$465 Cheap Flights from Lyon (LYS) to San Francisco (SFO)

View $465 flight on Mon, Sep 22, 2025Opens in a new window

Popular airlines from Saint-Exupery Airport (LYS) to San Francisco Intl. Airport (SFO)

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Cheap Flights from Lyon to San Francisco (LYS-SFO)

Prices were available within the past 7 days and start at $465 for one-way flights and $523 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

TAP Portugal
Thu, Aug 21 - Wed, Sep 3
LYS
Lyon
SFO
San Francisco
$523 Roundtrip, found 6 hours ago
$523
Roundtrip
found 6 hours ago
Select TAP Portugal flight, departing Thu, Aug 21 from Lyon to San Francisco, returning Wed, Sep 3, priced at $523 found 6 hours ago
TAP Portugal
Thu, Aug 21 - Wed, Sep 3
LYS
Lyon
SFO
San Francisco
$552 Roundtrip, found 6 hours ago
$552
Roundtrip
found 6 hours ago
Select TAP Portugal flight, departing Thu, Aug 21 from Lyon to San Francisco, returning Wed, Sep 3, priced at $552 found 6 hours ago
TAP Portugal
Thu, Aug 21 - Mon, Sep 1
LYS
Lyon
SFO
San Francisco
$554 Roundtrip, found 3 days ago
$554
Roundtrip
found 3 days ago
Select TAP Portugal flight, departing Thu, Aug 21 from Lyon to San Francisco, returning Mon, Sep 1, priced at $554 found 3 days ago
Lufthansa
Tue, Sep 30 - Tue, Oct 21
LYS
Lyon
SFO
San Francisco
$699 Roundtrip, found 2 days ago
$699
Roundtrip
found 2 days ago
Select Lufthansa flight, departing Tue, Sep 30 from Lyon to San Francisco, returning Tue, Oct 21, priced at $699 found 2 days ago
Air Canada
Tue, Sep 30 - Tue, Oct 21
LYS
Lyon
SFO
San Francisco
$706 Roundtrip, found 2 days ago
$706
Roundtrip
found 2 days ago
Select Air Canada flight, departing Tue, Sep 30 from Lyon to San Francisco, returning Tue, Oct 21, priced at $706 found 2 days ago
British Airways
Tue, Sep 30 - Tue, Oct 21
LYS
Lyon
SFO
San Francisco
$717 Roundtrip, found 2 days ago
$717
Roundtrip
found 2 days ago
Select British Airways flight, departing Tue, Sep 30 from Lyon to San Francisco, returning Tue, Oct 21, priced at $717 found 2 days ago
Iberia
Thu, Sep 4 - Tue, Sep 16
LYS
Lyon
SFO
San Francisco
$723 Roundtrip, found 3 days ago
$723
Roundtrip
found 3 days ago
Select Iberia flight, departing Thu, Sep 4 from Lyon to San Francisco, returning Tue, Sep 16, priced at $723 found 3 days ago
Brussels Airlines
Thu, Sep 4 - Tue, Sep 16
LYS
Lyon
SFO
San Francisco
$724 Roundtrip, found 3 days ago
$724
Roundtrip
found 3 days ago
Select Brussels Airlines flight, departing Thu, Sep 4 from Lyon to San Francisco, returning Tue, Sep 16, priced at $724 found 3 days ago
Austrian Airlines
Tue, Sep 30 - Tue, Oct 21
LYS
Lyon
SFO
San Francisco
$743 Roundtrip, found 2 days ago
$743
Roundtrip
found 2 days ago
Select Austrian Airlines flight, departing Tue, Sep 30 from Lyon to San Francisco, returning Tue, Oct 21, priced at $743 found 2 days ago
Scandinavian Airlines
Tue, Sep 30 - Tue, Oct 21
LYS
Lyon
SFO
San Francisco
$792 Roundtrip, found 2 days ago
$792
Roundtrip
found 2 days ago
Select Scandinavian Airlines flight, departing Tue, Sep 30 from Lyon to San Francisco, returning Tue, Oct 21, priced at $792 found 2 days ago
Flights from Lyon (LYS) to San Francisco (SFO)
Origin airport
Saint-Exupery
Destination airport
San Francisco Intl.
Airlines serving
Aer Lingus, Air Canada, Air France, American Airlines, Austrian Airlines, British Airways, Brussels Airlines, Delta, Iberia, KLM, Lufthansa, Scandinavian Airlines, TAP Portugal, Turkish Airlines, United
Roundtrip price
$523
Distance
5819 mi

Lyon to San Francisco Flights

The cheapest times to fly from Lyon to San Francisco

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lyon to San Francisco are during the month of August. You can find some of the cheapest flights from Lyon to San Francisco with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lyon to San Francisco

Sunday is one of the best days to book for cheap flights from Lyon to San Francisco: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lyon to San Francisco

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lyon to San Francisco in 2025. You can also book with separate airlines for your outbound and return journeys, from $465 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lyon to San Francisco flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lyon to San Francisco airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Saint-Exupery Airport (LYS) to San Francisco Intl. Airport (SFO) cost?
Discover the latest flight deals from LYS to SFO by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from LYS to SFO?
The cheapest flights from LYS to SFO are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from LYS to SFO?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from LYS to SFO. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Saint-Exupery Airport (LYS) to San Francisco Intl. Airport (SFO)?
You'll have to book a flight with a layover if you're traveling from Saint-Exupery Airport (LYS) to San Francisco Intl. Airport (SFO). There are no daily direct flights on this route. However, just filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from LYS to SFO?
Generally you'll have the most choice when it comes to flights on a Friday. Tuesdays are often the quietest.* But this can change based on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Saint-Exupery Airport (LYS) to San Francisco Intl. Airport (SFO)?
To avoid possible delays on the Saint-Exupery Airport (LYS) to San Francisco Intl. Airport (SFO) route, travel before 3 PM. Later flights are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Saint-Exupery Airport (LYS) to San Francisco Intl. Airport (SFO) last-minute?
Holding off until just before your trip to book a ticket from LYS to SFO generally means paying more. While you might find some last-minute offers, they're not always guaranteed. Keep your travel schedule open for a better chance of scoring a bargain.
Is it cheaper to book a LYS to SFO flight and hotel package?
You can save money by securing a LYS to SFO flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one place. Once you've chosen your preferred flights and accommodations, you can add extras such as activities, car rentals and tours.
Can I cancel or change the date of my flight from Saint-Exupery Airport (LYS) to San Francisco Intl. Airport (SFO)?
If you booked your LYS to SFO flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of fare you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

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*Available to One Key members.