$112 Cheap Flights from Knoxville (TYS) to Milwaukee (MKE)
Popular airlines from McGhee Tyson Airport (TYS) to General Mitchell Intl. Airport (MKE)
American AirlinesAmerican Airlines
UnitedUnited
Southwest AirlinesSouthwest Airlines
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Cheap Flights from Knoxville to Milwaukee (TYS-MKE)
Alternative airports near Milwaukee
Prices were available within the past 7 days. Prices and availability are subject to change.
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Knoxville (TYS) to Milwaukee (MKE) at a glance
Travel to Milwaukee (MKE) from Knoxville (TYS) with a selection of airlines catering to this domestic short-haul route. Evaluate options from both full-service and budget carriers to discover the itinerary that aligns with your travel plans, schedule, and budget as you prepare to explore Milwaukee's renowned attractions and neighborhoods. Gather essential details for flights from McGhee Tyson Airport (TYS) to General Mitchell International Airport (MKE) to kickstart your adventure.
- Fastest (typical) flight duration: around 3 hours in-flight, plus roughly 1h 30m layover with one stop
- Route distance: roughly 500 miles (800 km)
- Flights per week: around 10 departures on average
- Typical fares (one-way): economy tickets often range from $105–$370, depending on seasonality and how far ahead you book
Flights from McGhee Tyson Airport (TYS) to General Mitchell International Airport (MKE)
Based on the latest traveler bookings, here are the top airlines favored for journeys from Knoxville to Milwaukee, typically offering one-stop services. Common layover options include O'Hare International Airport (ORD) with a layover of about 1 hour and 15 minutes, Hartsfield-Jackson Atlanta International Airport (ATL) with approximately 1 hour and 45 minutes, and Charlotte-Douglas International Airport (CLT) with a layover of around 1 hour and 15 minutes. These choices allow you to balance price, total travel time, and cabin class to find the ideal itinerary.
- American Airlines: This major airline provides one-stop service and is responsible for about 39% of departures on this route. One-way tickets generally range from $105 to $350, with a flight duration of around 3 hours and a total travel time of approximately 4 hours and 45 minutes, including layover.
- Delta: Another full-service option, Delta accounts for around 37% of departures on this route, offering one-stop flights. Fares usually fall between $110 and $375, with an in-flight time of 3 hours and a total journey time close to 4 hours and 45 minutes, factoring in a layover.
- United: Representing about 19% of departures, United Airlines provides one-stop service with one-way fares typically ranging from $105 to $485. Expect around 3 hours of flight time, with the overall travel duration being roughly 4 hours and 45 minutes, including any layover.
- Southwest Airlines: A budget-friendly choice, Southwest offers one-stop flights and makes up approximately 5% of departures on this route. One-way fares typically range from $115 to $255, with an in-flight duration of 3 hours and a total travel time of about 4 hours and 45 minutes, including a layover.
Best time to fly from Knoxville (TYS) to Milwaukee (MKE)
The most popular months for travelers flying from Knoxville to Milwaukee are January, March, and April, when peak temperatures in Milwaukee reach up to 43.7°F in April. If you prefer quieter travel, consider December, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 29.7°F. For better deals, February and December usually offer the lowest average one-way fares around $190. Flight availability peaks in August, with approximately 14 flights per week, making it easier to find convenient departure times. June has the fewest flights, with approximately 8 flights per week.
- Cheapest time to fly: February and December usually offer good deals with average one-way fares around $190, roughly 8% cheaper than the yearly average.
- More budget-friendly months to fly: October and March typically offer average one-way fares of around $192.
- Most flight options: August has the highest number of flights from Knoxville to Milwaukee, with approximately 14 flights per week, giving you more flexibility in scheduling your trip.
| Month | Temperature | Demand | Weekly Flights | Average one-way Fare |
| January | 22.1°F (-5.5°C) | Moderately High | 9 | $207 |
| February | 23.5°F (-4.7°C) | Average | 10 | $190 |
| March | 34.7°F (1.5°C) | Moderately High | 10 | $193 |
| April | 43.7°F (6.5°C) | Moderately High | 11 | $204 |
| May | 54.9°F (12.7°C) | Moderately Low | 11 | $193 |
| June | 64.9°F (18.3°C) | Moderately Low | 8 | $268 |
| July | 71.4°F (21.9°C) | Average | 11 | $220 |
| August | 70.7°F (21.5°C) | Average | 14 | $214 |
| September | 64.2°F (17.9°C) | Average | 11 | $216 |
| October | 52.0°F (11.1°C) | Average | 11 | $191 |
| November | 39.2°F (4.0°C) | Average | 11 | $211 |
| December | 29.7°F (-1.3°C) | Moderately Low | 9 | $190 |
*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.
Alternative route from Knoxville (TYS) to Milwaukee (MKE)
- Knoxville to Kenosha (TYS-ENW): Kenosha Regional Airport (ENW) is located approximately 24 miles from General Mitchell International Airport (MKE).
How to find the best prices for flights from Knoxville (TYS) to Milwaukee (MKE)
Getting some of the best deals on flights from Knoxville to Milwaukee is all about timing and flexibility. Here are some key tips to help you save:
- Best times to book and fly: cheaper fares are generally available when booking 2 to 8 weeks in advance, which coincides with when most travelers make their reservations. Morning departures between 5 AM and 12 PM not only tend to offer lower prices but are also the most popular flight times. Additionally, flying on Thursday provides both affordability and increased travel demand.
- Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
- Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
- Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
- Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
- Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.
*Members only. Savings vary and are not available on all bundles. Select hotels.
Arriving at General Mitchell International Airport from McGhee Tyson Airport
Milwaukee welcomes travelers from Knoxville with a range of transport options based on price, convenience, and proximity. For departures, McGhee Tyson Airport is roughly a 20-minute drive (covering about 15 miles) from central Knoxville. Here's how to reach Milwaukee efficiently:
- Hotel transfer: Transfers offer a convenient way to reach your hotel in Milwaukee, with private rides that can be arranged in advance.
- Car rental: Renting a car from General Mitchell International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at General Mitchell International Airport on Expedia.
- Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
- Public transportation: From General Mitchell International Airport, the Milwaukee Airport Bus Station (a bus station) is conveniently located just 0.1 miles away on foot, while the Milwaukee Airport Station (a train station) is about 1.8 miles from the airport by car. For metro travel, the Michigan & Jackson Tram Stop (a metro station) is situated approximately 7.8 miles away, also reachable by car.
Knoxville to Milwaukee Flights
The cheapest times to fly from Knoxville to Milwaukee
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Milwaukee are during the month of November. You can find some of the cheapest flights from Knoxville to Milwaukee with Expedia's search tool and vast selection of airlines.
The best time to book a flight from Knoxville to Milwaukee
Sunday is one of the best days to book for cheap flights from Knoxville to Milwaukee: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from Knoxville to Milwaukee
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Milwaukee in 2026. You can also book with separate airlines for your outbound and return journeys, from $112 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Milwaukee flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Milwaukee airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
Frequently Asked Questions
How much does a flight from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.) cost?
You can find cheap one-way flights from $112 and cheap return flights $238 Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.) with Expedia. One-way flights typically cost between $159 and $580, and return flights often range between $245 and $974. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.) ticket fares go up or down.
*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.)?
The cheapest month to fly from TYS to MKE is November when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.)?
Enter TYS to MKE and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.)?
Delta is one of the cheapest airlines offering connecting flights from Knoxville (TYS) to Milwaukee (MKE) starting from around $213. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.
*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.)?
To find a cheap flight from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.)?
The earliest flight from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.) generally departs at around 5:00 AM, operated by American Airlines. Catching this flight gives you a head start on your day in Milwaukee. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.)?
The most popular departure times for flights from McGhee Tyson (TYS) to General Mitchell Intl. (MKE) are in the early morning, from 6am to 9am. About 27% of passengers prefer this time window. Many major carriers, including American Airlines, offer flights during this window. This timing is popular as it allows you to start your day early and arrive in Milwaukee with plenty of time to explore.
How long does it take to fly from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.)?
Flights from TYS to MKE with one stop typically take around 6 hours, covering approximately 536 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.)?
You can fly first class between TYS and MKE. First class cabins are available on:
- American Airlines
- Delta Air Lines
- United Airlines
How do I earn miles on a Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.) flight with Expedia?
It's easy to earn miles on a Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.
*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Milwaukee from McGhee Tyson (TYS)?
From McGhee Tyson (TYS), you can fly into General Mitchell Intl. (MKE) to reach Milwaukee. Some flights may connect through major hubs like Washington Dulles Intl. (IAD), Charlotte-Douglas Intl. (CLT), LaGuardia (LGA) before reaching Milwaukee. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.) at the last minute?
Typically, booking a last minute flight from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.) flight and hotel package?
Securing a Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.) Milwaukee Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.)?
If you booked your Knoxville, TN (TYS-McGhee Tyson) to Milwaukee, WI (MKE-General Mitchell Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.
Travel information
Origin airport | McGhee Tyson Airport |
|---|---|
Destination airport | General Mitchell Intl. Airport |
Distance | 535 miles away |
Airlines serving | American Airlines, United, Southwest Airlines, Delta |
Popular airline | American Airlines |
Roundtrip price | $238 |