Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured St. Charles Independent Hotels

See all 241 Hotels in St. Charles
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

315 Chestnut St, St. Louis
4.0 out of 5.0
4.3 out of 5 (1,640 reviews)
Comfortable Very much enjoyed my stay at this hotel. The staff was welcoming and helpful. The room was extremel … - 

$119

$119
City Place St. Louis - Downtown Hotel

City Place St. Louis - Downtown Hotel

200 North 4th Street, St. Louis
3.5 out of 5.0
3.2 out of 5 (1,248 reviews)
Great location near the Arch and downtown Overall this was a fine place to stay. It is not a four or five star place but the rooms are HUGE a … - 

$93

$93
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive, Maryland Heights
3.5 out of 5.0
3.7 out of 5 (478 reviews)
Great Time. Enjoyed playing the games and listening ,watching the awesome performance of the Platinum Rock Lege … - 

$103

$103
Red Roof Inn St Louis - Westport

Red Roof Inn St Louis - Westport

11837 Lackland Rd, Maryland Heights
2.0 out of 5.0
3.0 out of 5 (280 reviews)
Safe place to stay! First night we checked in late and room was back side of the other building!!!What a story :) room … - 

$49

$49
HoteLumiere at the Arch

HoteLumiere at the Arch

999 N. 2nd St., St. Louis
4.0 out of 5.0
2.8 out of 5 (93 reviews)
Had never stayed here before - Got a good deal on a room - was nice to be so close to the casino - … - 

$125

$125
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

2211 Market Street, St. Louis
3.0 out of 5.0
4.3 out of 5 (500 reviews)
Good location, downtown. This was so much better than the last place I stayed in St. Louis. Good location just north of Unio … - 

$120

$120
Airport Plaza Inn & Conference Center

Airport Plaza Inn & Conference Center

4534 Long Road, Bridgeton
3.0 out of 5.0
3.1 out of 5 (771 reviews)
Stayed for one night, easy check in, check out. Room was clean, staff was very nice, breakfast was … - 

$69

$69
The Parkway Hotel

The Parkway Hotel

4550 Forest Park Ave, St. Louis
3.0 out of 5.0
4.2 out of 5 (474 reviews)
Great location The staff were very helpful. The room was clean and comfortable. - 

$139

$139
Clayton Plaza Hotel

Clayton Plaza Hotel

7750 Carondelet Avenue, St. Louis
3.5 out of 5.0
4.0 out of 5 (586 reviews)
Good Propert Confortable stay Hearty breakfast Nice clean rooms - 

$109

$109
The Hotel Majestic St. Louis

The Hotel Majestic St. Louis

1019 Pine St, St. Louis
4.0 out of 5.0
3.9 out of 5 (473 reviews)
Well maintained older hotel Great, friendly staff. Older hotel but well maintained. The rooms are small but comfortable and it … - 

$116

$116
St. Louis City Center Hotel

St. Louis City Center Hotel

400 S 14th St, St. Louis
3.5 out of 5.0
3.5 out of 5 (876 reviews)
Extremely convenient! We are Cards fan and travel yearly to St. Louis to see them play. As season ticket holder, we also … - 

$103

$103
Motel 6 Hazelwood

Motel 6 Hazelwood

5781 Campus Ct, Hazelwood
2.0 out of 5.0
3.2 out of 5 (312 reviews)
My room not available. After two hours finally the room I reserved. The rest of the weekend was fin … - 

$40

$40
Motel 6 Maryland Heights, MO

Motel 6 Maryland Heights, MO

12330 Dorsett Rd, Maryland Heights
2.0 out of 5.0
2.9 out of 5 (83 reviews)
A place to sleep Rooms needed a good cleaning and repairs. Bed was comfty and bathroom was clean - 

$31

$31
Pear Tree Inn Airport - St. Louis - St. Ann, MO

Pear Tree Inn Airport - St. Louis - St. Ann, MO

10810 Pear Tree Ln, St. Ann
2.5 out of 5.0
4.3 out of 5 (255 reviews)
One night near airport What a great spot. I was staying there because of a very, very, very early flight. I stopped in the … - 

$95

$95
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

2 South 4th Street, St. Louis
3.0 out of 5.0
4.6 out of 5 (870 reviews)
Can't beat it! Between the free "kick back" food and beverages, free breakfast, location, and overall comfort of t … - 

$150

$150
Hawthorn Suites by Wyndham St. Louis Westport Plaza

Hawthorn Suites by Wyndham St. Louis Westport Plaza

1881 Craigshire Rd, Maryland Heights
3.0 out of 5.0
4.2 out of 5 (171 reviews)
Great staff, facility and breakfast Loved it here. Very quiet - housekeeping wasn't great on a daily basis but it was initially clean. … - 

$82

$82
The Westin St. Louis

The Westin St. Louis

811 Spruce St, St. Louis
4.5 out of 5.0
4.6 out of 5 (910 reviews)
Westin I liked the location and how clean the room was. - 

$139

$139
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

1 Ameristar Blvd, St. Charles
4.5 out of 5.0
4.5 out of 5 (301 reviews)
Great hotel Nice clean hotel with friendly staff. The only complaint I have us that with all the restaurants do … - 

$134

$134
Hotel Avyan

Hotel Avyan

2625 Lafayette Ave, St. Louis
2.5 out of 5.0
3.6 out of 5 (160 reviews)
close to every thing we had trouble in the room but they moved us right away to an other room close by - 

$75

$75
La Quinta Inn & Suites St. Louis Airport - Riverport

La Quinta Inn & Suites St. Louis Airport - Riverport

13615 Riverport Drive, Maryland Heights
3.0 out of 5.0
4.0 out of 5 (191 reviews)
Great oasis Very pleasant experience,Good people,Good location,Exceptional service,Home away from home,Would re … - 

$84

$84
Map

Recently booked St. Charles hotels

Best Western Plus The Charles Hotel
3.0 out of 5.0
Last booking: 28 minutes ago
Super 8 St Charles
2.0 out of 5.0
Last booking: 2 hours ago
Comfort Suites
2.5 out of 5.0
Last booking: 6 hours ago
Americas Best Value Inn & Suites-St. Charles Inn/St. Louis
2.5 out of 5.0
Last booking: 7 hours ago
Fairfield by Marriott St Charles
2.5 out of 5.0
Last booking: 9 hours ago
Ameristar Casino Resort and Spa
4.5 out of 5.0
Last booking: 13 hours ago
Rodeway Inn Saint Charles
2.0 out of 5.0
Last booking: 22 hours ago
Wingate by Wyndham St. Charles MO
3.0 out of 5.0
Last booking: 25 hours ago
Embassy Suites St. Louis - St. Charles
3.5 out of 5.0
Last booking: 26 hours ago

Independent St. Charles Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in St. Charles, St. Louis. Known for well-appointed rooms and friendly, personalized service, each of the top Independent St. Charles hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some St. Charles Independent locations may even offer extra little benefits and discounts for frequent travelers.