$109 Cheap American Airlines flights Des Moines (DSM) to Las Vegas (LAS)

Finding cheap one-way American Airlines flights from DSM to LAS from $109 on Expedia is a cinch — just filter by “Price (lowest to highest).” Or check out our affordable round-trip fares from $217 for your next getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for round-trip or one-way flights to Las Vegas in January or June. You could find lower fares with American Airlines during these off-peak times.

For cheap American Airlines fares from Des Moines Intl. Airport (DSM) to Harry Reid Intl. Airport (LAS), start searching one to three months before your planned departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact the overall cost. Sunday is typically the cheapest, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your flight on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To figure out if there’s a direct trip from DSM to LAS with American Airlines or other airlines, check the “Nonstop” filter when looking for tickets.

To find the earliest departures from DSM to LAS with American Airlines, filter your results by “Morning” and “Early Morning.” Booking an early flight usually means you’re less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Harry Reid Intl. Airport (LAS) is the primary Las Vegas hub for American Airlines flights from Des Moines Intl. Airport (DSM).

Changes are generally free within 24 hours of making your booking, but your airline may add a charge after that. For further information about altering your reservation, check out your “Trips,” select your flight and click on “Manage Booking.” If you want the flexibility to adjust your plans without being charged, check the “Changes included” and “No cancel fee” filters when organizing your next escape.