Title: Top 10 Hotels in Whetsell, SC from $63 - Competitive Prices | Expedia.com [Vacation Rentals in Whetsell](https://expedia.com/Whetsell-Vacation-Rentals.d553248635974902828.Travel-Guide-VacationRentals)[Car Rentals in Whetsell](https://expedia.com/Car-Rentals-In-Whetsell.d553248635974902828.Car-Rental-Guide)[Whetsell Vacation Packages](https://expedia.com/Whetsell.d553248635974902828.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Whetsell Pet-friendly [](https://www.expedia.com/Hotel-Search?destination=Whetsell%2C+South+Carolina%2C+United+States+of+America®ionId=553248635974902828&latLong=33.333771%2C-80.590096&adults=2&startDate=2026-03-11&d1=2026-03-11&endDate=2026-03-13&d2=2026-03-13&amenities=PETS) Pool [](https://www.expedia.com/Hotel-Search?destination=Whetsell%2C+South+Carolina%2C+United+States+of+America®ionId=553248635974902828&latLong=33.333771%2C-80.590096&adults=2&startDate=2026-03-11&d1=2026-03-11&endDate=2026-03-13&d2=2026-03-13&amenities=POOL) Great for families [](https://www.expedia.com/Hotel-Search?destination=Whetsell%2C+South+Carolina%2C+United+States+of+America®ionId=553248635974902828&latLong=33.333771%2C-80.590096&adults=2&startDate=2026-03-11&d1=2026-03-11&endDate=2026-03-13&d2=2026-03-13&travelerType=family_friendly) Condo [](https://www.expedia.com/Hotel-Search?destination=Whetsell%2C+South+Carolina%2C+United+States+of+America®ionId=553248635974902828&latLong=33.333771%2C-80.590096&adults=2&startDate=2026-03-11&d1=2026-03-11&endDate=2026-03-13&d2=2026-03-13&lodging=CONDO) ## Check prices for these dates Tonight [Feb 25 - Feb 26](https://www.expedia.com/Hotel-Search?regionId=553248635974902828&startDate=2026-02-25&endDate=2026-02-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 26 - Feb 27](https://www.expedia.com/Hotel-Search?regionId=553248635974902828&startDate=2026-02-26&endDate=2026-02-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=553248635974902828&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=553248635974902828&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Whetsell hotels ![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/278d9dc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/5f0b6fe1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/5ef3d5ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/6fa02d10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Santee by IHG [](https://www.expedia.com/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information) Santee 8.2/10 Very Good (1,000 reviews) "Everything was great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julie $119 nightly $132 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/6c8567ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/1f93ecf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/0af71c77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/7dca4a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Santee [](https://www.expedia.com/Orangeburg-Hotels-Econo-Lodge.h905358.Hotel-Information) Santee 6.4/10 (310 reviews) "Last minute arrangements stay was quiet and peaceful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Iasia $69 nightly $76 total Mar 11 - Mar 12 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Econo-Lodge.h905358.Hotel-Information) ![Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/fc94b516.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Queen Bed with Sofa bed, Non Smoking (Non Smoking/Interior Hall) | Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/91286f8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/0b55a618.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Santee [](https://www.expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) Santee 8.0/10 Very Good (1,013 reviews) "Clean rooms, nice staff, decent breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dale $101 nightly $112 total Mar 5 - Mar 6 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/8136c59d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/5b49de0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/9e846421.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/070e1043.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Santee [](https://www.expedia.com/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) Santee 6.6/10 (645 reviews) "A good option if traveling with pets. The hotel is clean and well maintained but dated. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen $63 nightly $70 total Mar 3 - Mar 4 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/cd0ca695.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/50891687.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/4c792a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/e77a8624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Santee I-95 [](https://www.expedia.com/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information) Santee 6.0/10 (477 reviews) "Clean room but needs an exhaust fan in the bathroom " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leesa $59 nightly $66 total Mar 3 - Mar 4 Total with taxes and fees [](https://www.expedia.com/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/d2da67e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/320acff9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/756b4cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee [](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) Santee 8.0/10 Very Good (1,424 reviews) "Room were very clean and staff was very helpful. I would stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charolette $80 nightly $89 total Feb 26 - Feb 27 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/044c704d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Jetted Tub | Desk, laptop workspace, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ec6d0d77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ab86ecd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Santee Inn [](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) Santee 8.8/10 Excellent (1,000 reviews) "Courteous reception,clean rooms and great breakfast! Have been there many times in the last 15 years and I will return.!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Roger $112 nightly $124 total Feb 26 - Feb 27 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/28717b40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/5b7ee831.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bathtub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/ebe97e99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/eeb5fa18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Santee [](https://www.expedia.com/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) Santee 7.0/10 Good (702 reviews) "Nice quiet room and a delicious breakfast at a reasonable rate." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joseph B $62 nightly $69 total Feb 26 - Feb 27 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/11da224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/40f69ad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/99021580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Santee [](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) Santee 9.2/10 Wonderful (732 reviews) "Large, clean room, friendly staff, nice breakfast. Would stay again. Also a nice Mexican restaurant nearby for dinner. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan $102 nightly $113 total Mar 4 - Mar 5 Total with taxes and fees [](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2fd60881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2262fc91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/77599f7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/dc3438b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Santee [](https://www.expedia.com/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information) Santee 6.8/10 (443 reviews) "The staff was very friendly and helpful. Room was clean and beds were so comfortable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathy $75 nightly $83 total Feb 26 - Feb 27 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information) ![Free breakfast](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/d82e6496.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/fcd98400.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking | Iron/ironing board, free cribs/infant beds, free rollaway beds](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/1ffbf2b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5472b058.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Santee-I-95 [](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) Santee 9.6/10 Exceptional (1,000 reviews) "Liked the size of the room, the staff and the breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Virginia $125 nightly $139 total Mar 3 - Mar 4 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/3029fb89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/d654e116.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/e78e5670.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Santee [](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) Santee 9.8/10 Exceptional (1,000 reviews) "Room had everything we wanted... very clean & fresh, microwave, fridge, comfy beds. Hotel was very nice and close to everything needed." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marcia $125 nightly $139 total Mar 3 - Mar 4 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/d34bd120.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/13247169.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/41ed20e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/2def81ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Santee I-95 [](https://www.expedia.com/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) Santee 6.4/10 (551 reviews) "The grounds and property were clean and you could tell they take pride in what they're offering." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric [](https://www.expedia.com/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) ![Panoramic Tent | Lake view](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/caef79e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Bedroom, Non Smoking, Lake View | Individually decorated, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/b0419165.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Tent | Living area](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/9123f55d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Bedroom, Non Smoking, Lake View | Living area](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/ee0f57db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bells Marina & Resort [](https://www.expedia.com/Eutawville-Hotels-Bells-Marina-Resort.h91244689.Hotel-Information) Eutawville 8.6/10 Excellent (90 reviews) "Super quaint, quiet, nice little get away." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen $108 nightly $120 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Eutawville-Hotels-Bells-Marina-Resort.h91244689.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/110000000/109320000/109319000/109318932/e17744ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/110000000/109320000/109319000/109318932/ad05322a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/110000000/109320000/109319000/109318932/38babe0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/110000000/109320000/109319000/109318932/515ae417.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Budget Inn By Belvilla St George I-95 [](https://www.expedia.com/Reevesville-Hotels-Budget-Inn-St-George-I-95.h109318932.Hotel-Information) St. George 7.6/10 Good (183 reviews) "This is a great value for a budget hotel. It's an older complex but clean and well maintained. It's close to decent food options for tired travelers and the front desk staff was pleasant and helpful. If you are looking for a convient, well priced stopover, I recommend this location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kim $65 nightly $72 total Mar 3 - Mar 4 Total with taxes and fees [](https://www.expedia.com/Reevesville-Hotels-Budget-Inn-St-George-I-95.h109318932.Hotel-Information) ![Room, 1 King Bed, Non Smoking | Premium bedding, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/e088653f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/a66aad1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/e85d0e8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/59cd1b4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham St George [](https://www.expedia.com/St-George-Hotels-Days-Inn-By-Wyndham-St-George.h18873.Hotel-Information) St. George 7.6/10 Good (1,000 reviews) "Clean, relaxing, friendly staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Smith $100 nightly $111 total Feb 26 - Feb 27 Total with taxes and fees [](https://www.expedia.com/St-George-Hotels-Days-Inn-By-Wyndham-St-George.h18873.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/c1880a3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/efa2345e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/3a41c72c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hair dryer, towels](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/bc8b5a93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Peach Tree Inn [](https://www.expedia.com/St-George-Hotels-Peach-Tree-Inn.h2911319.Hotel-Information) St. George 7.4/10 Good (169 reviews) "Clean rooms and pleasant staff. Could use newer towels. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patricia $68 nightly $73 total Feb 26 - Feb 27 Total with taxes and fees [](https://www.expedia.com/St-George-Hotels-Peach-Tree-Inn.h2911319.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/7000000/6140000/6132900/6132858/c62bc9b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6140000/6132900/6132858/43fe19ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/7000000/6140000/6132900/6132858/815a509d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/7000000/6140000/6132900/6132858/4d4cc6a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Saint George, SC – I-95 [](https://www.expedia.com/St-George-Hotels-Knights-Inn-Saint-George.h6132858.Hotel-Information) St. George 6.6/10 (191 reviews) "The room is clean and a nice size ,water was hot for a nice relaxing shower.The bed is very comfortable Just wish had a coffee maker in room .very friendly check in .would definitely recommend." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janice $64 nightly $71 total Feb 26 - Feb 27 Total with taxes and fees [](https://www.expedia.com/St-George-Hotels-Knights-Inn-Saint-George.h6132858.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/890000/889300/889204/666bcafd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/890000/889300/889204/f02ed3ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/890000/889300/889204/e5d82d39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/890000/889300/889204/e2987c1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge St. George [](https://www.expedia.com/St-George-Hotels-Econo-Lodge-St-George.h889204.Hotel-Information) St. George 6.4/10 (266 reviews) "It was nice all together " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marcia $59 nightly $63 total Mar 11 - Mar 12 Total with taxes and fees [](https://www.expedia.com/St-George-Hotels-Econo-Lodge-St-George.h889204.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/57000000/56230000/56228900/56228813/962a9377.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, 1 King Bed, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/57000000/56230000/56228900/56228813/11ccce69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/57000000/56230000/56228900/56228813/d3f2bbda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/57000000/56230000/56228900/56228813/27b2c420.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn St George, SC [](https://www.expedia.com/Walterboro-St-George-Hotels-Red-Roof-Inn-St-George.h56228813.Hotel-Information) St. George 7.4/10 Good (656 reviews) "Breakfast was an overstatement!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nicki $75 nightly $84 total Mar 2 - Mar 3 Total with taxes and fees [](https://www.expedia.com/Walterboro-St-George-Hotels-Red-Roof-Inn-St-George.h56228813.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-11&endDate=2026-03-12®ionId=553248635974902828&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=HTG_SPRING_PROMO_553248635974902828) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FWhetsell-Hotels.d553248635974902828.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FWhetsell-Hotels.d553248635974902828.Travel-Guide-Hotels) ## Top Whetsell Hotel Reviews ![Baymont by Wyndham Santee](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3_y.jpg) ### Baymont by Wyndham Santee 10/10 Excellent "The lady at the check in was so sweet. True definition of southern hospitality & charm. She could put sweet tea to shame. The room was clean, cozy, and quiet. Though I didn’t get to stay the full night I thoroughly enjoyed my time while I was there. Will definitely be back. And give that sweet lady a raise, promotion and more please and thank you. " [](https://expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Comfort Inn & Suites Santee](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e_y.jpg) ### Comfort Inn & Suites Santee 10/10 Excellent "Staff was friendly, room was clean, pleasant stay. " [](https://expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Holiday Inn Santee by IHG](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/c82722a1_y.jpg) ### Holiday Inn Santee by IHG 10/10 Excellent "Ashley at the front desk was amazing. Personable and professional…she’s a keeper !!!" [](https://expedia.com/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information) ![Fairfield Inn & Suites by Marriott Santee](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb_y.jpg) ### Fairfield Inn & Suites by Marriott Santee 10/10 Excellent "The room was spacious. " [](https://expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Best Western Plus Santee Inn](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/6d1459c3_y.jpg) ### Best Western Plus Santee Inn 10/10 Excellent "Room was nice, clean and convenient. Great breakfast." [](https://expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Fairfield Inn by Marriott Orangeburg](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/aa173c27_y.jpg) ### Fairfield Inn by Marriott Orangeburg 10/10 Excellent "Fine" [](https://expedia.com/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information) ![Hampton Inn Santee-I-95](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276_y.jpg) ### Hampton Inn Santee-I-95 10/10 Excellent "Very clean amenities " [](https://expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Tru By Hilton Santee](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/5c693db6_y.jpg) ### Tru By Hilton Santee 10/10 Excellent "No frills but comfortable, clean, modern establishment with friendly, welcoming staff. Better than most conveniently situated motels near 95\. Good value. " [](https://expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Days Inn by Wyndham St George](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/2eadf4bd_y.jpg) ### Days Inn by Wyndham St George 10/10 Excellent "Staff was nice. Room was clean. Great location." [](https://expedia.com/St-George-Hotels-Days-Inn-By-Wyndham-St-George.h18873.Hotel-Information) ## More cheap stays in Whetsell ![Baymont by Wyndham Santee](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Baymont by Wyndham Santee 249 Britain Street Santee SC $80 nightly $89 total Feb 26 - Feb 27 Total with taxes and fees 8/10 Very Good! (1,424 reviews) [](https://expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Fairfield Inn by Marriott Orangeburg](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/aa173c27_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Fairfield Inn by Marriott Orangeburg 663 Citadel Road Orangeburg SC $84 nightly $93 total Mar 5 - Mar 6 Total with taxes and fees 8.4/10 Very Good! (728 reviews) [](https://expedia.com/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information) ![Days Inn by Wyndham St George](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/2eadf4bd_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn by Wyndham St George 139 Motel Dr St. George SC $100 nightly $111 total Feb 26 - Feb 27 Total with taxes and fees 7.6/10 Good! (1,000 reviews) [](https://expedia.com/St-George-Hotels-Days-Inn-By-Wyndham-St-George.h18873.Hotel-Information) ![Tru By Hilton Santee](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/5c693db6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Tru By Hilton Santee 263 Britain St. and 273 Britain St. Santee SC $102 nightly $113 total Mar 4 - Mar 5 Total with taxes and fees 9.2/10 Wonderful! (732 reviews) [](https://expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Fairfield Inn & Suites by Marriott Santee](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Fairfield Inn & Suites by Marriott Santee 9074 Old Number Six Hwy Santee SC $125 nightly $139 total Mar 3 - Mar 4 Total with taxes and fees 9.8/10 Exceptional! (1,000 reviews) [](https://expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Hampton Inn Santee-I-95](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Santee-I-95 9060 Old Number Six Hwy Santee SC $125 nightly $139 total Mar 3 - Mar 4 Total with taxes and fees 9.6/10 Exceptional! (1,000 reviews) [](https://expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ## Hotels in Whetsell with star-rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 1 properties [](https://expedia.com/4Star-Whetsell-Hotels.s40-0-d553248635974902828.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 6 properties [](https://expedia.com/3Star-Whetsell-Hotels.s30-0-d553248635974902828.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 41 properties [](https://expedia.com/2Star-Whetsell-Hotels.s20-0-d553248635974902828.Travel-Guide-Filter-Hotels) ## Frequently asked questions ### What is the best area to stay in Whetsell? > This area is the heart of Whetsell, offering a blend of historic architecture and modern amenities. Main Street is lined with local shops, art galleries, and diverse dining options, leading down to the scenic Riverwalk along the Whetsell River. It's a very walkable district, making it convenient for exploring on foot. > > > Couples will find the Historic Downtown ideal for a refined and relaxing getaway. The area offers boutique hotels, intimate restaurants, and easy access to cultural attractions like the Whetsell Art Museum and evening strolls along the Riverwalk, which features beautifully maintained gardens and public art installations. > > > For solo travelers looking for convenience and a central base, the Historic Downtown also provides excellent options. ### When is the best time to go to Whetsell? > During spring, temperatures are mild, typically ranging from the low 60s to mid-70s Fahrenheit. This period is ideal for enjoying the blooming gardens and taking part in local festivals without the intense heat and humidity of summer. Travelers who enjoy comfortable weather for walking and sightseeing will find this time particularly appealing. > > > Fall also offers comfortable temperatures, generally from the low 60s to high 70s Fahrenheit, along with lower humidity. The changing foliage provides a scenic backdrop for exploring the area's natural beauty, such as the trails around Lake Whetsell. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Whetsell hotel booking with Expedia? > \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo. ### How much is the nightly rate at a Whetsell hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Providence Hotels ](https://www.expedia.com/Providence-Hotels.d553248635975849205.Travel-Guide-Hotels) - [Bowman Hotels ](https://www.expedia.com/Bowman-Hotels.d553248634998681915.Travel-Guide-Hotels) - [4 Star Hotels in Bowman ](https://www.expedia.com/4Star-Bowman-Hotels.s40-0-d553248634998681915.Travel-Guide-Filter-Hotels) - [Reevesville Hotels ](https://www.expedia.com/Reevesville-Hotels.d553248634998787689.Travel-Guide-Hotels) - [St. George Hotels ](https://www.expedia.com/St-George-Hotels.d183948.Travel-Guide-Hotels) - [Holly Hill Hotels ](https://www.expedia.com/Holly-Hill-Hotels.d3000455972.Travel-Guide-Hotels) - [Pet-Friendly Hotels in St. George ](https://www.expedia.com/St-George-Hotels-Pet-Friendly-Hotel.0-0-d183948-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - 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