$141 Cheap Delta flights Tucson (TUS) to Des Moines (DSM)

Grab cheap return Delta Air Lines flights from $308 from TUS to DSM by organizing your results from "Price (lowest to highest)" on Expedia. Or search for deals from $141 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Begin your search one to three months ahead of your travel date to score cheap fares on Delta Air Lines flights from Tucson Intl. Airport (TUS) to Des Moines Intl. Airport (DSM). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Nail your timing, and you can enjoy significant savings on domestic trips.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Filter your results by "Morning" and "Early Morning" to browse the earliest flights from TUS to DSM. Setting off early means flight cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Delta Air Lines makes flying from TUS to DSM enjoyable with an excellent in-flight experience and a rewarding loyalty program. You also have the chance to earn points with Delta SkyMiles. Make sure you sign up to Expedia's free One Key™ rewards program to earn OneKeyCash™*, which can be redeemed on future bookings.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.