Cheap Flights from Siena (SAY) to San Francisco (SFO)

Popular airlines from Ampugnano Airport (SAY) to San Francisco Intl. Airport (SFO)

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Frequently asked questions

How much does a flight from Siena (SAY-Ampugnano) to San Francisco Intl. Airport (SFO) cost?
Snag a cheap one-way flight or cheap return flight from Siena (SAY-Ampugnano) to San Francisco Intl. Airport (SFO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Siena (SAY-Ampugnano) to San Francisco Intl. Airport (SFO)?
Traveling in can help you save, as it's the cheapest month for flights between SAY and SFO. You'll typically find the lowest prices during the off-season.
What is the cheapest airline that flies from Siena (SAY-Ampugnano) to San Francisco Intl. Airport (SFO)?
To find the cheapest airline that'll fly you from SAY to SFO, use Expedia's filter tool. Tailor your search based on your travel style, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Siena (SAY-Ampugnano) to San Francisco Intl. Airport (SFO)?
There are no daily nonstop flights departing from Siena (SAY-Ampugnano) to San Francisco Intl. Airport (SFO). But you can choose flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be on your way before you know it.
What day of the week has the most flights from SAY to SFO?
Friday is usually the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can vary depending on various factors, including the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Siena (SAY-Ampugnano) to San Francisco Intl. Airport (SFO)?
To avoid possible delays on the Siena (SAY-Ampugnano) to San Francisco Intl. Airport (SFO) route, aim to travel before 3 PM. Departures after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Siena (SAY-Ampugnano) to San Francisco Intl. Airport (SFO) last-minute?
Booking your plane ticket from SAY to SFO just before your journey is generally more expensive. However, if you're flexible with your departure times and dates, you could land a cheap last-minute fare.
Is it cheaper to book a SAY to SFO flight and hotel package?
You can save money by booking a SAY to SFO flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. Once you've selected your preferred accommodations and flights, you can add extras like activities, car rentals and tours.
Can I cancel or change the date of my flight from Siena (SAY-Ampugnano) to San Francisco Intl. Airport (SFO)?
Generally, it's possible to reschedule or cancel your SAY to SFO flight. However, for bookings made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Origin airport
Ampugnano
Destination airport
San Francisco Intl.
Distance
6138 mi

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Siena to San Francisco Flights

The cheapest times to fly from Siena to San Francisco

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Siena to San Francisco are during the month of . You can find some of the cheapest flights from Siena to San Francisco with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Siena to San Francisco

Sunday is one of the best days to book for cheap flights from Siena to San Francisco: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Siena to San Francisco

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Siena to San Francisco in 2026. You can also book with separate airlines for your outbound and return journeys, from one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Siena to San Francisco flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Siena to San Francisco airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Siena to San Francisco Flights

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*Available to One Key members.