Title: $49 Cheap flights from Santa Isabel - Expedia.com ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # $49 Cheap flights from Santa Isabel [View $49 flight on Fri, Apr 17, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:SJU,to:FLL,departure:4/17/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:48.98&airProductToken=AQoxCi8IxnISBDQ5MTUYsqIBIOVaKPjJigMwq8uKAzhFQABYAWoEUENfMXIHSzE0SVBOMhIMCAEQARgBKgJGOTIAGAEiBAgBEAEoAigDMA0) [Santa Isabel Travel Guide](https://expedia.com/Santa-Isabel.dx6035096)[Hotels in Santa Isabel](https://expedia.com/Santa-Isabel-Hotels.d6035096.Travel-Guide-Hotels)[Car Rentals in Santa Isabel](https://expedia.com/Car-Rentals-In-Santa-Isabel.d6035096.Car-Rental-Guide)[Santa Isabel Vacation Packages](https://expedia.com/Santa-Isabel.d6035096.Destination-Travel-Guides) ## Popular airlines from Santa Isabel - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_B6.svg) JetBlue Airways - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UA.svg) United - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DL.svg) Delta - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_F9.svg) Frontier Airlines - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_NK.svg) Spirit Airlines - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_WN.svg) Southwest Airlines - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## Cheapest flights from Santa Isabel These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![Frontier Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/F9.gif) Fri, Apr 17 - Sun, Apr 19 SJU San Juan FLL Fort Lauderdale $99 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:SJU,to:FLL,departure:4/17/2026TANYT&leg2=from:FLL,to:SJU,departure:4/19/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:98.96&airProductToken=AQoxCi8IxnISBDQ5MTUYsqIBIOVaKPjJigMwq8uKAzhFQABYAWoEUENfMXIHSzE0SVBOMhIMCAEQARgBKgJGOTIAGAEiBAgBEAEoAigDMA0) ![Spirit Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/nk.gif) Tue, Apr 14 - Wed, Apr 15 SJU San Juan MIA Miami $99 Roundtrip found 2 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:SJU,to:MIA,departure:4/14/2026TANYT&leg2=from:MIA,to:SJU,departure:4/15/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:99.00&airProductToken=AQouCiwIzpYBEgM0NjEYsqIBIIwCKMeqigMw86uKAzhXQABYAWoCUlByBldBMTROUgouCiwIzpYBEgMyNjMYjAIgsqIBKJC7igMwqryKAzhXQABYAWoCUlByBldBMTROUhIMCAEQARgBKgJOSzIAGAEiBAgBEAEoAigDKAQwDQ) ![Spirit Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/nk.gif) Thu, Apr 16 - Sun, Apr 19 SJU San Juan PHL Philadelphia $124 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:SJU,to:PHL,departure:4/16/2026TANYT&leg2=from:PHL,to:SJU,departure:4/19/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:123.48&airProductToken=AQovCi0IzpYBEgQxNDkxGLKiASDvWSjxvIoDMOS-igM4R0AAWAFqAlJQcgZHQTE0TlISCggBEAEYASoCTksYASIECAEQASgCKAMoBDAN) ![Frontier Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/F9.gif) Wed, Apr 8 - Sun, Apr 12 SJU San Juan EWR New York $141 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:SJU,to:EWR,departure:4/8/2026TANYT&leg2=from:EWR,to:SJU,departure:4/12/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:140.48&airProductToken=AQoyCjAIxnISBDMxMTEYsqIBIMSNASjn5IkDMObmiQM4RUAAWAFqBFBDXzFyB1owN1hQTjISCggBEAEYASoCRjkYASIECAEQASgCKAMwDQ) ![Frontier Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/F9.gif) Tue, Apr 7 - Sun, Apr 12 SJU San Juan JFK New York $141 Roundtrip found 1 hour ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:SJU,to:JFK,departure:4/7/2026TANYT&leg2=from:JFK,to:SJU,departure:4/12/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:140.96&airProductToken=AQoxCi8IxnISBDM1NDgYsqIBIKlRKKHaiQMwmtyJAzhFQABYAWoEUENfMXIHWjA3RVBOMgoxCi8IxnISBDM1NDcYqVEgsqIBKPuUigMw6JaKAzhFQABYAWoEUENfMXIHWjE0WVBOMhIKCAEQARgBKgJGORgBIgQIARABKAIoAzAN) ![Frontier Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/F9.gif) Thu, Apr 9 - Sun, Apr 12 SJU San Juan SDQ Santo Domingo $144 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:SJU,to:SDQ,departure:4/9/2026TANYT&leg2=from:SDQ,to:SJU,departure:4/12/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:143.89&airProductToken=AQowCi4IxnISAjk3GLKiASDygAEop_KJAzD18okDOEVAAFgBagRQQ18xcgdLMDdSTU4yCjAKLgjGchICOTgY8oABILKiASjwmIoDMLaZigM4RUAAWAFqBFBDXzFyB0sxNFlNTjISDAgBEAEYASoCRjkyABgBIgQIARABKAIoAzAN) ![Spirit Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/nk.gif) Sat, Apr 4 - Wed, Apr 8 SJU San Juan MCO Orlando $149 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:SJU,to:MCO,departure:4/4/2026TANYT&leg2=from:MCO,to:SJU,departure:4/8/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:148.99&airProductToken=AQotCisIzpYBEgM0NjMYsqIBIMxwKNm1iQMwnLeJAzhHQABYAWoCUlByBUdBM05SCi0KKwjOlgESAzQ2MBjMcCCyogEo4uSJAzCF5okDOEdAAFgBagJSUHIFR0EzTlISCggBEAEYASoCTksYASIECAEQASgCKAMoBDAN) ![Frontier Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/F9.gif) Sat, Apr 18 - Sun, Apr 19 SJU San Juan TPA Tampa $165 Roundtrip found 7 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:SJU,to:TPA,departure:4/18/2026TANYT&leg2=from:TPA,to:SJU,departure:4/19/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:164.96&airProductToken=AQphCi8IxnISBDEwMTUYsqIBIO9ZKKfTigMwoNWKAzhFQABYAWoEUENfMXIHSzIxUFBDNAouCMZyEgQyODM1GO9ZIPMDKIraigMwuNuKAzhFQABYAWoEUENfMXIHSzIxUFBDNAoxCi8IxnISBDM5ODAY8wMgsqIBKKDnigMw0eiKAzhFQABYAWoEUENfMXIHWjE0SlBOMhIKCAEQARgBKgJGORgBIgQIARABKAIoAzAN) ![JetBlue Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/b6.gif) Thu, Oct 1 - Mon, Oct 5 BQN Aguadilla FLL Fort Lauderdale $222 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BQN,to:FLL,departure:10/1/2026TANYT&leg2=from:FLL,to:BQN,departure:10/5/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:222.00&airProductToken=AQovCi0IwmwSBDIwNzIYgWwg5VookqWZAzCtppkDOExAAFgBagJETnIIUEkyQVJFTDEKLwotCMJsEgQyMDcxGOVaIIFsKMDQmQMw1dGZAzhMQABYAWoCRE5yCFVJMkFSRUwxEgoIARABGAEqAkI2GAEiBAgBEAEoAigEKAYwAQ) ![Cape Air](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/9k.gif) Fri, May 22 - Wed, May 27 MAZ Mayagüez SDQ Santo Domingo $388 Roundtrip found 2 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MAZ,to:SDQ,departure:5/22/2026TANYT&leg2=from:SDQ,to:MAZ,departure:5/27/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:387.08&airProductToken=AQpaCikIuZYBEgI0MRiMyAEgsqIBKNTYjQMwiNmNAzhCQABYAWoCRVJyA0JJUAotCMJsEgIzNxiyogEg8oABKOHjjQMwnuSNAzhQQAFYAWoCQU5yCFBJN1FSRVk1ClsKLgjCbBIDMjM4GPKAASCyogEo75GOAzCpko4DOFBAAFgBagJBTnIIUEk3UVJFWTUKKQi5lgESAjQwGLKiASCMyAEoyZuOAzD7m44DOEJAAVgBagJFUnIDQklQEgwIARABGAEqAkI2MgAYASIECAEQASgCKAMoBDAB) ## How to Find Cheap Flights from Santa Isabel #### How much is a flight from Santa Isabel? This week, flights from Santa Isabel are available between $99 – $388\. #### How to find cheap flights from Santa Isabel? Expedia makes it easy to compare cheap flights from Santa Isabel to many destinations. Check out excellent deals on domestic and international flights from Santa Isabel. Once you select an offer, use our filters and sort by “Price (Lowest)” to see some of the cheapest and suitable options. #### How can I get the best deal on flights from Santa Isabel? On Expedia, you have some of best airline ticket deals at your fingertips. Whether it’s a beach escape with your partner, a family vacation with your kids, or business trip with colleagues, these low airline ticket prices mean more savings for you. An excellent strategy for finding some of the best deals on flights from Santa Isabel is to be flexible with your dates. Within each offer, you can compare prices for similar timeframes using our “Show flexible dates” feature. Depending on your destination, direct flights from Santa Isabel may be more expensive. Airlines with strict bag policies or fees can also impact your costs. #### What is the best airline to fly from Santa Isabel? At Expedia, we give you all the available options from our reputable partners. Select the airline that best suits your preferences and membership loyalties. You can fly from Santa Isabel with: Frontier Airlines, Spirit Airlines, JetBlue Airways, Cape Air. #### What is the best month to fly from Santa Isabel? One of the cheapest times to fly from Santa Isabel airport(s) is April, based on the current list of flights available now. Prices on plane tickets vary considerably throughout the year due to availability and seasonal demand. #### Are there any last-minute flights from Santa Isabel? Expedia is the place to find last-minute flights from Santa Isabel, making it easy for you to compare prices on flights in the near future for different combinations of travel dates and from multiple airlines. We source some of the best deals for you and display some of the best offers available over the next 2 weeks. #### Why book your ticket with Expedia? Booking flights from Santa Isabel with Expedia is the obvious choice to get low prices, save money, and see more value from every dollar spent. We show you some of the best deals happening right now and provide a vast inventory of airlines and flight routes to choose from, so you can find some of the cheapest flights from Santa Isabel. You can customize your journey to your timeline, route preferences, budget, rewards programs, and more. #### Can I change/cancel my flight? Some flights can be changed or canceled, but fees and refunds will depend on the unique terms of your flight agreement. Airlines have different rules and restrictions for exchanging or refunding flights. For more information, go to your itinerary or visit our [customer service portal](https://www.expedia.com/service/). We recommend choosing flights with no change fees for the most flexibility. Filter by “Flexible change policies” to see flights with no change fees. \*Data specialists from both ARC and Expedia Group analysed ARC's global flight data to distil actionable information to help people save money on travel. While it's impossible to guarantee when to find the lowest prices, after examining the variables, we were able to observe trends. Analysis based on ARC, round-trip flight data between 1 October 2017 - 30 September 2018 for Economy and Premium cabin ATPs on a global basis. ## Travel information ## Flights from Santa Isabel: Essential Travel Information | Cheapest flight from Santa Isabel | $99 (roundtrip) | | --------------------------------------- | ------------------------------------------------------------- | | Best airlines to fly from Santa Isabel | Frontier Airlines, Spirit Airlines, JetBlue Airways, Cape Air | | Cheapest month to fly from Santa Isabel | April | | Santa Isabel IATA code | SJU | | Santa Isabel Country/State | Puerto Rico | | Airline ticket deals from Santa Isabel | $99 - $388 | \*Flight schedules are subject to change. \*Available to One Key members. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [All-Inclusive Resorts in Puerto Rico ](https://www.expedia.com/Destinations-In-Puerto-Rico-All-Inclusive-Hotel.0-0-d148-tAllinclusiveHotel.Hotel-Filter-Destinations) - 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