Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Key West 4 Star Hotels

See all 321 Hotels in Key West
24 North Hotel Key West

24 North Hotel Key West

3820 North Roosevelt Boulevard, Key West
4.5 out of 5.0
4.1 out of 5 (1,067 reviews)
very nice hotel close enough to downtown key westlost my key card a couple times eh sh** happens right? they had no problem in replacing it cleaning always came while i was gone made everything look good and the beds are really comfortable
  Dec 12, 2017

$161

$161
Southernmost Beach Resort

Southernmost Beach Resort

1319 Duval Street, Key West
4.5 out of 5.0
4.5 out of 5 (3,114 reviews)
Nice hotel roomI purchased a superior queen room with a veranda but it looks at the back of the lobby. This is a very large resort be sure of the location of your room as it can vary greatly.
  Dec 15, 2017

$194

$194
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue, Key West
4.5 out of 5.0
4.5 out of 5 (311 reviews)
Amazing!!!Absolutely stunning hotel! Beautiful rooms, grounds, and views.
  Dec 12, 2017

$166

$166
Sheraton Suites Key West

Sheraton Suites Key West

2001 S Roosevelt Blvd, Key West
4.0 out of 5.0
4.3 out of 5 (2,094 reviews)
Nice hotelThis hotel is nice. The shuttle is very useful to go to downtown.
  Dec 12, 2017

$151

$151
Hilton Garden Inn Key West,The Keys Collection

Hilton Garden Inn Key West,The Keys Collection

3850 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.1 out of 5 (343 reviews)
Just 1 night.Check-in was quick. Didn't even fill anything out. Room was clean, well decorated, and quiet. Shower was great. Location is a bit out of the way, but trolley is just out front, and buy a trolley ticket if you want to get around, as downtown is NOT car friendly. Going back in a couple months, and ...
  Dec 13, 2017

$146

$146
The Gates Hotel Key West

The Gates Hotel Key West

3824 N Roosevelt Blvd, Key West
4.5 out of 5.0
4.3 out of 5 (1,076 reviews)
Nice Hotel -- Beautiful Poor and Bar AreaThe Gates is a nice hotel at the very north end of Key West. The have a shuttle that runs every hour or half hour depending on the time of day to get you down to the Mallory Square/Duval Street area. The pool and pool bar areas are beautiful and they have a sister property next door that gives you ...
  Dec 7, 2017

$169

$169
Silver Palms Inn

Silver Palms Inn

830 Truman Ave, Key West
4.0 out of 5.0
4.4 out of 5 (2,471 reviews)
Great location!Perfect location to be able to get to Duval St. You are a bit away from the action but it is very accessible. It is three blocks from Duval St and we felt safe walking. You can also rent bikes from the hotel which we perfect for exploring the island. I highly recommend the bikes. We could not have ...
  Dec 15, 2017

$179

$179
The Marker Waterfront Resort Key West

The Marker Waterfront Resort Key West

200 William Street, Key West
4.5 out of 5.0
4.5 out of 5 (853 reviews)
Great ResortValet parking is sweet, however know that there is a $30/day parking fee on top of the $35/day resort fee. Bar and restaurant highly priced so either plan to spend or find a cheaper venue. I would have stayed on the resort to enjoy cocktails around the pools if cheaper. Also, $80 for breakfast for ...
  Dec 12, 2017

$175

$175
Margaritaville Key West Resort & Marina

Margaritaville Key West Resort & Marina

245 Front Street, Key West
4.5 out of 5.0
4.3 out of 5 (170 reviews)
Beautiful hotel and experience We were given an upgrade for no apparent reason except good customer service and kindness. It was amazing! Thank you Margarittaville.... see you again for sure!!
  Dec 11, 2017

$231

$231
Heron House - Adult Only

Heron House - Adult Only

512 Simonton St, Key West
4.0 out of 5.0
4.3 out of 5 (1,507 reviews)
Very nice place to stay, close to everything in Key West. Rooms were very nice & clean. Staff very friendly and helpful. Great value.
  Nov 30, 2017

$149

$149
Map

The get-go of any much-needed holiday starts with selecting a spot. Key West has been a popular local with tourists because it offers so much to see and do. Yet, "location, location, location" applies to more than just your vacation destination. When you want to make your holiday especially memorable, it's all about where you start each new day.

Lodgings as Stunning as the City

Key West saw its fair share of visitors this past year. Our review section provides reviews which may help you choose which resort is ideal for your holiday. When you book a 4-star suite you can relax knowing that these properties aim to meet your needs. You won't need to search long for a refreshing swim, gourmet lunch, or to sustain your workout schedule during your vacation, thanks to everything these hotels provide. They aim to make the facilities and grounds welcoming from the moment you step out of your car and with every step throughout the hotel. Key West has dozens of marvelous hotels that create the absolute perfect holiday.

Rooms have been designed to keep your utmost comfort in mind, with amenities like ultra-comfortable bedding, and in-room coffee or tea, and designer bathroom products. So, lay back and unwind. Moreover, if you find that you are need of anything further, you can rest easy the staff will work their best to ensure you remain pleased during your stay. These properties are so lovely that you'll regret the day you have to check-out.

Book a 4-Star Hotel in Key West Today!

A holiday to Key West should be one that you'll recollect for years to come, and booking a 4-star hotel will help create memories that are nothing but fantastic. Make sure to book soon. With so few accommodations, and plenty of people desiring to travel to Key West, you may miss out on your perfect room.

Recently booked 4 Star Hotels in Key West

Southernmost Beach Resort
4.5 out of 5.0
Last booking: 4 minutes ago
Hyatt Centric Key West Resort and Spa
4.5 out of 5.0
Last booking: 9 minutes ago
Oceans Edge Key West Resort, Hotel & Marina
4.5 out of 5.0
Last booking: 29 minutes ago
Orchid Key Inn
4.0 out of 5.0
Last booking: 38 minutes ago
Seascape Inn
3.5 out of 5.0
Last booking: 46 minutes ago
Chelsea House Hotel - Key West
2.5 out of 5.0
Last booking: 51 minutes ago
Heron House - Adult Only
4.0 out of 5.0
Last booking: 2 hours ago
Almond Tree Inn
3.5 out of 5.0
Last booking: 2 hours ago
Coconut Mallory Resort And Marina By Kees Vacations
0.0 out of 5.0
Last booking: 2 hours ago