$121 Cheap American Airlines flights Chicago (ORD) to Des Moines (DSM)

Finding cheap one-way American Airlines flights from ORD to DSM from $121 on Expedia is a cinch — just filter by “Price (lowest to highest).” Alternatively, check out our budget-friendly round-trip fares from $137 for your next exciting adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

January is one of the least expensive months to get away to Des Moines with American Airlines. You could also find fantastic deals on return and one-way fares in December.

Start searching one to three months ahead of your departure date to find cheaper fares on American Airlines flights from O’Hare Intl. Airport (ORD) to Des Moines Intl. Airport (DSM). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Nail your timing, and you can enjoy significant savings on domestic flights.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

American Airlines has direct flights from O’Hare Intl. Airport (ORD) to Des Moines Intl. Airport (DSM), with 21 departures every week. Simply select the “Nonstop” and “Airline” filters during your search on Expedia to see all direct American Airlines flights to DSM.

Take off from O’Hare Intl. Airport (ORD) for Des Moines Intl. Airport (DSM) on a nonstop American Airlines flight, and you’ll be airborne for about 1h 28m.

American Airlines operates the most flights from O’Hare Intl. Airport (ORD) to Des Moines Intl. Airport (DSM) on Thursday. With up to 3 daily departures, you’ll get the most choice and flexibility on this day.

Leaving ORD at 10:03AM UTC-6, the earliest American Airlines flight to DSM arrives at 11:35AM UTC-6. Flying earlier in the day means you’re less likely to encounter delays.* Prefer to travel later? The last American Airlines flight from ORD to DSM departs at 8:35PM UTC-6 and touches down at 10:08PM UTC-6.*Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Take an American Airlines flight from O’Hare Intl. Airport (ORD) to Des Moines, and you’ll likely land at Des Moines Intl. Airport (DSM). This is the airline’s main hub in this destination.

You’ll likely be seated on an Embraer 170 or a Bombardier CRJ when flying American Airlines from O’Hare Intl. Airport (ORD) to Des Moines Intl. Airport (DSM). However, keep in mind that a different aircraft could be assigned to your route due to operational requirements.

Depending on the type of ticket you purchased, a fee may apply if you cancel or change your flight more than 24 hours after it’s been confirmed. To secure tickets with more flexibility, select our “No cancel fee” or “Changes included” filter when you look for flights. For more information on changing or canceling your reservation, head to “Trips,” select your flight and click on “Manage Booking.”