Uptown - Upper Duval, FL

Key West

Key West Butterfly and Nature Conservatory featuring zoo animals, animals and flowers
Key West Butterfly and Nature Conservatory showing zoo animals, animals and flowers
South Beach which includes a beach and a coastal town as well as a large group of people
South Beach showing a beach, swimming and a luxury hotel or resort
Key West Butterfly and Nature Conservatory featuring signage

Popular places to visit

Southernmost Point featuring signage as well as a large group of people

Southernmost Point

Snap a memorable photograph from the edge of North America at this monumental landmark.

Southernmost Point
South Beach featuring a sandy beach and general coastal views as well as a small group of people

South Beach

Head to the southernmost beach of the continental United States to relax and swim in the waters where famous writer Tennessee Williams once took his daily swim.

South Beach
Key West Butterfly and Nature Conservatory showing animals, zoo animals and food

Key West Butterfly and Nature Conservatory

With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.

Key West Butterfly and Nature Conservatory

Things to do

Miami to Key West Day Trip with Activity Options

Miami to Key West Day Trip with Activity Options

$39
per adult
84% of travellers recommend
Miami to Key West Day Trip with Activity Options
Entertainer in character at the Shipwreck Treasure Museum in Key West

Shipwreck Treasure Museum Tickets

$19
per adult
76% of travellers recommend
Shipwreck Treasure Museum Tickets
Sunset Dinner Cruise with Unlimited Open Bar

Sunset Dinner Cruise in Key West with Live Music & Unlimited Open Bar!

$90
per adult
88% of travellers recommend
Sunset Dinner Cruise in Key West with Live Music & Unlimited Open Bar!
Passengers enjoying the shade on the Conch Tour Train in Key West

Key West Conch Tour Train

$45
per adult
88% of travellers recommend
Key West Conch Tour Train
Sunset Sail in Key West with Beverages Included

Sunset Sail in Key West with Beverages Included

$79
per adult
98% of travellers recommend
Sunset Sail in Key West with Beverages Included
Florida: Key West Overseas Highway Self-Driving Tour

Florida: Key West Overseas Highway App-Based Driving Audio Tour

$17
per traveler
80% of travellers recommend
Florida: Key West Overseas Highway App-Based Driving Audio Tour
See all activities in Key West

Uptown - Upper Duval Hotel Deals

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$280 nightly
The price is $315 total per night from Dec 17 to Dec 18
$315 total
Dec 17 - Dec 18
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.6/10 Excellent! (2,903 reviews)
We liked everything about the property from the multiple pools, activities and the beach.

Reviewed on Nov 29, 2025

Southernmost Beach Resort and Guesthouses
The Reach Key West, Curio Collection by Hilton

The Reach Key West, Curio Collection by Hilton

4 out of 5
1435 Simonton Street Key West FL
$239 nightly
The price is $269 total per night from Dec 18 to Dec 19
$269 total
Dec 18 - Dec 19
Total with taxes and fees
Book a stay at this beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.4/10 Very Good! (1,020 reviews)
Excellent. Will come back

Reviewed on Nov 29, 2025

The Reach Key West, Curio Collection by Hilton
The Southernmost Inn - Adults Only

The Southernmost Inn - Adults Only

3 out of 5
525 United Street Key West FL
$149 nightly
The price is $168 total per night from Dec 16 to Dec 17
$168 total
Dec 16 - Dec 17
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.2/10 Very Good! (1,209 reviews)
Love the charm and hospitality. Always a fun and relaxing time

Reviewed on Nov 28, 2025

The Southernmost Inn - Adults Only
Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$162 nightly
The price is $183 total per night from Dec 8 to Dec 9
$183 total
Dec 8 - Dec 9
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (1,245 reviews)
Great place! Clean room. Friendly staff. And a bar right out front of motel. What more could you want?? Highly recommend this place. Quiet area of KW. Away from all the hoopla

Reviewed on Dec 1, 2025

Southwinds Motel
Kona Kai Oasis

Kona Kai Oasis

3 out of 5
630 South Street Key West FL
$219 nightly
The price is $246 total per night from Dec 7 to Dec 8
$246 total
Dec 7 - Dec 8
Total with taxes and fees
Stay at this guesthouse in Key West. Enjoy free WiFi, free parking, and a garden. Our guests praise the helpful staff in our reviews. Popular attractions Duval ...
8/10 Very Good! (575 reviews)
Convenient

Reviewed on Nov 30, 2025

Kona Kai Oasis
Southernmost House

Southernmost House

4 out of 5
1400 Duval Street Key West FL
$370 nightly
The price is $416 total per night from Dec 21 to Dec 22
$416 total
Dec 21 - Dec 22
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free breakfast, free WiFi, and room service. Our guests praise the helpful staff and the property condition ...
9.2/10 Wonderful! (1,007 reviews)
Great location. Loved the history of this Southernmost House. I did a lot of investigating for an historical accommodation in Key West, this matched my checklist perfectly! History, architecture, superior accommodations, great oceanfront view and delightful heated pool. Breakfast was top notch and ...

Reviewed on Nov 25, 2025

Southernmost House
See all 2,775 properties in Uptown - Upper Duval
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Uptown - Upper Duval

Key West Historic District

Old Town Key West

4.5/5(226 area reviews)

Old Town, the historic heart of Key West, boasts a central business district and numerous tourist attractions. Explore the Key West Aquarium, Ernest Hemingway House, Mallory Square, and more in this vibrant area.

Old Town Key West
Key West featuring a marina, a coastal town and general coastal views

Downtown Key West

If you're spending some time in Downtown Key West, Duval Street and Ernest Hemingway Home and Museum are top sights worth seeing.

Downtown Key West
Harry S. Truman Little White House which includes a house and cycling

Bahama Village

5/5(38 area reviews)

Bahama Village is noteworthy for its historic sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.

Bahama Village
Clarence S. Higgs Memorial Beach Park which includes landscape views, tropical scenes and a sandy beach

Casa Marina

While visiting Casa Marina, you might make a stop by sights like Clarence S. Higgs Memorial Beach Park and Florida Keys Beaches.

Casa Marina
Audubon House and Tropical Gardens featuring a house

Key West Historic District

4.5/5(4,033 area reviews)

Old Town Key West boasts a rich history with 2485 historic buildings, and is home to popular attractions like Ernest Hemingway House and Mallory Square. Enjoy the lively atmosphere in the central business district.

Key West Historic District
Great location for great pictures, very nice beach

White Street Gallery District

When in White Street Gallery District, you can plan a visit to Duval Street and Clarence S. Higgs Memorial Beach Park, some noteworthy sights in the nearby area.

White Street Gallery District
See our Where To Stay guide

Uptown - Upper Duval, FL

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