$119 Cheap Delta flights New Orleans (MSY) to Des Moines (DSM)

Use the "Price (lowest to highest)" filter on Expedia to look for cheap Delta Air Lines round-trip flights from $237 from MSY to DSM. Affordable one-way tickets from $119 are also on offer.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for cheap Delta Air Lines flights from Louis Armstrong New Orleans Intl. Airport (MSY) to Des Moines Intl. Airport (DSM) one to three months prior to your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare type and journey, the ideal day to book a domestic flight is usually Sunday and the most expensive tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Sort your results by "Early Morning" and "Morning" to browse the earliest departures from MSY to DSM. Heading off early means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Delta Air Lines makes flying from MSY to DSM enjoyable with a rewarding loyalty program and an excellent in-flight experience. You could even start earning points with Delta SkyMiles. Be sure to sign up to Expedia's free One Key™ rewards program to earn OneKeyCash™*, which can be redeemed on future bookings.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.