$306 Cheap Flights from Panama City (PTY) to San Francisco (SFO)

View $306 flight on Wed, Sep 24, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)

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Cheap Flights from Panama City to San Francisco (PTY-SFO)

Prices were available within the past 7 days and start at $306 for one-way flights and $507 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Wed, Sep 17 - Wed, Oct 15
PTY
Panama City
SFO
San Francisco
$507 Roundtrip, found 2 days ago
$507
Roundtrip
found 2 days ago
Select United flight, departing Wed, Sep 17 from Panama City to San Francisco, returning Wed, Oct 15, priced at $507 found 2 days ago
Copa
Fri, Oct 10 - Sat, Oct 18
PTY
Panama City
SFO
San Francisco
$507 Roundtrip, found 9 hours ago
$507
Roundtrip
found 9 hours ago
Select Copa flight, departing Fri, Oct 10 from Panama City to San Francisco, returning Sat, Oct 18, priced at $507 found 9 hours ago
United
Thu, Oct 30 - Sat, Nov 8
PTY
Panama City
SFO
San Francisco
$511 Roundtrip, just found
$511
Roundtrip
just found
Select United flight, departing Thu, Oct 30 from Panama City to San Francisco, returning Sat, Nov 8, priced at $511 just found
United
Thu, Oct 30 - Sat, Nov 8
PTY
Panama City
SFO
San Francisco
$517 Roundtrip, just found
$517
Roundtrip
just found
Select United flight, departing Thu, Oct 30 from Panama City to San Francisco, returning Sat, Nov 8, priced at $517 just found
Delta
Thu, Oct 9 - Mon, Oct 20
PTY
Panama City
SFO
San Francisco
$521 Roundtrip, found 9 hours ago
$521
Roundtrip
found 9 hours ago
Select Delta flight, departing Thu, Oct 9 from Panama City to San Francisco, returning Mon, Oct 20, priced at $521 found 9 hours ago
United
Mon, Aug 4 - Wed, Nov 5
PTY
Panama City
SFO
San Francisco
$524 Roundtrip, found 3 days ago
$524
Roundtrip
found 3 days ago
Select United flight, departing Mon, Aug 4 from Panama City to San Francisco, returning Wed, Nov 5, priced at $524 found 3 days ago
American Airlines
Thu, Oct 30 - Sat, Nov 8
PTY
Panama City
SFO
San Francisco
$526 Roundtrip, just found
$526
Roundtrip
just found
Select American Airlines flight, departing Thu, Oct 30 from Panama City to San Francisco, returning Sat, Nov 8, priced at $526 just found
United
Sun, Aug 24 - Sun, Aug 31
PTY
Panama City
SFO
San Francisco
$528 Roundtrip, found 3 days ago
$528
Roundtrip
found 3 days ago
Select United flight, departing Sun, Aug 24 from Panama City to San Francisco, returning Sun, Aug 31, priced at $528 found 3 days ago
United
Thu, Oct 30 - Sat, Nov 8
PTY
Panama City
SFO
San Francisco
$533 Roundtrip, just found
$533
Roundtrip
just found
Select United flight, departing Thu, Oct 30 from Panama City to San Francisco, returning Sat, Nov 8, priced at $533 just found
avianca
Sat, Aug 30 - Wed, Sep 3
PTY
Panama City
SFO
San Francisco
$551 Roundtrip, found 5 hours ago
$551
Roundtrip
found 5 hours ago
Select avianca flight, departing Sat, Aug 30 from Panama City to San Francisco, returning Wed, Sep 3, priced at $551 found 5 hours ago

Find the cheapest month to fly from Panama City (PTY) to San Francisco (SFO)

August is typically the cheapest month to fly

From $469 - $855 per traveler.

Graph displaying average flight prices per month

Alternative airports near San Francisco

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Norman Y. Mineta San Jose Intl. SJC. Cheapest option available. Average driving time to city center is 50 minutes. Flights from $748
SJC
Norman Y. Mineta San Jose Intl.
Cheapest
Average driving time to city center50 min
Flights from $748
Flights from Panama City (PTY) to San Francisco (SFO)
Origin airport
Tocumen Intl.
Destination airport
San Francisco Intl.
Airlines serving
American Airlines, Copa, Delta, United, avianca
Roundtrip price
$506
Distance
3320 mi
Average flight time
5 hours 45 mins

Panama City to San Francisco Flights

The cheapest times to fly from Panama City to San Francisco

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to San Francisco are during the month of September. You can find some of the cheapest flights from Panama City to San Francisco with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to San Francisco

Sunday is one of the best days to book for cheap flights from Panama City to San Francisco: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to San Francisco

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to San Francisco in 2025. You can also book with separate airlines for your outbound and return journeys, from $306 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to San Francisco flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to San Francisco airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO) cost?
You'll find cheap return fares from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO) starting from $507. Book a seat and take off on your trip. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a United flight leaving PTY on August 1 2025 and touching down at SFO. The price was last updated on July 9 2025 and has not changed since.
What is the cheapest month to fly from PTY to SFO?
The cheapest flights from PTY to SFO are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
Fly nonstop from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO) on a Copa Airlines flight.
What is the cheapest airline that flies from PTY to SFO?
With tickets starting at $517 for a one-way journey from PTY to SFO, United is currently the cheapest airline on this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from PTY on August 5 2025. Prices were last updated on July 9 2025 and have not changed since.
How many flights per day from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
On average, only 1 direct flight departs each day from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO). Seeking more options? Use Expedia's filter tool to discover flights with layovers and squeeze another destination into your itinerary.
What are the most popular departure times for flights from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
More people fly between PTY and SFO at 6 PM than at any other point in the day. Looking to skip the crowds? Try choosing a quieter departure window and it's possible you'll save on your ticket as well.
What day of the week has the most flights from PTY to SFO?
If you depart on a Friday, you'll get the greatest range of choices for flights from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO).
What is the earliest flight from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
Catch the earliest flight at around 12:38PM UTC-5, leaving from Tocumen Intl. Airport (PTY). You'll be flying for roughly 7h 55m, touching down at San Francisco Intl. Airport (SFO) at approximately 5:33PM UTC-8.
How long does it take to fly from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
Flights from PTY to SFO have an average travel time of 7 hours and 56 minutes. The distance between the two airports is 3,300 mi.
What airline has the least delays from PTY to SFO?
With 97% of flights generally arriving as scheduled, United Airlines has the best on-time performance for direct flights from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO). To check your flight status and get notified if anything changes, head to the Expedia App.
What is the best time to fly from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
To avoid potential delays on the Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO) route, travel before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for San Francisco from Tocumen Intl. Airport (PTY)?
If you're flying on a direct flight from Tocumen Intl. Airport (PTY) to San Francisco, San Francisco Intl. Airport (SFO) is the only airport you can land at.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO) last-minute?
Booking your flight from PTY to SFO just before your journey is typically more expensive. But if there's some wiggle room with your itinerary, you could score a cheap last-minute fare.
Is it cheaper to book a PTY to SFO flight and hotel package?
You'll typically save money by securing a PTY to SFO flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one place. After selecting your preferred flights and accommodations, consider adding extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to San Francisco Intl. Airport (SFO)?
If you booked your PTY to SFO flight in the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of fare you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

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