Photo by Rebecca Friedland

Find hotels near UCSF Mission Bay, San Francisco from $105

Start date: Check-in selected.
To Date
End date: Check-out
  • Upfront pricing

    Our total price for your stay includes taxes and fees
  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for UCSF Mission Bay hotels

LUMA Hotel San Francisco

LUMA Hotel San Francisco
4.0 star property
0.4 mi from UCSF Mission Bay
9.6 out of 10, Exceptional, (2391)
"Staff were so nice, the rooms were clean will definitely come back "
United States
Karla
$195 nightly
The price is $230
Dec 24 - Dec 25
Total with taxes and fees
LUMA Hotel San Francisco

Galleria Park Hotel

Galleria Park Hotel
4.0 star property
Financial District, 1.6 mi from UCSF Mission Bay
9.6 out of 10, Exceptional, (1012)
"I had a great stay. The room was nice, the bed was comfortable, and the staff were very helpful."
United States
Luke
$153 nightly
The price is $180
Dec 25 - Dec 26
Total with taxes and fees
Galleria Park Hotel

Orchard Garden Hotel

Orchard Garden Hotel
4.0 star property
Chinatown, 1.7 mi from UCSF Mission Bay
9.6 out of 10, Exceptional, (1004)
"Had a really good time here the room was so comfortable and there’s lots to eat in the neighborhood and very walkable. The staff was so sweet and had good recommendations "
United States
Natasha
$125 nightly
The price is $146
Jan 3 - Jan 4, 2026
Total with taxes and fees
Orchard Garden Hotel

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square
3.5 star property
1.6 mi from UCSF Mission Bay
9.4 out of 10, Exceptional, (3093)
"Great hotel, great location, super friendly all staff "
Mexico
Claudia
$89 nightly
The price is $105
Dec 24 - Dec 25
Total with taxes and fees
Chancellor Hotel on Union Square

Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA
4.0 star property
South of Market, 1.4 mi from UCSF Mission Bay
9.4 out of 10, Exceptional, (1303)
"Very nice and view was incredible "
United States
Morgan
$191 nightly
The price is $225
Jan 1 - Jan 2, 2026
Total with taxes and fees
Hyatt Regency San Francisco Downtown SOMA

The St. Regis San Francisco

The St. Regis San Francisco
5.0 star property
South of Market, 1.3 mi from UCSF Mission Bay
9.4 out of 10, Exceptional, (696)
"Impeccable service; nice room, overall great experience"
United States
Karla
$407 nightly
The price is $480
Dec 26 - Dec 27
Total with taxes and fees
The St. Regis San Francisco

citizenM San Francisco Union Square

citizenM San Francisco Union Square
4.0 star property
Union Square, 1.4 mi from UCSF Mission Bay
9.4 out of 10, Exceptional, (1431)
"Great service, great room!!"
United States
Arlindo
$119 nightly
The price is $140
Dec 24 - Dec 25
Total with taxes and fees
citizenM San Francisco Union Square

Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco
5.0 star property
South of Market, 1.4 mi from UCSF Mission Bay
9.4 out of 10, Exceptional, (1005)
"Clean rooms , Safety and helpful staff members "
United States
Christina
$385 nightly
The price is $453
Dec 28 - Dec 29
Total with taxes and fees
Four Seasons Hotel San Francisco

Hotel Nikko San Francisco

Hotel Nikko San Francisco
4.5 star property
Union Square, 1.5 mi from UCSF Mission Bay
9.4 out of 10, Exceptional, (2658)
"Great service, great location, great hotel. "
United States
Laura
$191 nightly
The price is $225
Jan 4 - Jan 5, 2026
Total with taxes and fees
Hotel Nikko San Francisco

Hyatt Place San Francisco Downtown

Hyatt Place San Francisco Downtown
3.0 star property
0.7 mi from UCSF Mission Bay
9.2 out of 10, Wonderful, (1880)
"Great stay. "
United States
Jon
$169 nightly
The price is $199
Dec 24 - Dec 25
Total with taxes and fees
Hyatt Place San Francisco Downtown

Hotel VIA

Hotel VIA
4.0 star property
0.7 mi from UCSF Mission Bay
9.2 out of 10, Wonderful, (1505)
"The staff was amazing and made my stay feel good. "
United States
Omaly
$161 nightly
The price is $190
Dec 25 - Dec 26
Total with taxes and fees
Hotel VIA

InterContinental San Francisco by IHG

InterContinental San Francisco by IHG
4.0 star property
South of Market, 1.1 mi from UCSF Mission Bay
9.2 out of 10, Wonderful, (1036)
"Great stay as always "
United States
JoAnn
$191 nightly
The price is $225
Dec 25 - Dec 26
Total with taxes and fees
InterContinental San Francisco by IHG

The Clancy, Autograph Collection by Marriott

The Clancy, Autograph Collection by Marriott
4.0 star property
South Park, 1.2 mi from UCSF Mission Bay
9.2 out of 10, Wonderful, (1004)
"cleanliness,good service, convenient location"
United States
Harry
$195 nightly
The price is $230
Dec 29 - Dec 30
Total with taxes and fees
The Clancy, Autograph Collection by Marriott

Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco
5.0 star property
Financial District, 1.5 mi from UCSF Mission Bay
9.2 out of 10, Wonderful, (1005)
"Just a spectacular place to stay! Beautifully appointed. All staff were very friendly and accommodating We will definitely be back!"
United States
Mandana
$269 nightly
The price is $317
Jan 2 - Jan 3, 2026
Total with taxes and fees
Palace Hotel, a Luxury Collection Hotel, San Francisco

Beacon Grand, A Union Square Hotel

Beacon Grand, A Union Square Hotel
4.0 star property
Union Square, 1.6 mi from UCSF Mission Bay
9.2 out of 10, Wonderful, (1819)
"Amazing place"
Australia
David
$172 nightly
The price is $203
Jan 5 - Jan 6, 2026
Total with taxes and fees
Beacon Grand, A Union Square Hotel

The Clift Royal Sonesta San Francisco

The Clift Royal Sonesta San Francisco
4.0 star property
1.6 mi from UCSF Mission Bay
9.2 out of 10, Wonderful, (1368)
"Staff was amazing. The rooms felt clean and the hotel was very well maintained."
United States
Misty
$182 nightly
The price is $214
Jan 5 - Jan 6, 2026
Total with taxes and fees
The Clift Royal Sonesta San Francisco

Inn At Union Square

Inn At Union Square
3.5 star property
1.6 mi from UCSF Mission Bay
9.2 out of 10, Wonderful, (1012)
"Everything was perfect location staff room and that continental breakfast was delicious Thankyou "
United Kingdom
robert
$140 nightly
The price is $165
Jan 4 - Jan 5, 2026
Total with taxes and fees
Inn At Union Square

Taj Campton Place

Taj Campton Place
5.0 star property
Union Square, 1.6 mi from UCSF Mission Bay
9.2 out of 10, Wonderful, (1003)
"Wonderful Staff and hospitality."
United States
Rachel
$208 nightly
The price is $244
Dec 25 - Dec 26
Total with taxes and fees
Taj Campton Place

Canopy by Hilton San Francisco SoMa

Canopy by Hilton San Francisco SoMa
4.0 star property
South Park, 1.1 mi from UCSF Mission Bay
9.0 out of 10, Wonderful, (1004)
"Good room , good service, good location "
United States
Albina
$147 nightly
The price is $173
Dec 30 - Dec 31
Total with taxes and fees
Canopy by Hilton San Francisco SoMa

W San Francisco

W San Francisco
4.5 star property
South Park, 1.2 mi from UCSF Mission Bay
9.0 out of 10, Wonderful, (1008)
"Great location and good accommodations "
United States
Michael
$189 nightly
The price is $222
Dec 29 - Dec 30
Total with taxes and fees
W San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top UCSF Mission Bay Hotel Reviews

Hotels near other UCSF Mission Bay attractions

Frequently asked questions

What are the top-rated hotels near UCSF Mission Bay?
Discovering the top-rated hotels near UCSF Mission Bay ensures a delightful stay in San Francisco for travelers seeking comfort and convenience.

Omni San Francisco Hotel

Omni San Francisco Hotel is a luxurious 4.5-star hotel located just 2.1 miles from UCSF Mission Bay, with an outstanding review rating of 9.6. Guests can indulge in a range of amenities including 24-hour fitness facilities, in-room massage services, and premium bedding for a restful night. The hotel features designer toiletries and plush bathrobes, ensuring a comfortable stay. With valet parking and electric car charging stations, accessibility is a priority for travelers.

Orchard Garden Hotel

The Orchard Garden Hotel, rated 9.6 by travelers, is a charming 4-star hotel situated 2.4 miles from UCSF Mission Bay. Guests are treated to a rooftop terrace and a lovely garden, perfect for relaxation after a day of exploring the city. With daily housekeeping and a concierge service, the hotel ensures a seamless experience. Premium bedding and designer toiletries enhance comfort, while nearby fitness facilities and shopping options offer convenience for every traveler.

LUMA Hotel San Francisco

LUMA Hotel San Francisco is a modern 4-star hotel located just a short 6-minute walk from UCSF Mission Bay, earning a stellar review rating of 9.6. This hotel features elegant Frette Italian sheets and air conditioning for a refreshing stay. Guests can take advantage of valet parking and accessible fitness facilities. With a focus on comfort, the hotel also provides premium bedding and designer toiletries, making it a top choice for travelers.
What hotels are within walking distance to UCSF Mission Bay?
Discover exceptional hotels perfect for your stay near UCSF Mission Bay, whether you're looking for top-rated comfort or convenient amenities.

LUMA Hotel San Francisco

LUMA Hotel San Francisco, rated 9.6 by travelers, is a stylish 4-star hotel just a 6-minute walk from UCSF Mission Bay. Guests enjoy luxurious touches such as Frette Italian sheets and designer toiletries in stylish rooms. The hotel also features daily housekeeping, a fitness center, and valet parking, ensuring a comfortable stay. With its traditional design and climate control amenities, it's a perfect retreat for travelers seeking elegance and convenience.

Hotel VIA

Hotel VIA offers a vibrant stay with a review rating of 9.2 and is located a 14-minute walk from UCSF Mission Bay. This 4-star hotel boasts a stunning rooftop terrace and a fitness center, ideal for relaxation and workouts. Guests appreciate the comfortable accommodations featuring premium bedding and designer toiletries. The hotel also provides convenient amenities such as valet parking and a snack bar, making it a popular choice for visitors to the area.

Hyatt Place San Francisco Downtown

Hyatt Place San Francisco Downtown is a reliable option with a review rating of 9.2, situated 14 minutes away from UCSF Mission Bay. This 3-star hotel offers daily housekeeping and complimentary breakfast, ensuring a pleasant start to the day. Guests can unwind on the terrace or take advantage of convenient self-parking options. With its focus on comfort and accessibility, it caters to travelers looking for a balanced stay in the heart of San Francisco.
How much is a hotel near UCSF Mission Bay?
Staying near UCSF Mission Bay is a treat, with plenty of hotels from $105 offering incredible amenities. If you're leaning toward a little luxury, prices can rise, especially in peak season. Be sure to book in advance to enjoy more options and potentially better rates, especially if you're planning a vacation during weekends or around public holidays.
What are the most popular family-friendly hotels near UCSF Mission Bay?
For families seeking top-rated accommodations near UCSF Mission Bay, these hotels offer family-friendly amenities and a welcoming atmosphere for all ages.

Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco is a luxurious 5-star retreat just 1.8 miles from UCSF Mission Bay, rated 9.4 by travelers. This family-friendly hotel features connecting rooms and a supervised childcare service, ensuring a comfortable stay for families. Guests will appreciate the outdoor pool, daily housekeeping, and kids' meals available at the on-site restaurant, making it a perfect choice for families with young children.

Argonaut Hotel

Argonaut Hotel, a delightful 4.5-star hotel located 3.5 miles from UCSF Mission Bay, boasts an impressive review rating of 9.4. This hotel caters to families with amenities such as free cribs and a range of children's toys and games. Guests can enjoy daily housekeeping, a spa, and valet parking, all while being close to the vibrant waterfront, perfect for family outings.

Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf is a charming 4-star hotel situated 3.3 miles from UCSF Mission Bay, with an excellent review rating of 9.0. Families will find this hotel welcoming, featuring connecting rooms, a playground, and an arcade game room for entertainment. Additional amenities include an outdoor pool, complimentary breakfast for children, and a garden area, making it an excellent choice for family travelers.
Are there any 5-star hotels near UCSF Mission Bay?
Exploring top-rated 5-star hotels near UCSF Mission Bay is a fantastic way to enhance any visit to San Francisco.

Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco offers an exceptional stay just 1.8 miles from UCSF Mission Bay, with a remarkable review rating of 9.4. This 5-star hotel provides a luxurious experience with amenities such as a full-service spa, wellness classes like yoga, and a beautiful terrace for relaxation. Guests can indulge in 24-hour room service and enjoy the soothing spa treatments, including massages and body wraps, ensuring a rejuvenating stay.

1 Hotel San Francisco

1 Hotel San Francisco, situated 2.3 miles from UCSF Mission Bay, is renowned for its eco-friendly luxury, achieving a review rating of 9.2. This 5-star hotel captivates travelers with its rooftop garden and views of the water. The hotel offers a variety of wellness treatments at the spa, alongside a fitness center and private hot tubs. Unique features such as a hydrotherapy treatment room and aromatherapy treatments create an inviting atmosphere for relaxation.

The Ritz-Carlton, San Francisco

The Ritz-Carlton, San Francisco, located 2.0 miles from UCSF Mission Bay, is another splendid choice with a review rating of 9.4. This distinguished 5-star hotel features elegant rooms, with premium bedding and designer toiletries. Guests can unwind at the full-service spa or enjoy delicious meals at the on-site restaurant. The hotel also provides valet parking and has a lovely garden area, adding to its charm.
Which hotels near UCSF Mission Bay offer the best views?
Discovering the ideal hotels with stunning views near UCSF Mission Bay can elevate your San Francisco experience.

Argonaut Hotel

With a travelers' rating of 9.4, the Argonaut Hotel is a charming 4.5-star hotel located 3.5 miles from UCSF Mission Bay. Nestled by the waterfront, it features ocean views and is near iconic historic sites. Guests can unwind at the on-site spa or enjoy a meal at the restaurant while taking in the beautiful surroundings. The hotel also offers valet parking and a 24-hour fitness center, ensuring a convenient and enjoyable stay for all.

1 Hotel San Francisco

Rated by travelers at an impressive 9.2, 1 Hotel San Francisco is a luxurious 5-star retreat located just 2.3 miles from UCSF Mission Bay. This hotel boasts a rooftop garden and private balconies with ocean views, offering travelers a perfect spot to relax. Travelers can indulge in the full-service spa featuring hydrotherapy treatments and Swedish massages, or take advantage of the fitness center accessible 24 hours. With amenities like valet parking and a tranquil hot tub, this hotel perfectly combines comfort and scenic beauty.

Hotel Zephyr San Francisco

Hotel Zephyr San Francisco is a vibrant 4-star hotel rated 8.6 by travelers, located 3.2 miles from UCSF Mission Bay. This hotel offers mesmerizing ocean views, perfect for watching the sunset. Guests can enjoy a range of amenities including a fitness center open 24 hours and outdoor spaces for relaxation. The hotel also features a game room and is close to local attractions, making it an exciting stay for those looking to explore the city.
What are the best affordable hotels near UCSF Mission Bay?
For travelers seeking affordable yet top-rated hotels near UCSF Mission Bay, there are several excellent options that promise comfort and convenience.

Star Motel

Star Motel is a budget-friendly choice located just 3.9 miles from UCSF Mission Bay, offering travelers a remarkable review rating of 9.6. Guests can enjoy complimentary toiletries and free WiFi, ensuring a comfortable stay. The motel also features various parking options, including secured and covered self-parking, making it easy for those traveling with vehicles.

Holiday Inn Express and Suites Fisherman's Wharf by IHG

Situated only 3.3 miles from UCSF Mission Bay, Holiday Inn Express and Suites is a 3-star hotel with a great traveler rating score of 9.2. This family-friendly hotel offers free breakfast daily and cribs upon request, making it ideal for travelers traveling with children. Additional amenities include free WiFi and valet parking, ensuring a straightforward experience for all travelers.

Marriott Vacation Club®, San Francisco

Marriott Vacation Club®, located just 3.1 miles from UCSF Mission Bay, boasts a review rating of 9.2 and is perfect for those seeking a comfortable stay. This 3-star hotel offers complimentary WiFi and toiletries, along with accessible fitness facilities and premium bedding for a restful night. Families will appreciate the availability of cribs and connecting rooms, making it a versatile choice for any traveler.
What are the best boutique hotels near UCSF Mission Bay?
For those seeking delightful boutique hotels near UCSF Mission Bay, San Francisco offers some top-rated options that combine charm and comfort.

Hotel Emblem San Francisco

Hotel Emblem San Francisco is a vibrant 4-star boutique hotel located a mere 2.0 miles from UCSF Mission Bay, receiving a remarkable review rating of 9.4 from travelers. This family-friendly haven features convenient amenities such as valet parking and onsite mountain biking, making it ideal for adventure seekers. Guests will appreciate the boutique charm and the close nearby local shopping and dining.

Taj Campton Place

Taj Campton Place stands out as a luxurious 5-star boutique hotel, situated just 1.8 miles from UCSF Mission Bay, with an impressive travelers' rating of 9.2. This romantic escape offers 24-hour room service and premium bedding for a plush stay. Guests can enjoy the waterfront views, and enjoy nearby windsurfing and beach activities, ensuring a memorable stay.
Are there any hotels with pools close to UCSF Mission Bay?
Finding the perfect hotel with a pool near UCSF Mission Bay is a breeze with these top-rated options that cater to your relaxation needs.

Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf is a stylish 4-star hotel just 3.3 miles from UCSF Mission Bay. This hotel, rated 9.0 by travelers, features a shared outdoor pool with umbrellas and sun loungers, perfect for a refreshing dip. Guests enjoy amenities such as free cribs, a 24-hour fitness center, and a variety of fun activities for children, making it an excellent choice for family-friendly accommodation.

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf is a 4-star hotel located just 3.2 miles from UCSF Mission Bay, featuring a heated outdoor pool with sun loungers and umbrellas, perfect for relaxation. Rated 9.0 by travelers, this hotel also offers complimentary buffet breakfast and a fitness center accessible 24 hours a day. Guests can enjoy a traditional design and are just a short distance from the beach.

Soma House

Soma House is a cozy 3.5-star accommodation situated 2.0 miles from UCSF Mission Bay. With a review rating of 7.6, it boasts an outdoor pool with sun loungers and a secure environment, ideal for families and relaxation. Guests appreciate the complimentary breakfast and valet parking, ensuring a convenient and comfortable stay.
What are the best pet-friendly hotels near UCSF Mission Bay?
For travelers looking for top-rated pet-friendly hotels near UCSF Mission Bay, San Francisco offers some wonderful options that welcome both you and your furry friends.

InterContinental Mark Hopkins by IHG

InterContinental Mark Hopkins is a luxurious 4-star hotel located just 2.2 miles from UCSF Mission Bay, a remarkable travelers' rating of 9.2. This elegantly designed hotel welcomes pets with thoughtful amenities like food and water bowls, ensuring a comfortable stay for both travelers and their furry companions. Enjoy additional features such as a historic ambiance, valet parking, and a fitness center, making it a great choice for a memorable visit.

The Clift Royal Sonesta San Francisco

The Clift Royal Sonesta San Francisco, a stunning 4-star hotel located only 2.1 miles from UCSF Mission Bay, features an impressive travelers' rating of 9.2. This pet-friendly hotel allows dogs and offers amenities like food and water bowls to accommodate your furry friends. Guests can enjoy a range of services, including 24-hour fitness facilities, unique boutique shopping nearby, and comfortable accommodations, ensuring a pleasant stay in the heart of the city.

Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf is a charming 4-star hotel situated 3.3 miles from UCSF Mission Bay, with a strong travelers' rating of 9.0. This pet-friendly haven offers essential amenities for pets, including food and water bowls, ensuring your pet feels right at home. Guests can take advantage of the outdoor pool, fitness facilities, and a beautiful terrace, making this hotel a delightful place to relax after exploring the nearby attractions.
Can I book a fully refundable hotel close to UCSF Mission Bay?
Most bookings on Expedia are refundable if canceled within 24-48 hours of arrival, though this depends on the hotel's individual cancellation policy, which you should check in your booking confirmation. If free cancellation is available, you can cancel directly through your Expedia account by going to "My Trips" and selecting your reservation. To find fully refundable hotel options, simply enter "UCSF Mission Bay", set your travel dates, and use the "Fully refundable" filter under "Deals & Discounts" on the results page. Alternatively, explore deals with free cancellation options on Expedia.
Can I find Expedia discounts for hotels near UCSF Mission Bay?
To look for discounts on hotels near UCSF Mission Bay, join One Key™—our free travel rewards program. One Key members always get our best prices and earn OneKeyCash™* on eligible bookings for every dollar spent. Another way to save is by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

Explore a world of travel with Expedia