$214 Cheap United flights Chicago (ORD) to Des Moines (DSM)

Landing cheap one-way United Airlines flights from ORD to DSM from $214 on Expedia is simple — just filter by "Price (lowest to highest)." Or check out our affordable round-trip fares from $189 for your next exciting adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

For cheap United Airlines fares from O'Hare Intl. Airport (ORD) to Des Moines Intl. Airport (DSM), start searching one to three months before your intended departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also affect the cost. Sunday is usually the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your journey on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

The first United Airlines flight from ORD to DSM departs at 9:00AM UTC-6, landing at 10:38AM UTC-6. If you prefer to jet off later, the last United Airlines flight leaves ORD at 8:20PM UTC-6 and touches down at DSM at 9:52PM UTC-6. Flying before midday is often a smart choice as morning flights are less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Offering a rewarding loyalty program, United Airlines is a favorite of many travelers departing from ORD to DSM. Plus, if you're a United Mileage Plus and One Key™ member booking through Expedia, you can earn OneKeyCash™* on eligible flights along with your airline miles.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.