$311 Cheap Flights from Panama City (PTY) to San Francisco (SFO)

View $311 flight on Sat, Apr 18, 2026Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)

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Cheap Flights from Panama City to San Francisco (PTY-SFO)

Prices were available within the past 7 days and start at $311 for one-way flights and $562 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Wed, Apr 29 - Wed, May 6
PTY
Panama City
SFO
San Francisco
$562 Roundtrip, found 15 hours ago
$562
Roundtrip
found 15 hours ago
Select avianca flight, departing Wed, Apr 29 from Panama City to San Francisco, returning Wed, May 6, priced at $562 found 15 hours ago
avianca
Wed, Feb 11 - Sat, Feb 21
PTY
Panama City
SFO
San Francisco
$572 Roundtrip, found 1 hour ago
$572
Roundtrip
found 1 hour ago
Select avianca flight, departing Wed, Feb 11 from Panama City to San Francisco, returning Sat, Feb 21, priced at $572 found 1 hour ago
Aeromexico
Wed, Feb 11 - Sat, Feb 21
PTY
Panama City
SFO
San Francisco
$579 Roundtrip, found 1 hour ago
$579
Roundtrip
found 1 hour ago
Select Aeromexico flight, departing Wed, Feb 11 from Panama City to San Francisco, returning Sat, Feb 21, priced at $579 found 1 hour ago
avianca
Thu, Oct 30 - Sun, Nov 2
PTY
Panama City
SFO
San Francisco
$579 Roundtrip, found 1 hour ago
$579
Roundtrip
found 1 hour ago
Select avianca flight, departing Thu, Oct 30 from Panama City to San Francisco, returning Sun, Nov 2, priced at $579 found 1 hour ago
avianca
Wed, Feb 11 - Sat, Feb 21
PTY
Panama City
SFO
San Francisco
$582 Roundtrip, found 1 hour ago
$582
Roundtrip
found 1 hour ago
Select avianca flight, departing Wed, Feb 11 from Panama City to San Francisco, returning Sat, Feb 21, priced at $582 found 1 hour ago
avianca
Thu, Oct 30 - Sun, Nov 2
PTY
Panama City
SFO
San Francisco
$584 Roundtrip, found 1 hour ago
$584
Roundtrip
found 1 hour ago
Select avianca flight, departing Thu, Oct 30 from Panama City to San Francisco, returning Sun, Nov 2, priced at $584 found 1 hour ago
Aeromexico
Tue, Dec 23 - Wed, Jan 7
PTY
Panama City
SFO
San Francisco
$586 Roundtrip, found 16 hours ago
$586
Roundtrip
found 16 hours ago
Select Aeromexico flight, departing Tue, Dec 23 from Panama City to San Francisco, returning Wed, Jan 7, priced at $586 found 16 hours ago
Copa
Mon, Mar 2 - Tue, Mar 24
PTY
Panama City
SFO
San Francisco
$639 Roundtrip, found 3 days ago
$639
Roundtrip
found 3 days ago
Select Copa flight, departing Mon, Mar 2 from Panama City to San Francisco, returning Tue, Mar 24, priced at $639 found 3 days ago
United
Sat, Dec 20 - Sun, Jan 4
PTY
Panama City
SFO
San Francisco
$649 Roundtrip, found 1 hour ago
$649
Roundtrip
found 1 hour ago
Select United flight, departing Sat, Dec 20 from Panama City to San Francisco, returning Sun, Jan 4, priced at $649 found 1 hour ago
American Airlines
Wed, Mar 18 - Wed, Mar 25
PTY
Panama City
SFO
San Francisco
$653 Roundtrip, found 4 days ago
$653
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Mar 18 from Panama City to San Francisco, returning Wed, Mar 25, priced at $653 found 4 days ago

Find the cheapest month to fly from Panama City (PTY) to San Francisco (SFO)

September is typically the cheapest month to fly

From $469 - $678 per traveler.

Alternative airports near San Francisco

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Norman Y. Mineta San Jose Intl. SJC. Cheapest option available. Average driving time to city center is 50 minutes. Flights from $512
SJC
Norman Y. Mineta San Jose Intl.
Cheapest
Average driving time to city center50 min
Flights from $512

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO) cost?
Lock in a cheap one-way flight from $311 or cheap return flight from $562 from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
The cheapest month to fly from PTY to SFO is April, when there's less demand. Off-peak months are generally when you'll find cheap fares for travel between these airports.
Which airlines fly direct from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
Fly nonstop from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO) on a Copa Airlines flight.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
Use the filter tool on Expedia to compare different airlines and find the most affordable carrier that'll fly you from PTY to SFO. Then, sort your results by "Price (lowest to highest)" to pick up a good deal.
How many flights per day from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
On average, only 1 direct flight departs each day from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO). Seeking more options? Use Expedia's filter tool to discover flights with layovers and squeeze another destination into your itinerary.
What are the most popular departure times for flights from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
More people fly between PTY and SFO at 6 PM than at any other point in the day. Looking to skip the crowds? Try choosing a quieter departure window and it's possible you'll save on your ticket as well.
What day of the week has the most flights from PTY to SFO?
If you depart on a Friday, you'll get the greatest range of choices for flights from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO).
What is the earliest flight from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
Catch the earliest flight at around 12:38PM UTC-5, leaving from Tocumen Intl. Airport (PTY). You'll be flying for roughly 7h 55m, touching down at San Francisco Intl. Airport (SFO) at approximately 5:33PM UTC-8.
How long does it take to fly from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
Flights from PTY to SFO have an average travel time of 7 hours and 56 minutes. The distance between the two airports is 3,300 mi.
What airline has the least delays from PTY to SFO?
With 97% of flights generally arriving as scheduled, United Airlines has the best on-time performance for direct flights from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO). To check your flight status and get notified if anything changes, head to the Expedia App.
What is the best time to fly from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
To avoid potential delays on the Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO) route, travel before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for San Francisco from Tocumen Intl. Airport (PTY)?
If you're flying on a direct flight from Tocumen Intl. Airport (PTY) to San Francisco, San Francisco Intl. Airport (SFO) is the only airport you can land at.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO) last-minute?
Booking your flight from PTY to SFO just before your journey is typically more expensive. But if there's some wiggle room with your itinerary, you could score a cheap last-minute fare.
Is it cheaper to book a PTY to SFO flight and hotel package?
You'll typically save money by securing a PTY to SFO flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one place. After selecting your preferred flights and accommodations, consider adding extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
If you booked your PTY to SFO flight in the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of fare you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

Travel information

Origin airport
Tocumen Intl.
Destination airport
San Francisco Intl.
Airlines serving
Aeromexico, American Airlines, Copa, Delta, United, avianca
Roundtrip price
$562
Distance
3320 mi
Average flight time
5 hours 43 mins

Book with confidence

Panama City to San Francisco Flights

The cheapest times to fly from Panama City to San Francisco

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to San Francisco are during the month of April. You can find some of the cheapest flights from Panama City to San Francisco with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to San Francisco

Sunday is one of the best days to book for cheap flights from Panama City to San Francisco: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to San Francisco

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to San Francisco in 2025. You can also book with separate airlines for your outbound and return journeys, from $311 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to San Francisco flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to San Francisco airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Panama City to San Francisco Flights

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*Available to One Key members.