$178 Cheap United flights San Francisco (SFO) to Des Moines (DSM)

Landing cheap one-way United Airlines flights from SFO to DSM from $178 on Expedia is simple — just filter by "Price (lowest to highest)." Alternatively, check out our affordable return fares from $247 for your next adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Start searching one to three months before your departure to find cheaper fares on United Airlines flights from San Francisco Intl. Airport (SFO) to Des Moines Intl. Airport (DSM). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Get your timing spot on, and you can enjoy significant savings on domestic journeys.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Filter your results by "Early Morning" and "Morning" to find the earliest flights from SFO to DSM. Heading off early means you're 20% less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Depart from SFO to DSM with United Airlines and enjoy a range of perks starting with a rewarding loyalty program. When you book through Expedia as a United Mileage Plus and One Key™ member, you may also earn OneKeyCash™* to redeem on select future travel purchases.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.