Title: Mayesville Vacation Rentals from $250: Search Short-Term Rentals | Expedia.com

[Mayesville Travel Guide](https://expedia.com/Mayesville.dx3000456025)[Hotels in Mayesville](https://expedia.com/Mayesville-Hotels.d3000456025.Travel-Guide-Hotels)[Flights to Mayesville](https://expedia.com/Cheap-Flights-To-Mayesville.d3000456025.Travel-Guide-Flights)[Car Rentals in Mayesville](https://expedia.com/Car-Rentals-In-Mayesville.d3000456025.Car-Rental-Guide)[Mayesville Vacation Packages](https://expedia.com/Mayesville.d3000456025.Destination-Travel-Guides)

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## Check prices for these dates

In two weeks

[Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=3000456025&startDate=2026-02-27&endDate=2026-03-01&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=3000456025&startDate=2026-04-10&endDate=2026-04-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 8 - May 10](https://www.expedia.com/Hotel-Search?regionId=3000456025&startDate=2026-05-08&endDate=2026-05-10&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 5 - Jun 7](https://www.expedia.com/Hotel-Search?regionId=3000456025&startDate=2026-06-05&endDate=2026-06-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Find vacation rentals that suit your style

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Mayesville%2C+South+Carolina%2C+United+States+of+America&regionId=3000456025&latLong=33.987658%2C-80.208132&adults=2&startDate=2026-05-10&d1=2026-05-10&endDate=2026-05-13&d2=2026-05-13&lodging=APARTMENT)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Mayesville%2C+South+Carolina%2C+United+States+of+America&regionId=3000456025&latLong=33.987658%2C-80.208132&adults=2&startDate=2026-05-10&d1=2026-05-10&endDate=2026-05-13&d2=2026-05-13&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Mayesville%2C+South+Carolina%2C+United+States+of+America&regionId=3000456025&latLong=33.987658%2C-80.208132&adults=2&startDate=2026-05-10&d1=2026-05-10&endDate=2026-05-13&d2=2026-05-13&lodging=COTTAGE)

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## Top Mayesville Hotel Reviews

![Tru by Hilton Sumter](https://images.trvl-media.com/lodging/22000000/21320000/21314200/21314165/9f3c2a3f_y.jpg)

### Tru by Hilton Sumter

10/10 Excellent

"This hotel is modern, clean and in a great location. All the staff members were courteous and very helful during the snow storm. Highly recommended. "

[](https://expedia.com/Sumter-Hotels-Tru-By-Hilton-Sumter.h21314165.Hotel-Information)

![SureStay Hotel by Best Western Manning](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/e6b95688_y.jpg)

### SureStay Hotel by Best Western Manning

10/10 Excellent

"2nd time at this clean,comfortable establishment. Great job cleaning staff! The outside area is well maintained & clean. Staff friendly, and breakfast is provided which is appreciated and good."

[](https://expedia.com/Sumter-Hotels-SureStay-Hotel-By-Best-Western-Manning.h569301.Hotel-Information)

![Holiday Inn Express Sumter by IHG](https://images.trvl-media.com/lodging/2000000/1060000/1050300/1050239/67f6e033_y.jpg)

### Holiday Inn Express Sumter by IHG

10/10 Excellent

"The room was awesome, the complimentary breakfast delicious, and the staff was very helpful and super nice!"

[](https://expedia.com/Sumter-Hotels-Holiday-Inn-Express-Sumter.h1050239.Hotel-Information)

![Hyatt Place Sumter / Downtown](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514748/dfc7158d_y.jpg)

### Hyatt Place Sumter / Downtown

10/10 Excellent

"Great job "

[](https://expedia.com/Sumter-Hotels-Hyatt-Place-Sumter-Downtown.h22514748.Hotel-Information)

![Comfort Suites Sumter](https://images.trvl-media.com/lodging/1000000/50000/42900/42862/8963a411_y.jpg)

### Comfort Suites Sumter

10/10 Excellent

"The room was very clean. The staff was very professional. And engaging always willing and ready to help"

[](https://expedia.com/Sumter-Hotels-Comfort-Suites-Sumter.h42862.Hotel-Information)

![SpringHill Suites Sumter](https://images.trvl-media.com/lodging/9000000/8320000/8313500/8313401/d8d13945_y.jpg)

### SpringHill Suites Sumter

10/10 Excellent

"Yes spotless"

[](https://expedia.com/Sumter-Hotels-SpringHill-Suites-Sumter.h8313401.Hotel-Information)

![Baymont by Wyndham Manning](https://images.trvl-media.com/lodging/1000000/120000/119200/119159/2643428b_y.jpg)

### Baymont by Wyndham Manning

10/10 Excellent

"Clean. Good value. "

[](https://expedia.com/Sumter-Hotels-Baymont-By-Wyndham-Manning.h119159.Hotel-Information)

![Affordable Suites Sumter SC](https://images.trvl-media.com/lodging/3000000/2920000/2917500/2917461/634c117a_y.jpg)

### Affordable Suites Sumter SC

10/10 Excellent

"Had some issues with door keys constantly but overall decent nice place very quite and laid back"

[](https://expedia.com/Sumter-Hotels-Affordable-Suites-Sumter-SC.h2917461.Hotel-Information)

![Best Inn of Manning](https://images.trvl-media.com/lodging/121000000/120760000/120759500/120759451/1438b095_y.jpg)

### Best Inn of Manning

10/10 Excellent

"No complaints "

[](https://expedia.com/Manning-Hotels-Best-Inn-Of-Manning.h120759451.Hotel-Information)

## Find out more about Mayesville

**Everything you need to know about Mayesville vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Mayesville vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Mayesville vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Mayesville vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Mayesville. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Mayesville in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $250 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Mayesville rentals**

At Expedia, we put the best Mayesville vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Mayesville rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Mayesville vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Mayesville. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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- [Vacation Homes in Mayesville ](https://expedia.com/Mayesville-Private-Vacation-Homes.d3000456025-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Motels in Mayesville ](https://expedia.com/Mayesville-Motels.d3000456025-aaMotels.Travel-Guide-Accommodation)
- [Cottages in Mayesville ](https://expedia.com/Mayesville-Cottages.d3000456025-aaCottages.Travel-Guide-Accommodation)
- [Apartments in Mayesville ](https://expedia.com/Mayesville-Apartments.d3000456025-aaApartments.Travel-Guide-Accommodation)
- [Farmstay in Mayesville ](https://expedia.com/Mayesville-Agritourism.d3000456025-aaAgritourism.Travel-Guide-Accommodation)
- [B&B in Mayesville ](https://expedia.com/Mayesville-Bed-And-Breakfast.d3000456025-aaBedAndBreakfast.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find a vacation rental in Mayesville?

### What are some of the best vacation rentals that Mayesville has to offer?

### What can I see and do in Mayesville?

### What are vacation rentals like in Mayesville?

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