow entrance sandwiched between a Hampton Inn and a Wendy’s exit. I missed it the first time. I’m not sure whether this is a new property or an old motel that was renovated and rebranded as a Best Western hotel. In any case it is well maintained and attractive. It’s a couple of miles from downtown Manning so eating options are basically fast food. Breakfast buffet was OK. Good value., by Anonymous traveler, August 24, 2024, rated 10/10 Excellent

### [Holiday Inn Express & Suites Orangeburg by IHG](https://www.expedia.com/Orangeburg-Hotels-Holiday-Inn-Express-Hotel-Suites-Orangeburg.h597750.Hotel-Information)

![A Holiday Inn Express & Suites hotel with a prominent sign, a central entrance, and a symmetrical facade.](https://images.trvl-media.com/lodging/1000000/600000/597800/597750/c596ba00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Orangeburg
- Review: The roadway coming into the hotel is in rough shape. Been this way for years., by Deborah, February 13, 2024, rated 10/10 Excellent

### [Baymont by Wyndham Santee](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information)

![A hotel room with a bed, bedside table, lamp, and a mirror.](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/d2da67e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: 249 Britain Street, Santee, SC, 29142, US
- Location: Santee
- Star rating: 2.5/5
- Guest rating: 8/10 (1513 reviews)
- Review: The staff were efficient. The room was spacious and good for one night stop, by Angel, October 26, 2024, rated 10/10 Excellent

### [Holiday Inn Santee by IHG](https://www.expedia.com/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information)

![A water park with a pool, slides, and umbrellas.](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/9e3b16c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: 139 Bradford Blvd, Santee, SC, 29142-8932, US
- Location: Santee
- Star rating: 3/5
- Guest rating: 8.2/10 (1000 reviews)
- Review: I love this place! They are always so friendly and my two kitties get to stay with me., by Catherine, June 21, 2015, rated 10/10 Excellent

### [Fairfield Inn by Marriott Orangeburg](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information)

![A stone fireplace with a television mounted above it, a small statue on the mantel, and a wooden cabinet to the left.](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/ae964a26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: 663 Citadel Road, Orangeburg, SC, 29118-9720, US
- Location: Orangeburg
- Star rating: 3/5
- Guest rating: 8.4/10 (852 reviews)
- Review: Was nice place to stay. Breakfast was excellent and your staff was great at breakfast and at front desk upon our arrival., by Barry, February 28, 2023, rated 10/10 Excellent

### [Comfort Inn & Suites Santee](https://www.expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information)

![A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/fc94b516.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: 221 Britain St, Santee, SC, 29142, US
- Location: Santee
- Star rating: 2.5/5
- Guest rating: 8/10 (1000 reviews)
- Review: Comfortable clean and convenient. Would stay here again., by Doug, May 2, 2023, rated 10/10 Excellent

### [Hampton Inn Manning](https://www.expedia.com/Sumter-Hotels-Hampton-Inn-Manning.h1418684.Hotel-Information)

![A hotel lobby with multiple seating areas, a reception desk, and a television.](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/c2c672f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Manning
- Review: I spent a night at the hotel and i really like the place. The room is clean and comfortable and it has all the amenities you can ask for, by Anonymous traveler, January 23, 2017, rated 10/10 Excellent

### [Comfort Inn & Suites Orangeburg](https://www.expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites.h1990272.Hotel-Information)

![A hotel room with two beds, a desk, and a chair. There are wall-mounted lamps and a large window with curtains.](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990272/2dd4e6c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Orangeburg
- Review: Traveled from Florida to get our grandchildren from Pa. This was the "halfway point". Our room was clean, comfortable, and the kids loved the pool, The breakfast was excellent. The staff was very friendly. We will be staying here again in a couple weeks when we return the kids!, by Ken, June 5, 2015, rated 10/10 Excellent

### [Travelodge by Wyndham Santee](https://www.expedia.com/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information)

![A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/28717b40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: 9117 Old Number Six Hwy, Santee, SC, 29142, US
- Location: Santee
- Star rating: 2/5
- Guest rating: 7.2/10 (789 reviews)
- Review: Quick stop on the way to my home in Florida. Bed was comfortable, TV worked, refrigerator worked, water was hot, shower was good, coffee pot worked. WiFi worked, parking right outside your door. Santee is a quiet town, so I felt safe. Got a bagel with cream cheese for breakfast, had other things available., by Laurie, December 2, 2023, rated 10/10 Excellent

## Find out more about Santee

### Top reasons to visit Santee

- **Outdoor Recreation:**  Santee offers a variety of outdoor activities, from hiking scenic trails to fishing in picturesque lakes.
- **Golfing Paradise:**  Play at scenic golf courses surrounded by beautiful landscapes, perfect for enthusiasts of all skill levels.
- **Romantic Getaways:**  Ideal for couples, Santee provides a peaceful atmosphere for a romantic retreat amidst nature.
- **Family-Friendly Atmosphere:**  With budget-friendly accommodations and activities, Santee is great for family vacations.
- **Charming Local Community:**  Enjoy the friendly locals and explore nearby parks, adding to the authentic experience.

### Find great hotels in and around Santee

Discover a variety of hotel accommodations in Santee, South Carolina, perfect for all types of travelers. Whether you're seeking a cozy motel, a pet-friendly hotel, or a welcoming space for LGBTQIA visitors, Santee has options to meet your needs. Enjoy convenient amenities ideal for business travel and leisure alike, making your stay comfortable and enjoyable. Explore the best hotels and suites in Santee for a memorable getaway.

- **[Baymont by Wyndham Santee: ](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information)** A budget-friendly hotel with a guest rating of 8.0, Baymont by Wyndham Santee is perfect for travelers seeking a comfortable and pet-friendly stay. Located in Santee, this hotel caters to both leisure and business travelers, making it an ideal choice for those who need to mix work with relaxation. Guests can enjoy amenities like complimentary breakfast and Wi-Fi, while pets are welcome with certain restrictions. The hotel's welcoming atmosphere and convenient location make it a solid choice for your stay.
- **[Fairfield Inn by Marriott Orangeburg: ](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information)** With a guest rating of 8.4, Fairfield Inn by Marriott Orangeburg is situated 19 miles from Santee, providing a great option for business travelers. This budget-friendly hotel emphasizes comfort and convenience, featuring spacious rooms equipped with modern amenities. Guests can take advantage of complimentary breakfast and high-speed internet access, ensuring they are well-fed and connected throughout their stay. The hotel’s professional staff is dedicated to making your visit enjoyable and productive.
- **[Best Western Plus Santee Inn: ](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information)** Boasting a guest rating of 8.8, Best Western Plus Santee Inn is another excellent budget-friendly option located in Santee. This hotel combines business travel needs with a pet-friendly environment, allowing guests to bring their furry companions along. With amenities like a dog exercise area, complimentary breakfast, and free Wi-Fi, guests will find everything they need for a comfortable stay. The friendly staff and convenient location make it a top choice for both relaxation and productivity.

### Where to stay near Santee

Santee, South Carolina, is a hidden gem for outdoor enthusiasts and families alike. With its picturesque lakes and scenic trails, visitors can immerse themselves in nature's beauty. The friendly atmosphere and budget-friendly options make it an ideal spot for a romantic getaway or a fun family vacation. Explore nearby campgrounds for an authentic experience, and enjoy the perfect trip to Santee filled with unforgettable excursions and friendly locals.

- **[Summerton: ](https://www.expedia.com/Summerton-Hotels.d163488.Travel-Guide-Hotels)** Located 11 miles from Santee, Summerton is a charming city that attracts visitors year-round, with peak travel periods in March to April and July. Known for its stunning outdoor scenery, this destination is perfect for those seeking a romantic getaway or outdoor adventures. Enjoy activities such as golfing and exploring the local recreational areas. Summerton's proximity to beautiful lakes, a national state park, and picturesque islands makes it an ideal spot for nature enthusiasts and those looking to unwind in serene surroundings.
- **[Vance: ](https://www.expedia.com/Vance-Hotels.d3000456153.Travel-Guide-Hotels)** Just 5 miles from Santee, Vance is a delightful city that experiences high seasonal travel, particularly in March to April and July. This area is well-loved for its outdoor spaces and scenic beauty, making it a great destination for couples and adventure seekers alike. Visitors can take advantage of the local golf courses and recreational areas, while the nearby beach and national state park offer additional opportunities for exploration and relaxation. Vance is a hidden gem that promises a refreshing escape from the everyday hustle.
- **[Elloree: ](https://www.expedia.com/Elloree-Hotels.d3000455923.Travel-Guide-Hotels)** Situated 6 miles away from Santee, Elloree is a quaint city that enjoys a steady flow of visitors throughout the year, with peak times in March, July, and September. This city is ideal for those who appreciate outdoor activities and beautiful landscapes. Golf enthusiasts will find plenty of options, while the local recreational areas provide ample opportunities for leisure. Elloree is also conveniently located near a lake, national state park, and urban park, making it a perfect base for exploring the natural beauty of the region.

### Things to do in Santee

Santee, South Carolina, is perfect for outdoor enthusiasts and couples seeking a romantic getaway. Visitors can enjoy a variety of activities, including exploring recreational areas and playing golf at scenic courses. With its beautiful landscapes and engaging outdoor options, Santee promises an enjoyable vacation experience for all types of travelers.

**Shopping**

Santee offers unique shopping experiences at local shops and the Santee Outlets, where you can find discounts on brand-name merchandise. If you're up for a drive, head to the nearby town of Summerton for charming boutiques and specialty stores that feature handmade gifts and local crafts.

**Recreation**

In Santee, the Santee Cooper Resort provides a serene escape with wellness activities like yoga classes and nature walks along scenic trails. The Santee State Park offers peaceful surroundings and opportunities for fishing, hiking, and birdwatching, allowing you to reconnect with nature and rejuvenate your spirit.

**Adventure**

Explore Lake Marion for thrilling boating and fishing adventures. Enjoy kayaking through tranquil waters and spot local wildlife. For hiking enthusiasts, the Santee State Park trails offer scenic views and a chance to connect with nature.

**Nightlife**

Experience the lively atmosphere at the Santee Sports Bar, where you can enjoy a game on the big screen and grab a cold beer. For a more relaxed vibe, visit the Lake Marion Pub for some live music and a friendly crowd.

*\*Distances are measured in a straight line; actual driving distances may vary depending on the route.*

### Booking tips and Expedia advantages for Santee

- **The most and least expensive months on average to stay in a hotel:**  The cheapest months to stay in Santee are December to February, where the prices are slightly lower. This is in comparison to May and October to November, where prices are slightly higher.
- **The most and least expensive days on average to stay in a hotel:**  The least expensive day to stay in Santee is Monday. The most expensive day to stay in Santee is Saturday.
- **Find cheap hotels on Expedia:**  Utilize Expedia’s search tool to customize your preferences, such as budget, desired location, and the type of hotel you’re looking for. To find the best prices and deals, be sure to sort the price filter from lowest to highest.
- **Consider bundling your trip:**  You can save money by combining your Santee hotel reservation with your flights and activities by booking a package through Expedia.

### Find the best attractions in and around Santee

Santee, South Carolina, is perfect for outdoor enthusiasts and those seeking a romantic getaway, offering beautiful scenery and recreational activities. Visitors can explore nearby national and state parks, picturesque islands, and serene lakes, making it an ideal destination for those wanting to immerse themselves in nature. Whether you're looking to relax on the beach or embark on scenic adventures, Santee has something for everyone to enjoy.

- **[Taw Caw Creek: ](https://www.expedia.com/Taw-Caw-Creek-Hotels.0-l553248635976195616-0.Travel-Guide-Filter-Hotels)** Located 9 miles from Santee, Taw Caw Creek offers a picturesque setting perfect for outdoor activities. Enjoy its serene beach, romantic vibes, and stunning scenery while swimming, fishing, or simply relaxing by the water.
- **[Santee Indian Mound and Fort Watson Site: ](https://www.expedia.com/Santee-Indian-Mound-And-Fort-Watson-Site-Hotels.0-l908645736573743104-0.Travel-Guide-Filter-Hotels)** Just 4 miles away from Santee, this cultural site provides a fascinating glimpse into the area's history. Explore the ancient Indian mound and learn about the historic Fort Watson, making for an enriching experience.
- **[Santee State Park: ](https://www.expedia.com/Santee-State-Park-Hotels.0-l6140632-0.Travel-Guide-Filter-Hotels)** Situated within Santee, Santee State Park is a haven for adventure seekers. With its beautiful landscapes and outdoor activities like hiking and camping, it's ideal for those looking to immerse themselves in nature.

### Best time to go to Santee

The best time to visit Santee is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are slightly high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

| **Calendar Month** | **Temperature** | **Precipitation** | **Cloudiness** | **Occupancy** | **Pricing**   |
| ------------------ | --------------- | ----------------- | -------------- | ------------- | ------------- |
| January            | 47.3°F (8.5°C)  | Light Rain        | Mostly Sunny   | Average       | Slightly Low  |
| February           | 51.4°F (10.8°C) | Light Rain        | Mostly Sunny   | Average       | Slightly Low  |
| March              | 56.8°F (13.8°C) | Light Rain        | Mostly Sunny   | Slightly High | Average       |
| April              | 64.4°F (18.0°C) | Light Rain        | Mostly Sunny   | Slightly High | Average       |
| May                | 72.0°F (22.2°C) | Light Rain        | Mostly Sunny   | Average       | Slightly High |
| June               | 78.6°F (25.9°C) | Light Rain        | Mostly Sunny   | Average       | Average       |
| July               | 81.5°F (27.5°C) | Light Rain        | Mostly Sunny   | Slightly High | Average       |
| August             | 79.9°F (26.6°C) | Light Rain        | Mostly Sunny   | Average       | Average       |
| September          | 75.4°F (24.1°C) | Light Rain        | Mostly Sunny   | Average       | Average       |
| October            | 66.4°F (19.1°C) | Light Rain        | Mostly Sunny   | Slightly Low  | Slightly High |
| November           | 56.1°F (13.4°C) | Light Rain        | Mostly Sunny   | Slightly Low  | Slightly High |
| December           | 51.3°F (10.7°C) | Light Rain        | Mostly Sunny   | Slightly Low  | Slightly Low  |

### The nearest major airports for your trip to Santee

When planning your trip to Santee, South Carolina, you have several airport options. Charleston International Airport ([CHS](https://www.expedia.com/Charleston-Intl-Airport-Hotels.0-aCHS-0.Travel-Guide-Filter-Hotels)) is located 49 miles away, with nearby luxury hotels such as [The Charleston Place](https://www.expedia.com/Charleston-Hotels-Charleston-Place.h28504.Hotel-Information), [Hotel Bennett](https://www.expedia.com/Charleston-Hotels-Hotel-Bennett.h22649862.Hotel-Information), and [The Dewberry Charleston](https://www.expedia.com/Charleston-Hotels-The-Dewberry-Charleston.h12880056.Hotel-Information), all offering convenient transportation services. [MYR](https://www.expedia.com/Myrtle-Beach-Intl-Airport-Hotels.0-aMYR-0.Travel-Guide-Filter-Hotels)tle Beach International Airport (MYR), situated 90 miles from Santee, has excellent accommodations like Hilton Grand Vacations Club Ocean Enclave and [DoubleTree Resort by Hilton Myrtle Beach Oceanfront](https://www.expedia.com/Myrtle-Beach-Hotels-DoubleTree-Resort-By-Hilton-Myrtle-Beach.h845521.Hotel-Information), ensuring easy access to the airport. Lastly, Columbia Metropolitan Airport ([CAE](https://www.expedia.com/Columbia-Metropolitan-Airport-Hotels.0-aCAE-0.Travel-Guide-Filter-Hotels)) is also 49 miles away, with quality hotels including Graduate by Hilton Columbia and [Doubletree by Hilton Columbia](https://www.expedia.com/Columbia-Hotels-Doubletree-By-Hilton-Columbia.h1090.Hotel-Information), providing accessible transportation to the airport.

## Frequently Asked Questions

### What is the best area to stay in Santee?

The best area to stay in Santee is along the US-15 and US-301 corridors, particularly around the Santee National Wildlife Refuge.

This area is the primary hub for visitors, offering easy access to Lake Marion and several golf courses. Hotels here are conveniently located near local restaurants and shops, making it a practical base for exploring the region.

For couples looking for a relaxing getaway, staying near the Santee National Wildlife Refuge offers a quiet setting with opportunities for birdwatching and enjoying nature. Many accommodations in this vicinity provide pleasant views and direct access to outdoor activities.

Golf enthusiasts will find the hotels along the US-15 and US-301 corridors ideal.

### What are the best hotels in Santee that travelers recommend?

Two highly recommended hotels in Santee are the [Best Western Plus Santee Inn](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) and the [Holiday Inn Santee by IHG](https://www.expedia.com/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information).

The Best Western Plus Santee Inn, with an 8.8 rating, is praised by guests for its nice, clean rooms and comfortable beds. Travelers also appreciate the delicious complimentary continental breakfast and good amenities, including an outdoor pool and private indoor hot tub. It is conveniently located near Santee State Park, just 3.2 miles away.

Another excellent choice is the 3-star Holiday Inn Santee by IHG, which has an 8.2 rating. Guests frequently mention the clean, quiet rooms and comfortable beds, as well as the friendly and helpful staff. The hotel features an indoor pool and offers room service, making it a convenient stay. It is also located close to Santee State Park, approximately 2.9 miles away.

### What are the best family hotels in Santee?

For family-friendly hotels in Santee, consider the [Fairfield Inn & Suites by Marriott Santee](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information), the [Hampton Inn Santee-I-95](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information), or the [Holiday Inn Santee by IHG](https://www.expedia.com/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information).

The Fairfield Inn & Suites by Marriott Santee, with an exceptional 9.8 rating, is highly regarded by families. Guests praise the excellent and friendly staff, comfortable and clean rooms, and a great complimentary buffet breakfast. The hotel offers a pool, highchairs, cribs, and sofa beds, making it well-suited for families. Santee State Park is conveniently located just 3.3 miles away.

Another excellent option for families is the Hampton Inn Santee-I-95, boasting a 9.6 rating. This hotel features a pool, sofa beds, and complimentary cribs and rollaway beds. Travelers frequently highlight the friendly and helpful staff, comfortable and clean rooms, and a delicious breakfast. It is also located just 3.3 miles from Santee State Park.

The 3-star Holiday Inn Santee by IHG, rated 8.2, provides amenities such as connecting rooms, a pool, and complimentary cribs and sofa beds. Guests often comment on the clean and quiet rooms, friendly and helpful staff, and comfortable beds. Free WiFi and self-parking are also available. Santee State Park is a short 2.9 miles from the hotel. Find more [child-friendly accommodations in Santee](https://www.expedia.com/Santee-Hotels-Family-Hotel.0-0-d9953-tFamilyHotel.Travel-Guide-Filter-Hotels)

### What hotels in Santee offer free breakfast?

For hotels in Santee that offer complimentary breakfast, consider the [Fairfield Inn & Suites by Marriott Santee](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information), [Hampton Inn Santee-I-95](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information), [Tru By Hilton Santee](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information), [Best Western Plus Santee Inn](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information), or [Baymont by Wyndham Santee](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information).

The 3-star Fairfield Inn & Suites by Marriott Santee boasts an impressive 9.8 rating and offers free buffet breakfast, along with free WiFi and free self-parking. Guests consistently praise the excellent and friendly staff, comfortable and clean rooms, and a great location. It is also conveniently located just 3.3 miles from Santee State Park.

Another excellent option is the 3-star Hampton Inn Santee-I-95, which has a 9.6 rating. This hotel provides free breakfast and free WiFi, and guests frequently mention the friendly and helpful staff, comfortable and clean rooms, and delicious breakfast. It is also 3.3 miles from Santee State Park.

The Tru By Hilton Santee, with a 9.2 rating, is a 3-star hotel that features free buffet breakfast, free WiFi, and free self-parking. Travelers often highlight the nice and clean rooms, friendly and helpful staff, and excellent breakfast. This hotel is located 3.0 miles from Santee State Park.

The 3-star Best Western Plus Santee Inn, rated 8.8, offers complimentary continental breakfast, free WiFi, and free self-parking. Guests appreciate the nice and clean rooms, delicious free breakfast, and comfortable beds. Santee State Park is 3.2 miles away.

Finally, the Baymont by Wyndham Santee, with an 8.0 rating, provides free continental breakfast, free WiFi, and free self-parking. Reviewers often mention the nice and clean rooms, amazing staff, and great value. It is situated 3.0 miles from Santee State Park. Find more [hotels with free breakfast in Santee](https://www.expedia.com/Santee-Hotels-Hotels-With-Complimentary-Breakfast.0-0-d9953-tHotelswithComplimentaryBreakfast.Travel-Guide-Filter-Hotels)

### What are the top pet-friendly hotels in Santee?

For top pet-friendly hotels in Santee, consider the [Fairfield Inn & Suites by Marriott Santee](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) or the [Holiday Inn Santee by IHG](https://www.expedia.com/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information).

The Fairfield Inn & Suites by Marriott Santee, with an impressive 9.8 rating, is an excellent choice for travelers with pets. Guests consistently praise the excellent and friendly staff, comfortable and clean rooms, and a great location. It also features a dedicated dog exercise area, making it very convenient for pet owners. Santee State Park is just 3.3 miles away, offering outdoor activities for you and your pet.

Another great option is the 3-star Holiday Inn Santee by IHG, rated 8.2\. This hotel is known for its clean and quiet rooms and friendly, helpful staff. Guests frequently mention the comfortable beds and the nice on-site bar. Santee State Park is conveniently located just 2.9 miles from the hotel. See more [pet-friendly hotels in Santee](https://www.expedia.com/Santee-Hotels-Pet-Friendly-Hotel.0-0-d9953-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)

### What are the best budget hotels in Santee?

For the best budget hotels in Santee, consider the [Fairfield Inn & Suites by Marriott Santee](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) and the [Baymont by Wyndham Santee](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information).

The Fairfield Inn & Suites by Marriott Santee stands out with an exceptional 9.8 rating. Guests frequently praise the excellent and friendly staff, the comfortable and clean rooms, and the great breakfast options, including a complimentary buffet. It also offers free WiFi and convenient self-parking, making it a great choice for travelers. Santee State Park is just 3.3 miles away.

Another highly-rated option is the Baymont by Wyndham Santee, which has a solid 8.0 rating. Customers often mention the nice and clean rooms, the amazing staff, and the comfortable beds. A complimentary continental breakfast is provided, along with free WiFi and free self-parking. This hotel is located just 3.0 miles from Santee State Park. View all [budget hotels in Santee](https://www.expedia.com/Santee-Hotels-Cheap-Hotels.0-0-d9953-tCheapHotels.Travel-Guide-Filter-Hotels)

### What are the most romantic hotels in Santee for couples?

For romantic hotels in Santee for couples, consider the [Best Western Plus Santee Inn](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) or the [Waterfront Condo on Lake Marion](https://www.expedia.com/Santee-Hotels-Spacious-Condo-On-Beautiful-Lake-Marion.h102018216.Hotel-Information).

The 3-star Best Western Plus Santee Inn, with an 8.8 rating, offers comfortable and clean rooms with a complimentary continental breakfast. Guests frequently praise the helpful front desk staff and the super comfortable beds. For a romantic touch, this hotel features private indoor hot tubs. It is also conveniently located adjacent to the Santee Cooper Country Club.

Alternatively, the Waterfront Condo on Lake Marion, with an exceptional 10.0 rating, provides a more private and scenic romantic experience. This accommodation boasts stunning water views of Lake Marion and features a patio, great for enjoying the surroundings. It's also well-suited for couples who enjoy golf, with a golf course located nearby.

### What are the best hotels in Santee near Santee State Park?

For hotels in Santee near Santee State Park, the [Fairfield Inn & Suites by Marriott Santee](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) and the [Hampton Inn Santee-I-95](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) are excellent choices.

The Fairfield Inn & Suites by Marriott Santee has an outstanding 9.8 rating. Guests consistently praise the excellent and friendly staff, comfortable and clean rooms, and a great breakfast with free buffet options. It is located just 3.3 miles from Santee State Park and offers amenities like a pool, highchairs for children, and cribs, making it suitable for families.

Another highly-rated option is the Hampton Inn Santee-I-95, with a 9.6 rating. This hotel is also 3.3 miles from Santee State Park and features a pool, free cribs, and complimentary breakfast. Guests frequently mention the friendly and helpful staff, comfortable and clean rooms, and delicious breakfast.

The [Tru By Hilton Santee](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information), rated 9.2, is another great option, located 3.0 miles from the park. Guests appreciate the nice and clean rooms, friendly and helpful staff, and excellent complimentary breakfast.

The [Best Western Plus Santee Inn](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information), with an 8.8 rating, is 3.2 miles from Santee State Park. It offers a pool, free continental breakfast, and comfortable beds. Guests highlight the nice and clean rooms and delicious free breakfast.

Finally, the 3-star [Holiday Inn Santee by IHG](https://www.expedia.com/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information), rated 8.2, is the closest to the park at 2.9 miles. This hotel provides a pool, free cribs, and comfortable beds. Guests often comment on the clean and quiet rooms and the friendly and helpful staff.

### Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santee.

### How much is the nightly rate at a Santee hotel?

Prices for hotels in Santee often vary, but you can find a great deal from $65 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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