$363 Cheap Flights from Florence (FLO) to Des Moines (DSM)

View $363 flight on Mon, Mar 30, 2026Opens in a new window

Popular airlines from Florence, SC (FLO-Florence Regional) to Des Moines International Airport (DSM)

Cheap Flights from Florence to Des Moines (FLO-DSM)

Prices were available within the past 7 days and start at $363 for one-way flights and $515 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Apr 16 - Mon, Apr 20
FLO
Florence
DSM
Des Moines
$515 Roundtrip, found 6 days ago
$515
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Apr 16 from Florence to Des Moines, returning Mon, Apr 20, priced at $515 found 6 days ago
American Airlines
Thu, Apr 16 - Mon, Apr 20
FLO
Florence
DSM
Des Moines
$520 Roundtrip, found 6 days ago
$520
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Apr 16 from Florence to Des Moines, returning Mon, Apr 20, priced at $520 found 6 days ago
American Airlines
Thu, Apr 16 - Mon, Apr 20
FLO
Florence
DSM
Des Moines
$528 Roundtrip, found 6 days ago
$528
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Apr 16 from Florence to Des Moines, returning Mon, Apr 20, priced at $528 found 6 days ago
American Airlines
Thu, Apr 16 - Mon, Apr 20
FLO
Florence
DSM
Des Moines
$533 Roundtrip, found 6 days ago
$533
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Apr 16 from Florence to Des Moines, returning Mon, Apr 20, priced at $533 found 6 days ago
American Airlines
Thu, Apr 16 - Mon, Apr 20
FLO
Florence
DSM
Des Moines
$585 Roundtrip, found 6 days ago
$585
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Apr 16 from Florence to Des Moines, returning Mon, Apr 20, priced at $585 found 6 days ago
American Airlines
Thu, Apr 16 - Mon, Apr 20
FLO
Florence
DSM
Des Moines
$590 Roundtrip, found 6 days ago
$590
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Apr 16 from Florence to Des Moines, returning Mon, Apr 20, priced at $590 found 6 days ago
American Airlines
Thu, Apr 16 - Mon, Apr 20
FLO
Florence
DSM
Des Moines
$595 Roundtrip, found 6 days ago
$595
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Apr 16 from Florence to Des Moines, returning Mon, Apr 20, priced at $595 found 6 days ago

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Frequently asked questions

How much does a flight from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.) cost?
You can find cheap one-way flights from $363 and cheap return flights from $515 FLO to DSM with Expedia. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see our cheapest fares first, and use the Price Tracking tool to receive alerts when FLO to DSM ticket fares go up or down.
What is the cheapest month to fly from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
The cheapest month to fly from FLO to DSM is April when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
Enter FLO to DSM and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
American Airlines is just the carrier that flies from Florence, SC (FLO) to Des Moines, IA (DSM). Use Expedia's flight search tool to compare airlines on this route and find our cheapest option for your trip. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
To find a cheap flight from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
The earliest flight from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.) typically departs at around 11:05 AM, operated by American Airlines. This is a seasonal service available in June, and a late morning departure can give you a relaxed start to your travel day. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
How long does it take to fly from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
Flights from FLO to DSM with one stop typically take around 7 hours, covering approximately 911 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
Select the "Business class" and "First class" filters when looking for FLO to DSM flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.) flight with Expedia?
It's easy to earn miles on a Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Des Moines from Florence Regional (FLO)?
From Florence Regional (FLO), you can fly into Des Moines Intl. (DSM) to reach Des Moines. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.) at the last minute?
Typically, booking a last minute flight from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.) flight and hotel package?
Securing a Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.) Des Moines Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
If you booked your Florence, SC (FLO-Florence Regional) to Des Moines, IA (DSM-Des Moines Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Florence Regional
Destination airport
Des Moines Intl.
Roundtrip price
$514
Distance
911 mi

Book with confidence

Florence to Des Moines Flights

The cheapest times to fly from Florence to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Des Moines are during the month of April. You can find some of the cheapest flights from Florence to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Florence to Des Moines

Sunday is one of the best days to book for cheap flights from Florence to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Florence to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Des Moines in 2026. You can also book with separate airlines for your outbound and return journeys, from $363 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Florence to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Florence to Des Moines Flights

*Flight schedules are subject to change.

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*Available to One Key members.