$184 Cheap American Airlines flights Des Moines (DSM) to Cancun (CUN)

Grab affordable round-trip American Airlines flights from $397 from DSM to CUN by sorting your results from "Price (lowest to highest)" on Expedia. Or search for options from $184 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Check for American Airlines flights from DSM to CUN about one month before you want to go. The most affordable time to reserve an international flight is generally 18 to 29 days ahead of your travel date when you can save 17% versus booking four to five months in advance. No matter your itinerary and fare class, the best day of the week to book international airfare is usually Sunday. Friday can be the most expensive. Passengers booking on a Sunday can save 17% on average compared to those who book on a Friday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Sort your results by "Morning" and "Early Morning" to find the earliest departures from DSM to CUN. Leaving early means flight cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.